LOCUS       NM_009054               4204 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus tripartite motif-containing 27 (Trim27), mRNA.
ACCESSION   NM_009054 XR_105515 XR_106761
VERSION     NM_009054.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4204)
  AUTHORS   Chen,Y., Xiang,Y., Miao,X., Kuai,L., Ding,X., Ma,T., Li,B. and
            Fan,B.
  TITLE     METTL14 promotes IL-6-induced viability, glycolysis and
            inflammation in HaCaT cells via the m6A modification of TRIM27
  JOURNAL   J Cell Mol Med 28 (3), e18085 (2024)
   PUBMED   38146129
  REMARK    GeneRIF: METTL14 promotes IL-6-induced viability, glycolysis and
            inflammation in HaCaT cells via the m6A modification of TRIM27.
REFERENCE   2  (bases 1 to 4204)
  AUTHORS   Wei,X., Zhang,T., Ma,C., Zhang,M., Jin,L., Ma,X. and Zhang,Z.
  TITLE     TRIM27 ameliorates ischemic stroke by regulating NLRP3
            inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
  JOURNAL   Exp Neurol 371, 114599 (2024)
   PUBMED   37914066
  REMARK    GeneRIF: TRIM27 ameliorates ischemic stroke by regulating NLRP3
            inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling.
REFERENCE   3  (bases 1 to 4204)
  AUTHORS   Ning,M., Liu,Y., Wang,D., Wei,J., Hu,G. and Xing,P.
  TITLE     Knockdown of TRIM27 alleviated sepsis-induced inflammation,
            apoptosis, and oxidative stress via suppressing ubiquitination of
            PPARgamma and reducing NOX4 expression
  JOURNAL   Inflamm Res 71 (10-11), 1315-1325 (2022)
   PUBMED   35962797
  REMARK    GeneRIF: Knockdown of TRIM27 alleviated sepsis-induced
            inflammation, apoptosis, and oxidative stress via suppressing
            ubiquitination of PPARgamma and reducing NOX4 expression.
REFERENCE   4  (bases 1 to 4204)
  AUTHORS   Wang,Y., Luo,W., Huang,L., Xiao,J., Song,X., Li,F., Ma,Y., Wang,X.,
            Jin,F., Liu,P., Zhu,Y., Kitazato,K., Wang,Y. and Ren,Z.
  TITLE     A novel lncRNA linc-AhRA negatively regulates innate antiviral
            response in murine microglia upon neurotropic herpesvirus infection
  JOURNAL   Theranostics 11 (19), 9623-9651 (2021)
   PUBMED   34646390
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4204)
  AUTHORS   Li,X.K., Xu,X.Z., Cong,Q., Zhao,F., Yang,Y.Y., Li,A.Q. and Ma,J.
  TITLE     Tri-domain proteins 27 reduce inflammation and apoptosis in HK-2
            cells and protect against acute kidney injury in mice
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (23), 12258-12266 (2020)
   PUBMED   33336745
  REMARK    GeneRIF: Tri-domain proteins 27 reduce inflammation and apoptosis
            in HK-2 cells and protect against acute kidney injury in mice.
REFERENCE   6  (bases 1 to 4204)
  AUTHORS   Kalyanaraman,S., Copeland,N.G., Gilbert,D.G., Jenkins,N.A. and
            Gautam,N.
  TITLE     Structure and chromosomal localization of mouse G protein subunit
            gamma 4 gene
  JOURNAL   Genomics 49 (1), 147-151 (1998)
   PUBMED   9570961
REFERENCE   7  (bases 1 to 4204)
  AUTHORS   Hasegawa,N., Iwashita,T., Asai,N., Murakami,H., Iwata,Y.,
            Isomura,T., Goto,H., Hayakawa,T. and Takahashi,M.
  TITLE     A RING finger motif regulates transforming activity of the rfp/ret
            fusion gene
  JOURNAL   Biochem Biophys Res Commun 225 (2), 627-631 (1996)
   PUBMED   8753810
REFERENCE   8  (bases 1 to 4204)
  AUTHORS   Cao,T., Shannon,M., Handel,M.A. and Etkin,L.D.
  TITLE     Mouse ret finger protein (rfp) proto-oncogene is expressed at
            specific stages of mouse spermatogenesis
  JOURNAL   Dev Genet 19 (4), 309-320 (1996)
   PUBMED   9023983
REFERENCE   9  (bases 1 to 4204)
  AUTHORS   Amadou,C., Ribouchon,M.T., Mattei,M.G., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Avoustin,P. and Pontarotti,P.
  TITLE     Localization of new genes and markers to the distal part of the
            human major histocompatibility complex (MHC) region and comparison
            with the mouse: new insights into the evolution of mammalian
            genomes
  JOURNAL   Genomics 26 (1), 9-20 (1995)
   PUBMED   7782091
REFERENCE   10 (bases 1 to 4204)
  AUTHORS   Isomura,T., Tamiya-Koizumi,K., Suzuki,M., Yoshida,S., Taniguchi,M.,
            Matsuyama,M., Ishigaki,T., Sakuma,S. and Takahashi,M.
  TITLE     RFP is a DNA binding protein associated with the nuclear matrix
  JOURNAL   Nucleic Acids Res 20 (20), 5305-5310 (1992)
   PUBMED   1437549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI530745.1, BQ573214.1, AK031744.1, CA549428.1 and AC138330.4.
            
            [WARNING] On Apr 6, 2024 this sequence was replaced by NM_009054.4.
            
            On Jul 27, 2011 this sequence version replaced NM_009054.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031744.1, BC069924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AI530745.1         1-223
            224-282             BQ573214.1         196-254
            283-1138            AK031744.1         1-856
            1139-1149           CA549428.1         190-200
            1150-3232           AK031744.1         868-2950
            3233-3243           AC138330.4         47145-47155         c
            3244-4204           AK031744.1         2962-3922
FEATURES             Location/Qualifiers
     source          1..4204
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.67 cM"
     gene            1..4204
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /note="tripartite motif-containing 27"
                     /db_xref="GeneID:19720"
                     /db_xref="MGI:MGI:97904"
     exon            1..984
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
     CDS             565..2106
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /EC_number="2.3.2.27"
                     /note="ret finger protein; tripartite motif protein 27;
                     tripartite motif-containing protein 27; RING-type E3
                     ubiquitin transferase TRIM27"
                     /codon_start=1
                     /product="zinc finger protein RFP"
                     /protein_id="NP_033080.2"
                     /db_xref="CCDS:CCDS36607.1"
                     /db_xref="GeneID:19720"
                     /db_xref="MGI:MGI:97904"
                     /translation="MASGSVAECLQQETTCPVCLQYFVEPMMLDCGHNICCACLARCW
                     GAAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREP
                     LKLYCEQDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNRLDHLRRVKDLKKRR
                     RAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGA
                     ITQFSCNISHLSGLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEK
                     IHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDN
                     LRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSV
                     CRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFY
                     NVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHS
                     METSP"
     exon            985..1080
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1311
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1334
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1450
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1483
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1510
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..4204
                     /gene="Trim27"
                     /gene_synonym="Gm19403; Rfp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaaggagcc gaggcctagc cactaagagg aaactcagca gaagactacg ggcccacaga
       61 cgcttggagt gacccgacgc cactgccagg ggacactctg ctcccactgc acgcgacagc
      121 cacgaccgac tcccgggctg ggtgccgggg acccaggact gtgcagagga aacccgcttt
      181 cccgccccga gagagcagag cggcgcggga agccaggccc cgcccccggc ccacctcttc
      241 cgctcggccc tgaggagtct gcgcggccgc gggacccctt ccgacgcggc cacgttgccc
      301 ggtgagccag cccgcggcgc ccggttcccg actcccctcg gctcggctct cagccgggct
      361 ccggggccca ggcctcctcc ccgtgctgtc ggtgaggagc agctgtgcgg ggacgggtct
      421 ggccgcccga gagctccgcg cgcgtctgcg atccccgcgc cggaggcccc gccccgctcc
      481 ggagccgaga agcggagcga gcgcgctgag ctccgacaga gctcggctcc gggctcatgc
      541 cctgcggccc agccggcccg cgccatggcc tccgggagcg tggccgagtg cctgcagcag
      601 gagaccacct gccccgtgtg ccttcagtac ttcgtggagc ctatgatgct cgactgcggc
      661 cacaacatct gttgcgcgtg cctggcccgc tgctggggtg ccgcggagac taacgtgtcg
      721 tgtccgcagt gccgggagac cttcccgcag cgccacatgc gacccaaccg gcacctggcc
      781 aacgtgaccc agctggtgaa gcagctgcgc accgagcggc cgtcggggcc cggcggcgag
      841 atgggcgtgt gcgagaagca ccgggagcct ctgaagctgt actgcgagca ggaccagatg
      901 cccatctgcg tggtgtgcga ccgctcgcgc gagcaccgcg gccacagcgt gctgcccctg
      961 gaggaggcgg tggagggctt caaggagcaa atccagaacc gactggacca cctaagaaga
     1021 gtgaaagact tgaagaagag acggcgggca cagggggagc aggcccgagc tgagcttttg
     1081 agcctgactc agatggagag ggaaaaaatt gtctgggagt ttgagcagct ctatcactcg
     1141 ttgaaggagc atgagtaccg cctgttggct cgccttgagg agctcgactt ggccatctat
     1201 aacagcatca acggggccat cactcagttc tcctgcaaca tctcccacct cagtggcctg
     1261 attgcccaac tggaagagaa gcagcagcag cccacgcggg agctcttaca ggacattgga
     1321 gacacactga gcagggctga aagaatcagg atccctgagc cctggatcac acccccagat
     1381 ctacaagaga aaatccatat ttttgcccaa aaatgtctgt ttttgacaga aagtctaaaa
     1441 cagttcacag aaaagatgca gtcagatatg gagaagatcc aagagttgag agaggctcag
     1501 ttatactcag ttgatgtaac cctggaccca gacacagcct atcccagtct gattctttct
     1561 gataatcttc ggcaagtacg gtacagttac ctccagcagg atcttccaga caaccctgag
     1621 cgattcaatc tgtttccctg tgtcttgggc tctccatgtt tcatcgctgg gagacattac
     1681 tgggaggtag aggtgggaga taaagccaag tggaccatag gtgtctgtga agactcggtg
     1741 tgcagaaaag gtggggtgac ctcagccccc cagaatggat tctgggcagt gtcattgtgg
     1801 tatgggaaag aatattgggc tcttacatcc ccaatgactg cactacccct gcggacccct
     1861 ctccagagag tagggatttt cttggactat gatgctggtg aggtttcctt ctacaatgtg
     1921 acagagagat gccatacctt tactttctct cacgctacct tctgtgggcc agtccggccc
     1981 tacttcagcc taagctactc gggagggaag agcgcagctc ctttgatcat ctgccctatg
     2041 agtgggattg atgggttttc tggccatgtt gggaatcatg gtcattccat ggagacctct
     2101 ccgtgaggaa gtgaacgtag accacaagtg ctgttgcctg taatcctacc ccaggcacaa
     2161 gggatcttgt cctgattcct gtccatcaaa attgggtgtc cttaccattt ccgtgcccct
     2221 acagtgagag acaagatgtc catccatggt ctctactgca ttttcccttc ccttgcagat
     2281 tgtgagatgt aatgaaaagt attgctattt cccagaaata aaaactagat tcctcctgtg
     2341 tttcatacgt tttgtttttg ttatgactga aggacataaa agaataggat ttggatttgg
     2401 agacccactt tccagaatct tgtcctggct tctcttcatg tggatcacaa tacggaaagt
     2461 atgagccaaa taaaaccatt cctccccagg gggcttttgt cagtgtttgt catagcaaga
     2521 gagacacaac ttaaggtgcc agattcgtaa gctattgcta tgatagactg accttgtttt
     2581 gcaaaggatt ttggaagtgt ttgtaacttt ggtttggaaa ttaagagtgt tgagaaatgc
     2641 agatgataaa cttaggaagt ttcagggggg aacaaagact gggtaatttt gtactatatt
     2701 tgaattaaga atgtgtggtt tctgcacagc tggggctgaa gaattgactg tgaataacaa
     2761 gacaccaata ccactgacgt gaaacttgtt tttctacaac agtcaatgct ggttacctgg
     2821 ggctaaagaa tcaactaatt aacagaaggc cggcactatt gaggtgaaat ctaggaagta
     2881 tttcctcagg gtcagcacac aaaagtagtg gtccagagag ggccaagact gcatcttggg
     2941 cctggtctat ttaaaaagtc tccagtaagc agtggtcctc tggtaatcct tcagttcctg
     3001 cctcctggtt ccagccctga gcgcctgccc tggtatctat cactcagtga taggctgtaa
     3061 tatggaagtg taatccaaat aaaccctttc ctccccaggg tgcttttttg gtcagtattt
     3121 taccataaca gtagagagca aactgagaca tttctggacc atgtctcctt tttaagaact
     3181 caggatggat aacaagactg ttgaaatgac acacacaccc ttctcatttt tctttcatga
     3241 aatggtacct ctactctgtt ttgttttttt gtttttggtt ttttcgagac agggtttctc
     3301 tgtgtagcct tggctgtcct ggaactcact ttgtagacca ggctggcctc gaactcagaa
     3361 atccgcctgc ctctgcctcc cgagtgctgg gattaaaggc gtgtgccacc acgcccggct
     3421 tttttgtttt gttttgtttt tttgtttttg ggatacctct actctgattg tatccataaa
     3481 tatggcctag ttttggttac agttatttta cattaatggt gaaaaatgac tctgcctatg
     3541 tagtgacata aaatttaact ggtgtctctg cctaggtgac tttctaatgg ctttgctccc
     3601 ttcattctgt tgaaaggtct ctcttggtgc taggtgcata tatctaagat aatccttgga
     3661 gtgtttgtga gctagaggtg tttaggtagt agtgactgta tccttttggg atcagctgta
     3721 ccattagagg cctttggagg gagaagctat aatcactttg agcaagccct accatggttc
     3781 ttagccctgc ttccttttgg gtacatgcct tgctgtgttt accacctaaa agtgaggtgg
     3841 actaacgtct catttgcaat agccaacttt atttagtgtt ggacaattta tactcttggg
     3901 gatttaagaa ggtttacatt gagtgaactg tacaatctca aggacaagtc acatgtgcca
     3961 agaaacactt ttttccatac aggcacataa atggataaca ataaccagtt gtaattaata
     4021 atctctaaac ttgctcctat ctgatacacc tgggaagaat gtggaaactc attctaagtc
     4081 catgattttg aagaaactga ggttacaaga ctggtctttt ttttcttggg gttttctcac
     4141 aagcactcga ttcctcttgc atgactcctt cccaacacta aaaataaagt gaatatgttt
     4201 gtgt
//
