LOCUS       NM_009546               5596 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tripartite motif-containing 25 (Trim25), mRNA.
ACCESSION   NM_009546 XM_126545
VERSION     NM_009546.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5596)
  AUTHORS   Han,S., Guo,J., Kong,C., Li,J., Lin,F., Zhu,J., Wang,T., Chen,Q.,
            Liu,Y., Hu,H., Qiu,T., Cheng,F. and Zhou,J.
  TITLE     ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting
            TRIM25-mediated ubiquitination of ACSL3
  JOURNAL   Clin Transl Med 14 (9), e70024 (2024)
   PUBMED   39285846
  REMARK    GeneRIF: ANKRD1 aggravates renal ischaemia-reperfusion injury via
            promoting TRIM25-mediated ubiquitination of ACSL3.
REFERENCE   2  (bases 1 to 5596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5596)
  AUTHORS   Sun,D., Li,S., Chen,S., Zhang,S., Gu,Q., Shen,Y., Wei,F. and
            Wang,N.
  TITLE     TRIM25 inhibition attenuates inflammation, senescence, and
            oxidative stress in microvascular endothelial cells induced by
            hyperglycemia
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 262 (1), 81-91 (2024)
   PUBMED   37367995
  REMARK    GeneRIF: TRIM25 inhibition attenuates inflammation, senescence, and
            oxidative stress in microvascular endothelial cells induced by
            hyperglycemia.
REFERENCE   4  (bases 1 to 5596)
  AUTHORS   Elabd,S., Pauletto,E., Solozobova,V., Eickhoff,N., Padrao,N.,
            Zwart,W. and Blattner,C.
  TITLE     TRIM25 targets p300 for degradation
  JOURNAL   Life Sci Alliance 6 (12), e202301980 (2023)
   PUBMED   37770115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5596)
  AUTHORS   Tong,Y., Li,J., Peng,M., Qian,Q., Shi,W., Chen,Z. and Liu,B.
  TITLE     ATAD2 drives colorectal cancer progression by regulating TRIM25
            expression via a positive feedback loop with E2F transcriptional
            factors
  JOURNAL   Biochem Biophys Res Commun 594, 146-152 (2022)
   PUBMED   35085891
  REMARK    GeneRIF: ATAD2 drives colorectal cancer progression by regulating
            TRIM25 expression via a positive feedback loop with E2F
            transcriptional factors.
REFERENCE   6  (bases 1 to 5596)
  AUTHORS   Das,N., Wang,J. and Dey,S.K.
  TITLE     Uterine preparation for implantation in the mouse is associated
            with coordinate expression of estrogen-responsive finger protein
            and estrogen receptor
  JOURNAL   Mol Reprod Dev 46 (4), 499-506 (1997)
   PUBMED   9094097
REFERENCE   7  (bases 1 to 5596)
  AUTHORS   Orimo,A., Inoue,S., Ikeda,K., Noji,S. and Muramatsu,M.
  TITLE     Molecular cloning, structure, and expression of mouse
            estrogen-responsive finger protein Efp. Co-localization with
            estrogen receptor mRNA in target organs
  JOURNAL   J Biol Chem 270 (41), 24406-24413 (1995)
   PUBMED   7592654
REFERENCE   8  (bases 1 to 5596)
  AUTHORS   Law,D.J., Prasad,M.A., King,S.E., Spranger,K.D., Lee,Y.H.,
            Fox,R.E., Collins,E.E., Gebuhr,T.C., Miller,D.E. and Petty,E.M.
  TITLE     Localization of the human estrogen-responsive finger protein (EEP)
            gene (ZNF147) within a YAC contig containing the myeloperoxidase
            (MPO) gene
  JOURNAL   Genomics 28 (2), 361-363 (1995)
   PUBMED   8530055
REFERENCE   9  (bases 1 to 5596)
  AUTHORS   Inoue,S., Orimo,A., Matsuda,Y., Inazawa,J., Emi,M., Nakamura,Y.,
            Hori,T. and Muramatsu,M.
  TITLE     Chromosome mapping of human (ZNF147) and mouse genes for
            estrogen-responsive finger protein (efp), a member of the RING
            finger family
  JOURNAL   Genomics 25 (2), 581-583 (1995)
   PUBMED   7789997
REFERENCE   10 (bases 1 to 5596)
  AUTHORS   Inoue,S., Orimo,A., Hosoi,T., Kondo,S., Toyoshima,H., Kondo,T.,
            Ikegami,A., Ouchi,Y., Orimo,H. and Muramatsu,M.
  TITLE     Genomic binding-site cloning reveals an estrogen-responsive gene
            that encodes a RING finger protein
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11117-11121 (1993)
   PUBMED   8248217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK169562.1, AL646096.8 and BC028430.1.
            
            On Apr 13, 2007 this sequence version replaced NM_009546.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154533.1, AK169562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3370              AK169562.1         2-3371
            3371-4828           AL646096.8         87990-89447
            4829-5596           BC028430.1         1-768
FEATURES             Location/Qualifiers
     source          1..5596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 54.34 cM"
     gene            1..5596
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /note="tripartite motif-containing 25"
                     /db_xref="GeneID:217069"
                     /db_xref="MGI:MGI:102749"
     exon            1..680
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1991
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /EC_number="6.3.2.n3"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 25; zinc finger protein
                     147; tripartite motif-containing protein 25;
                     ubiquitin/ISG15-conjugating enzyme TRIM25;
                     estrogen-responsive finger protein; RING-type E3 ubiquitin
                     transferase TRIM25"
                     /codon_start=1
                     /product="E3 ubiquitin/ISG15 ligase TRIM25"
                     /protein_id="NP_033572.2"
                     /db_xref="CCDS:CCDS36278.1"
                     /db_xref="GeneID:217069"
                     /db_xref="MGI:MGI:102749"
                     /translation="MAELNPLAEELSCSVCLELFKEPVTTPCGHNFCMSCLDETWVVQ
                     GPPYRCPQCRKVYQVRPQLQKNTVMCAVVEQFLQAEQARTPVDDWTPPARFSASSAAT
                     QVACDHCLTEIAVKTCLVCMASFCQEHLRPHFDSPAFQDHPLQSPIRDLLRRKCTQHN
                     RLRELFCPEHGECICHICLVEHKTCSPTTLSQASADLEYKLRNKLTIMHSHINGATKA
                     LEDVRSKQQCVQDSMKRKMEQLRQEYMEMKAVIDAAETSSLRKLKEEEKRVYGKFDTI
                     YQVLVKKKSEMQKLKAEVELIMDKGDEFEFLEKAAKLQGESTKPVYIPKIDLDHDLIM
                     GIYQGAADLKSELKHSIKKLQKKSEEHNGSGNKGDQTQSTFKPVQPSKKTIQEKKTKK
                     TPVAPGPPSHFSPNKLPTFGAPGQSLDSKATSPDAAPKASAAQPDSVGVKAKVLENFL
                     TKSRTELLEYFVKVIFDYNTAHNKVSLSNKYTTASVSDGLQHYRSHPQRFTYCSQVLG
                     LHCYKNGIHYWEVELQKNNFCGVGICYGSMERQGPESRLGRNPNSWCVEWFNNKISAW
                     HNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVTEKVHLMYKFKVDFTEALYPAFWVFS
                     AGTTLSICSK"
     exon            681..776
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1010
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1179
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1242
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1266
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1365
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1464
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..5563
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5542..5547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /note="hexamer: AATAAA"
     polyA_site      5563
                     /gene="Trim25"
                     /gene_synonym="EFP; Zfp147"
                     /note="major polyA site"
ORIGIN      
        1 gattccttcc tcgctgcttc ttaagtaccg cgcggtaggg tgcgcagctg tccctgcgcg
       61 tcacgtcggg tgagcccacg agcgcgatgg cggagctgaa tcctctggcc gaggagctgt
      121 cctgctccgt ctgcctggag ctcttcaagg aacctgtcac cactccgtgc ggccacaatt
      181 tctgcatgtc atgcctggat gagacgtggg tcgtccaggg cccgccgtac cgatgcccgc
      241 aatgtcgcaa agtgtaccag gtgcgcccgc agctgcaaaa gaacacggta atgtgcgcgg
      301 tggtggagca gttcctgcag gccgagcagg cgcggacccc ggtggacgac tggacgcctc
      361 ctgcccgctt ctccgcctcc agcgcagcca cccaggtggc ctgcgaccac tgcctgacgg
      421 agatcgcagt gaagacgtgc ctcgtgtgca tggcctcttt ctgccaggag cacttgaggc
      481 ctcacttcga cagtccggcc ttccaggatc accccctaca gtcgcccatt cgtgaccttc
      541 tgcgccgcaa atgtacccag cacaaccgcc ttcgggaatt gttttgtccc gagcatggcg
      601 agtgcatctg ccatatctgc ttggtagagc acaagacctg ctcccctacg accctaagtc
      661 aagccagcgc cgacctggag tacaaactga ggaataaact cactatcatg cacagccaca
      721 tcaatggggc aaccaaagca ttggaggatg tgagatccaa gcaacagtgt gtgcaggatt
      781 ctatgaagag gaagatggaa cagctgagac aggagtatat ggaaatgaag gctgtcatcg
      841 acgcagcaga gaccagctcc ttgcgcaagt taaaggagga ggagaagaga gtctacggaa
      901 aattcgacac catctaccag gttctcgtca agaagaagag tgagatgcag aaactgaagg
      961 cagaggttga gctcattatg gacaaagggg atgagtttga gtttctggag aaagctgcaa
     1021 aattgcaagg agagtcaaca aaaccagtct acatccctaa gatagatctg gatcatgatt
     1081 tgataatggg aatctaccaa ggggcggcgg acctcaagag tgaactgaag cactccatta
     1141 agaagctaca gaagaagtct gaggagcaca atggctcagg taacaaggga gaccagacac
     1201 agtccacttt taaacccgta caaccttcga agaagaccat tcaagaaaag aagaccaaga
     1261 aaacccctgt tgctcccggc cctccctccc acttctcacc taacaagttg cccacctttg
     1321 gagctcctgg ccaatcactg gattcaaaag caacttcccc tgatgccgca cccaaagcca
     1381 gtgctgcaca gccagactct gtaggagtca aggctaaggt gctagaaaac ttcttaacca
     1441 agtccagaac ggagcttctg gagtatttcg tgaaagtcat cttcgactac aataccgccc
     1501 acaacaaagt gtctctgtca aacaagtaca ccaccgcctc tgtgtccgat gggctccagc
     1561 actaccggtc ccatccccag aggttcacct actgctctca ggtcctgggg ctgcactgct
     1621 acaagaacgg cattcactac tgggaggtgg aactacagaa gaacaacttc tgcggcgtag
     1681 gcatctgcta cggcagcatg gaacggcagg gccccgagag ccggctgggc cgcaacccca
     1741 actcatggtg tgtggagtgg ttcaataaca agatctctgc ctggcacaac aacgtggaga
     1801 agactctgcc ctccaccaag gccactcgag tcggcgtgct gctcaactgt gaccacggct
     1861 tcgtcatttt ctttgcggtc accgaaaagg tgcacctgat gtacaagttc aaggtggact
     1921 tcaccgaagc tctgtaccca gccttctggg tgttctcggc cggtaccacc ctctctatct
     1981 gctccaaata gccaggtccc taggctagcc acagacactt gggcttgctg gggaacatcc
     2041 aagactggag ggaactctga acttgtgagt ccctatcaga taagaaattg ggaggggagc
     2101 tggggaaggg gtgggaagaa tcaaagggga ggtttaggct cagaaagggg tggggtgatt
     2161 gtcttgtgga tggagaagca tatctacctc ctcatgcccc cgagggcagg gtgacctcct
     2221 gccagtgttc tgggaaatct ctccaggctg ctagttactt gggcagagcc tcagagagta
     2281 aaattattag tgttcctgtt gtcttacaga aaaatctata gctgttagtc atgttctttc
     2341 tcaggtgaca gatgtccacc ctattctact ctctggggta gccttcagat ctttgtgttt
     2401 tgattatggc ctagattttt gtttgtttta aagccagctg tagtggtgcg tgcacttaat
     2461 ccgagccttt gggaaataga agcagacgca gcttgatgag ttcgaggaca gcctgatgta
     2521 tatagtgggt tttaggacag cttgtctctg aaaaacaaaa atccagttct tgagttctgt
     2581 atgtgtatgt gtgtgtatat atatatatat atattatcat ctctttggtg ctggggtctg
     2641 aatctatggc ctttacccct gagctacatc cctactctga atttccatat aacccttccc
     2701 ccacaaggaa ccttttgtag ataaggctgc agcctgtgtt gatttgtgtc aaggtaaccc
     2761 agacctggtt gagacggaag tctctccctc ttcaaggggc agttctctgg ggacatgttg
     2821 acggtggcca tggagttaga ggcctttcgt cccatagcct aggccagggg tggaggttga
     2881 ggaacagaac cctggctgga ttgtgggagc cctgatggct ttgctcttac tgttatcttg
     2941 ccttgacagc tgttcccaac agtaatgtcc ccatcctctg gattgtagat actgggctga
     3001 tggctataaa tgccgccatt tgccttttgt ggcttctgtc acagttaagt ggacagccac
     3061 accacattcc caaagcctac catcatggag actggctgtg tgtggttgct tcaggaacct
     3121 tgctagatca cctattggtg gacagcctgt ggcctgaagc gagagacgag cgggagatag
     3181 ctggaatcct gtttatctct agccacagat tacaggccca gtgatgagtc agacccgtca
     3241 cctgcccgac cctttctgct ctcttcctca tttttgagcc aattccagat gttcatgtag
     3301 accaaactac aggttaggaa gactttgaag gatgaggaaa cagtaaataa ataacaagga
     3361 gagtccaggc agtggctgtt ttctctgctg tctttcacac agtgaaaatg gcccgggcca
     3421 taaagggcaa ggatggatgg ctgactggga tctccccacc tcctgtcgtg atgccaaatc
     3481 cagaagatgt gaggatttga cctcttgtga caggagtcca gctctctctt tcctaagcgg
     3541 ggagctcctg cttgcaagca ttcttatgaa gagaggtcac catagggaag gtaggcccta
     3601 gaccttttca tttgatggat atttgagaac acatctcagg tctttatgga attccaggct
     3661 cttagtattg gcattcccga cagacgtgtg atctgtgtct tctcccagag gaatattcta
     3721 ttccctttaa gcatctttac agggaacatg tccctgtaga tggtatgtgg gctttgaaag
     3781 atttcttcct ttgccacaca aattcttggc gatacttctc caactttgaa ggtgcccaaa
     3841 aagcttcttt gctggtcttg ttttgagcct tgtttgaggc cagatcagac ttgggaaaca
     3901 actaggttca gagaagtgga acaccaagga ttaactcagg agtcctgcat gggctcttct
     3961 gcagaaaagg agccggacag tcaggactct ttccccaggc agtgtgcagc tcaggctagg
     4021 aaggcatgcg tccctctgtt tatgagagac ccaagcaggc aaccaaagcc cagagctgtg
     4081 caagatgctt tggagttgtg agtggagggg tgtacccttg ctgtctggta cttttctgtt
     4141 tgcagtgata agaccttacc ttaaccataa gcatttctgg gtagatggac taagagttca
     4201 tcagagtgca catctcactt ggctctttgc agagtcaggc aggtgggaag gtgggggatg
     4261 gctctgctca agtcctcttg tcattccaac atggaagaga ctcctaacgt gggtgaccaa
     4321 gaaaacccca gggccctgta gacatacaga aatttccaga aatgttgatg taaaatcctg
     4381 tcgttgatca agatactggg gactgtctca gtcactgtgg tgtgataaac taaaggtgga
     4441 atctttgtat ttttctgatc actcagaaat tgattttttt tacctattac taatagcgat
     4501 attttatatt ttctactatt gattattaat taattactaa tgttttcact atgacttctt
     4561 gaacctagtg tttttagagg taattcatta agataatcaa tcattcattg tacagggcaa
     4621 ggctggctgc tgtaccttac tttgtatgca aacagcatcc agcatcctct ctggattgag
     4681 gtgtgggtga aagatgtcac tcaagctgaa atccactgtc gaggtaccca ccccctaaga
     4741 gctactgccc agggccactg ggtgctcagg ccctgctccg gaagcctgct atagcgtagc
     4801 tcagatcaca tgaaactgga taaagaacac tcaagagaga gaacttagct tcaagacagt
     4861 gccagggtgg gacactgatg agggataagc ctgcttgagt aaccggcaag ctgcagtggg
     4921 aacccagagc ttgcttgaat atttttcttg cggttgcata gacttgacca tttctatcgt
     4981 aagttaaatg gtgaaatgga aaagtcttga ccagagataa accctattca tgatcttctc
     5041 tacataggac tctttggctg ttaaagaatt acgcttgcct ttgtcgctgg tgtgggtgtg
     5101 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgcgca cgcgcttgtg
     5161 cttgcatgag tgcgtgttta agttctcgga atttcctgag aggatggagt gccattgtta
     5221 tttgtctgcc ttgtgcctga cacagcggaa tttatgtcaa gagatgaccc agcatggtag
     5281 ctagccacta ccagcttggt gattgattac agggttgagg tcagcccaag acttctgtga
     5341 atcctgtcta cagatgatgg ttcaattcca gctccagttg agacctagtg caatttccct
     5401 gcagatgaac acatagctgt gctttaggct gatgcacccg tgtcctgtga cggcaggaca
     5461 gggaggctgt gtgctcgaga cccatctaga ccttgccctg tttgtgtctt tatttgactg
     5521 cttctgattc tttttctttt gaataaagtt caaatcataa gtgaaaaaaa aaaaaaaaaa
     5581 aaaaaaaaaa aaaaaa
//
