LOCUS       NM_023655               2830 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus tripartite motif-containing 29 (Trim29), mRNA.
ACCESSION   NM_023655
VERSION     NM_023655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Wang,J., Wang,L., Lu,W., Farhataziz,N., Gonzalez,A., Xing,J. and
            Zhang,Z.
  TITLE     TRIM29 controls enteric RNA virus-induced intestinal inflammation
            by targeting NLRP6 and NLRP9b signaling pathways
  JOURNAL   Mucosal Immunol (2024) In press
   PUBMED   39396665
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Wang,J., Lu,W., Zhang,J., Du,Y., Fang,M., Zhang,A., Sungcad,G.,
            Chon,S. and Xing,J.
  TITLE     Loss of TRIM29 mitigates viral myocarditis by attenuating
            PERK-driven ER stress response in male mice
  JOURNAL   Nat Commun 15 (1), 3481 (2024)
   PUBMED   38664417
  REMARK    GeneRIF: Loss of TRIM29 mitigates viral myocarditis by attenuating
            PERK-driven ER stress response in male mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Xu,X., Qin,Z., Zhang,C., Mi,X., Zhang,C., Zhou,F., Wang,J.,
            Zhang,L. and Hua,F.
  TITLE     TRIM29 promotes podocyte pyroptosis in diabetic nephropathy through
            the NF-kB/NLRP3 inflammasome pathway
  JOURNAL   Cell Biol Int 47 (6), 1126-1135 (2023)
   PUBMED   36841942
  REMARK    GeneRIF: TRIM29 promotes podocyte pyroptosis in diabetic
            nephropathy through the NF-kB/NLRP3 inflammasome pathway.
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Deng,Y., Li,Z., Sun,X., Ma,N., Song,L., Chen,D. and Gao,F.
  TITLE     TRIM29 (Tripartite Motif Containing 29) Alleviates NLRC4 (NLR
            Family CARD Domain Containing Protein 4) Inflammasome Related
            Cerebral Injury via Promoting Proteasomal Degradation of NLRC4 in
            Ischemic Stroke
  JOURNAL   Stroke 54 (5), 1377-1389 (2023)
   PUBMED   37021569
  REMARK    GeneRIF: TRIM29 (Tripartite Motif Containing 29) Alleviates NLRC4
            (NLR Family CARD Domain Containing Protein 4) Inflammasome Related
            Cerebral Injury via Promoting Proteasomal Degradation of NLRC4 in
            Ischemic Stroke.
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   7  (bases 1 to 2830)
  AUTHORS   Wang,L., Yang,H., Abel,E.V., Ney,G.M., Palmbos,P.L., Bednar,F.,
            Zhang,Y., Leflein,J., Waghray,M., Owens,S., Wilkinson,J.E.,
            Prasad,J., Ljungman,M., Rhim,A.D., Pasca di Magliano,M. and
            Simeone,D.M.
  TITLE     ATDC induces an invasive switch in KRAS-induced pancreatic
            tumorigenesis
  JOURNAL   Genes Dev 29 (2), 171-183 (2015)
   PUBMED   25593307
  REMARK    GeneRIF: ATDC up-regulates CD44 in mouse and human PanIN lesions
            via activation of beta-catenin signaling, leading to the induction
            of an epithelial-to-mesenchymal transition (EMT) phenotype
            characterized by expression of Zeb1 and Snail1.
REFERENCE   8  (bases 1 to 2830)
  AUTHORS   Yuan,Z., Peng,L., Radhakrishnan,R. and Seto,E.
  TITLE     Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC
            (TRIM29) protein
  JOURNAL   J Biol Chem 285 (50), 39329-39338 (2010)
   PUBMED   20947501
  REMARK    GeneRIF: Histone deacetylase 9 (HDAC9) regulates the functions of
            the ATDC (TRIM29) protein
REFERENCE   9  (bases 1 to 2830)
  AUTHORS   Yuan,Z., Villagra,A., Peng,L., Coppola,D., Glozak,M.,
            Sotomayor,E.M., Chen,J., Lane,W.S. and Seto,E.
  TITLE     The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated
            functions
  JOURNAL   Mol Cell Biol 30 (12), 3004-3015 (2010)
   PUBMED   20368352
  REMARK    GeneRIF: ATDC increases cell proliferation via inhibition of p53
            nuclear activities.
REFERENCE   10 (bases 1 to 2830)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167973.4, BB612224.1, AK013219.1 and AK028448.1.
            
            On Nov 15, 2007 this sequence version replaced NM_023655.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028448.1, BC027353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               AC167973.4         107509-108278
            771-949             BB612224.1         1-179
            950-2819            AK013219.1         1-1870
            2820-2830           AK028448.1         2053-2063
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.28 cM"
     gene            1..2830
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /note="tripartite motif-containing 29"
                     /db_xref="GeneID:72169"
                     /db_xref="MGI:MGI:1919419"
     exon            1..917
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1877
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /note="tripartite motif protein 29"
                     /codon_start=1
                     /product="tripartite motif-containing protein 29"
                     /protein_id="NP_076144.2"
                     /db_xref="CCDS:CCDS52775.1"
                     /db_xref="GeneID:72169"
                     /db_xref="MGI:MGI:1919419"
                     /translation="MEGADACRSNGASPEARDTRSPPGPSGSLENGTKADSKDTKTTN
                     GHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGR
                     RSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEVRRNSYPRADSSL
                     LARAKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIR
                     DFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKE
                     QLQLKIIEIEDDVEKWQKEKDRIKSFTTNEKAILEQNFRDLVRELEKQKEEVRAALEQ
                     REQDAVDQVKVIVDALDERAKVLHEDKQTREQLHNISDSVLFLQEFGALMSNYSLPPP
                     LPTYHVLLEGEGLGQSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRY
                     MNSYTSSYGNEWSTPDTMKRYSMYLTPKGGGRTSYQPSSPSRLSKETNQKNFNNLYGT
                     KGNYTSRVWEYTSTVQNSEDMPTVQGNSSFSLKGFPSLLRSQVPKAQPQTWKSGKQTL
                     LSHYRPFYVNKGSGIGSNEAP"
     exon            918..1013
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1247
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1446
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1548
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1641
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1737
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1814
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2830
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2823
                     /gene="Trim29"
                     /gene_synonym="1110047J21Rik; 2810431N19Rik;
                     4732461M22Rik"
                     /note="major polyA site"
ORIGIN      
        1 caggtgtgtc cctgggctct ggctgccagc cccacttcgt gccccgagac atccgctgaa
       61 gccacctgcc acgagacccc aaccagcaga cacaggctag caagtgacct accatggaag
      121 gtgccgatgc ctgcaggagc aatggggcca gcccggaagc cagggacacc cgcagcccac
      181 cgggtcccag cggcagccta gagaatggca ctaaagcaga cagtaaggac accaagacaa
      241 ccaacgggca cagtggggag gtgacagagg gcaagaccct gggcagtgcc ctgaagtcag
      301 gggaggggaa gagtggccta ttttccagca atgagtggcg caggcctatc atccagtttg
      361 tggagtctgt cgacgacaaa ggctccagtt acttcagtat ggactctgcg gaaggcagga
      421 ggtcccctta tgcggggctc cagttggggg cttccaagaa acctcctgtg acctttgctg
      481 agaaggggga gctgcgaaag tccattttct ccgagccccg caaacccacg gtgaccatcg
      541 tggagcccgg ggaagtccgc aggaatagct accccagggc tgactccagc ctcctggcgc
      601 gggcaaagtc gggctccgag gaggtgctgt gcgactcctg catcggcaac aagcagaagg
      661 ccgtcaagtc ctgcctggtg tgccaggctt ccttctgtga gctgcatctg aagccccacc
      721 tggagggcgc tgccttccgg gaccaccagc tgctcgagcc catccgagac ttcgaggccc
      781 gaaaatgtcc cttgcacggc aagactatgg agctcttctg tcagaccgac cagacctgca
      841 tctgttatct ctgcatgttc caggagcaca agaaccacag caccgtgacg gtggaggagg
      901 ccaaggcaga gaaggagacc gagctgtcac tgcaaaagga acagctgcaa ctgaagatca
      961 ttgagattga agatgatgtt gagaagtggc aaaaggagaa agaccggatc aagagcttta
     1021 ccaccaacga gaaggcgatc ctggagcaga acttcaggga cctggtgagg gagctggaga
     1081 agcagaagga ggaagtacgg gctgcactgg agcagcggga gcaggatgct gtggaccaag
     1141 tgaaggtgat cgtggatgct ctggatgaga gggccaaggt gctgcacgag gacaagcaga
     1201 cccgagagca gctgcacaac atcagtgact cggtgctgtt cctgcaggaa tttggtgcat
     1261 tgatgagcaa ttactctctc cctccacctc tgcccaccta ccatgtcctg ctggagggag
     1321 aggggctggg acagtctctt ggcaactgca aggatgacct gctcaatgtg tgcatgcgtc
     1381 atgttgagaa gatgtgcaag gccgatttga gccgcaactt cattgagagg aaccatatgg
     1441 aaaatggtgg ggaccatcgc tacatgaaca gctacaccag cagctatggg aacgagtgga
     1501 gcacgcctga caccatgaaa agatactcca tgtacctcac gcccaagggt gggggccgga
     1561 catcctacca gccatcctcg cctagccgcc tctccaagga gaccaaccag aagaatttta
     1621 acaatctgta tggcacaaaa ggcaactata cctccagggt ctgggagtac acatccacgg
     1681 ttcagaattc tgaggatatg cccacggtgc aaggcaactc ctccttctcc ctgaaaggct
     1741 ttccctccct cctccggagc caagttccca aggcccagcc tcagacttgg aaatctggca
     1801 agcagactct gctgtctcac taccggccat tctatgtcaa caagggcagc ggcatcggat
     1861 ccaacgaggc gccctgagtt caggatggag gaagctgcac tcccccatcc tcctgttgct
     1921 cctgctttgc aagctgctgt tctttctccc gggcaggagc ccagccccac cctgccctca
     1981 cacagtctct ggcagcccta cggggcactc ttgcttcctc tgctcctttc tgtttggtga
     2041 cagacagtca ctgtgacttc taggtataaa gccaagagac ctaccacagg ggcatgagcc
     2101 agctgggctc ctttctcata cactaagccc acacggtgct ggtctgtcca cctgcccagg
     2161 ctctgccaca tcaggcttgg tgaccatttc cctccactag gtacctagtt acggcagcct
     2221 ctttgctccc gtcccttggg ctcatgttgt attgtcagcc tgagcctgtc aggaggagat
     2281 gggtcccgtg tgtcctcttg catccacctt actacagtat ggctggtctt ggccacgcct
     2341 tagaggatgc tctcagcatc ttggcttttt cctggtccag cagagaggtt ctgccatgtc
     2401 ctctttgagg ctgcaaaacc ggagaacggg ctgtcctaac tggcaagagg attgtagcct
     2461 agacatttct ctgccattgc ttggaagagc agttccccag gtgcgccaca atccactcat
     2521 gaaaattggc ctatagacgt tcactactat gggaatttga tgctcttcac ggtaatggcc
     2581 agcaggaggg ctggtaagag tggtgtcact taagatgtac catccgtatc aggagagcca
     2641 gcctccatcc acgtcacatg tcactgggct ttgagagagc caaatcagga acagcactgg
     2701 atgttgggag cttgtctccc actctgggct gacggggcct catgagccag cttgcagggg
     2761 tggggagggg cacttttggc ttacgcttcc ccctccctga ataaaccatt tgtctcttta
     2821 cgacgactct
//
