LOCUS       NM_146077               2248 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tripartite motif-containing 31 (Trim31), mRNA.
ACCESSION   NM_146077
VERSION     NM_146077.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Zhao,Z., Song,X., Wang,Y., Yu,L., Huang,G., Li,Y., Zong,R., Liu,T.,
            Ji,Q., Zheng,Y., Liu,B., Zhu,Q., Chen,L., Gao,C. and Liu,H.
  TITLE     E3 ubiquitin ligase TRIM31 alleviates dopaminergic
            neurodegeneration by promoting proteasomal degradation of VDAC1 in
            Parkinson's Disease model
  JOURNAL   Cell Death Differ 31 (11), 1410-1421 (2024)
   PUBMED   38918620
  REMARK    GeneRIF: E3 ubiquitin ligase TRIM31 alleviates dopaminergic
            neurodegeneration by promoting proteasomal degradation of VDAC1 in
            Parkinson's Disease model.
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Xue,J., Jiang,C., Chen,X. and Wang,L.
  TITLE     Trim31 deficiency exacerbates airway inflammation in asthma by
            enhancing the activation of the NLRP3 inflammasome
  JOURNAL   Int Immunopharmacol 138, 112591 (2024)
   PUBMED   38981220
  REMARK    GeneRIF: Trim31 deficiency exacerbates airway inflammation in
            asthma by enhancing the activation of the NLRP3 inflammasome.
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Yu,Q., Shi,H., Ding,Z., Wang,Z., Yao,H. and Lin,R.
  TITLE     The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome
            activation in Helicobacter pylori-associated gastritis by
            regulating ROS and autophagy
  JOURNAL   Cell Commun Signal 21 (1), 1 (2023)
   PUBMED   36597090
  REMARK    GeneRIF: The E3 ubiquitin ligase TRIM31 attenuates NLRP3
            inflammasome activation in Helicobacter pylori-associated gastritis
            by regulating ROS and autophagy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Jahan,S., Awaja,N., Hess,B., Hajjar,S., Sad,S. and Lohnes,D.
  TITLE     The transcription factor Cdx2 regulates inflammasome activity
            through expression of the NLRP3 suppressor TRIM31 to maintain
            intestinal homeostasis
  JOURNAL   J Biol Chem 298 (10), 102386 (2022)
   PUBMED   35985421
  REMARK    GeneRIF: The transcription factor Cdx2 regulates inflammasome
            activity through expression of the NLRP3 suppressor TRIM31 to
            maintain intestinal homeostasis.
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Liu,B., Zhang,M., Chu,H., Zhang,H., Wu,H., Song,G., Wang,P.,
            Zhao,K., Hou,J., Wang,X., Zhang,L. and Gao,C.
  TITLE     The ubiquitin E3 ligase TRIM31 promotes aggregation and activation
            of the signaling adaptor MAVS through Lys63-linked
            polyubiquitination
  JOURNAL   Nat Immunol 18 (2), 214-224 (2017)
   PUBMED   27992402
  REMARK    GeneRIF: this paper identifies TRIM31, an E3 ubiquitin ligase of
            the TRIM family of proteins, as a regulator of MAVS aggregation
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Song,H., Liu,B., Huai,W., Yu,Z., Wang,W., Zhao,J., Han,L.,
            Jiang,G., Zhang,L., Gao,C. and Zhao,W.
  TITLE     The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome
            activation by promoting proteasomal degradation of NLRP3
  JOURNAL   Nat Commun 7, 13727 (2016)
   PUBMED   27929086
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Watanabe,M., Tsukiyama,T. and Hatakeyama,S.
  TITLE     TRIM31 interacts with p52(Shc) and inhibits Src-induced
            anchorage-independent growth
  JOURNAL   Biochem Biophys Res Commun 388 (2), 422-427 (2009)
   PUBMED   19665990
  REMARK    GeneRIF: TRIM31 attenuates c-Src signaling via p52(Shc) under
            anchorage-independent growth conditions and is potentially
            associated with growth activity of cells in the gastrointestinal
            tract.
REFERENCE   10 (bases 1 to 2248)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CR956641.9.
            
            On Nov 17, 2006 this sequence version replaced NM_146077.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026666.1, AK033650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-638               CR956641.9         119232-119869       c
            639-734             CR956641.9         118012-118107       c
            735-965             CR956641.9         116120-116350       c
            966-988             CR956641.9         112563-112585       c
            989-1104            CR956641.9         111977-112092       c
            1105-1179           CR956641.9         110665-110739       c
            1180-1221           CR956641.9         110178-110219       c
            1222-2248           CR956641.9         107782-108808       c
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     gene            1..2248
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /note="tripartite motif-containing 31"
                     /db_xref="GeneID:224762"
                     /db_xref="MGI:MGI:2385051"
     exon            1..638
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1748
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 31; RING-type
                     E3 ubiquitin transferase TRIM31"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM31"
                     /protein_id="NP_666189.1"
                     /db_xref="CCDS:CCDS28728.1"
                     /db_xref="GeneID:224762"
                     /db_xref="MGI:MGI:2385051"
                     /translation="MAGQPLACQLQEEVTCPICMEILQDPVTIDCGHNFCLQCISQVG
                     KTSEKIQCPLCKLSVNKNTFRPNKLLASLAEKIQSMDPADIQAEKEDSRCQRHKEKLH
                     YFCEQDGAFLCVVCRDSKDHKSHNVTLIDEAAQNYKVQIESQAQDLGQKDKKIIEEKK
                     QGEGAIWAFRAQVDLEKLKIHEEFKLLRQRLDEEESFLLSRLDWLEQQGAKQLRQYVT
                     VTEKQLNSLRKLTKSLKIRLQSSSMELLKDIKDALSRGKEFQFLNPNPVPEDLEKKCS
                     EAKARHESIIKTLTELKDDMNAEGKRDKSAFMNSLNKEEKESWSLLQKNNSVLPTSVP
                     VTLDKSSADPDLTFSQDLKKVTLYIVAGKASNRQAKPRPFYPFHCVRGSPGLSSGRQV
                     WEAEIRGPSGGACIVGVVTELARGAQSQTVSAQSYIWALRISPSGCQPFTNCKAQEYL
                     QVCLKKVGVYVNHDCGEVVFYDAITSKHIYTFQTSFDGKVFPLFGLQVACSHITLSP"
     exon            639..734
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            735..965
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            966..988
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1104
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1179
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1221
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..2248
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /note="hexamer: ATTAAA"
     polyA_site      2246
                     /gene="Trim31"
                     /gene_synonym="HCG1; HCGI; RNF"
                     /note="major polyA site"
ORIGIN      
        1 cagggagaga ggactgacca tctgttttct tctctttaga atattcccca tttatcgctg
       61 actcttttct gtcattattt atttaacccc cccttccctc attctcctct aatcctctcc
      121 ctgagatact cttcaacctc tgcctcctgc ttccttctct cttacaagca ccaggccttg
      181 gatttctgta ctttcacatc tcagattagc cctgctgttc catcatggca ggccaacctc
      241 tggcctgcca actgcaggag gaggtgacct gccccatctg catggaaatt ctacaagatc
      301 ctgtcaccat tgactgtggg cacaacttct gcctgcagtg tatcagtcag gttggaaaaa
      361 cgtcagaaaa gatccaatgt cctctctgca aactctctgt gaataagaat acgttcaggc
      421 ccaataagct gctggctagt cttgcagaga agatccaaag tatggatcct gctgacatcc
      481 aagcagaaaa ggaagactca agatgtcaga ggcacaagga aaagctacat tacttctgcg
      541 agcaggatgg ggcattcctc tgtgtggtgt gtcgtgactc caaggaccac aagtctcaca
      601 atgtcacctt gatagatgag gctgcccaga actacaaggt gcagattgag tcacaggccc
      661 aagatttggg gcaaaaggac aagaaaataa ttgaagagaa aaaacaaggt gaaggggcaa
      721 tctgggcgtt cagggcccag gtggatctag agaaactaaa gatccatgag gaattcaagc
      781 tcctgcgcca gagactagat gaggaagaga gtttcctcct gtccaggctg gactggctgg
      841 agcagcaggg agccaagcag ttgagacaat atgtcactgt gacagagaag cagctgaact
      901 ctctaaggaa gctcactaaa tccttgaaaa taaggctgca atcatcatcc atggagctac
      961 taaaggacat taaagacgcc ttgagcaggg gtaaggaatt tcagtttctc aacccaaacc
     1021 cagttcctga ggacctggag aaaaaatgca gtgaagcaaa agcaaggcat gagtccatca
     1081 taaaaaccct gacagaactc aaagacgata tgaatgccga agggaagaga gataaaagcg
     1141 cattcatgaa cagcctgaat aaagaagaaa aggagagctg gagcctgtta cagaagaata
     1201 attcagtgtt gcccacctca gtccctgtga ccctggacaa gtcctcagct gacccagacc
     1261 tcaccttttc tcaggatcta aagaaagtga ccttgtatat tgtagctgga aaagcttcca
     1321 ataggcaggc aaaacctcga ccattctacc ctttccactg tgtgaggggt tccccaggcc
     1381 tctcctcagg ccgccaggtg tgggaggcag aaatccgggg gccctcaggt ggggcatgca
     1441 ttgtgggcgt ggttacagag ttggcgcgag gggcccagag tcaaaccgtg agcgcgcaga
     1501 gctacatatg ggcactgcgg atctcgccct ctggatgcca gccattcacc aattgtaaag
     1561 cccaggagta cctccaggtc tgtcttaaga aagtgggtgt ctatgtgaat catgactgtg
     1621 gagaggtcgt cttctatgat gccatcacta gcaaacacat ctatactttc caaacttcct
     1681 ttgacgggaa ggtcttcccc cttttcgggc tccaagttgc ctgcagccat atcaccctga
     1741 gcccttaggg ctgctcgctt gtgtgttcct cagtctcttc ccacctatca ctcaggacgg
     1801 gatgagacaa atggtagaag tgaagtgtgg ccctactctg acactctaca tgccacacaa
     1861 tcacctgatg tttcctctcc ctgtctcccc caagtagaga agacagtgga atacccccca
     1921 aagactatac acgaggtttt tcagtgctgc acttggtagc aggacctcag aaaagcttct
     1981 ggctgcaccc tgctgacaca ggggtgcaag gcgctgtcca acacattggc tgctgctttc
     2041 tctactgtat tacctgaaac tcttgtgact catcctttcc tgagatctga gaaccagagg
     2101 ttgtacagag tcggccagtt ctgtgccaat gccccgtttg tagatttgga caatctacaa
     2161 tcaagaataa aaccttttga catttcaaag caactttgtc atcctcaaca gctctgtctt
     2221 ctaattaaaa gcaaaattgt aaaccacc
//
