LOCUS       NM_053084               3196 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 32 (Trim32), transcript
            variant 1, mRNA.
ACCESSION   NM_053084
VERSION     NM_053084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3196)
  AUTHORS   Choi,J.H., Jeong,S.Y., Kim,J., Woo,J.S. and Lee,E.H.
  TITLE     Tripartite motif-containing protein 32 regulates Ca2+ movement in
            skeletal muscle
  JOURNAL   Am J Physiol Cell Physiol 323 (6), C1860-C1871 (2022)
   PUBMED   36374170
  REMARK    GeneRIF: Tripartite motif-containing protein 32 regulates Ca[2+]
            movement in skeletal muscle.
REFERENCE   2  (bases 1 to 3196)
  AUTHORS   Chen,Z., Tian,L., Wang,L., Ma,X., Lei,F., Chen,X. and Fu,R.
  TITLE     TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and
            Inflammatory Injury in Podocytes Induced by High Glucose by
            Modulating the Akt/GSK-3beta/Nrf2 Pathway
  JOURNAL   Inflammation 45 (3), 992-1006 (2022)
   PUBMED   34783942
  REMARK    GeneRIF: TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress,
            and Inflammatory Injury in Podocytes Induced by High Glucose by
            Modulating the Akt/GSK-3beta/Nrf2 Pathway.
REFERENCE   3  (bases 1 to 3196)
  AUTHORS   Sun,Y.Y., Chen,W.J., Huang,Z.P., Yang,G., Wu,M.L., Xu,D.E.,
            Yang,W.L., Luo,Y.C., Xiao,Z.C., Xu,R.X. and Ma,Q.H.
  TITLE     TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in
            Developing Cerebral Cortex
  JOURNAL   Cells 11 (3), 449 (2022)
   PUBMED   35159260
  REMARK    GeneRIF: TRIM32 Deficiency Impairs the Generation of Pyramidal
            Neurons in Developing Cerebral Cortex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3196)
  AUTHORS   Zhu,J.W., Jia,W.Q., Zhou,H., Li,Y.F., Zou,M.M., Wang,Z.T., Wu,B.S.
            and Xu,R.X.
  TITLE     Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in
            Mid-Aged Mice
  JOURNAL   Front Aging Neurosci 13, 697494 (2021)
   PUBMED   34421574
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3196)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3196)
  AUTHORS   Horn,E.J., Albor,A., Liu,Y., El-Hizawi,S., Vanderbeek,G.E.,
            Babcock,M., Bowden,G.T., Hennings,H., Lozano,G., Weinberg,W.C. and
            Kulesz-Martin,M.
  TITLE     RING protein Trim32 associated with skin carcinogenesis has
            anti-apoptotic and E3-ubiquitin ligase properties
  JOURNAL   Carcinogenesis 25 (2), 157-167 (2004)
   PUBMED   14578165
REFERENCE   7  (bases 1 to 3196)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3196)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 3196)
  AUTHORS   Vogel,S.N., Johnson,D., Perera,P.Y., Medvedev,A., Lariviere,L.,
            Qureshi,S.T. and Malo,D.
  TITLE     Cutting edge: functional characterization of the effect of the
            C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for
            a dominant negative mutation
  JOURNAL   J Immunol 162 (10), 5666-5670 (1999)
   PUBMED   10229796
REFERENCE   10 (bases 1 to 3196)
  AUTHORS   Qureshi,S.T., Lariviere,L., Leveque,G., Clermont,S., Moore,K.J.,
            Gros,P. and Malo,D.
  TITLE     Endotoxin-tolerant mice have mutations in Toll-like receptor 4
            (Tlr4)
  JOURNAL   J Exp Med 189 (4), 615-625 (1999)
   PUBMED   9989976
  REMARK    Erratum:[J Exp Med 1999 May 3;189(9):following 1518]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY280460.1, BC034104.1, BE855341.1 and BG073447.2.
            
            On Jun 16, 2009 this sequence version replaced NM_053084.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY280460.1, AF347694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               BY280460.1         1-392
            393-2316            BC034104.1         332-2255
            2317-2657           BE855341.1         202-542
            2658-3196           BG073447.2         1-539               c
FEATURES             Location/Qualifiers
     source          1..3196
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 34.43 cM"
     gene            1..3196
                     /gene="Trim32"
                     /gene_synonym="1810045E12Rik; 3f3; BBS11; Zfp117"
                     /note="tripartite motif-containing 32"
                     /db_xref="GeneID:69807"
                     /db_xref="MGI:MGI:1917057"
     exon            1..84
                     /gene="Trim32"
                     /gene_synonym="1810045E12Rik; 3f3; BBS11; Zfp117"
                     /inference="alignment:Splign:2.1.0"
     exon            85..3196
                     /gene="Trim32"
                     /gene_synonym="1810045E12Rik; 3f3; BBS11; Zfp117"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2131
                     /gene="Trim32"
                     /gene_synonym="1810045E12Rik; 3f3; BBS11; Zfp117"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 32; tripartite
                     motif-containing protein 32; RING-type E3 ubiquitin
                     transferase TRIM32; zinc finger protein 117; bM468K2.2
                     (tripartite motif protein 32)"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM32"
                     /protein_id="NP_444314.2"
                     /db_xref="CCDS:CCDS18270.1"
                     /db_xref="GeneID:69807"
                     /db_xref="MGI:MGI:1917057"
                     /translation="MAAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTI
                     CRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCR
                     GCGRRLPRQFCRSCGVVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLREL
                     TGELQRRKAALEGVSRDLQARYKAVLQEYGHEERRIQEELARSRKFFTGSLAEVEKSN
                     SQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETADEEEPELTASLPRELTL
                     QDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAGEEGAASSASASVTFREMDMSPEEV
                     APSPRASPAKQRSSEAASGIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQSEVLVADR
                     GNYRIQVFNRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCHGLIGVTDSY
                     DNSLKVYTMDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGAGVVK
                     YSCLCSAVRPKFVTCDAEGTVYFTQGLGLNVENRQNEHHLEGGFSIGSVGPDGQLGRQ
                     ISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGI
                     ALTPKGQLLVLDCWDHCVKIYSYHLRRYSTP"
     regulatory      3169..3174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim32"
                     /gene_synonym="1810045E12Rik; 3f3; BBS11; Zfp117"
                     /note="hexamer: AATAAA"
     polyA_site      3194
                     /gene="Trim32"
                     /gene_synonym="1810045E12Rik; 3f3; BBS11; Zfp117"
                     /note="major polyA site"
ORIGIN      
        1 gaaggacgtg ctagcgcatg cgcagaaggc agcgggcggg tgggctggca gcggtggact
       61 cgcgtcggag ctgcgggcgg tcagcaggaa tctgacactg gggcatgaat attaagctgt
      121 gtggctctaa gctgtgttag caggaacctt cactggaaga gcaatggctg cggctgcagc
      181 agcttctcac ctgaacctgg atgccctccg ggaagtgcta gaatgtccca tctgcatgga
      241 gtccttcact gaagagcagc tgcgacccaa gctgctgcac tgtggccata ccatctgccg
      301 ccagtgtctg gagaagctcc tggccagcag catcaatggc gtccgctgcc ccttttgcag
      361 caagattact cgcatcacca gcctgaccca gctgaccgac aacctgacgg tgctgaagat
      421 cattgacaca gctgggctca gtgaggccgt cggcctgctc atgtgccgag gctgtggccg
      481 gcggctgcct cggcagttct gccgaagctg tggtgtggtg ttgtgtgaac cctgccggga
      541 ggcagatcac caaccccctg gccactgcac acttccggtc aaggaggcag ctgaggagcg
      601 gcggagggac ttcggggaga agttgactcg tctaagggaa cttactggag agctgcagag
      661 gaggaaggca gccttggagg gcgtctccag ggatcttcag gcaaggtata aggctgttct
      721 tcaagaatat ggccatgagg aacgccgcat ccaggaagag ctagcccgct ctcggaagtt
      781 cttcacaggc tccttggctg aggttgagaa gtccaacagt caagtggtag aggagcagag
      841 ctacctactc aacattgctg aggtgcaggc cgtgtctcgc tgtgactact ttctagcgaa
      901 gatcaagcaa gctgatgtag ccctcctgga ggagacagcg gatgaggagg agcccgagct
      961 cactgccagc ctaccccggg agcttaccct gcaagatgtg gagctcctta aggtaggaca
     1021 cgttggtcct ctgcaaattg gccaggctgt taagaagccc cggacagtta acatggaaga
     1081 ttcctgggca ggggaggagg gagcagcatc ttctgcctca gcctcggtaa cctttagaga
     1141 gatggacatg agccctgagg aagtagctcc cagccctagg gcttcccccg cgaaacagcg
     1201 gagttctgag gcagcttccg gtatccagca gtgtctgttt ctcaagaaga tgggggcgaa
     1261 aggcagcact cccggcatgt tcaatcttcc agtcagtctc tatgtgacca gtcagagtga
     1321 ggtgctggtt gccgaccggg gcaactatcg tatccaagtg ttcaaccgca aaggcttttt
     1381 gaaggagatc cgccgcagcc ccagcggcat tgatagcttc gtgctaagct tccttggagc
     1441 cgacttgccc aatctcactc cactttcagt ggccatgaac tgccatgggc tgattggtgt
     1501 cactgatagc tacgacaact cccttaaagt ctataccatg gatggccact gtgtggcctg
     1561 tcacaggagc cagctgagca aaccatgggg catcacagcc ctaccatctg gccagtttgt
     1621 ggtgactgac gtggaaggcg ggaagctctg gtgtttcact gtagaccgag gagcaggagt
     1681 ggtcaaatac agctgcctct gcagtgctgt gaggcccaag tttgtcacct gtgatgctga
     1741 aggcacagtc tacttcaccc aaggcttggg gctcaatgtg gaaaaccgac agaatgaaca
     1801 ccacctggag ggtggcttct ccatcggttc tgttggcccc gatgggcagc tgggccggca
     1861 aatcagccac ttcttctctg agaatgaaga tttccgctgc atcgctggca tgtgtgtaga
     1921 tgctcggggc gacctcattg tggcagatag cagccgcaag gaaattctcc attttcccaa
     1981 gggcggtggc tacagcgtcc ttattcgaga gggccttacc tgtccagtgg gcatcgccct
     2041 cacacccaag gggcagctgc tggtcttgga ctgttgggat cactgcgtca agatctacag
     2101 ctatcatctg agaagatatt ccacccctta aaagatgagg agaaatacca ctttcttctt
     2161 tccctcaata gagtttcctt ccctttcctt ccttcgttgt tgatggtgcc gtagagtaga
     2221 tgtggcctgt ggcctgattc tagtagggtt gctctagaat cgtagaagct ctagttttca
     2281 gtgattttgt ttgttatgcc cctcttcccc ccccccctcc ccttttctcc ttctaacttt
     2341 agagcttaga gctttaccag gtaccttatc ccaagtagaa tagatgatgc tcttagcaga
     2401 agttgcttag aagttaggta cttccaaggc tttagtaaag agaaccactt tagtcctttg
     2461 cccttgtgtt tgaaatttgt attggtattg aatagtcatt gatatttccc tttggactat
     2521 gaggtcccta gtctactgtc tccttcctgt tacagtgtgc ttcgtctgtg gctttaaatc
     2581 tggctgcatt ctgtgtgcat gctccagtgg gatctgcttg acccttcagt gatattatat
     2641 tctgtagcat gatgtctcct ttgatcacct ttaccagtgt gagagtatat cattaagtgc
     2701 caccaaaggt gacacatagt ccctttgaaa gcaggacctc ttgacgggaa tttctgccac
     2761 catagattgt cttctcattg aagatgtgcc agaggatggt ttgactgacc ctagttggat
     2821 agtgttgaac acttcagtcc agaaatcact tgccttttaa aggagtttat aggttagaat
     2881 tatgccatgg ccaaggcaga cgggaacata taagcagatg ctaacatatc cagcaaatgt
     2941 gggatatttt ctagggctca aagcgttttg tactccttcc actgacctat gctaagagtt
     3001 attgaaagaa ttgtgtaatg tgagcttcga ccaacaatgt gaggaggttg acacatccat
     3061 tttcattact aaagaacaaa ctgttaggta gctagctctg tattttcttc aagtgagtgc
     3121 atattgtttg actttgagat ttagctctgt tctatcaagc attaaactaa taaaagtaat
     3181 aactttcttc atcact
//
