LOCUS       NM_001033235            2197 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 40 (Trim40), transcript
            variant 1, mRNA.
ACCESSION   NM_001033235 XM_111691 XM_139933 XM_290002 XM_907980
VERSION     NM_001033235.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2197)
  AUTHORS   Kang,S., Kim,J., Park,A., Koh,M., Shin,W., Park,G., Lee,T.A.,
            Kim,H.J., Han,H., Kim,Y., Choi,M.K., Park,J.H., Lee,E., Cho,H.S.,
            Park,H.W., Cheon,J.H., Lee,S. and Park,B.
  TITLE     TRIM40 is a pathogenic driver of inflammatory bowel disease
            subverting intestinal barrier integrity
  JOURNAL   Nat Commun 14 (1), 700 (2023)
   PUBMED   36755029
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2197)
  AUTHORS   Shen,Y., Tang,K., Chen,D., Hong,M., Sun,F., Wang,S., Ke,Y., Wu,T.,
            Sun,R., Qian,J. and Du,Y.
  TITLE     Riok3 inhibits the antiviral immune response by facilitating
            TRIM40-mediated RIG-I and MDA5 degradation
  JOURNAL   Cell Rep 35 (12), 109272 (2021)
   PUBMED   34161773
  REMARK    GeneRIF: Riok3 inhibits the antiviral immune response by
            facilitating TRIM40-mediated RIG-I and MDA5 degradation.
REFERENCE   3  (bases 1 to 2197)
  AUTHORS   Zhao,C., Jia,M., Song,H., Yu,Z., Wang,W., Li,Q., Zhang,L., Zhao,W.
            and Cao,X.
  TITLE     The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune
            Responses by Targeting MDA5 and RIG-I
  JOURNAL   Cell Rep 21 (6), 1613-1623 (2017)
   PUBMED   29117565
  REMARK    GeneRIF: TRIM40 binds to MDA5 and RIG-I and promotes their K27- and
            K48-linked polyubiquitination via its E3 ligase activity, leading
            to their proteasomal degradation. TRIM40 deficiency enhances
            RLR-triggered signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR956641.9 and AK136498.1.
            
            On Feb 18, 2010 this sequence version replaced NM_001033235.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                CR956641.9         127874-127953
            81-475              AK136498.1         2-396
            476-476             CR956641.9         128632-128632
            477-2197            AK136498.1         397-2117
FEATURES             Location/Qualifiers
     source          1..2197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     gene            1..2197
                     /gene="Trim40"
                     /gene_synonym="Gm319; Gm35; Gm865"
                     /note="tripartite motif-containing 40"
                     /db_xref="GeneID:195359"
                     /db_xref="MGI:MGI:2684881"
     exon            1..149
                     /gene="Trim40"
                     /gene_synonym="Gm319; Gm35; Gm865"
                     /inference="alignment:Splign:2.1.0"
     exon            150..997
                     /gene="Trim40"
                     /gene_synonym="Gm319; Gm35; Gm865"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1093
                     /gene="Trim40"
                     /gene_synonym="Gm319; Gm35; Gm865"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1309
                     /gene="Trim40"
                     /gene_synonym="Gm319; Gm35; Gm865"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1332
                     /gene="Trim40"
                     /gene_synonym="Gm319; Gm35; Gm865"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2197
                     /gene="Trim40"
                     /gene_synonym="Gm319; Gm35; Gm865"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcaggagg aatctcttca ccttctccct agtttcacag gcatgtgagt gtatataatt
       61 ggcataattc aagaagaacc ggctcatctg ctggtcttct ccctaggtct ggagaccaag
      121 aaaatgaagt tgaaaaggag agatttgagg gtcactgaca aggttccacc ttaagaggtt
      181 agtggtatca aacagcagca gtgagccctg tagggaacca gccccagagg ggacacataa
      241 agttctgtct gaattctccc tgccagccac acagtagaga ctgtcagctt gtcgttgata
      301 gtttacttct ggccatgacc gtaacaaggt ggcctaaaat ttagctttaa actgtaaaac
      361 gattgcacag aaaactctca aaacagaatt ggggtttgga gctcctgctt cctccaggtc
      421 tgtggaagaa ttgtataagg aatagtttca agtttagcaa atactgagtt ttttttgaaa
      481 tccctgcagg attgtgtctc ttatagtcca gactctggac tctctgatag tggacagtgg
      541 ccttaagtcc aggccccagt ccactttatc ttgctccaga tcaccttcta ccgagccctt
      601 tcacatggga caatctggcc ttcaaaagac ccagtgggga gactagtgag gtgggaccat
      661 gggctctctt gacaaggaca accaggacat ttgtcctatc tgcctggatc ccctgaagga
      721 ggctgtgagc accgactgca gacatctctt ctgccgcatg tgcctgaccc agcacatgga
      781 taaggcttca gtctctggga ttctcagctg cccagtctgc aggaagccat gttccgaggg
      841 ggtccttgga gacaattaca tctgccacac ccaccagaag agggtgcgca ggttctgtga
      901 ggctagcgga catctcttgt gtgaggaatg cctccaatcc cctgaacacc agtcccatac
      961 tgaactctcc attgaaaatg ccatcagcca ctacaaggaa agactcaacc ggagaagcag
     1021 gaagctcaga aaggaccttg ggaaccttca acagctgaag gctcaggaaa agaagatgct
     1081 gcaggctctg caggtggatt gtgagtgtca caggctaaga actgacctgc agaaccaaga
     1141 ccaaaccaag gaacaactga aggctctccc atggcattgg ctggaccaag aggacttacc
     1201 agaggaggtg gccaagatct ttagcttctc tgaggcagta acacagctca gcatcctggt
     1261 ttctggcctg gaaaggatgg ccaaggatct ggatgccagc accctgaagg atgccagtga
     1321 cttactggac aggagcgcac cacagaaatt agaaggactt ctctctcgtg tttctccagc
     1381 tggtccaaag ctcagttagt cttcctggta tattctcatc ctcacagctc ccatctgatg
     1441 atctagcttc tgacgctggg acataatctc cttcctaagc cagacttgag cttgtggctc
     1501 ccactgctgt gaccagacat ttcagatctc catataactg tgtgctgatg attgcaccta
     1561 ctgcccatgg tctcgtgggc atcgaaacat ctggatgaaa gagcagagtg agcccacctc
     1621 agcttatgga gtttggcagg tttattgggt actagctctt ctgactctga tagaacctcc
     1681 tgtttgtaca gcccacactg accattcatt atgactgttg catgcagact tgagggtgat
     1741 ttccacagtc ctcaccctca tgttcaggta cttgtaactt tgtcctctgg agaatgagtg
     1801 ccatcagtga cttgcttctc attaaaggaa tatagcagaa gtaatgaagg tcaactctag
     1861 tggccataga cgctttcttg ctgatagaca cattcaagag actctttttg ctaaagttgg
     1921 ggacgctgag gggaaagatt tgtgggcagc tcctagtttc ctagagcggc ctccatcttc
     1981 tgggtgacaa gaatcaggga acctgggctt tacagttgca gtaaaccctt ccaccaccac
     2041 aagtaaagtt ggaagtagat acttctggga actgaaaatg cccccactaa tcaccctgtc
     2101 cctgcccata gtttccataa ggactggaaa attgtaaaaa caattttctc ttacttctgt
     2161 atctgttttt ataataaact tccctattat ttaaacc
//
