LOCUS       NM_001025599            3231 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus tripartite motif-containing 26 (Trim26), transcript
            variant 1, mRNA.
ACCESSION   NM_001025599
VERSION     NM_001025599.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Li,T., Zhong,W., Li,M., Shao,Z., Zhang,G., Wang,W., Gao,Z., Tan,X.,
            Xu,Z., Luo,F. and Song,G.
  TITLE     TRIM26 deficiency enhancing liver regeneration through macrophage
            polarization and beta-catenin pathway activation
  JOURNAL   Cell Death Dis 15 (6), 453 (2024)
   PUBMED   38926362
  REMARK    GeneRIF: TRIM26 deficiency enhancing liver regeneration through
            macrophage polarization and beta-catenin pathway activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Zhao,G., Li,Y., Chen,T., Liu,F., Zheng,Y., Liu,B., Zhao,W., Qi,X.,
            Sun,W. and Gao,C.
  TITLE     TRIM26 alleviates fatal immunopathology by regulating inflammatory
            neutrophil infiltration during Candida infection
  JOURNAL   PLoS Pathog 20 (1), e1011902 (2024)
   PUBMED   38166150
  REMARK    GeneRIF: TRIM26 alleviates fatal immunopathology by regulating
            inflammatory neutrophil infiltration during Candida infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Nakagawa,T., Hosogane,M., Nakagawa,M., Morohoshi,A., Funayama,R.
            and Nakayama,K.
  TITLE     Transforming Growth Factor beta-Induced Proliferative Arrest
            Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by
            MYC
  JOURNAL   Mol Cell Biol 38 (5), e00449-17 (2018)
   PUBMED   29203640
  REMARK    GeneRIF: Sustained exposure of cells to TGF-beta resulted in
            recovery from proliferative arrest in association with
            amplification of the Myc proto-oncogene, with MYC inhibiting TRIM26
            induction by TGF-beta.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Wang,P., Zhao,W., Zhao,K., Zhang,L. and Gao,C.
  TITLE     TRIM26 negatively regulates interferon-beta production and
            antiviral response through polyubiquitination and degradation of
            nuclear IRF3
  JOURNAL   PLoS Pathog 11 (3), e1004726 (2015)
   PUBMED   25763818
  REMARK    GeneRIF: Our findings delineate a novel mechanism for the
            termination of IRF3 activation in nucleus through TRIM26-mediated
            IRF3 ubiquitination and degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Zhao,W., Li,Q., Ayers,S., Gu,Y., Shi,Z., Zhu,Q., Chen,Y., Wang,H.Y.
            and Wang,R.F.
  TITLE     Jmjd3 inhibits reprogramming by upregulating expression of
            INK4a/Arf and targeting PHF20 for ubiquitination
  JOURNAL   Cell 152 (5), 1037-1050 (2013)
   PUBMED   23452852
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3231)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 3231)
  AUTHORS   Yoshino,M., Xiao,H., Jones,E.P. and Fischer Lindahl,K.
  TITLE     BAC/YAC contigs from the H2-M region of mouse Chr 17 define gene
            order as Znf173-Tctex5-mog-D17Tu42-M3-M2
  JOURNAL   Immunogenetics 47 (5), 371-380 (1998)
   PUBMED   9510555
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF168373.1, BC037110.2 and BQ176978.1.
            
            On Nov 14, 2013 this sequence version replaced NM_001025599.2.
            
            Transcript Variant: This variant (1) has an alternate splice site
            in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3042268.1,
                                           SRR7345562.4095872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CF168373.1         1-41
            42-3198             BC037110.2         1-3157
            3199-3231           BQ176978.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     gene            1..3231
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /note="tripartite motif-containing 26"
                     /db_xref="GeneID:22670"
                     /db_xref="MGI:MGI:1337056"
     exon            1..119
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            120..227
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            228..700
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1900
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 173; tripartite motif protein
                     26; tripartite motif protein TRIM26"
                     /codon_start=1
                     /product="tripartite motif-containing protein 26"
                     /protein_id="NP_001020770.2"
                     /db_xref="CCDS:CCDS37613.1"
                     /db_xref="GeneID:22670"
                     /db_xref="MGI:MGI:1337056"
                     /translation="MAVSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTSDIR
                     PISGNRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDNGRQPGELAREPQDMKLC
                     ERHQEKLHYYCEDDGKLLCVMCRESREHRPHTAVLVEKAALPHREKILNHLNTLRRDR
                     DKIQGFQAKGEADILAALTKLQEQRQYIVAEFKQGHQFLKKREQHLLDQLATLEQLLT
                     EGREKFKTRGVSELDRLTLVISELEGKARQPAAELMQDVCTTQDTKDFANKYPRKKFW
                     IGKAIPHMVKRKAGEFSDKLLSLQRGLRQFQGKLLRDLEYKTVSVTLDPQSASGYLHL
                     SEDWKCVTYTGQYQSDCLLPQQFDCEPGVLGSKGFTWGKVYWEVELEREGWSEDEEEG
                     EEEEEGEEEEEDEEVGYGDGYEDWETDEEDESLGEEEEEEEEEEEEVQESCMVGVAKD
                     SVKRKGDLSLRPEDGVWALRLSPSGIWANTSPEAQLFPVLRPRRVGIALDYEGGTVTF
                     TNAESQELIYTFTTTFTRRLVPFLWLKWPGARLLLRP"
     exon            701..796
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1027
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1045
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1068
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1184
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1217
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..3216
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2651..2656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /note="hexamer: AATAAA"
     polyA_site      2672
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /note="major polyA site"
     regulatory      3174..3179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /note="hexamer: AATAAA"
     polyA_site      3216
                     /gene="Trim26"
                     /gene_synonym="Zfp173; Zfp1736"
                     /note="major polyA site"
ORIGIN      
        1 gggcccggag ctcccggaga ctgctgggcg gggagactgt ggtgccggct gcttgctcag
       61 gacctacccc gcggagcagc tccagggaga ggagtgaccc ggcccggaga gcggcgcggg
      121 tccaacccag acttacttca gtctcttcca gtccccagag ccagaagtga gcgggacccg
      181 gatgacgttc cacctggtgg cttggagccc tgcatgacca gaagcaggtc taaggaacag
      241 agacccccaa cctaagggtg caatggcagt gtcagccccc ttgaggagcc tggaggaaga
      301 ggtgacctgc tccatctgcc tggattacct gagggacccg gtgaccatcg actgtggcca
      361 tgtcttctgt cgcagctgca caagtgatat ccgccccata tcggggaacc ggcctgtctg
      421 cccgctctgc aagaagccct ttaagaagga gaacatccga cccgtgtggc agctagcaag
      481 tctggtggag aacattgaac ggctgaaggt ggacaatggc agacagccag gagagctcgc
      541 ccgcgagcca caggacatga agttgtgtga gcggcaccag gagaagctac actactactg
      601 tgaagatgat ggcaaactgt tgtgtgtgat gtgcagggag tcccgggagc accgccccca
      661 cactgcagtc ctggtggaga aagccgccct gcctcacaga gagaaaattc tgaaccactt
      721 gaacacccta aggagagaca gagacaaaat ccagggcttt caagccaagg gagaagctga
      781 tattctggct gcactgacaa agctgcagga gcagaggcag tacattgtgg cggaatttaa
      841 gcagggccac cagtttctaa agaagcggga gcagcacctg ctagaccagc tggccacctt
      901 ggagcagctc ctcaccgagg gcagggagaa gttcaagacc cggggcgtca gtgagcttga
      961 ccggttgact ctggtcatct ccgagctgga gggcaaggca cgacagccag ctgcagagct
     1021 gatgcaggat gtctgcacta cacaggacac caaggacttc gccaacaagt acccacggaa
     1081 gaagttctgg attgggaaag ccatccctca catggttaaa agaaaggcag gagaattctc
     1141 agataaactt ctttctctgc agcgaggcct gaggcagttc cagggcaagc tgctgagaga
     1201 cttggagtat aagacagtaa gcgtcaccct ggacccacag tcggccagtg gatacctaca
     1261 tctttcagag gactggaagt gtgtgaccta tactggccaa taccagagtg actgtctgct
     1321 cccccagcag tttgactgtg agccaggagt gttgggcagc aagggcttca catggggaaa
     1381 ggtatactgg gaagtagagt tggagagaga aggctggtca gaggatgaag aagaggggga
     1441 ggaggaagaa gaaggggaag aagaggaaga agacgaggag gttggctatg gggacggata
     1501 cgaagactgg gaaacagatg aagaagacga atcactgggg gaagaggaag aggaggaaga
     1561 ggaagaagaa gaagaagttc aggaaagctg catggtggga gtggccaaag actctgtgaa
     1621 gaggaaaggg gacctctccc tgcgaccaga agatggtgtg tgggcccttc ggctctcccc
     1681 ctcaggtatc tgggccaaca cgagcccaga ggcccagctg ttcccggtgc tgcggccccg
     1741 gagagtgggc atcgccctgg attatgaagg tggcactgtg acattcacca atgcagagtc
     1801 ccaggaactc atctatacct tcacgaccac cttcacccgg cgcctggttc ccttcctgtg
     1861 gctcaagtgg ccaggagcac gccttctgct gagaccctga actccagaac ccgcctgggt
     1921 caccctacag aaactttact tctctgagag tccaggactc tgagatgaag aaagattacc
     1981 tggatcccac acccatggaa acttcccttc tctgggatcc caaaactata atggaggaag
     2041 gttcctggcc agagcactag gaggaggaga gagagggaca tcacatccat tgccacccat
     2101 ctccccactg ccacggccaa agtctctcaa cactgtcacc ctatccatat atcttactca
     2161 gcttctcatt tcctctgagg tttcctgctc tgaagaccaa atgactccct ctttcctgaa
     2221 cacacccatt tgtcttgtcc ctgtgttctt tgttgagcag ggccttggca gcagcatttt
     2281 ctggttcagt tgttagccag tgcccacagg tagactttcc atcacatctg aagctgtttt
     2341 tgctgtcctc gaagttgagg taccccgtgc ccaaaaccac tctgttgcct acctttcctg
     2401 gtgtcttaaa tcacttttcc ttaccccaca agagttaaat atgcaaagat gcaagaatgg
     2461 atgtagtcat gacccacaga agtttccaag gccgtgtaag tttgtgtcct ggagtgctgg
     2521 tagaatcatc tcctagcgtg agtaccaaag tttctagcct caaacccaga cctgagtagg
     2581 taggactccc cagggacatc tgtgtttcag aaagcatcta ggtactatga ctcagatagt
     2641 gactgtgatc aataaattac ctctgcagag cagtccttgt gaaggaagtt tttaaaacaa
     2701 cccgaacatc ttgctcttga ccaggaggtc aagacctcgt tgctgacact atggagtgtc
     2761 cagattcact ttcctaggag atggactggg gaaggggaga gagggccatg aggaatctag
     2821 agagcctctg tcctaggtct tactatggag aaagggcctg cagtatcgcc ctgctgaccc
     2881 agctggtgcc catagttgaa catgagtccc tgcttagcca aaatgatgcc ccccttttta
     2941 tccttaaaca ttccagattt cttctgcccg tgcaagtgtt agctcctctt ggctcttgaa
     3001 cagactgttc ccagacactg gatcttggtg gcctcggagt caccacagcg tctcgagact
     3061 gaacacttcg tatgcatcac atgctgcctg agtcactagt acctacacag tggctccctc
     3121 accactcttt gttctagagt taatcatctt catttcctgt gtctttatta ctaaataaac
     3181 tacacatttt tctcagtggt cagaaatttc aagacaaaaa aaaaaaaaaa a
//
