LOCUS       NM_001361538            3832 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 23 (Trim23), transcript
            variant 1, mRNA.
ACCESSION   NM_001361538 XM_006517794
VERSION     NM_001361538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3832)
  AUTHORS   Quan,W. and Wang,L.
  TITLE     Tripartite motif containing 23 functions as a critical regulator in
            macrophages to control the pathological feature of diabetic
            nephropathy
  JOURNAL   Int Urol Nephrol 55 (5), 1263-1270 (2023)
   PUBMED   36449224
  REMARK    GeneRIF: Tripartite motif containing 23 functions as a critical
            regulator in macrophages to control the pathological feature of
            diabetic nephropathy.
REFERENCE   2  (bases 1 to 3832)
  AUTHORS   Cao,X., Zhou,Z., Tian,Y., Liu,Z., Cheng,K.O., Chen,X., Hu,W.,
            Wong,Y.M., Li,X., Zhang,H., Hu,R. and Huang,P.
  TITLE     Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion
            channel ANO1 protein levels
  JOURNAL   J Biol Chem 296, 100738 (2021)
   PUBMED   33957127
REFERENCE   3  (bases 1 to 3832)
  AUTHORS   Watanabe,M., Takahashi,H., Saeki,Y., Ozaki,T., Itoh,S., Suzuki,M.,
            Mizushima,W., Tanaka,K. and Hatakeyama,S.
  TITLE     The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation
            via stabilization of the adipogenic activator PPARgamma
  JOURNAL   Elife 4, e05615 (2015)
   PUBMED   25905670
  REMARK    GeneRIF: TRIM23 regulates adipocyte differentiation via
            stabilization of the adipogenic activator PPARgamma2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3832)
  AUTHORS   Arimoto,K., Funami,K., Saeki,Y., Tanaka,K., Okawa,K., Takeuchi,O.,
            Akira,S., Murakami,Y. and Shimotohno,K.
  TITLE     Polyubiquitin conjugation to NEMO by triparite motif protein 23
            (TRIM23) is critical in antiviral defense
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15856-15861 (2010)
   PUBMED   20724660
REFERENCE   5  (bases 1 to 3832)
  AUTHORS   Kudryashova,E., Wu,J., Havton,L.A. and Spencer,M.J.
  TITLE     Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a
            myopathy with a neurogenic component
  JOURNAL   Hum Mol Genet 18 (7), 1353-1367 (2009)
   PUBMED   19155210
REFERENCE   6  (bases 1 to 3832)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039280.1 and AC154216.1.
            
            On Mar 26, 2018 this sequence version replaced XM_006517794.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039280.1, AK036210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2965              AK039280.1         14-2978
            2966-3255           AK039280.1         2980-3269
            3256-3832           AC154216.1         49870-50446         c
FEATURES             Location/Qualifiers
     source          1..3832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.35 cM"
     gene            1..3832
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /note="tripartite motif-containing 23"
                     /db_xref="GeneID:81003"
                     /db_xref="MGI:MGI:1933161"
     exon            1..123
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1767
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor domain protein 1, 64kD; tripartite
                     motif protein TRIM23; GTP-binding protein ARD-1; E3
                     ubiquitin-protein ligase TRIM23; tripartite
                     motif-containing protein 23; ADP-ribosylation factor
                     domain-containing protein 1; RING-type E3 ubiquitin
                     transferase TRIM23"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM23 isoform 1"
                     /protein_id="NP_001348467.1"
                     /db_xref="CCDS:CCDS88515.1"
                     /db_xref="GeneID:81003"
                     /db_xref="MGI:MGI:1933161"
                     /translation="MAALAVNKPGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDK
                     VPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERL
                     QNGHIGQYGAAEEAIGTSGESIIRCDEDEAHVASVYCTVCATHLCSDCSQVTHSTKTL
                     AKHRRVPLADKPHEKTMCCQHQVHAIEFVCLEEGCQTSPLMCCVCKEYGKHQGHKHSV
                     LEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEH
                     VPGTAENARSCVRAYFSDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSQ
                     VSTACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTFT
                     KDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKF
                     TIWDVGGKHKLRPLWKHYYLNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALL
                     LIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQLV
                     AAGVLDVA"
     exon            124..286
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..408
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..687
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..870
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1086
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1221
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1351
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1462
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1587
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..3832
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /note="hexamer: AATAAA"
     polyA_site      3207
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /note="major polyA site"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /note="hexamer: ACTAAA"
     polyA_site      3377
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /note="major polyA site"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /note="hexamer: AATAAA"
     polyA_site      3733
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
                     /note="hexamer: AATAAA"
     polyA_site      3778
                     /gene="Trim23"
                     /gene_synonym="6330516O20Rik; Arfd1"
ORIGIN      
        1 agtaaaaggc tctcctgcag ctgtggcgcg gctccatcca ggatggctgc cctcgctgta
       61 aacaagcccg gagccggagt agacagtggg cggcagggca gccgggggac ggctgtggtg
      121 aaggttctgg agtgtggggt ttgtgaagat gtcttctctt tgcaaggaga taaagttcct
      181 cgcctcctcc tctgtggcca cacagtctgt catgactgtc ttactcgctt gcctctgcat
      241 ggaagagcaa tacgttgccc atttgatcga caagtaacag acctaggaga ctcaggtgta
      301 tggggtttga aaaagaactt tgctttactg gagcttttag aacgtttgca aaatgggcac
      361 attggtcagt atggagctgc agaagaggcc attgggacat ctggagagag catcattcgc
      421 tgtgatgaag atgaagctca cgttgcatct gtatattgca ctgtgtgtgc aactcacttg
      481 tgctcagact gttctcaagt tactcattct acaaagacat tagcaaagca taggcgtgtg
      541 cctctagctg ataaacctca tgagaaaacc atgtgctgtc agcaccaggt gcatgccatt
      601 gagtttgttt gcttggaaga aggttgtcaa actagtccac tcatgtgctg tgtctgcaaa
      661 gaatatggaa agcaccaagg tcacaagcat tcagtactgg aaccagaagc taatcagatc
      721 cgagcatcaa ttttagacat ggctcactgc atacggacct tcactgagga aatctcagat
      781 tattccagaa aattagttgg gattgttcag cacattgaag gaggagaaca aatagtagaa
      841 gatggaattg gaatggctca cacagaacat gtcccaggta ctgcagagaa tgcccgatca
      901 tgtgtcagag cttatttttc tgatttacat gaaactcttt gtcgtcaaga agaaatggct
      961 ctaagtgttg ttgatgccca tgttcgagaa aaactgattt ggcttaggca gcaacaagag
     1021 gatatgacta ttctcttgtc ccaggtctca acagcctgtc tccactgtga aaaaactctg
     1081 cagcaggatg attgcagagt tgtcttggca aaacaagaaa tcacaagatt actagaaaca
     1141 ctgcagaaac agcagcagca gtttacagag gttgcagatc atattcagtt ggatgccagt
     1201 attccagtca cttttacaaa ggacaataga gttcatattg gacccaaaat ggaaatccga
     1261 gtagtcacat taggattaga tggtgctgga aaaactacca ttttgttcaa gttaaaacaa
     1321 gatgaattta tgcaacctat tccaacaatt ggttttaatg tggaaactgt ggaatacaaa
     1381 aatctaaaat tcaccatttg ggatgtgggt ggaaaacaca aattaagacc attgtggaaa
     1441 cattattacc tcaatacaca agctgttgta tttgttgttg atagtagtca tagagacaga
     1501 attagtgaag cacacagtga acttgcaaag ttgttaacgg aaaaagaact ccgagatgcc
     1561 ttactcttga tttttgctaa caaacaggat gtagctggag cactttcagt agaagaaatc
     1621 actgaacttc tcagtctcca taaactatgc tgtggaagga gttggtatat tcagggctgt
     1681 gatgctcgaa gtggaatggg gctctacgaa gggttggact ggctgtcccg gcaacttgtg
     1741 gctgctggag tgttggatgt tgcttgattt taatgcagca gttgtttcat gcttatggtt
     1801 aacagttact ttgcatgtga tgcattctaa gaaattctac atctcaaatg tgataattaa
     1861 tttagtatgt gtatatatga atcctggact gagaaatgta ccattgtttt taaaaagtac
     1921 tctgtggcaa atttaaatga ccctgttaca ttggttaaat ggaggtttct tggatataca
     1981 cttttaaaag gtacattagg cattggaaac tttcagtgta tatatgtcct tatattgaga
     2041 gagaagtggt cacagacaat gagtagaagg tcctttattt tagtgaaaaa acagccagtg
     2101 gagtgcctaa cagagcttaa ggaagtatgg ctttacccca cctttttatt gtttttggcc
     2161 attgtgtact agaattgaag ctatattggg gtaataggat tgctttactt ccacatttag
     2221 cataacatcc ttagtgctgg ggtccataaa acatagaaaa tcattttttt ctacaatttt
     2281 attataactc tctcctaaag cattttgcat aacgcacagt gagaatgaaa tgttacctaa
     2341 gtggacctga tcattagacc agaactaaat taagaacaat aaaactgtga aagttgtttg
     2401 atcttcactc ataagaacca tttccaggac tgggcctaag tttatttccc aggtcatagc
     2461 cctaaattgc tcctttattt gttcaacaca ttttcttagg ctaagtaatg tgcatccttt
     2521 gttggtaaag tgtcgtaagt cacatgaaaa acctgtcacc tttacataaa cacattgaga
     2581 cctaaatagg aaactaccta taccttagga aaggtttttc aaacagtggg aatgctaatt
     2641 tctttaacat ggttttccaa gttaagtgca tttacttgac aataaaaagg atcaaggctc
     2701 tttaggacaa ggtctcagtt aaaaggaaga acatgtctaa agtaaaagaa acttttataa
     2761 aaagtttaca tttactatgg cagtgttgtg aataaaaatt aaattttgtg ttcttacagt
     2821 ttatttgtaa aagatactct tattatggaa gcatgatttc ttatatttaa ataggtagat
     2881 ctcctgttac taatgctctt taagatgaag ttgagagcta aatcttagtg caattgttac
     2941 aaggacagtg atttttaggt ggcaatgttc tggttcagtt ttttcaaata tacttttttt
     3001 tttttaaact taggagccag cactataaaa agcccatcaa atattatggg cagtatgtaa
     3061 ataaaaatat aataatttgc catttttcaa gaaagtaacc ggtcacgctg ttacaagtag
     3121 tttgtatgca tatgtaatac tttgtaatta aattatttaa tatttgactg attttagtaa
     3181 ctgtgaaaaa taaagatgtt gcatttattt gtgagacttt gaattgtttt ctgtagtagg
     3241 taactgaaaa tatgttgaca ctaagatgtg aacttgcttt tcttgtaaat taagaacttt
     3301 attatttctc taattttgtt aaactttgta gttcttattc ttaaaatata actaaactaa
     3361 ttttaaaatt gcttaaatct gactgtgacg tatacatact gtggtgtttg tgttactttt
     3421 tcttgggtgg gctcctaata ctgtgcataa tagttagatc ctttgagtag tcattgttaa
     3481 gactgtatta gtttcttcag ggaaatatca aactcgaaga atcaacagat gttttaagta
     3541 taatagtatt tgccttatat ctctgaagtt ctatattaca tctaattatt attgtatgaa
     3601 atatgtaaaa caggtatgtc aagtgtatat agctctggtc tgtaattcag aaatgattta
     3661 tagcctccag aagccattat ttgcacttac atatatgatc agtatagaaa gcaataaaat
     3721 gtttaagtta taaggagttg ttattctaaa aattgtttaa taaaccatgt atctagtatc
     3781 atgctagtta acaatttaag tcattattaa aattgggcat agctcaatag tc
//
