LOCUS       NM_183037               3132 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus tripartite motif-containing 46 (Trim46), transcript
            variant 2, mRNA.
ACCESSION   NM_183037 XM_355447
VERSION     NM_183037.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3132)
  AUTHORS   Melton,A.J., Palfini,V.L., Ogawa,Y., Oses Prieto,J.A.,
            Vainshtein,A., Burlingame,A.L., Peles,E. and Rasband,M.N.
  TITLE     TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not
            Axon Specification or Axon Initial Segment Formation
  JOURNAL   J Neurosci 44 (42), e0976242024 (2024)
   PUBMED   39251352
  REMARK    GeneRIF: TRIM46 Is Required for Microtubule Fasciculation In Vivo
            But Not Axon Specification or Axon Initial Segment Formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3132)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3132)
  AUTHORS   Bell,M., Bachmann,S., Klimek,J., Langerscheidt,F. and Zempel,H.
  TITLE     Axonal TAU Sorting Requires the C-terminus of TAU but is
            Independent of ANKG and TRIM46 Enrichment at the AIS
  JOURNAL   Neuroscience 461, 155-171 (2021)
   PUBMED   33556457
  REMARK    GeneRIF: Axonal TAU Sorting Requires the C-terminus of TAU but is
            Independent of ANKG and TRIM46 Enrichment at the AIS.
REFERENCE   4  (bases 1 to 3132)
  AUTHORS   Ichinose,S., Ogawa,T., Jiang,X. and Hirokawa,N.
  TITLE     The Spatiotemporal Construction of the Axon Initial Segment via
            KIF3/KAP3/TRIM46 Transport under MARK2 Signaling
  JOURNAL   Cell Rep 28 (9), 2413-2426 (2019)
   PUBMED   31461655
  REMARK    GeneRIF: The Spatiotemporal Construction of the Axon Initial
            Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling.
REFERENCE   5  (bases 1 to 3132)
  AUTHORS   Chowdhury,R., Laboissonniere,L.A., Wester,A.K., Muller,M. and
            Trimarchi,J.M.
  TITLE     The Trim family of genes and the retina: Expression and functional
            characterization
  JOURNAL   PLoS One 13 (9), e0202867 (2018)
   PUBMED   30208054
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3132)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   7  (bases 1 to 3132)
  AUTHORS   van Beuningen,S.F.B., Will,L., Harterink,M., Chazeau,A., van
            Battum,E.Y., Frias,C.P., Franker,M.A.M., Katrukha,E.A., Stucchi,R.,
            Vocking,K., Antunes,A.T., Slenders,L., Doulkeridou,S., Sillevis
            Smitt,P., Altelaar,A.F.M., Post,J.A., Akhmanova,A.,
            Pasterkamp,R.J., Kapitein,L.C., de Graaff,E. and Hoogenraad,C.C.
  TITLE     TRIM46 Controls Neuronal Polarity and Axon Specification by Driving
            the Formation of Parallel Microtubule Arrays
  JOURNAL   Neuron 88 (6), 1208-1226 (2015)
   PUBMED   26671463
  REMARK    GeneRIF: TRIM46 defines a unique axonal cytoskeletal compartment
            for regulating microtubule organization during neuronal
            development.
REFERENCE   8  (bases 1 to 3132)
  AUTHORS   Short,K.M. and Cox,T.C.
  TITLE     Subclassification of the RBCC/TRIM superfamily reveals a novel
            motif necessary for microtubule binding
  JOURNAL   J Biol Chem 281 (13), 8970-8980 (2006)
   PUBMED   16434393
REFERENCE   9  (bases 1 to 3132)
  AUTHORS   Vos,H.L., Mockensturm-Wilson,M., Rood,P.M., Maas,A.M., Duhig,T.,
            Gendler,S.J. and Bornstein,P.
  TITLE     A tightly organized, conserved gene cluster on mouse chromosome 3
            (E3-F1)
  JOURNAL   Mamm Genome 6 (11), 820-822 (1995)
   PUBMED   8597643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC082299.1 and AY251388.1.
            
            On Feb 9, 2006 this sequence version replaced NM_183037.1.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082299.1, AY251388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               BC082299.1         1-120
            121-2400            AY251388.1         1-2280
            2401-3132           BC082299.1         2396-3127
FEATURES             Location/Qualifiers
     source          1..3132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.02 cM"
     gene            1..3132
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /note="tripartite motif-containing 46"
                     /db_xref="GeneID:360213"
                     /db_xref="MGI:MGI:2673000"
     exon            1..183
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            184..445
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            446..789
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            790..933
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1029
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1283
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1405
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1708
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..2006
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..3122
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3100..3105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /note="hexamer: AATAAA"
     polyA_site      3120
                     /gene="Trim46"
                     /gene_synonym="TRIFIC"
                     /note="major polyA site"
ORIGIN      
        1 cgcagtgaca tctcaccctc cccacccctc ccttcacccc acccggctcc tgcattaagc
       61 cccgggttcg cagcagcagc caggatcggg cacccggggg cgggcgggca cagtagggcc
      121 atggctgagg gtgaggatat gcagaccttc acttccatca tggatgcact agtccgcatc
      181 agtacaagca tgaagaacat ggagaaggaa ctgctgtgcc cagtgtgcca agagatgtac
      241 aagcagccac tagtgctgcc ttgtacccac aacgtgtgcc aggcctgtgc ccgggaggtt
      301 ttgggccagc aggggtacat aggccatggt ggggatccga gttcggagcc cacttctcct
      361 gcttccaccc cttctacccg cagcccccgc ctctctcgga gaactctccc caagccagat
      421 cgcttggacc ggctccttaa gtcaggcttt gggacatacc ctgggcggaa gcgtggtgcc
      481 ttgcaccccc agacgatcct attcccgtgc ccagcctgcc aaggcgatgt ggagctgggg
      541 gagaggggcc tttccgggct tttccgaaac ctgaccctag agcgagtggt ggagaggtac
      601 cgccagagtg tgagtgtggg aggagccatc ctgtgccagt tgtgcaagcc cccaccacta
      661 gaggccacca agggctgcac agagtgtcga gctaccttct gtaacgaatg cttcaagctc
      721 ttccacccct ggggcactca gaaggcgcag catgagccca cgctacccac tctttcattc
      781 cgccccaagg gtctgatgtg tccagaccac aaggaagagg tgacccacta ctgtaagaca
      841 tgtcaacgac tggtgtgcca actctgcaga gtacggcgta cccacagtgg gcacaagatc
      901 acaccagtgc tcagtgccta ccaggccctc aaggataagc taacaaagag cctggcatac
      961 atcttgggaa accaggacac tgtgcagacc cagatttgtg agctggaaga gaccatcagg
     1021 cacactgagg tgagtggtca gcaagcaaaa gaggaggtgt cccagctggt tcggggacta
     1081 ggggctgtgc tggaagagaa gcgggcctca ctgcttcagg ccattgaaga atgccagcaa
     1141 gagcgcttat cccggctcag cgcccagatc catgaacacc agagcctgct ggatggctcg
     1201 ggtctggtgg gttatgcgca ggaagtcctt aaggaaacag accagccttg ttttgtacaa
     1261 gcagccaaac agctgcataa caggattgcc cgagccactg aggccctcca gacattccgg
     1321 ccagctgcca gctcctcctt ccgccactgc cagctggatg tggggcgtga gatgaagctg
     1381 ttgaccgagc ttagcttcct gagagtgccc gaggcgcccg tcatagacac ccaacgcacc
     1441 tttgcctatg atcaaatctt cctgtgctgg cggctgcccc ctcactcacc acctgcctgg
     1501 cattacaccg ttgagttccg gcgcacagat gtccccgccc agccaggccc tacacgctgg
     1561 cagcgccggg aagaggtgag gggcaccagc gcccttcttg agaaccccga cacgggctct
     1621 gtgtacgtgc tgcgtgtccg tggctgcaac aaggctggct acggagagta cagtgaagat
     1681 gtgcacctgc acacaccccc agcccctgtc ctgcacttct tccttgatgg ccgctggggt
     1741 gcgagccgag agcggctagc catcagcaag gaccagcgag cggtgcggag tatcccaggg
     1801 cttcccttgc tgctggctgc tgagcggctg ctcacgggct gccacctgag tgtggacgtg
     1861 gtcttgggtg atgtggctgt gacccagggc cgcagctact gggcctgtgc ggtagaccct
     1921 gcctcctact tggtcaaggt gggcgtcggg ctggagagca aacttcagga aagcttccag
     1981 ggtgccccgg atgtgatcag ccccagatac gacccggaca gtgggcacga cagcggtgcc
     2041 gaggacgctg ccgtggaggc gttaccaccc tttgctttcc tgaccatcgg catgggcaag
     2101 atcctgctgg gttccggagc gagttccaat gcagggctga cagggaggga tggccccacc
     2161 gccagctgca cagtgcccct gccaccccgc ctaggtatct gtttggacta cgagcggggg
     2221 cgggtctcct tcctggatgc cgtgtccttc cgtgggctgc tcgagtgccc cctggactgc
     2281 tcagggcctg tgtgccctgc cttctgcttc attgggggtg gcgctgttca gctgcaggag
     2341 cccgtgggca ccaagcctga gaggaaagtc accattgggg gctttgccaa actggactga
     2401 gccgttcagg ccccctctca gacctgagtt ctgctcccca agtctctggc atcgagtttg
     2461 ttttcccaac agcttctctc ccagactttc cctaaccatg tggccctgcc ccataccttg
     2521 ccagcggtgt cttcccaggg cttcccttga ctaagggact ttcctctgct tctctctgga
     2581 tgtccttcat tctctgtgtt acctgttggc ctaggccgca ggctcatcat gtctctgacc
     2641 caggccccgc ccttggcatc ataaccaagg catagaaagc cctgttccgt ccctggcctg
     2701 tgctcctgag ccttactggg agggagggca cctggaacac tggatatgac taacaactct
     2761 gcccttgcct tgccaagccc ccctacccca ctaatgctga ctgcagcctt ggcagccagg
     2821 ctttgagcct cccagtgaga cagaggagaa cctatcctgt tttatttggg tccctatacc
     2881 ctccagctgc atgtcccttc tgtccctctt ctcctcttgc atgctttacc tatccagcac
     2941 ccatgccaac gtgccaagtc tcccttggga actcagttaa ggctggtgtc cccattgggt
     3001 tgggccaagc taggcctctg gtgcctgcta ctgcctccgt acagtgggca ttgctaggcc
     3061 tgtgctgagc aacagctgta attttcatgg tttataaaca ataaactgtg acaccaggca
     3121 caaaaaaaaa aa
//
