LOCUS       NM_011588               3255 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus tripartite motif-containing 28 (Trim28), mRNA.
ACCESSION   NM_011588 XR_105088 XR_107865
VERSION     NM_011588.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3255)
  AUTHORS   Tang,J., Chen,Q., Xiang,L., Tu,T., Zhang,Y. and Ou,C.
  TITLE     TRIM28 Fosters Microglia Ferroptosis via Autophagy Modulation to
            Enhance Neuropathic Pain and Neuroinflammation
  JOURNAL   Mol Neurobiol 61 (11), 9459-9477 (2024)
   PUBMED   38647647
  REMARK    GeneRIF: TRIM28 Fosters Microglia Ferroptosis via Autophagy
            Modulation to Enhance Neuropathic Pain and Neuroinflammation.
REFERENCE   2  (bases 1 to 3255)
  AUTHORS   Lin,K.H., Hibbert,J.E., Flynn,C.G., Lemens,J.L., Torbey,M.M.,
            Steinert,N.D., Flejsierowicz,P.M., Melka,K.M., Lindley,G.T.,
            Lares,M., Setaluri,V., Wagers,A.J. and Hornberger,T.A.
  TITLE     Satellite cell-derived TRIM28 is pivotal for mechanical load- and
            injury-induced myogenesis
  JOURNAL   EMBO Rep 25 (9), 3812-3841 (2024)
   PUBMED   39143258
  REMARK    GeneRIF: Satellite cell-derived TRIM28 is pivotal for mechanical
            load- and injury-induced myogenesis.
REFERENCE   3  (bases 1 to 3255)
  AUTHORS   Xue,D., Zuo,Q., Chang,J. and Wu,X.
  TITLE     The correlation between TRIM28 expression and immune checkpoints in
            CRPC
  JOURNAL   FASEB J 38 (13), e23663 (2024)
   PUBMED   38958986
  REMARK    GeneRIF: The correlation between TRIM28 expression and immune
            checkpoints in CRPC.
REFERENCE   4  (bases 1 to 3255)
  AUTHORS   Morii,M., Kubota,S., Iimori,M., Yokomizo-Nakano,T., Hamashima,A.,
            Bai,J., Nishimura,A., Tasaki,M., Ando,Y., Araki,K. and Sashida,G.
  TITLE     TIF1beta activates leukemic transcriptional program in HSCs and
            promotes BCR::ABL1-induced myeloid leukemia
  JOURNAL   Leukemia 38 (6), 1275-1286 (2024)
   PUBMED   38734786
  REMARK    GeneRIF: TIF1beta activates leukemic transcriptional program in
            HSCs and promotes BCR::ABL1-induced myeloid leukemia.
REFERENCE   5  (bases 1 to 3255)
  AUTHORS   Xu,Y., Li,X., Cheng,F., Zhao,B., Fang,M., Li,Z. and Meng,S.
  TITLE     Heat shock protein gp96 drives natural killer cell maturation and
            anti-tumor immunity by counteracting Trim28 to stabilize Eomes
  JOURNAL   Nat Commun 15 (1), 1106 (2024)
   PUBMED   38321029
  REMARK    GeneRIF: Heat shock protein gp96 drives natural killer cell
            maturation and anti-tumor immunity by counteracting Trim28 to
            stabilize Eomes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3255)
  AUTHORS   Ryan,R.F., Schultz,D.C., Ayyanathan,K., Singh,P.B., Friedman,J.R.,
            Fredericks,W.J. and Rauscher,F.J. 3rd.
  TITLE     KAP-1 corepressor protein interacts and colocalizes with
            heterochromatic and euchromatic HP1 proteins: a potential role for
            Kruppel-associated box-zinc finger proteins in
            heterochromatin-mediated gene silencing
  JOURNAL   Mol Cell Biol 19 (6), 4366-4378 (1999)
   PUBMED   10330177
REFERENCE   7  (bases 1 to 3255)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 3255)
  AUTHORS   Chang,C.J., Chen,Y.L. and Lee,S.C.
  TITLE     Coactivator TIF1beta interacts with transcription factor C/EBPbeta
            and glucocorticoid receptor to induce alpha1-acid glycoprotein gene
            expression
  JOURNAL   Mol Cell Biol 18 (10), 5880-5887 (1998)
   PUBMED   9742105
REFERENCE   9  (bases 1 to 3255)
  AUTHORS   Kim,S.S., Chen,Y.M., O'Leary,E., Witzgall,R., Vidal,M. and
            Bonventre,J.V.
  TITLE     A novel member of the RING finger family, KRIP-1, associates with
            the KRAB-A transcriptional repressor domain of zinc finger proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15299-15304 (1996)
   PUBMED   8986806
REFERENCE   10 (bases 1 to 3255)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089337.1.
            
            On or before Dec 15, 2010 this sequence version replaced
            XR_107865.1, XR_105088.1, NM_011588.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089337.1, U67303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3255              BC089337.1         1-3255
FEATURES             Location/Qualifiers
     source          1..3255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.73 cM"
     gene            1..3255
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /note="tripartite motif-containing 28"
                     /db_xref="GeneID:21849"
                     /db_xref="MGI:MGI:109274"
     exon            1..910
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             568..3072
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /EC_number="2.3.2.27"
                     /note="transcriptional intermediary factor 1, beta;
                     tripartite motif protein 28; TIF1-beta; KRAB-A-interacting
                     protein; tripartite motif-containing protein 28; E3
                     SUMO-protein ligase TRIM28; RING-type E3 ubiquitin
                     transferase TIF1-beta"
                     /codon_start=1
                     /product="transcription intermediary factor 1-beta"
                     /protein_id="NP_035718.2"
                     /db_xref="CCDS:CCDS20823.1"
                     /db_xref="GeneID:21849"
                     /db_xref="MGI:MGI:109274"
                     /translation="MAASAAATAAASAATAASAASGSPGSGEGSAGGEKRPAASSAAA
                     ASAAASSPAGGGGEAQELLEHCGVCRERLRPERDPRLLPCLHSACSACLGPATPAAAN
                     NSGDGGSAGDGAMVDCPVCKQQCYSKDIVENYFMRDSGSKASSDSQDANQCCTSCEDN
                     APATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKTRDGERTVYCNVHKHEPL
                     VLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKNTK
                     EVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHW
                     TMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKF
                     QWDLNAWTKSAEAFGKIVAERPGTNSTGPGPMAPPRAPGPLSKQGSGSSQPMEVQEGY
                     GFGSDDPYSSAEPHVSGMKRSRSGEGEVSGLLRKVPRVSLERLDLDLTSDSQPPVFKV
                     FPGSTTEDYNLIVIERGAAAAAAGQAGTVPPGAPGAPPLPGMAIVKEEETEAAIGAPP
                     AAPEGPETKPVLMPLTEGPGAEGPRLASPSGSTSSGLEVVAPEVTSAPVSGPGILDDS
                     ATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSL
                     SLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSMEQPGGTLDL
                     TLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMND
                     AFGDTKFSAVLVEPPPLNLPSAGLSSQELSGPGDGP"
     exon            911..1023
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1156
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1292
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1409
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1524
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1671
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1786
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1893
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1930
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..1976
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2229
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2549
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2673
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2760
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2898
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3242
                     /gene="Trim28"
                     /gene_synonym="KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacctgcgc gctcaagcac gcgggttgcc agcctgggtg caccgtgcgg tgggcatggg
       61 agacgtcaag cacgcactct gcgggtgaat tcctcaccag cagcattgct actctggatc
      121 tagaggggcg gcagcgagtg gaagggaggg ccctggcgcg tgcgtaatct gcgccccgcc
      181 cccaggctgc ggtgcccaac gcgcgtgcgc ggcgtcgtcg gcgccagata tttctgtccc
      241 gcctccaggc cgcggctctt tctgcgagcg gcgcgcggtc aggcggttgt tcgcaagtct
      301 tgcggcgcga gtgtctcaga agcgagggag gaggcggcgc tggtggcggc gccgtcgtct
      361 gtacagaggc ccgcagccag cggcttggcc gcatctcgac agcgcctggg gcgcggcggg
      421 cgtcggccca ggagacgcgt ggcggcgctc ggcctcgcgg catcggcggc tgcctggccg
      481 ttggcggcga gcgcacttgc gcctgcgcag cgggctccgt gcccctcctc ccctgggcgg
      541 cccccccacc cccccggcgg cgtgtgaatg gcggcctcgg cggcagcgac tgcagcggcc
      601 tcggccgcga cggccgcctc ggcggcctct ggtagcccag ggtcgggcga gggctcggcg
      661 ggcggtgaga agcgtccggc tgcttcctca gccgcggcgg cctctgcagc cgcgtcgtcc
      721 cctgcggggg gcggtggcga ggcgcaggag cttctggagc actgcggcgt gtgtcgcgag
      781 cgcctgcggc ccgagcggga tcctcggctg ctgccctgtc tacattcggc ctgcagtgcc
      841 tgcctgggcc ccgctacacc cgccgcagcg aataattcgg gggatggcgg ctcggcgggc
      901 gacggcgcta tggtggattg tccagtgtgc aaacagcagt gctactccaa agacatcgtg
      961 gagaattatt ttatgcgtga tagtggcagt aaggcctctt ctgattccca ggatgctaac
     1021 cagtgctgca ctagctgtga agataatgcc ccagccacta gctattgtgt ggagtgctct
     1081 gaaccacttt gtgagacctg tgtggaggct caccagcggg tgaaatacac caaggaccac
     1141 actgtgcgct ccacaggacc tgctaagact cgagatggag agcgaacagt ctactgtaat
     1201 gtgcacaagc atgagcccct cgtgctgttc tgtgagagct gtgacacact cacctgccgc
     1261 gactgccagc tcaacgctca caaggaccat cagtaccagt ttttggaaga tgcagtgagg
     1321 aaccaacgta aactcttggc ttcactggtg aaacgtcttg gggacaaaca tgccacactt
     1381 cagaaaaaca ccaaggaggt tcgaagctcg atccgccagg tgtctgatgt gcagaagcga
     1441 gtgcaggttg atgtcaagat ggccattctg cagatcatga aggagctgaa taagcggggt
     1501 cgagttctgg tcaatgatgc ccagaaggtg accgagggtc agcaggaacg tctggagcgc
     1561 cagcactgga ccatgaccaa aattcagaag caccaggaac acattttgcg ttttgcctct
     1621 tgggctctgg agagtgataa caatacagct ctcttgctct ctaagaagct gatctatttc
     1681 cagctgcatc gggccctcaa aatgattgtg gatcctgtgg agcctcatgg tgagatgaag
     1741 tttcagtggg atctcaatgc ctggaccaag agtgctgaag cctttggcaa gattgtggct
     1801 gagcgtcctg gtacgaactc cacaggtcct gggcccatgg ctcctccaag agccccaggc
     1861 cctctaagca agcaaggttc tggcagtagc cagcccatgg aagtacaaga gggatatggc
     1921 tttgggtcag atgatcccta ttcaagtgca gagccgcatg tatcaggcat gaagcggtcc
     1981 cgctctggtg agggagaggt aagtggcctc ttaaggaagg tgccacgtgt gagccttgaa
     2041 cgcctggatc tggacctcac ctctgacagc cagccaccag tcttcaaggt ctttcctgga
     2101 agcactactg aggactacaa tctgattgtt attgagcgtg gtgctgctgc agcagctgct
     2161 ggtcaggctg ggactgtgcc accaggagcc cctggtgccc caccccttcc tggcatggcc
     2221 attgtcaagg aagaagagac agaagctgct attggagctc ccccggctgc ccccgagggt
     2281 cctgaaacca agcctgtgtt gatgcctctg actgaaggtc ctggtgccga gggacctcgt
     2341 ctagcttcac ctagtggcag taccagctca ggcttggagg tggtggctcc tgaggttacc
     2401 tcagccccag taagtgggcc aggtatcctg gatgacagtg ccactatctg ccgtgtctgc
     2461 cagaaaccag gtgacctggt catgtgtaac cagtgcgaat tttgcttcca cctggattgc
     2521 cacctccctg ccctgcagga tgttccaggg gaggaatgga gttgctcact ctgccacgtg
     2581 ctccctgacc taaaggagga agatggaagc ctcagcctgg atggagcaga tagcactggt
     2641 gtggtagcta aactctcacc agccaaccag cggaaatgtg agcgtgttct cctggccctg
     2701 ttctgccatg aaccatgccg tcccttgcat cagctggcta ccgactctac attctccatg
     2761 gagcagcctg gtggtaccct agacctgacc ttgattcgtg ctcgcctcca agagaagctg
     2821 tcacctcctt atagctcccc ccaggagttt gctcaagatg tgggccgcat gttcaaacag
     2881 ttcaacaagc tgactgagga caaggcagat gttcagtcca tcatcggctt gcagcgcttc
     2941 tttgagacac gcatgaatga tgcctttggt gacaccaagt tttctgctgt gctggtagaa
     3001 ccaccaccat tgaaccttcc cagtgctggc ctaagttctc aggagctctc tggccctggt
     3061 gatggcccct gaagctgggg ctcttgtggt cagcccagtc cagctctggt ctctgtattt
     3121 tcaccccata ccctgtcctt tggtggcctg actcctgttc ttgctggccc catcgtcccc
     3181 tcagtccctc ttcacaaaat ggtttttact tctgtggatt taataaaaac ttcactgagt
     3241 caaaaaaaaa aaaaa
//
