LOCUS       NM_145076               6191 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 24 (Trim24), transcript
            variant 1, mRNA.
ACCESSION   NM_145076
VERSION     NM_145076.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6191)
  AUTHORS   Hui,Z., Fu,Y., Chen,Y., Yin,J., Fang,H., Tu,Y., Gu,Y. and Zhang,J.
  TITLE     Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent
            IFNbeta1 transcription during macrophage activation
  JOURNAL   Inflamm Res 72 (7), 1441-1452 (2023)
   PUBMED   37326695
  REMARK    GeneRIF: Loss of TRIM24 promotes IL-10 expression via
            CBP/p300-dependent IFNbeta1 transcription during macrophage
            activation.
REFERENCE   2  (bases 1 to 6191)
  AUTHORS   Wei,W., Chen,Q., Liu,M., Sheng,Y., OuYang,Q., Feng,W., Yang,X.,
            Ding,L., Su,S., Zhang,J., Fang,L., Vidal-Puig,A., Wang,H.Y. and
            Chen,S.
  TITLE     TRIM24 is an insulin-responsive regulator of P-bodies
  JOURNAL   Nat Commun 13 (1), 3972 (2022)
   PUBMED   35803934
  REMARK    GeneRIF: TRIM24 is an insulin-responsive regulator of P-bodies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6191)
  AUTHORS   Xu,J., Zhong,Y. and Wang,Z.
  TITLE     Decrease in Tripartite Motif Containing 24 suppresses
            hypoxia-induced proliferation and migration of pulmonary arterial
            smooth muscle cells via the AKT/mammalian target of rapamycin
            complex 1 pathway
  JOURNAL   Bioengineered 13 (5), 13596-13606 (2022)
   PUBMED   35653796
  REMARK    GeneRIF: Decrease in Tripartite Motif Containing 24 suppresses
            hypoxia-induced proliferation and migration of pulmonary arterial
            smooth muscle cells via the AKT/mammalian target of rapamycin
            complex 1 pathway.
REFERENCE   4  (bases 1 to 6191)
  AUTHORS   Shah,V.V., Duncan,A.D., Jiang,S., Stratton,S.A., Allton,K.L.,
            Yam,C., Jain,A., Krause,P.M., Lu,Y., Cai,S., Tu,Y., Zhou,X.,
            Zhang,X., Jiang,Y., Carroll,C.L., Kang,Z., Liu,B., Shen,J.,
            Gagea,M., Manu,S.M., Huo,L., Gilcrease,M., Powell,R.T., Guo,L.,
            Stephan,C., Davies,P.J., Parker-Thornburg,J., Lozano,G.,
            Behringer,R.R., Piwnica-Worms,H., Chang,J.T., Moulder,S.L. and
            Barton,M.C.
  TITLE     Mammary-specific expression of Trim24 establishes a mouse model of
            human metaplastic breast cancer
  JOURNAL   Nat Commun 12 (1), 5389 (2021)
   PUBMED   34508101
  REMARK    GeneRIF: Mammary-specific expression of Trim24 establishes a mouse
            model of human metaplastic breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6191)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   6  (bases 1 to 6191)
  AUTHORS   Niederreither,K., Remboutsika,E., Gansmuller,A., Losson,R. and
            Dolle,P.
  TITLE     Expression of the transcriptional intermediary factor TIF1alpha
            during mouse development and in the reproductive organs
  JOURNAL   Mech Dev 88 (1), 111-117 (1999)
   PUBMED   10525195
REFERENCE   7  (bases 1 to 6191)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   8  (bases 1 to 6191)
  AUTHORS   Le Douarin,B., Nielsen,A.L., Garnier,J.M., Ichinose,H.,
            Jeanmougin,F., Losson,R. and Chambon,P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
REFERENCE   9  (bases 1 to 6191)
  AUTHORS   Le Douarin,B., Zechel,C., Garnier,J.M., Lutz,Y., Tora,L.,
            Pierrat,P., Heery,D., Gronemeyer,H., Chambon,P. and Losson,R.
  TITLE     The N-terminal part of TIF1, a putative mediator of the
            ligand-dependent activation function (AF-2) of nuclear receptors,
            is fused to B-raf in the oncogenic protein T18
  JOURNAL   EMBO J 14 (9), 2020-2033 (1995)
   PUBMED   7744009
REFERENCE   10 (bases 1 to 6191)
  AUTHORS   Miki,T., Fleming,T.P., Crescenzi,M., Molloy,C.J., Blam,S.B.,
            Reynolds,S.H. and Aaronson,S.A.
  TITLE     Development of a highly efficient expression cDNA cloning system:
            application to oncogene isolation
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5167-5171 (1991)
   PUBMED   2052597
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from S78221.1 and AC113501.7.
            
            On Jan 10, 2013 this sequence version replaced NM_145076.3.
            
            Summary: The protein encoded by this gene is part of the
            tripartite-motif containing family (TRIM), which are typified by
            the RING, B-box type 1, B-box type 2, and coiled-coil region
            domains. This protein, which also contains a PHD/TTC finger and
            bromodomain important for regulating nuclear receptors and binding
            chromatin, has important roles in differentiation, development, and
            tissue homeostasis. This protein has been reported to regulate the
            activity of the tumor suppressor p53 and of the retinoic acid
            receptor. A translocation event between this gene and Braf
            transforming gene, which results in the fusion protein T18, has
            been reported in hepatocellular carcinomas. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056959.1, AB221637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4038              S78221.1           1-4038
            4039-6191           AC113501.7         109311-111463
FEATURES             Location/Qualifiers
     source          1..6191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.07 cM"
     gene            1..6191
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /note="tripartite motif-containing 24"
                     /db_xref="GeneID:21848"
                     /db_xref="MGI:MGI:109275"
     exon            1..664
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            665..783
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            784..931
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1064
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1181
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1296
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1443
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1561
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1830
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2007
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2181
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2317
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2390
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2559
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2888
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3021
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3096
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3246
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..6191
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4017..4022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /note="hexamer: ATTAAA"
     polyA_site      4038
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /note="major polyA site"
     regulatory      6157..6162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
                     /note="hexamer: ATTAAA"
     polyA_site      6168
                     /gene="Trim24"
                     /gene_synonym="A130082H20Rik; D430004I05Rik; TIF1;
                     TIF1-alpha; Tif1a; TIF1alpha"
ORIGIN      
        1 ggtggtccaa ggggcccgag agaaaggctg ctaggcacgg gcgggcgcgc tgggcggaat
       61 cgagcgtctc ggtggcggtt tgcctatcgg cccgcgcggc ggcgtcgcgg tgcgggaacc
      121 ggtccccgtt gacagctccg cgtcttccgg ccgcgccact cgggaggtgg cttcctccct
      181 gtgctccctc cgcgagtccg ttcggcctcg gagaagcggg aggcggcggc ggctgcggag
      241 gtcgtcgggg gcggcgggcg gtgagcgcgc tcccgcttcc ccggcggcgg ccgcaggaca
      301 atggaggtgg ctgtggagaa ggcggcggcg gcagcggctc cggccggagg ccccgcagcg
      361 gcggcgccga gcggggagaa tgaggccgag agccggcagg gcccggactc ggagagcggc
      421 ggcgaggcgt cccggctcaa cctgttggac acttgcgccg tgtgccacca gaacatccag
      481 agccgggtgc ccaagctgct gccctgcctg cactcgttct gccagcgctg tttgcccgcg
      541 ccgcagcgct atctcatgct gacggcgccc gcgctgggct cggcagagac ccctccaccc
      601 gctcccgccc ccgcccccgc cccgggctcc ccggccggtg gtccttcgcc attcgccacc
      661 caagttggag tcattcgatg cccagtttgc agtcaagagt gtgctgagag acacatcata
      721 gacaactttt ttgtgaagga caccactgaa gttcctagta gtacagtaga aaagtctaat
      781 caggtatgta caagctgtga agacaatgca gaagctaatg ggttttgtgt agagtgtgtt
      841 gaatggctct gcaagacatg tattagagct caccagaggg tgaagttcac aaaagaccac
      901 acagtcaggc agaaagaaga agtatctcca gaggcagttg gggtgaccag tcagcgacca
      961 gtgttttgtc ccttccataa aaaggagcag ttgaaacttt actgtgaaac atgtgataaa
     1021 ctgacctgtc gagactgcca gctgctagaa cacaaagaac acaggtatca atttatagaa
     1081 gaagcttttc agaatcaaaa agtgatcata gatactctaa tcaccaaact gatggaaaaa
     1141 acaaaatata taaagtatac aggaaatcag atccaaaata ggataattga aataaatcaa
     1201 aaccaaaagc aggtggaaca ggatattaaa gttgccatct tcacattgat ggtggagata
     1261 aacaaaaaag ggaaagctct gctgcaccag cttgagagtc ttgcaaagga ccatcgaatg
     1321 aaactcatgc aacaacagca ggaagtggct gggctttcta agcagttaga gcacgtcatg
     1381 catttttcta aatgggctgt ttccagtggc agcagcacag ccttgctgta cagcaagcgg
     1441 ctgattacat acaggttacg gcaccttctt cgtgcaaggt gtgatgcttc tcctgtgacc
     1501 aacaccacca tccagtttca ctgtgatcct agtttctggg ctcaaaatat tatcaacttg
     1561 ggttctttag taatcgagga taaagagagc cagccacaaa tgcctaagca gaatcctgtc
     1621 gtggagcaga gttcacagcc accaggtggt ttaccttcca accagttatc caagttccca
     1681 acacagatca gcctagctca gttacgactc cagcatattc agcaacaggt aatggctcag
     1741 aggcaacagg tgcaacggag gccagcacct gtgggtttac caaaccctag aatgcagggg
     1801 cccatccagc agccttccat ctctcatcag catccgccac cacgcttaat aaactttcag
     1861 aatcacagcc ctaagcccaa tggaccagtt cttcctcctt atcctcagca gctgagatat
     1921 tcaccaagcc agaatgtacc tcggcagaca acaataaagc ccaacccctt gcaaatggct
     1981 tttttggctc aacaggccat aaaacagtgg cagatcagca gtgtacaggc tccgcccaca
     2041 actgccagca gctcctcctc cacgccgtcc agccccacaa tcacaagtgc agctgggtac
     2101 gatggaaaag cttttagttc acccatgatt gatctgagtg caccggtggg agggtcttac
     2161 aatcttcctt ctcttccaga tattgattgt tcaagtacta taatgttgga caacattgca
     2221 aggaaagaca caggtgtaga tcacgcccag ccgaggcctc cgtcaaacag aacggtgcag
     2281 tcaccaaatt catcagtgcc atctccaggc cttgcagggc ctgttactat gactagcgtc
     2341 catcccccaa tacgttcacc tagtgcctcc agtgttggaa gtcgaggaag ctctggctct
     2401 tccagcaaac cagcaggagc tgattctact cacaaggtcc cagtagtcat gctggagcca
     2461 attcgaataa aacaggaaaa cagtggacca cctgaaaatt atgattttcc tgttgttata
     2521 gtaaaacaag aatcagatga agaatctaga cctcaaaata ctaactatcc aagaagcata
     2581 cttacctccc tcctcttaaa cagcagtcag agctctgctt ctgaggaaac cgtgttacga
     2641 tctgatgccc ctgatagtac aggagatcag cctggactcc atcaagaaaa ttcctcaaat
     2701 ggaaagtctg agtggtcgga tgcctcccag aagtcccctg tgcatgtcgg agagacgagg
     2761 aaggaggatg accccaatga agactggtgt gctgtttgtc aaaatggtgg ggaactccta
     2821 tgctgtgaga aatgtcctaa agtattccat cttacttgtc atgtgcccac cttgacaaat
     2881 tttccaagtg gagaatggat ctgtactttc tgccgagact tatctaagcc agaggttgac
     2941 tatgattgtg atgttcccag tcaccactca gagaaacgga aaagtgaagg ccttactaag
     3001 ttaacgccaa tagacaaaag gaaatgtgaa cgcctacttc tgtttcttta ctgccatgaa
     3061 atgagcctgg ctttccaaga ccctgttcct ctaactgtgc ctgattatta taaaataatt
     3121 aaaaacccaa tggacttgtc aaccatcaag aaaagacttc aggaggatta ttgcatgtat
     3181 acaaagcctg aagactttgt agctgatttt agattgatct ttcaaaactg tgctgaattc
     3241 aatgagcctg attctgaagt agccaatgct ggtataaaac ttgaaagcta ttttgaagaa
     3301 cttctaaaga atctttatcc agaaaaaagg tttcctaagg tagaattcag gcatgaagca
     3361 gaagactgta agttcagtga cgactcagac gatgactttg tacagccccg gaagaagcgt
     3421 ctcaagagca ccgaggatcg ccagctgctt aagtaacgcc gcactgggcc agcgcgctgt
     3481 gctagagatt tctcatcaaa actaaagaca gcaaaaggct tgtcagtgat ctaagggttt
     3541 gtgagctctc tgctctgttt ttgctgttta ctggactttg gtttctttca taacccattt
     3601 ctttaacctc ttgtcaatga aaataaaaag aagaggaagg aaggaaatgt gtacaagaat
     3661 aaaagaagga agagaaggta gaaaaagaag aaagagcaaa gaaggaaaag acattcttcc
     3721 ccttgttgga tttcatacag gagcctggag tgagtgctac actaagaaag aaatagagtt
     3781 tgacataagt tgagatttta gtgtgatctg gatgtgtgat aatccatttt tagaatatta
     3841 atttcattac ccattaatta tggccaactg taaggagata gtcctgttac tattcttaaa
     3901 tgaagtcctc cccaaacgtg aatggaagca gagttctttg ccaggctgcc tgccggaaaa
     3961 ggtgtagaca gatgctacta agacaccaaa tagtgtccat gtaagatggc aactgcatta
     4021 aaaaaaaatc aggaaaaaca aatgtttggt tattgttttg ttttatcttg tctgttagag
     4081 atgctgggca tagcagttct aaagggccat tctctcatgg attgctagat cggccttttc
     4141 ttcagcttcg gtgagggagg aagtgtgtgt gtcaagtgtt gctgtttgat ccgcccctcc
     4201 actctcccct tactgtgcag agctgcaagt tgctagtggc ttttctttct tttgggggga
     4261 gaagggcgga gtggttgggt tttttgagac attatttctg cagtattact gtagtcctgg
     4321 ctgtcctgga attcactctg tagaccagga tggcctcaaa cttagagacc tacctgccgc
     4381 tgcctcccaa atgctgggat taaaagtgtg agccaaaggc tcacagtcac actcagtaga
     4441 agcatcaaat atacaatagg gggcaccaat atttgataga tttctatagc ttgtgccctg
     4501 gggctgccct gttgaagttc cctgaatggg ctttcaatct gtctttctca tttcaaataa
     4561 gcggatgttg tggagttggg aagagatcat ttgggggaag gggaaggaat tctaggaact
     4621 attctttgtt ggctttctgt ttccttgatt tgttttttaa caactttata tttcatcttt
     4681 gatctgcctt aattcagaat ttaattttct ttaggagaaa aaagattcct tttgcttgtt
     4741 tggtggtttt tttggggggt gtggggggag ctcagataaa caaagcacca aatgagatta
     4801 aggtagaata aaatcattga gtactgttgt actagcccaa tatttgacaa aatacaataa
     4861 cagttttagt ttgccatagt aaatttttag tattaaagca ttttaattgt ttgactagag
     4921 aaattttttt ctttaggttg acagaacagc tgacctgagg atttatttgg tcacatgacc
     4981 tcccctgaat taaaatgtag ctggacatag tagccgtggt ggcatgcaca cactcacaat
     5041 gccagcactt agaaggtgga ggcaggagaa tgggaagttg aaggtcatcg tccgctgtgt
     5101 gagccgctgt gggggaggag cagggagacg gtgacttctg tgtagcatta ttccagagct
     5161 acaattgttt cttgccttaa tagcaataga tcccttttat ctaaacaacc tgtataatac
     5221 tcgttataca tgaccactct aacagtcttc atccgttttc taaatgtgtg ttgtgtgctg
     5281 atgtttgtcg tgttgatttg aacatgcagc tggcacttgt tctggaaaca gtctgaacaa
     5341 agtttgacag tgcacagacc cttggggaaa tagggtttta tgttcagttc agtctggcct
     5401 tcagctctgg cccttctacc tctacctccc tggttcaggg actaaagtag tgtgcgacca
     5461 tgccctcagc tttggggttg gttggtttgc ttgcttgctt gctctcttgc tagctttatt
     5521 atttgtggga agtggttaca cttgtgattt agtccagcat tttaagtgta gcagctgtga
     5581 accattttta ttttaatatt ttaaagattt atttttttat ttcatatgta tgcatgtttg
     5641 tctgcatata cgtatgtgca tcatgtgtgt gcctggtgcc cacccaccta ggctagaaga
     5701 gggcattgga taccctggaa gtgacgttag agaggatggt cagacaccga ccgtatgggt
     5761 gctgggaacc aaacctgagt cctctgcaag agcaataaat gctcttaacc actgagccat
     5821 ctcaagctcc ggctgtggaa ctctgagcaa tacctttctt tttgctatct tagaatactg
     5881 ttctctggta gattgtcttc cataactgtc acctgagtta aaacagtact tatgtaaatt
     5941 attttgagaa ttatcactaa gggggaggta gggcttaaat aaggtaaata taatttttat
     6001 gtattttagc cagaatgtct actgatctat cccagtcact attatattct atggcgcagt
     6061 aacctttcaa aagaatgtta catttcacca ttaacagttt ttgctgaatg aaagacagtt
     6121 gagtaccatg tttcctgtaa tgatatttaa taatatatta aaagtaaatg tcttgagttt
     6181 tttctacaag t
//
