LOCUS       NP_001344396             496 aa            linear   ROD 06-OCT-2024
DEFINITION  tripartite motif-containing protein 30A [Mus musculus].
ACCESSION   NP_001344396 XP_006507534
VERSION     NP_001344396.1
DBSOURCE    REFSEQ: accession NM_001357467.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 496)
  AUTHORS   Schafer,A., Marzi,A., Furuyama,W., Catanzaro,N.J., Nguyen,C.,
            Haddock,E., Feldmann,F., Meade-White,K., Thomas,T., Hubbard,M.L.,
            Gully,K.L., Leist,S.R., Hock,P., Bell,T.A., De la Cruz,G.E.,
            Midkiff,B.R., Martinez,D.R., Shaw,G.D., Miller,D.R., Vernon,M.J.,
            Graham,R.L., Cowley,D.O., Montgomery,S.A., Schughart,K., de
            Villena,F.P.M., Wilkerson,G.K., Ferris,M.T., Feldmann,H. and
            Baric,R.S.
  TITLE     Mapping of susceptibility loci for Ebola virus pathogenesis in mice
  JOURNAL   Cell Rep 43 (5), 114127 (2024)
   PUBMED   38652660
REFERENCE   2  (residues 1 to 496)
  AUTHORS   Afolabi,L.O., Bi,J., Chen,L., Yang,X. and Wan,X.
  TITLE     Suppression of protein quality control system by TRIM30a sensitises
            tumour cells to NK cell-mediated immune surveillance
  JOURNAL   Immunology 171 (1), 60-76 (2024)
   PUBMED   37753964
  REMARK    GeneRIF: Suppression of protein quality control system by TRIM30a
            sensitises tumour cells to NK cell-mediated immune surveillance.
REFERENCE   3  (residues 1 to 496)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 496)
  AUTHORS   Lee,M., Liu,Y.C., Chen,C., Lu,C.H., Lu,S.T., Huang,T.N., Hsu,M.T.,
            Hsueh,Y.P. and Cheng,P.L.
  TITLE     Ecm29-mediated proteasomal distribution modulates excitatory GABA
            responses in the developing brain
  JOURNAL   J Cell Biol 219 (2) (2020)
   PUBMED   31910261
REFERENCE   5  (residues 1 to 496)
  AUTHORS   Da Silva,F., Massa,F., Motamedi,F.J., Vidal,V., Rocha,A.S.,
            Gregoire,E.P., Cai,C.L., Wagner,K.D. and Schedl,A.
  TITLE     Myocardial-specific R-spondin3 drives proliferation of the coronary
            stems primarily through the Leucine Rich Repeat G Protein coupled
            receptor LGR4
  JOURNAL   Dev Biol 441 (1), 42-51 (2018)
   PUBMED   29859889
REFERENCE   6  (residues 1 to 496)
  AUTHORS   Tareen,S.U., Sawyer,S.L., Malik,H.S. and Emerman,M.
  TITLE     An expanded clade of rodent Trim5 genes
  JOURNAL   Virology 385 (2), 473-483 (2009)
   PUBMED   19147168
REFERENCE   7  (residues 1 to 496)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (residues 1 to 496)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (residues 1 to 496)
  AUTHORS   Ben-Zur,T. and Wides,R.
  TITLE     Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse
            chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human
            chromosome Xq25
  JOURNAL   Genomics 58 (1), 102-103 (1999)
   PUBMED   10331952
REFERENCE   10 (residues 1 to 496)
  AUTHORS   Patarca,R., Freeman,G.J., Schwartz,J., Singh,R.P., Kong,Q.T.,
            Murphy,E., Anderson,Y., Sheng,F.Y., Singh,P., Johnson,K.A. et al.
  TITLE     rpt-1, an intracellular protein from helper/inducer T cells that
            regulates gene expression of interleukin 2 receptor and human
            immunodeficiency virus type 1
  JOURNAL   Proc Natl Acad Sci U S A 85 (8), 2733-2737 (1988)
   PUBMED   2965815
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1988 Jul;85(14):5224]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122400.4 and AC142110.4.
            
            On Oct 28, 2017 this sequence version replaced XP_006507534.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.3011282.1,
                                           SRR17253012.1820967.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.69 cM"
     Protein         1..496
                     /product="tripartite motif-containing protein 30A"
                     /note="regulatory protein, T lymphocyte 1; tripartite
                     motif protein 30; tripartite motif-containing protein 30;
                     down regulatory protein of interleukin-2 receptor;
                     tripartite motif-containing 30"
                     /calculated_mol_wt=57199
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          95..133
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          205..210
                     /region_name="Highly hydrophilic"
                     /note="propagated from UniProtKB/Swiss-Prot (P15533.2)"
     Region          268..276
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P15533.2)"
     Region          289..492
                     /region_name="SPRY"
                     /note="SPRY domain; cl02614"
                     /db_xref="CDD:470632"
     CDS             1..496
                     /gene="Trim30a"
                     /gene_synonym="Rpt-1; Rpt1; Trim30"
                     /coded_by="NM_001357467.1:267..1757"
                     /db_xref="CCDS:CCDS40068.1"
                     /db_xref="GeneID:20128"
                     /db_xref="MGI:MGI:98178"
ORIGIN      
        1 massvlemik eevtcpicle llkepvsadc nhsfcracit lnyesnrntd gkgncpvcrv
       61 pypfgnlrpn lhvaniverl kgfksipeee qkvnicaqhg eklrlfcrkd mmvicwlcer
      121 sqehrghqta lieevdqeyk eklqgalwkl mkkakicdew qddlqlqrvd wenqiqinve
      181 nvqrqfkglr dlldskenee lqklkkekke vmekleesen eledqtelvr dlisdvehhl
      241 elstlemlqg ancvlrrsqs lslqqpqtvp qkrkrtfqap dlkgmlqvyq glmdiqqywv
      301 hmtlharnna viainkekrq iqyrsyntvp vseiyhlgvl gypalssgkh ywevdisrsd
      361 awllglndgk caqpqlhske emgikknlhs qikqnvlfqp kcgywvigmk npsvykafde
      421 csithnssil vislpdrpsr vgvfldrkag tlsfydvsnc galiyrfydp afpvevypyf
      481 npmkcsepmt icgpps
//
