LOCUS       NM_197987               5637 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 37 (Trim37), transcript
            variant 2, mRNA.
ACCESSION   NM_197987 XM_109795
VERSION     NM_197987.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5637)
  AUTHORS   Ge,Y., Zhao,R., Li,B., Xiao,B., Zhou,L. and Zuo,S.
  TITLE     Aerobic glycolysis and tumor progression of hepatocellular
            carcinoma are mediated by ubiquitin of P53 K48-linked regulated by
            TRIM37
  JOURNAL   Exp Cell Res 421 (2), 113377 (2022)
   PUBMED   36252649
  REMARK    GeneRIF: Aerobic glycolysis and tumor progression of hepatocellular
            carcinoma are mediated by ubiquitin of P53 K48-linked regulated by
            TRIM37.
REFERENCE   2  (bases 1 to 5637)
  AUTHORS   Liu,J., Li,S., Fei,X., Nan,X., Shen,Y., Xiu,H., Cormier,S.A.,
            Lu,C., Guo,C., Wang,S., Cai,Z. and Wang,P.
  TITLE     Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37
            degradation mediates particulate matter-induced lung metastasis
  JOURNAL   Autophagy 18 (5), 971-989 (2022)
   PUBMED   34524943
  REMARK    GeneRIF: Increased alveolar epithelial TRAF6 via
            autophagy-dependent TRIM37 degradation mediates particulate
            matter-induced lung metastasis.
REFERENCE   3  (bases 1 to 5637)
  AUTHORS   Zhao,L., Hao,Y., Song,Z., Fan,Y. and Li,S.
  TITLE     TRIM37 negatively regulates inflammatory responses induced by virus
            infection via controlling TRAF6 ubiquitination
  JOURNAL   Biochem Biophys Res Commun 556, 87-92 (2021)
   PUBMED   33839419
  REMARK    GeneRIF: TRIM37 negatively regulates inflammatory responses induced
            by virus infection via controlling TRAF6 ubiquitination.
REFERENCE   4  (bases 1 to 5637)
  AUTHORS   Han,C., Xia,X., Jiao,S., Li,G., Ran,Q. and Yao,S.
  TITLE     Tripartite motif containing protein 37 involves in thrombin
            stimulated BV-2 microglial cell apoptosis and interleukin 1beta
            release
  JOURNAL   Biochem Biophys Res Commun 516 (4), 1252-1257 (2019)
   PUBMED   31301768
  REMARK    GeneRIF: TRIM37 has a role in apoptosis and IL-1beta release in
            mouse BV-2 microglia that involves PPARgamma ubiquitination; it is
            increased in mononuclear leukocytes of intracerebral hemorrhage
            patients
REFERENCE   5  (bases 1 to 5637)
  AUTHORS   Bhatnagar,S., Gazin,C., Chamberlain,L., Ou,J., Zhu,X., Tushir,J.S.,
            Virbasius,C.M., Lin,L., Zhu,L.J., Wajapeyee,N. and Green,M.R.
  TITLE     TRIM37 is a new histone H2A ubiquitin ligase and breast cancer
            oncoprotein
  JOURNAL   Nature 516 (7529), 116-120 (2014)
   PUBMED   25470042
REFERENCE   6  (bases 1 to 5637)
  AUTHORS   Wajapeyee,N., Malonia,S.K., Palakurthy,R.K. and Green,M.R.
  TITLE     Oncogenic RAS directs silencing of tumor suppressor genes through
            ordered recruitment of transcriptional repressors
  JOURNAL   Genes Dev 27 (20), 2221-2226 (2013)
   PUBMED   24105743
REFERENCE   7  (bases 1 to 5637)
  AUTHORS   Kallijarvi,J., Hamalainen,R.H., Karlberg,N., Sainio,K. and
            Lehesjoki,A.E.
  TITLE     Tissue expression of the mulibrey nanism-associated Trim37 protein
            in embryonic and adult mouse tissues
  JOURNAL   Histochem Cell Biol 126 (3), 325-334 (2006)
   PUBMED   16514549
  REMARK    GeneRIF: We here show that the mouse Trim37 gene presents several
            alternative splice variants, including a testis-specific transcript
            with an additional 3' exon.
REFERENCE   8  (bases 1 to 5637)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   9  (bases 1 to 5637)
  AUTHORS   Lehesjoki,A.E., Reed,V.A., Mark Gardiner,R. and Greene,N.D.
  TITLE     Expression of MUL, a gene encoding a novel RBCC family ring-finger
            protein, in human and mouse embryogenesis
  JOURNAL   Mech Dev 108 (1-2), 221-225 (2001)
   PUBMED   11578880
REFERENCE   10 (bases 1 to 5637)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK140822.1, BC058678.1 and
            BY457310.1.
            
            On Jan 10, 2013 this sequence version replaced NM_197987.1.
            
            Summary: The protein encoded by this gene is part of the
            tripartite-motif containing family (TRIM), which is typified by the
            RING, B-box type 1, B-box type 2, and coiled-coil region domains.
            In mouse this protein is proposed to oligomerize through its coiled
            coil domain and has been reported to be expressed in neural
            crest-derived tissues as well as in tissues whose development is
            regulated by mesenchymal-epithelial interactions. In humans,
            mutations in this gene are associated with mulibrey
            (muscle-liver-brain-eye) nanism, an autosomal recessive disorder
            characterized by prenatal onset growth failure, cardiomyopathy and
            dysmorphic features. [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140822.1, BC058678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK140822.1         2-3
            3-5633              BC058678.1         1-5631
            5634-5637           BY457310.1         428-431
FEATURES             Location/Qualifiers
     source          1..5637
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.93 cM"
     gene            1..5637
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /note="tripartite motif-containing 37"
                     /db_xref="GeneID:68729"
                     /db_xref="MGI:MGI:2153072"
     exon            1..420
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..3285
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase TRIM37; tripartite
                     motif-containing protein 37; TRAF encompassing factor 3;
                     RING-type E3 ubiquitin transferase TRIM37"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM37 isoform 2"
                     /protein_id="NP_932104.1"
                     /db_xref="CCDS:CCDS25210.1"
                     /db_xref="GeneID:68729"
                     /db_xref="MGI:MGI:2153072"
                     /translation="MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWL
                     TEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKL
                     SVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISL
                     VQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELL
                     ESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSY
                     DSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAG
                     LPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNR
                     QNDTVILRFQVRSPTFFQKCRDQHWYITQLEAAQTGYIQQINNLKERLTIELSRTQKS
                     RDLSPPDNHLSPQNDDSPETRTKKAGSCSDMLLEGGPTCASVRETKEDEDEEEKIQNE
                     DYHHELSDGDLDLDLVGEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN
                     SMELEEGELMEDAAAAGPPGSSHSYVGASSRMSRRTHLCSAATSSLLDIDPLILIHLL
                     DLKDRSSMENLWGLQPRPSASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQ
                     MAEVRCMKTDVKTTLSDIKGSSVASTDMQTNLFCADQAALTTCGPENSGRLQDLGMEL
                     LAKSSVAGCYIRNPTNKKNSPKSARAIAGSLSLRRAVDSGENSRSKGDCQVLAEGSSG
                     SSQSGSRHSSPRALTHGIIGDLLPKSEDRQCKALDSDAVVVAVFNGLPTVEKRRKMVT
                     LGTNAKGGRLEGMQMADLESHSEAGEVQPTLPEGASAAPEEGMSSDSDIECDTENEEQ
                     EEHTSMGAFNDPFLAQPPDEDSHSSFPDGEQIDPENLHFNPDEGGGR"
     exon            421..522
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..563
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..680
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            681..768
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..891
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1015
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1083
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1208
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1259
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1341
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1418
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1598
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1713
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1932
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2069
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2155
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2350
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2659
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2782
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2972
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3091
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3202
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..5637
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4414..4419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /note="hexamer: AATAAA"
     polyA_site      4434
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /note="major polyA site"
     regulatory      5615..5620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
                     /note="hexamer: AATAAA"
     polyA_site      5633
                     /gene="Trim37"
                     /gene_synonym="1110032A10Rik; 2810004E07Rik; MUL; TEF3"
ORIGIN      
        1 gccgcgcctc tagctgccct ggttaccgtt ggtgtttgcg aattctctgt ggcgcctgtt
       61 ccgccccgga cgggccccgc ggcggttttc acacgcgcgc gccggcgtca cgtgggccag
      121 ggctcccacg cggacgcagg ccagctgctg aggcgggagg aaggcgttgc ggctaccgct
      181 agcccttccc tctccgcccc agggctggcg cgcggataaa aaaaaatggc gaaatgcggg
      241 gtagccggtg gggaacccga cgggatgggg cgcggaggtg gcactgttgt gggagcctgc
      301 tgaggtgagc gcagctgacc tggcgacctc gggccggcgc ctgacagcgc agacacggac
      361 tccgagggtc gccgagggcc ccgccgagag ccggaggcaa tggatgagca gagtgtggag
      421 agcattgctg aggttttccg atgtttcatt tgtatggaga aattgcggga tgctcgactg
      481 tgtcctcatt gctccaagct ctgttgtttc agctgtatta ggcgctggct gacagagcaa
      541 agagctcagt gtcctcactg tcgtgctcca ctccagctac gggaactggt gaactgtcgt
      601 tgggcggaag aagtgacaca gcagcttgac actctccagc tgtgtagtct caccaaacat
      661 gaagaaaatg agaaagacaa atgtgaaaat caccatgaaa aacttagtgt gttttgctgg
      721 acttgtaaga agtgtatctg ccatcagtgt gcactttggg gaggaatgca tggtggacac
      781 acgtttaaac ctttggcaga aatttatgaa caacatgtca ctaaagtgaa tgaagaggta
      841 gccaaacttc gtcgacgtct catggagctg atcagcttag ttcaagaagt ggaaagaaat
      901 gtagaagctg taagaaatgc aaaggacgag cgtgttcggg aaattaggaa tgcggtagag
      961 atgatgattg cacgactaga tacacagctg aagaataagc tcataactct catgggtcag
     1021 aagacatctc ttactcaaga aacggagctg ttggaatctt tacttcagga ggtagaacat
     1081 cagttgcggt cttgcagtaa gagcgagctg atctccaaga gctcagagat cctaatgatg
     1141 ttccagcaag ttcaccgaaa gcccatggca tcctttgtca ccacacctgt cccaccagac
     1201 tttaccagtg aattggtacc atcctatgat tcagctactt ttgttttaga gaacttcagc
     1261 actttgcggc agagagcaga tcctgtttac agtccgcctc ttcaagtttc aggactttgt
     1321 tggaggttaa aagtttaccc agatggaaat ggagttgtac gtggctatta tttatctgta
     1381 tttttggaac tatcggctgg cttgcctgaa acttccaagt atgaatatcg tgtagaaatg
     1441 gttcaccagt cgtgcaatga tcctacaaaa aatatcattc gagaatttgc atctgacttt
     1501 gaagttggag agtgctgggg ctacaatagg ttttttcgtt tggatttact tgcaaacgaa
     1561 ggatacttga accgacaaaa tgatacagtg attttaaggt ttcaggtgcg ctcaccaaca
     1621 ttttttcaaa aatgccggga tcagcactgg tatattactc agttggaagc tgcacagact
     1681 ggttatatcc aacaaataaa caatcttaaa gagagactga ctattgagct gtcccgaact
     1741 cagaaatcca gagatctgtc accaccagat aatcatctta gccctcaaaa tgatgattct
     1801 cctgagacac gaactaagaa agctgggtca tgctctgaca tgcttctgga aggcggtcct
     1861 acttgcgctt ctgtacgaga gaccaaggaa gatgaagatg aggaggagaa gattcagaat
     1921 gaagactatc atcatgagct ctcggatgga gatctggacc tggatcttgt tggagaagat
     1981 gaagtgaatc accttgatgg cagcagctct tctgctagtt ctacagcaac aagcaacaca
     2041 gaagaaaacg atattgatga ggagaccatg tctggggaaa atgatgtaga atataacagt
     2101 atggagctgg aagagggaga gctcatggaa gatgcagctg ctgcaggtcc tccaggtagt
     2161 agccacagct atgtgggtgc cagtagcaga atgtcaagaa gaacacattt atgctctgca
     2221 gctaccagta gcttactaga cattgatcct ttaatcttaa tacatttatt ggatcttaag
     2281 gaccggagca gtatggaaaa cctgtggggt ttacagcctc gcccgtctgc ttcactgttg
     2341 cagcccacag catcatattc tcgaaaagat aaagatcaaa ggaagcagca agcgatgtgg
     2401 cgtgtgccct ctgacctaaa gatgctgaaa aggctcaaaa cacagatggc tgaagtccgg
     2461 tgtatgaaga ctgatgtgaa gactacgctg tcagatataa agggcagcag tgttgcttcc
     2521 acagacatgc agacaaacct attctgtgct gaccaggcag ctctgactac ctgtggaccc
     2581 gaaaactctg gtagattaca ggatttggga atggagcttc tagcaaagtc atcagtggct
     2641 ggctgttaca tacgaaaccc cacaaataag aagaattccc ccaagtcagc tcgggccata
     2701 gcaggcagtc tgtcactccg aagagctgtg gactctggag aaaatagccg ttcaaaggga
     2761 gactgtcagg ttctggctga aggctcctcg ggaagctctc agtctgggag cagacacagc
     2821 tccccccggg ctctgacaca cggcatcatt ggggatcttc tgcccaaaag tgaagaccga
     2881 cagtgcaaag ccttggattc tgacgctgtg gttgttgcag ttttcaatgg tttacctact
     2941 gttgagaaga gaaggaaaat ggtcaccttg gggactaatg caaaaggagg tcgtctggaa
     3001 ggaatgcaga tggcagattt ggaaagtcat tctgaagctg gggaggtaca gcccacacta
     3061 cctgaaggag cctcagccgc ccctgaggaa ggaatgagta gtgacagcga cattgaatgt
     3121 gacactgaga acgaggagca ggaagaacac accagcatgg gcgcgttcaa cgatccgttc
     3181 ctggctcagc cccccgatga agattcacat tccagttttc ctgatggtga acaaatagac
     3241 cctgaaaatc tccacttcaa ccctgatgaa ggaggtggaa ggtaattgcc agacatgaga
     3301 gccgagctac aagctacctg gtccctgaaa tttgttggaa attggtgctc aaaattgtca
     3361 gcagtcagat aatcagactt atttagtccc atttcttttt gtcatctcta cctgaaatag
     3421 cagttctgaa actattagaa ggcacacaat tccagcaggg tgcagtagta tatgtggaaa
     3481 agattaaggc aaaagagttc tttccaatat aatgaactaa cagtgtagtg ctcaattaat
     3541 ttagcaaatt agtacattaa caaaggcagc ttgtctactg taacagaaag ccagctaagt
     3601 gccagaaagt acctggaggc attgcatgat ctgatctggc tcagcatcgg tgcgcttctg
     3661 tctttgactg acacatggtt tagatggcca tggttaggtt tttcattagg ctgtgatttc
     3721 attaaggctt gtataatagt gaaaaggaag agtgcttata aacagacttt gctcagtgga
     3781 cacttttcct gagtaactgc agcaatgtta gacagactct tttctttgaa atatgacgat
     3841 agaccaaatt ttatgttttt ctcacttgtt caagtattgg cataccgggt aatggcaccc
     3901 cttctctcag ttatgtgacc tttacaggtg tcgtttcaaa tgagctcagt cattggggat
     3961 tggttctatg catggtcatt tggacgcatg taagattact taaagttgtt catcttttct
     4021 gcttcctgaa acataactat agtgcaacaa atatttttga acaatatatt tccattggtt
     4081 ggaccttgat ctcagtgagt gcatctaaag atttatgcat atacatgaag ctgtgttcaa
     4141 ggctttcttg catattccca attagtccaa accccaaatg attgccaaat tttgctactg
     4201 tgctcctgtg tttgtgtttg agctgttgta tgtttgtaaa tgtcacactt aaagctggcc
     4261 aagagactgt tgaagaagcg tggatgtgca taggagagca ccccccccac ctgcatgtac
     4321 ttagtgcctc ctctgtgtcc catggtgata gcttgcttgc tgaatgctgt gactcatagt
     4381 ttactgttct cttaacagct tgcacttttc gttaataaaa ttaacttgag aaaatgtgcc
     4441 tctgcagttt attcaaagtg ggaccagaag caccactccc cctcttaaat tttttgctgt
     4501 ggctgtttag cagtgtagac aaggacattt tcttatggca ttgggctaat aatcattcct
     4561 tttaaaacca aaagatttct tcataaataa taaaatatat ggaaagaata attcttactc
     4621 caatccctag ctatcttata ttctaaaatg tccaacaagt aggtggcatt ttacttttgg
     4681 tattttgact cttctgggga agaggctcag agcccttgca tgctaggcaa gcatgttact
     4741 cctgagctaa agttgtccgg gatacccagt gtttcgatga tggcaggagc tgcactatgg
     4801 ccaccttggc tgtgcttgaa ggcaggtggg gagaagggca gaggcatgat ggtagaatcc
     4861 cttgctgtgt ctgcttgccc tgggctctta cactgtgtat cagattctcc cctaataatc
     4921 catctttcct gcatcgcttt atagaaacaa aacaaaagac cttttctctt tttcgttggt
     4981 cataattttt tattagtttt tctgttgtac tttattcagc ataaggtgtg tttgttttgt
     5041 gtgcatgtgt gtgcgcatgt gtttacgcat gtacacgata gaggtcagag gacaccttag
     5101 gtgccattcc tgggtagcca tctactttca ttttacttga aaccttcctt aaatacctag
     5161 ttatttatct taggggtttt taaattttta tttatgtgta tgtgcatggg tgtctgaggc
     5221 cacagctgca cctgatgctc aggtgcaggg aattccgctc acaaagcctc tggaaagctt
     5281 gagaacccag ccaccacctc tctaaccctg gcttgccttc tttttccttc ccgttctttc
     5341 tttttgtggc agggtctcac tatgtagccc tggctggcct agaattctct ttgtagacga
     5401 ggctgcctct gccttttcat ttcatgtgct ggggttaaag gtgtgaatgt gagcatattg
     5461 tttttgaaca attctgacaa cttgattgta ttcttcagta atctttgaga tggacaagtt
     5521 gtgtattgtt cccacttggc aaatttgggg agactgtgct gctctaaggt tggacaccat
     5581 gcttttttca gttcattatg cttaaccaaa caccaataaa aagctgaaca attgtcc
//
