LOCUS       NM_001029935            1480 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 38 (Trim38), mRNA.
ACCESSION   NM_001029935 XM_111412
VERSION     NM_001029935.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Matos-Rodrigues,G.E., Tan,P.B., Rocha-Martins,M., Charlier,C.F.,
            Gomes,A.L., Cabral-Miranda,F., Grigaravicius,P., Hofmann,T.G.,
            Frappart,P.O. and Martins,R.A.P.
  TITLE     Progenitor death drives retinal dysplasia and neuronal degeneration
            in a mouse model of ATRIP-Seckel syndrome
  JOURNAL   Dis Model Mech 13 (10) (2020)
   PUBMED   32994318
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Kim,K., Kim,J.H., Kim,I., Seong,S. and Kim,N.
  TITLE     TRIM38 regulates NF-kappaB activation through TAB2 degradation in
            osteoclast and osteoblast differentiation
  JOURNAL   Bone 113, 17-28 (2018)
   PUBMED   29753717
  REMARK    GeneRIF: our data suggest that TRIM38 plays a critical role in bone
            remodeling as a negative regulator of NF-kappaB in both osteoclast
            and osteoblast differentiation.
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Hu,M.M., Liao,C.Y., Yang,Q., Xie,X.Q. and Shu,H.B.
  TITLE     Innate immunity to RNA virus is regulated by temporal and
            reversible sumoylation of RIG-I and MDA5
  JOURNAL   J Exp Med 214 (4), 973-989 (2017)
   PUBMED   28250012
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Hu,M.M., Yang,Q., Xie,X.Q., Liao,C.Y., Lin,H., Liu,T.T., Yin,L. and
            Shu,H.B.
  TITLE     Sumoylation Promotes the Stability of the DNA Sensor cGAS and the
            Adaptor STING to Regulate the Kinetics of Response to DNA Virus
  JOURNAL   Immunity 45 (3), 555-569 (2016)
   PUBMED   27637147
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Hu,M.M., Xie,X.Q., Yang,Q., Liao,C.Y., Ye,W., Lin,H. and Shu,H.B.
  TITLE     TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and
            Inflammatory Responses by Two Sequential and Distinct Mechanisms
  JOURNAL   J Immunol 195 (9), 4415-4425 (2015)
   PUBMED   26392463
  REMARK    GeneRIF: Data show that tripartite motif-containing 38 protein
            (Trim38) deficiency potentiates toll like receptors TLR3/4-mediated
            signaling in primary immune cells.
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Zhao,W., Wang,L., Zhang,M., Wang,P., Yuan,C., Qi,J., Meng,H. and
            Gao,C.
  TITLE     Tripartite motif-containing protein 38 negatively regulates TLR3/4-
            and RIG-I-mediated IFN-beta production and antiviral response by
            targeting NAP1
  JOURNAL   J Immunol 188 (11), 5311-5318 (2012)
   PUBMED   22539786
  REMARK    GeneRIF: TRIM38 is a negative regulator for Toll like receptor
            (TLR) and retinoic acid-inducible gene (RIG)-I-mediated IFN-beta
            production by targeting Nck-associated protein NAP1 for
            ubiquitination and subsequent proteasome-mediated degradation.
REFERENCE   7  (bases 1 to 1480)
  AUTHORS   Zhao,W., Wang,L., Zhang,M., Yuan,C. and Gao,C.
  TITLE     E3 ubiquitin ligase tripartite motif 38 negatively regulates
            TLR-mediated immune responses by proteasomal degradation of TNF
            receptor-associated factor 6 in macrophages
  JOURNAL   J Immunol 188 (6), 2567-2574 (2012)
   PUBMED   22323536
  REMARK    GeneRIF: ur findings defined a novel function for TRIM38 to prevent
            excessive TLR-induced inflammatory responses through proteasomal
            degradation of TRAF6.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590388.4.
            
            On Jan 26, 2013 this sequence version replaced NM_001029935.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150836.1, SRR12282455.10733668.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AL590388.4         105390-105837       c
            449-544             AL590388.4         102406-102501       c
            545-775             AL590388.4         99937-100167        c
            776-798             AL590388.4         99021-99043         c
            799-911             AL590388.4         98808-98920         c
            912-1480            AL590388.4         96850-97418         c
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.92 cM"
     gene            1..1480
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /note="tripartite motif-containing 38"
                     /db_xref="GeneID:214158"
                     /db_xref="MGI:MGI:2684869"
     exon            1..448
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1447
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /EC_number="2.3.2.27"
                     /note="RING finger protein 15; zinc finger protein RoRet;
                     E3 SUMO-protein ligase TRIM38; tripartite motif-containing
                     protein 38"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM38"
                     /protein_id="NP_001025106.1"
                     /db_xref="CCDS:CCDS26370.1"
                     /db_xref="GeneID:214158"
                     /db_xref="MGI:MGI:2684869"
                     /translation="MGSDFSTVKIRKVTSCSICKAMMSHPVSINCGHSYCKSCIQSYY
                     CNVSPKTGWKMLGCPLCSSPFSLENLRPNKELETIIDMIKGMEEQDQDMVCEEHEEKF
                     NRFCEDDGQLLCWRCYWEDRHKGHTLAHVKDVYQNYKEKLQNTMTKLRELQENHEVQI
                     HFITHQINAWKDAVEDRRQTIKSNFKNLQSFLQEEEKFYLWRLENEEKEMLVQLEGSE
                     ANLQQTFERAQCQIQELEAKCQGSAQKLLQDVKNTLSRCEAMKRNPLKADPLKVHTKC
                     NVSELYFDVKTILRRHQVSVILDPSTAHLDLALTKGGRLVTYKRCPRDLQARSSAKRF
                     YGLPCVLGCEGFTSGRYYFEVSVENATSWDLGVCVENVHRGFNMKKEPESGFWTIKMS
                     EEDGLEALTSTPTPPLHLIEKPQILGVFLDYEAGAVSFYSVTTGSHIFTFPKASFQDT
                     LRPFFQVYQYSPLFLPAINNQ"
     exon            449..544
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /inference="alignment:Splign:2.1.0"
     exon            545..775
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /inference="alignment:Splign:2.1.0"
     exon            776..798
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /inference="alignment:Splign:2.1.0"
     exon            799..911
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1480
                     /gene="Trim38"
                     /gene_synonym="Gm23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccacattt ggaaacttct cagaaaaagc catgggctca gactttagca cggtgaagat
       61 aagaaaggtc acttcttgct ccatctgcaa ggccatgatg tctcacccag tgagcatcaa
      121 ctgtggacac agctactgca aatcctgcat acagagctat tattgcaatg tcagcccaaa
      181 aacagggtgg aagatgttgg gctgtccttt gtgtagtagt ccatttagct tagagaacct
      241 caggcccaac aaggagctag aaaccataat tgatatgatc aaggggatgg aagagcagga
      301 tcaagacatg gtgtgtgagg aacatgaaga gaagttcaat cgcttttgtg aagatgacgg
      361 tcaactcctc tgctggcgct gttattggga agatcggcac aaaggtcata ccttggctca
      421 tgtgaaagat gtgtaccaga actacaagga aaaactccag aacaccatga caaaattgcg
      481 tgaactccaa gagaatcacg aagttcagat acatttcata acacaccaaa taaatgcctg
      541 gaaggatgct gtagaggatc gtcggcaaac aatcaagtca aacttcaaga atctccagag
      601 ttttctacag gaagaagaga agttttatct ttggaggttg gaaaatgagg aaaaggagat
      661 gctggtgcag ctggaaggca gcgaggccaa tctacagcag acgtttgaga gagctcaatg
      721 ccaaattcag gaactggagg caaaatgtca gggctcagcc cagaaattgc tacaggacgt
      781 gaaaaacact ttgagcaggt gtgaggccat gaagcgaaac ccactgaagg ctgatcccct
      841 gaaggttcac actaaatgta atgtgtctga gctgtacttc gatgtgaaga cgatattacg
      901 acgtcaccaa gtcagcgtga tcctggaccc cagcacagcc caccttgacc tagctctgac
      961 taaaggtgga agattagtga cttacaaaag atgccccagg gatcttcagg caagatcttc
     1021 agccaagagg ttttatggtt taccctgtgt cctgggctgt gagggcttta cttcggggag
     1081 atattacttt gaagtctctg ttgagaatgc aaccagttgg gatttgggag tctgtgtaga
     1141 gaatgtgcac aggggcttta acatgaagaa ggagcctgag tctggattct ggaccatcaa
     1201 gatgtctgaa gaggacggcc ttgaagctct tacttctacc cctactcctc cccttcatct
     1261 gattgaaaag ccccagattc tgggagtttt cctagactat gaggctggag ctgtatcgtt
     1321 ttacagtgta actactggct ctcatatctt caccttccct aaggcttcct tccaggatac
     1381 tctgaggccc tttttccagg tttatcaata ttctcctttg ttcctgcctg ccataaataa
     1441 tcaatgaaag aagtaagtcc ctatgcctta agtagcctca
//
