LOCUS       NM_029979               3684 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus tripartite motif-containing 35 (Trim35), mRNA.
ACCESSION   NM_029979
VERSION     NM_029979.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Yang,B., Wang,Z., Niu,K., Li,T., Tong,T., Li,S., Su,L., Wang,Y.,
            Shen,C., Jin,X., Song,J. and Lu,X.
  TITLE     TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated
            amino acid transport and mTORC1 activation in fibroblasts
  JOURNAL   Cell Commun Signal 22 (1), 444 (2024)
   PUBMED   39304904
  REMARK    GeneRIF: TRIM35 triggers cardiac remodeling by regulating
            SLC7A5-mediated amino acid transport and mTORC1 activation in
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Lorenzana-Carrillo,M.A., Tejay,S., Nanoa,J., Huang,G., Liu,Y.,
            Haromy,A., Zhao,Y.Y., Mendiola Pla,M., Bowles,D.E., Kinnaird,A.,
            Michelakis,E.D. and Sutendra,G.
  TITLE     TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for
            Heart Failure
  JOURNAL   Circ Res 135 (2), 301-313 (2024)
   PUBMED   38860363
  REMARK    GeneRIF: TRIM35 Monoubiquitinates H2B in Cardiac Cells,
            Implications for Heart Failure.
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Du,Y., Chu,C.M., Zhuo,D. and Ning,J.Z.
  TITLE     The inhibition of TRIM35-mediated TIGAR ubiquitination enhances
            mitochondrial fusion and alleviates renal ischemia-reperfusion
            injury
  JOURNAL   Int J Biol Macromol 209 (Pt A), 725-736 (2022)
   PUBMED   35421414
  REMARK    GeneRIF: The inhibition of TRIM35-mediated TIGAR ubiquitination
            enhances mitochondrial fusion and alleviates renal
            ischemia-reperfusion injury.
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Xue,W., Kitzing,T., Roessler,S., Zuber,J., Krasnitz,A., Schultz,N.,
            Revill,K., Weissmueller,S., Rappaport,A.R., Simon,J., Zhang,J.,
            Luo,W., Hicks,J., Zender,L., Wang,X.W., Powers,S., Wigler,M. and
            Lowe,S.W.
  TITLE     A cluster of cooperating tumor-suppressor gene candidates in
            chromosomal deletions
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8212-8217 (2012)
   PUBMED   22566646
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Liu,M. and Huang,H.Y.
  TITLE     Identification and validation of novel C/EBPbeta-regulated genes in
            preadipocyte proliferation
  JOURNAL   Chin Med J (Engl) 123 (9), 1190-1194 (2010)
   PUBMED   20529561
  REMARK    GeneRIF: C/EBPbeta may regulate preadipocyte proliferation through
            activation of banp and trim35.
REFERENCE   7  (bases 1 to 3684)
  AUTHORS   Endersby,R., Majewski,I.J., Winteringham,L., Beaumont,J.G.,
            Samuels,A., Scaife,R., Lim,E., Crossley,M., Klinken,S.P. and
            Lalonde,J.P.
  TITLE     Hls5 regulated erythroid differentiation by modulating GATA-1
            activity
  JOURNAL   Blood 111 (4), 1946-1950 (2008)
   PUBMED   18063753
REFERENCE   8  (bases 1 to 3684)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   9  (bases 1 to 3684)
  AUTHORS   Lalonde,J.P., Lim,R., Ingley,E., Tilbrook,P.A., Thompson,M.J.,
            McCulloch,R., Beaumont,J.G., Wicking,C., Eyre,H.J.,
            Sutherland,G.R., Howe,K., Solomon,E., Williams,J.H. and
            Klinken,S.P.
  TITLE     HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member
            isolated from a hemopoietic lineage switch, is a candidate tumor
            suppressor
  JOURNAL   J Biol Chem 279 (9), 8181-8189 (2004)
   PUBMED   14662771
  REMARK    GeneRIF: isolated from monocytoid variant, but not parental J2E
            erythroleukemia cells; expressed in wide range of adult tissues; at
            different stages of embryogenesis, Hls5 was detected in the
            branchial arches, spinal cord, dorsal root ganglia, limb buds, and
            brain
REFERENCE   10 (bases 1 to 3684)
  AUTHORS   Kimura,F., Suzu,S., Nakamura,Y., Nakata,Y., Yamada,M., Kuwada,N.,
            Matsumura,T., Yamashita,T., Ikeda,T., Sato,K. and Motoyoshi,K.
  TITLE     Cloning and characterization of a novel RING-B-box-coiled-coil
            protein with apoptotic function
  JOURNAL   J Biol Chem 278 (27), 25046-25054 (2003)
   PUBMED   12692137
  REMARK    GeneRIF: a novel RING-B-box-coiled-coil (RBCC) protein that
            consists of an N-terminal RING finger, followed by a B-box zinc
            finger, a coiled-coil domain, and a B30.2 domain; cloning and
            characterization
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140329.3 and AF145374.1.
            
            On Mar 16, 2007 this sequence version replaced NM_029979.2.
            
            Sequence Note: The translation start codon selected for this RefSeq
            is conserved in rodent species. A possible downstream start codon,
            which shows better cross-species conservation, would shorten the
            protein by 15 aa. The shorter protein is described in the
            literature, including PMIDs:12692137 and 14662771. No experimental
            evidence exists to show which start codon is used in vivo.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus based on the presence of an upstream translation start
            codon, which is conserved in rodent species and is supported by
            available transcript data. A possible downstream start codon, which
            shows better cross-species conservation, would shorten the protein
            by 15 aa. The shorter protein is described in the literature,
            including PMIDs:12692137 and 14662771. No experimental evidence
            exists to show which start codon is used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF145374.1, AK075877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC140329.3         168928-168943
            17-1998             AF145374.1         1-1982
            1999-3684           AC140329.3         181642-183327
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.44 cM"
     gene            1..3684
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /note="tripartite motif-containing 35"
                     /db_xref="GeneID:66854"
                     /db_xref="MGI:MGI:1914104"
     exon            1..525
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1596
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 35; protein
                     Nc8; hemopoietic lineage switch protein 5;
                     macrophage-derived apoptosis-inducing RBCC protein"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM35"
                     /protein_id="NP_084255.2"
                     /db_xref="CCDS:CCDS27221.2"
                     /db_xref="GeneID:66854"
                     /db_xref="MGI:MGI:1914104"
                     /translation="MKAATPVVVTAAAPAMEPGPSVSPGPSRSFKEELLCAVCYDPFR
                     DAVTLRCGHNFCRRCVSGCWEVQTTPSCPVCKERAVPGELRTNHTLNNLVETLLREEA
                     EGARWTGRRSPRPCRAHRAPLTLFCLEDKELLCCACQADARHQEHRVQPIKDTAQDFR
                     AKCKNMEHVLREKAKAFWALRRTYEAIAKHNEVQTTWLEGRIRDEFDKLRDFLRVEEQ
                     ATLDAMKEESRKKHLQAEEKMKQLAEQTEALAREIERLQMEMKEDDMTFLMKHKSRKR
                     RLFCTVEPAPLQPGLLMDACKYLESLQYRVWKKMLGSVESVPFSLDPNTAAGWLKVAD
                     DLTSVINHGYRVQVENPERFSSAPCLLGSQVFSKGSHSWEVDVGGLPTWRVGVVRVQA
                     HAQAQAQADVGGEGHSHSCYHDTRSGFWYLCRTQGVDGDHCMTSDTATAPLVQAMPRR
                     LRVELECEEGELSFYDSERHCHLYTFHAHFGEVRPYFYLGASRGDGPPEPLRICHLRV
                     SIKEELDI"
     exon            526..621
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /inference="alignment:Splign:2.1.0"
     exon            622..852
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /inference="alignment:Splign:2.1.0"
     exon            853..875
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /inference="alignment:Splign:2.1.0"
     exon            876..994
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /inference="alignment:Splign:2.1.0"
     exon            995..3684
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3661..3666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /note="hexamer: CATAAA"
     polyA_site      3680
                     /gene="Trim35"
                     /gene_synonym="0710005M05Rik; A430106H13Rik; HLS5; Mair;
                     mKIAA1098; NC8"
                     /note="major polyA site"
ORIGIN      
        1 ttaagctccc agatcttcag cagggacaac gcccgcaggc taggcatgaa ggcggcgaca
       61 ccggtggtgg tgacggcggc tgctcctgcg atggagccgg gcccttctgt gtccccgggg
      121 ccttcgcgct ccttcaaaga ggagctgctg tgtgccgtgt gctacgaccc gttccgcgac
      181 gcagtaactc tgcgctgtgg ccacaacttc tgccgccggt gcgtgagcgg ctgctgggag
      241 gtgcagacga cgccctcgtg tccggtgtgc aaggaacgag cggtgcccgg ggagctgcgc
      301 accaaccaca cgctcaacaa cctggtggag accttgctgc gcgaggaggc tgagggcgcg
      361 cgctggaccg gtcgccggtc cccgcgcccc tgccgtgcgc accgtgcccc gctcacgctc
      421 ttctgcctgg aggacaagga gctgctgtgc tgtgcttgcc aggccgacgc ccggcaccaa
      481 gagcatcgtg tgcagcccat caaggacact gcgcaagact tccgggccaa gtgtaagaac
      541 atggagcatg tattgcgaga gaaagccaag gccttctggg ccctgaggcg cacctatgag
      601 gccattgcca agcacaatga ggtgcaaacg acttggctgg aaggccgcat ccgggatgag
      661 tttgacaagc tccgtgattt cctgagggtg gaggaacagg ccaccttgga tgccatgaag
      721 gaagagagca gaaagaagca cctgcaggct gaggagaaga tgaagcagct agcagaacag
      781 accgaggcgc tggctcggga gattgagcgt ctgcagatgg agatgaagga agatgacatg
      841 accttcctca tgaaacacaa gagccgaaaa cgccggctct tctgcaccgt ggagccagct
      901 cctctccagc ctggcttgct aatggatgca tgcaagtatc tggagtccct gcagtaccga
      961 gtctggaaga agatgcttgg atccgttgag tctgtgccct tcagcttgga tcccaacaca
     1021 gctgctggct ggctcaaagt ggctgatgac ctcacgagtg tcatcaacca tggctaccgc
     1081 gtgcaagtgg agaatccaga gcgcttctcc tcggcaccct gcctgctagg ctctcaagtg
     1141 ttctccaagg gctcccactc ttgggaggtg gatgtgggtg gcctgccaac ctggcgagtg
     1201 ggtgtggttc gggtgcaggc acatgcacag gcgcaggctc aggctgacgt aggtggtgaa
     1261 ggccactcac acagctgcta ccatgataca cgctcaggct tctggtacct gtgccgcacg
     1321 cagggtgtgg atggagacca ctgcatgact tccgacactg ccacagcccc tctggtccag
     1381 gccatgccgc gccgtctgcg tgtggagctg gagtgtgagg agggtgagct atccttctat
     1441 gactctgagc gccactgcca tctgtatacc ttccatgccc actttgggga ggtgaggccc
     1501 tacttctacc tgggagcctc tcgaggtgac ggtcccccgg aacctctgcg tatctgccac
     1561 ctgcgtgtct ccatcaaaga agagctggac atctgagctg cccacccctg acacatgcag
     1621 catactatat cctgtcttag cttttctgta gctccaaagt taggagccac ccaggaggtg
     1681 cttggctgag cctaggctct gtctacagtc atgctacctt caggatgtgg gttttctgtt
     1741 cttggattgc tggtatactg ttttctttgt aggatggcat tataatgtag gtgtagacta
     1801 tttttagaga tgatgaagcc agcctatcag gagatgcctc ttattgagtc tatttgtcat
     1861 ttatgtttcc caggaagagg tccttgtcag gccacacagg gaagccccag gatggtttga
     1921 gacaagagtg ggcaaagcct tcacctaggc tctcccaccc cagtaggaca agttaggtat
     1981 tggccagcct cactgagcat gcatggcttt agcatctggt ctgaaccagg agtccccgtg
     2041 ttggttccta ggacaggatt gtccttgact ctctctgtgg gaacactgta gggtgtgagg
     2101 tactctggaa tacagctcag agttgtgggt gtctcaggaa aggcagctcc agggcctttg
     2161 gcagtggtta aggactgacc agcctcaagt tagtgccata gaggccaaag caccagaatg
     2221 cagtgagtga gaagacagct agtgctgggt tggaacatga gccccactct gttactcagt
     2281 ctttcggcac ggaatcgaca ctggttggtc acctcatgct ttgaacgttt cctctggaat
     2341 tgtccagttt tctagaacac tttttaaacc tgtgtttcca catctgtgat ttgacactag
     2401 tccttggaaa tcactggagg aaggtatgag aaggagcctc agagaatgct gcttcagtca
     2461 gtgactgttg gtctgggaga cgagtcctgg ccttgctggc cttgtcttca ttggcttcca
     2521 cctgcctgtc cttgctctgc tctctgcaga ttccacccct ttcctttatg tgtccctctg
     2581 ccttttcttt ctcagtcatg cctgtagatg gagtctaatt gccaactaac caaatcccaa
     2641 gagatgttgt aaggaaaaaa taccatctca ggggtgccct gtcatcgtca agacctagga
     2701 cctagcatcc caatttcagc ctgcacccct cattacataa gacttgtttt aaaccacgcc
     2761 gattacccac taattggctc taaatgggtc atgtgcactt gtggattatc taacaagtgg
     2821 agacacagaa gaaaccctgg tgcaggccag gccgggagca gggacagtgt tggcaagcca
     2881 gcttgtgagt gtcagatgct tgggcaccac ggatgtgaaa ggtgcgcctg gtgcaatgta
     2941 tgtgtttggt taaagaaact ctctgaaatt actgttataa taagttttta aaagtttttt
     3001 ctttcttttt aattttcacc ttaactctta aatagggtaa tttcaatgac ctagactctt
     3061 agaaaaattt gacttacccc acaactgaca tgtttctttc agagcttttg taaacacaaa
     3121 ttcctagtgt aacttgtacc tgatctgtcc ttcccattgt aagattccat cgtgtgcagt
     3181 gaatgtgctg tgcaacttgt tagttgatgg acatttggct tgttgcagtg tgtttagctg
     3241 ttatgagttc tgctgctatg aaatttgtgt gcaagttttg tgtggctgtg tctcttgatt
     3301 ttctgtcata taccttggag tctgttttcc aggtcatatg ataattattt taagcccttt
     3361 ggggacttgc caagctgttt ctaagagagc cgtcccattt tctactccca ccggcagcag
     3421 gtgagggctg gtttgtaacg aattctctct gccctcttaa gctgaggaag ctggagtagg
     3481 tctcatttgc cctgtagttg cgatctctga tggctgggga gcatctttcc tcatgtttgc
     3541 tgtgtatctg cttcagagac ttcagggtgt ttgcccattg ggttgtctga ccttttatta
     3601 tgaaggttta caagtttgtt atgcattcta gataaaagtt cctttgtgtc agatgaatca
     3661 cataaaaatt ttcctcctaa ttca
//
