LOCUS       NM_053170               8870 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus tripartite motif-containing 33 (Trim33), transcript
            variant 1, mRNA.
ACCESSION   NM_053170 XM_131075
VERSION     NM_053170.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8870)
  AUTHORS   Tiniakou,I., Hsu,P.F., Lopez-Zepeda,L.S., Garipler,G., Esteva,E.,
            Adams,N.M., Jang,G., Soni,C., Lau,C.M., Liu,F.,
            Khodadadi-Jamayran,A., Rodrick,T.C., Jones,D., Tsirigos,A.,
            Ohler,U., Bedford,M.T., Nimer,S.D., Kaartinen,V., Mazzoni,E.O. and
            Reizis,B.
  TITLE     Genome-wide screening identifies Trim33 as an essential regulator
            of dendritic cell differentiation
  JOURNAL   Sci Immunol 9 (94), eadi1023 (2024)
   PUBMED   38608038
  REMARK    GeneRIF: Genome-wide screening identifies Trim33 as an essential
            regulator of dendritic cell differentiation.
REFERENCE   2  (bases 1 to 8870)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8870)
  AUTHORS   Yuan,C., Jin,G., Li,P., Wang,W., Ge,C., Pan,Y., Zhang,Q., Mo,J.,
            Kuang,D., Liu,L., Zhang,X., Liang,H., Zhang,W., Tang,X., Li,Z.,
            Liu,J., Xu,G., Chen,X., Ding,Z.Y. and Zhang,B.
  TITLE     Tubular cell transcriptional intermediary factor 1gamma deficiency
            exacerbates kidney injury-induced tubular cell polyploidy and
            fibrosis
  JOURNAL   Kidney Int 104 (4), 769-786 (2023)
   PUBMED   37482091
  REMARK    GeneRIF: Tubular cell transcriptional intermediary factor 1gamma
            deficiency exacerbates kidney injury-induced tubular cell
            polyploidy and fibrosis.
REFERENCE   4  (bases 1 to 8870)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8870)
  AUTHORS   Wang,F., Wang,W., Wu,X., Tang,C., Du,F., Lu,Z., Zhang,Z., Xu,H.,
            Cao,X. and Li,P.A.
  TITLE     Downregulation of TRIM33 Promotes Survival and
            Epithelial-Mesenchymal Transition in Gastric Cancer
  JOURNAL   Technol Cancer Res Treat 21, 15330338221114505 (2022)
   PUBMED   35929141
  REMARK    GeneRIF: Downregulation of TRIM33 Promotes Survival and
            Epithelial-Mesenchymal Transition in Gastric Cancer.
REFERENCE   6  (bases 1 to 8870)
  AUTHORS   Yan,K.P., Dolle,P., Mark,M., Lerouge,T., Wendling,O., Chambon,P.
            and Losson,R.
  TITLE     Molecular cloning, genomic structure, and expression analysis of
            the mouse transcriptional intermediary factor 1 gamma gene
  JOURNAL   Gene 334, 3-13 (2004)
   PUBMED   15256250
REFERENCE   7  (bases 1 to 8870)
  AUTHORS   Okubo,T. and Hogan,B.L.
  TITLE     Hyperactive Wnt signaling changes the developmental potential of
            embryonic lung endoderm
  JOURNAL   J Biol 3 (3), 11 (2004)
   PUBMED   15186480
REFERENCE   8  (bases 1 to 8870)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 8870)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 8870)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164089.4 and AY458590.1.
            
            On Nov 27, 2013 this sequence version replaced NM_053170.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY458590.1, SRR14777534.589626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-932               AC164089.4         94745-95676
            933-5661            AY458590.1         939-5667
            5662-8870           AC164089.4         171014-174222
FEATURES             Location/Qualifiers
     source          1..8870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..8870
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /note="tripartite motif-containing 33"
                     /db_xref="GeneID:94093"
                     /db_xref="MGI:MGI:2137357"
     exon            1..1154
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             587..4009
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase TRIM33; TIF1-gamma; ectodermin
                     homolog; tripartite motif-containing protein 33;
                     transcription intermediary factor 1-gamma; RING-type E3
                     ubiquitin transferase TRIM33"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM33 isoform 1"
                     /protein_id="NP_444400.2"
                     /db_xref="CCDS:CCDS38573.1"
                     /db_xref="GeneID:94093"
                     /db_xref="MGI:MGI:2137357"
                     /translation="MAENKGGGEAESGGGGSGSAPVTAGAAGPTAQEAEPPLAAVLVE
                     EEEEEGGRAGAEGGAAGPDDGGVAAASSSSAPAASVPAASVGSAVPGGAASTPAPAAA
                     PAPAPAPAPAPAPAPAPAPGSSSGPPLGPPASLLDTCAVCQQSLQSRREAEPKLLPCL
                     HSFCLRCLPEPERQLSVPIPGGSNGDVQQVGVIRCPVCRQECRQIDLVDNYFVKDTSE
                     APSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDV
                     SESVGTSGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQK
                     GAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGK
                     SLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLIT
                     FQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQ
                     VPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRLQQPPAPIPTTTATTQQ
                     HPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSAPQY
                     SMMQPHLQRQHSNPGHAGPFPVVSAHNPINPTSPTTATMANANRGPTSPSVTAIELIP
                     SVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALS
                     PGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKSAHSFKSDQVKVKQEPGTEEEI
                     CSFSGAVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDTLTGLENHVKTEPT
                     DISESCKQSGLSNLVNGKSPIRNLMHRSARIGGDGNSKDDDPNEDWCAVCQNGGDLLC
                     CEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNMQHSKKGKTAQGLS
                     PVDQRKCERLLLYLYCHELSIEFQEPVPVSIPNYYKIIKKPMDLSTVKKKLQKKHSQH
                     YQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKGDSEVAKAGKAVALYFED
                     KLSEIYSDRTFTPLPEFEQDEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK"
     exon            1155..1273
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1418
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1551
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1668
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1783
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1930
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2048
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2323
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2488
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2686
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2819
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2883
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3043
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3393
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3517
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3592
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3745
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3796
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..8870
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5632..5637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /note="hexamer: AATAAA"
     polyA_site      5654
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /note="major polyA site"
     regulatory      8839..8844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /note="hexamer: ATTAAA"
     polyA_site      8862
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
ORIGIN      
        1 cagcaacacc cagcgaagac ccaggtggtc cgcacctcct cggtaggagg cctccgcgac
       61 caagcgcgcg acaggtgaag cttccgcggt ggcgcgcccg tcgctgggga tggcgtcgcc
      121 gtggagacgc tcgctcgggg gcgaacgcaa gccggcctcc tactcctgca tgttttccct
      181 cccttcttcc cgcaccaccg cggcttcggc gctagcagcc acatcataga gacccagttc
      241 caccagctcc taccgagcta cacaactcca gccgggtggc aacagaccac accgaggcgc
      301 ggagctgcat cgcggtctgt cccgcgagcg cgcgcggccg gagttcccgc ctccctccgg
      361 aggacgtcgg tgcgtacgtg cgcgtgccca cccctcccgc cccgcgacgc gagggcgggg
      421 gcgccgcgtg cgcgcgcgct ctcgtgcgtt cgctcgctcg ctcgctcgct acttcgctcg
      481 ctctcggcgg ccgctcttgc tgtggctgcg gctgaggctg ggggcggcgg cggcggcgcg
      541 agcggcgggc ggcgcggggc ggtccggcgg gttcaaagag gaaaacatgg cggaaaacaa
      601 aggcggcggt gaggcagaga gtggcggcgg gggcagcggt agcgcgccgg taaccgccgg
      661 ggccgccggg cccacggcgc aggaggcgga gccgcctctc gccgcggtgc tggtggagga
      721 ggaggaggag gaaggcggca gggctggcgc ggagggcggt gcggctgggc ccgacgacgg
      781 gggggtggcc gcggcctcct caagctcggc cccggccgcc tcggtccccg cggcctcagt
      841 gggctccgcg gtccccggag gcgcggcatc gacgccggct ccagctgctg ccccagcccc
      901 ggccccggcc ccggccccgg ccccggcccc cgctcccgcc ccggctcctg gttcctcgtc
      961 ggggccacct ctcggaccac cagcctcgct tctggacacc tgcgcggtgt gtcagcagag
     1021 cttgcagagc cggcgcgagg cggagcccaa gctgctcccc tgcctgcact ccttctgcct
     1081 gcgctgtctg ccggagccgg agcgccagct cagcgtgccc atccctgggg gcagcaacgg
     1141 tgacgtccag caagttggtg taatacggtg tccagtatgt cgtcaagaat gtagacagat
     1201 agatcttgtg gataattatt ttgtgaaaga cacatctgaa gctcctagca gctctgatga
     1261 gaaatcagaa caggtatgta ctagttgtga agataatgca agtgcagttg gtttttgtgt
     1321 agaatgtgga gagtggctgt gtaagacatg cattgaagca catcaaagag taaaattcac
     1381 taaagaccac ctgatcagga aaaaagaaga tgtctcagag tctgttggaa catctggtca
     1441 gcgcccagtg ttttgtcctg tacataaaca agagcagttg aaactattct gtgaaacgtg
     1501 tgatagattg acgtgtagag actgtcaact tttggagcac aaagaacata ggtatcagtt
     1561 tttagaagag gcttttcaaa atcagaaagg tgcaattgaa aatctgttgg ctaagcttct
     1621 tgaaaagaag aattatgttc attttgcagc tacacaagtg cagaatagga ttaaagaagt
     1681 aaatgagact aacaaacgtg tagaacagga aattaaagtg gccatcttca cccttatcaa
     1741 tgaaattaat aagaaaggaa aatctctctt gcaacagcta gagaatgtta caaaagaaag
     1801 acagatgaag ttactacagc agcagaatga tatcacaggc ctctcccggc aggtgaagca
     1861 tgttatgaac tttacaaact gggccattgc aagtggcagc agcacggccc tactttatag
     1921 caagcgtctg attacttttc agttacgtca tattttgaaa gcccgatgtg atcctgttcc
     1981 tgctgccaat ggagcaattc gtttccattg tgatcccacc ttctgggcca aaaatgtagt
     2041 gaatttaggt aatctagtaa tagagagtaa gccagctcct ggttatactc ctaatgttgt
     2101 agttgggcaa gttcctccag ggacaaacca cattagtaaa acccctggac agattaattt
     2161 agcacagctt cgactccagc acatgcagca acaagtgtat gcacagaaac atcagcagtt
     2221 acaacagatg agactgcagc aaccaccagc tcctatacca acaacaacag caacaaccca
     2281 gcagcatcct aggcaagcag ccccacagat gttacaacaa cagcctccaa gattgatcag
     2341 tgtgcaaaca atgcaaagag gcaacatgaa ctgtggagca tttcaagccc atcaaatgag
     2401 actggctcag aatgctgcca gaataccagg gatccccagg cacagtgccc ctcagtattc
     2461 catgatgcag ccacatctcc aaagacaaca ttcaaatcca ggacatgctg gaccgtttcc
     2521 tgttgtatca gcacacaacc caatcaaccc aacaagtccc accacagcaa ctatggcaaa
     2581 tgcaaatcga ggtcccacca gcccgtctgt tacagcaata gaattaatac cctcagtcac
     2641 caatccagaa aaccttccat cgttgccaga tatcccacct atacagttgg aagatgctgg
     2701 ctcaagtagt ttagataatc tactgagtag atatatctca ggcagtcatc taccccctca
     2761 gcctacaagt accatgaatc cttccccagg accctctgcg ttatcacctg gatcttcagg
     2821 cttatccaat tctcacacac ctgtgagacc ccctagcacg tctagtactg gcagtcgagg
     2881 cagctgcgga tcatcaggaa gaactgctga gaaaagtgct catagtttca agtctgatca
     2941 ggtgaaggtc aagcaggaac ctgggactga agaagagata tgcagctttt caggagctgt
     3001 gaaacaagag aagacagagg atggcaggag gagtgcctgt atgttgagca gtcctgagag
     3061 tagtttgaca ccacctcttt caactaacct tcacctagag agtgagctgg atacattaac
     3121 aggcctggag aaccacgtga agactgaacc tacagatatc agtgaaagct gcaaacagtc
     3181 aggactcagt aacctagtca atggaaagtc tccaattcga aacctcatgc acaggtcggc
     3241 aaggattgga ggggatggca atagcaaaga tgatgaccca aatgaagact ggtgtgccgt
     3301 ctgccagaac ggaggggatc ttttgtgttg tgagaaatgt ccgaaggtct ttcatcttac
     3361 ctgtcatgtt ccaacacttc tcagctttcc aagtggagac tggatatgca cattttgcag
     3421 agatattggg aagccagaag ttgaatatga ttgtgataat atgcagcata gtaagaaggg
     3481 gaaaactgca caaggcttaa gccctgtgga ccaaaggaaa tgtgaacgtc ttctgcttta
     3541 cctctattgt cacgaattaa gtattgaatt ccaggagcct gttcctgttt cgataccaaa
     3601 ctactataaa attataaaga aaccgatgga tttatcaacg gtgaagaaga agcttcagaa
     3661 aaaacattcc cagcattacc aaatcccaga tgactttgtg gctgatgtcc gtttgatctt
     3721 caagaactgt gaaaggttta atgaaatgat gaaagttgtt caagtttatg cagacacaca
     3781 agagattaat ttgaagggtg attcagaagt agctaaggca gggaaagcag ttgcattgta
     3841 ctttgaagat aaactctcag agatctactc agacaggacc ttcactcctt tgccagagtt
     3901 tgagcaggac gaagatgatg gtgaagtaac agaagactct gacgaagatt ttatacagcc
     3961 tcgtagaaaa cgcctaaagt cagacgagag accagtacat ataaagtaaa atgactcgga
     4021 cttaaatcgg ttgttaagaa gaaggaaaca aaacaaaaca cccttttatt taagtgttgc
     4081 tggaatatcc tgtgtacagt ggttttacct ccttacagaa gctggtagct ttcatacagt
     4141 attagattga aataatggaa acagaaaaca ttcttgtcaa gaaaagggga gagaactctg
     4201 tttgcaactt taagaacaaa attagaagtg aaaaaatttg gggatttgct acaaatgaag
     4261 acggttctct ggctgttaga aatgtagatg atcatgtctg ataattggtg caggatactg
     4321 agttgggcaa gcctgcgaga tgtgtctctg ctggagcaca caggtactca agataactta
     4381 aaagccttcc cctccacaga tacaaatggg ttgttttctg gttaaaagtg agtacatgag
     4441 attccacttg aatgtcacta aagatgcatt gaatcatgcc actgcatttt ctctcatttt
     4501 gatctatttg gccttagttt ttaagttggt ttaaagaact cagcagtagt tttattttat
     4561 tcttagatgt agggtctagg aacataacca ttgatcgttt agtcaacttc ggtggtgtac
     4621 taaaatgatg ataactttta gtagtggatc atacagattt atggaagtca tttccagaaa
     4681 accctccaaa caattacact tactggtcaa atcatctgat cacgcagtta gtcattcccc
     4741 tgaaagcagg acatttattt cagaattttc tgtgtaggtt aattagattg agaaggtgac
     4801 aactttaacc tagtcttctt cataccagtt tccagtagac cactattggt aaacagaaat
     4861 ctgtcagcta ccaaatgtgt acaattttct gtatttcact ttgtcttatt tgtaaatagt
     4921 gagctcagac ttctggcaga tcagcaacat ttgctgagcc tgttttttaa gctaatgtgt
     4981 attcttacta atgttcctac caagaatgga tttgtaatat atgctgtcta tttctaatgt
     5041 tcacattcat attttgaggt tctatcttat tttaatagag aacagacgtc tcaaaaaatc
     5101 ttcagaagca gcttattatt gaaatatcaa aatactgaaa taaacccggt ggggttagat
     5161 tactcatctg tccaccaagt gggacacgtg catggactgg gggctttgaa tgacttagaa
     5221 gagaccttta agtaaatcct gagaacgagc caatccccac ttgaatggta attggaacaa
     5281 acccaacctt gttactacct gacggcagga gccgacctgc agcagacagg tgtgctcgct
     5341 cgggtttatc ttcctcctct gcgttgtgac gctcagatca agtgtgctct agactgtgtg
     5401 cgcctctccg ctggattaag agttgtagtc ctacttctgt atggacacag tagaatataa
     5461 agtgaccaaa gtagaattca acatcagaaa catttcaggt gtcagcagat gtgtggcaaa
     5521 tcatttgcct ctcaaaaagt tcaaagtaag gagttcagac tgtagacctc ctcagaaagc
     5581 tatttgacgt aaatgtcgaa gaagtgaata tttttagtgt gcattgaatc aaataaagtg
     5641 ctctaaagaa attattacac agattccttt gggttgtttt ttcttaaggg atgtgggtaa
     5701 agaggaggag tatttaggcc ttttcatact gcacttaaaa gagcttgatc gtgttattac
     5761 ctcatctcct ggcttccatt tagcttccct tataaattaa ccttcaaatc atttatcatt
     5821 ttattgaagt ttcaagtttg ttttttagga ggggaagaaa atttattttt aaaatgtttt
     5881 atttatatct atttcttttc tttgatttcc atgatttgac tttgtaagta aatgaatatc
     5941 taagggtaca tttttggcaa gtgggggcgc agaggtttga cgtcatttcc tgacacttct
     6001 gggttccggt gttttttatt tgcttctcat gtgagtcctt tacaaacttc ttagcagtaa
     6061 attacaaaca atctctgtta agtggagcaa acacagattg ttaagcaaat gtttctcaat
     6121 atttgaaacc ctgagagagc gtgtgttcca taaaggcatt ctcatgttac ttgttgtttt
     6181 gtttcccttt aacactatca atttagaagt ttctctctga caagtgttta ggaagctccg
     6241 tttttgttag caaaggtatc ctgctgctga ggaataaatt gctatcaaca agatggtcac
     6301 tttaaaccct ttttgcacac tgatcattgt gttttctagg ctgtccagct ttaaaataag
     6361 tatgactaaa aaatagaaaa acttaattct tattcaaatt atctcatttc cctatttata
     6421 tttttaaaat acaaacacag aaatctgttg actcccagat gtgggtatga tatccccatg
     6481 ttaataatct ttgttagaac ttgtacctta gatttggggg ggaaaagtcc acctattgat
     6541 gatcccttaa aatccttcaa agttcttgat gaacttaggg tcatttttcc aatcagaaaa
     6601 ctaagaataa atgttcctca gcctgccctg ctggccttaa tttacgtatc agcttacgta
     6661 tctcggcgct tgactctcct gcttgactga gtgaacaaac tgctgtattg ggcacagtgt
     6721 tagggtcagc ttagatcatg gaccttgttc tatatgtaaa catcaaactc ttaccacaga
     6781 gctatgataa agcattacat ctccgttgga atcaaagggt tgctttttcc cacttctgtt
     6841 tcttatgaag gactttaggt cattaaatgt ccgttctcat tcttttaaca ggtttgaggt
     6901 tttttttttt tagttaatcc aaagacataa tgctttaaag tgtgcaaatt atagttttat
     6961 cgattacctc agcaggtatc ctgccatgta attattagtg gtttaatgct agtaagctaa
     7021 cagattcagg tcttccgtct atgcccttaa gttgtggctt accacttgtt ttttctaaaa
     7081 tgtggatggg gaatagatgc tgtagtctcc tctcccttag cctttacatc tggtacccag
     7141 cctcattcac gtacacgtaa agtagccagc atcagattgg gtcagtaaat agttttgtta
     7201 attaaaaaaa ttaagaagac aaaagactac cctccctgag ttgaaacagc ttctttgagt
     7261 gagctgggga gatgacatgg gtaaaaagca cgtgttccac aagcatgagg ctctaacttt
     7321 gaatccccag cacctacata caggtgggtg cagtagtgtg tatctgtaag cccggggctc
     7381 ccacggaaag gtaggcagag gtagtctcca gaagcccatt ggccagctag cctggcctac
     7441 tcagtgctga gtccccgaag ttgttctctg acctgcaccc tagcacatgc gccctcacac
     7501 acaacataca ccctggtgta catgccatca cacaacttgt gagtatatac accacacatg
     7561 tgccctcaaa acgtacaagt ggatacacca tttttgcctc cttactaatt atctgctgaa
     7621 ggtgtttaag atttttaaag tgtattgaag ttggatcata aacctaacct agacgttaac
     7681 ttgtttctct cagttaatac ttccttgata aagcaataac actgcttcga gtctgttgcc
     7741 tagtaaatag catgtcatga tccttccgga tggtgatttt ataggaaagt ttgtatgcac
     7801 atcacccaat ctatctttta aaaaaaatta agaaatttaa atgtatgctg gaagtaatga
     7861 ccctatattg tggcatttta ttttaaaaaa ttggggaaaa ttgcatattt ttttaaaagt
     7921 agctgtttga gtaaaaaaaa aactgaaggt acttttttaa ggaaaaaatt tatatgccac
     7981 agtttacata gacatttcca atatcagcat ttactcttgg atacaatggc ttctttactt
     8041 ggctaaatgc atgttttctt tggtcaaaag tgcatctctg agatcttagt tacttatgtt
     8101 tccttacatt atccttcata tatttttatt gtatctagaa acaattatct ttaaaaaata
     8161 agctgggcat atttgtcaaa ctacagaatg tatagaatca aggttatccc ttttctagca
     8221 agtgttattt aaaactgaaa atgatacttg ttacattcaa gagatttcta cgaaggcacc
     8281 aaaatgattt ttaaatgtca caatgctcca tttgtggcta aatttcattg tttagaatgc
     8341 ctgctcctgc tctgaaaaat gtaggcattt actatgcttt aacgcagtga gtgatagatg
     8401 cacacctgta atatgaggtg tgcgcaatta gaaagcctgt tgattttcta cgtggacata
     8461 tacctacaca caaaggatta aactcacagc cttacgagtt ccttgcttcc aggatttcaa
     8521 ctggtctccc ctcattacta ctatttttgc acatagttaa actacccttc agaatggttc
     8581 tttaaaagtg ctgtttctgt ggtattgtat tctctaaatg atcatattta attttttaaa
     8641 caaggttaca atttctaatt gttctgttcc tgtgtttttt gctgagtgta ataaaagcaa
     8701 attttttctt tttatggtta tttaatacat tagctgcctg taaataattc ttgttacaat
     8761 gctctggaat gtgttgtaga agttgtacta gattagtttg aagccttgtt taaaacccac
     8821 attgttttgg ctatttctat taaatctaga aaattggcaa aagttttcaa
//
