LOCUS       NM_009277               2790 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus tripartite motif-containing 21 (Trim21), transcript
            variant 1, mRNA.
ACCESSION   NM_009277 XM_991802 XM_991824 XM_991845
VERSION     NM_009277.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Mehlmann,L.M., Uliasz,T.F., Yee,S.P., Kaback,D. and Lowther,K.M.
  TITLE     Generation and Characterization of a TRIM21 Overexpressing Mouse
            Line
  JOURNAL   Genesis 62 (5), e23616 (2024)
   PUBMED   39487578
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Yang,L., Hu,C., Chen,X., Zhang,J., Feng,Z., Xiao,Y., He,W., Cui,T.,
            Zhang,X., Yang,Y., Zhang,Y. and Yan,Y.
  TITLE     Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2
            nuclear translocation and astrocyte activation in experimental
            autoimmune encephalomyelitis
  JOURNAL   Elife 13, 98181 (2024)
   PUBMED   39264698
  REMARK    GeneRIF: Upregulated expression of ubiquitin ligase TRIM21 promotes
            PKM2 nuclear translocation and astrocyte activation in experimental
            autoimmune encephalomyelitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Guo,Y.Y., Gao,Y., Zhao,Y.L., Xie,C., Gan,H., Cheng,X., Yang,L.P.,
            Hu,J., Shu,H.B., Zhong,B., Lin,D. and Yao,J.
  TITLE     Viral infection and spread are inhibited by the polyubiquitination
            and downregulation of TRPV2 channel by the interferon-stimulated
            gene TRIM21
  JOURNAL   Cell Rep 43 (4), 114095 (2024)
   PUBMED   38613787
  REMARK    GeneRIF: Viral infection and spread are inhibited by the
            polyubiquitination and downregulation of TRPV2 channel by the
            interferon-stimulated gene TRIM21.
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Lin,M., Xian,H., Chen,Z., Wang,S., Liu,M., Liang,W., Tang,Q.,
            Liu,Y., Huang,W., Che,D., Guo,C., Idiiatullina,E., Fang,R.,
            Al-Azab,M., Chang,J., Wang,R., Li,X., Zuo,X., Zhang,Y., Zhao,J.,
            Tang,Y., Jin,S., He,Z., Feng,D., Lu,L., Zhang,K., Wu,Y., Bai,F.,
            Lew,A.M., Cui,J., Wu,Y., Gu,X. and Zhang,Y.
  TITLE     MCM8-mediated mitophagy protects vascular health in response to
            nitric oxide signaling in a mouse model of Kawasaki disease
  JOURNAL   Nat Cardiovasc Res 2 (8), 778-792 (2023)
   PUBMED   39195969
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Keeble,A.H., Khan,Z., Forster,A. and James,L.C.
  TITLE     TRIM21 is an IgG receptor that is structurally, thermodynamically,
            and kinetically conserved
  JOURNAL   Proc Natl Acad Sci U S A 105 (16), 6045-6050 (2008)
   PUBMED   18420815
  REMARK    GeneRIF: TRIM21 is a previously undescribed type of IgG receptor
            based on a non-Ig scaffold whose interaction at the fundamental
            level-structural, thermodynamic, and kinetic-is evolutionarily
            conserved.
REFERENCE   7  (bases 1 to 2790)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2790)
  AUTHORS   Kong,H.J., Anderson,D.E., Lee,C.H., Jang,M.K., Tamura,T.,
            Tailor,P., Cho,H.K., Cheong,J., Xiong,H., Morse,H.C. 3rd and
            Ozato,K.
  TITLE     Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase
            that ubiquitinates IRF-8 and enhances cytokine expression in
            macrophages
  JOURNAL   J Immunol 179 (1), 26-30 (2007)
   PUBMED   17579016
  REMARK    GeneRIF: Ro52 is an E3 ligase for interferon regulatory factor
            (IRF)-8 that acts in a non-degradation pathway of ubiquitination
            and contributes to the elicitation of innate immunity in
            macrophages.
REFERENCE   9  (bases 1 to 2790)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 2790)
  AUTHORS   Keech,C.L., Gordon,T.P. and McCluskey,J.
  TITLE     Structural differences between the human and mouse 52-kD Ro
            autoantigens associated with poorly conserved autoantibody activity
            across species
  JOURNAL   Clin Exp Immunol 104 (2), 255-263 (1996)
   PUBMED   8625517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ051157.1, AK171489.1 and BB681113.1.
            
            On Jan 18, 2014 this sequence version replaced NM_009277.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171489.1, AK141294.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                CJ051157.1         3-39
            38-747              AK171489.1         2-711
            748-2789            AK171489.1         713-2754
            2790-2790           BB681113.1         529-529
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.76 cM"
     gene            1..2790
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /note="tripartite motif-containing 21"
                     /db_xref="GeneID:20821"
                     /db_xref="MGI:MGI:106657"
     exon            1..94
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     exon            95..163
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..595
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1588
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /EC_number="2.3.2.27"
                     /note="Sjogren syndrome antigen A1; tripartite motif
                     protein 21; 52 kDa Ro protein; 52kD Ro/SSA autoantigen;
                     SS-A; ro(SS-A); sjoegren syndrome type A antigen;
                     tripartite motif-containing protein 21; 52 kDa
                     ribonucleoprotein autoantigen Ro/SS-A; RING-type E3
                     ubiquitin transferase TRIM21"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM21"
                     /protein_id="NP_033303.3"
                     /db_xref="CCDS:CCDS40051.1"
                     /db_xref="GeneID:20821"
                     /db_xref="MGI:MGI:106657"
                     /translation="MSLEKMWEEVTCSICLDPMVEPMSIECGHCFCKECIFEVGKNGG
                     SSCPECRQQFLLRNLRPNRHIANMVENLKQIAQNTKKSTQETHCMKHGEKLHLFCEED
                     GQALCWVCAQSGKHRDHTRVPIEEAAKVYQEKIHVALEKLRKGKELAEKMEMDLTMQR
                     TDWKRNIDTQKSRIHAEFALQNSLLAQEEQRQLQRLEKDQREYLRLLGKKEAELAEKN
                     QALQELISELERRIRGSELELLQEVRIILERSGSWNLDTLDIDAPDLTSTCPVPGRKK
                     MLRTCWVHITLDRNTANSWLIISKDRRQVRMGDTHQNVSDNEERFSNYPMVLGAQRFS
                     SGKMYWEVDVTQKEAWDLGVCRDSVQRKGQFSLSPENGFWTIWLWQDSYEAGTSPQTT
                     LHIQVPPCQIGIFVDYEAGVVSFYNITDHGSLIYTFSECVFAGPLRPFFNVGFNYSGG
                     NAAPLKLCPLKM"
     exon            596..691
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..922
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..945
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1046
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..2790
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /note="hexamer: AATAAA"
     polyA_site      2788
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /note="major polyA site"
ORIGIN      
        1 ctgcctctga gaggaaactg aaagtgaaat ttggactgca ggcttgcaaa agcgaagctg
       61 ggagcacata actaaagctg aggaccctgg ttagaaactc ggtttcccct tctgcctggc
      121 ttgctcagtg ggtgaggccg gaggagaggc tcctgtcatt cagattccac ggcagatatc
      181 accctctaca acctcaaaaa tgtctctgga aaagatgtgg gaggaggtca cctgttctat
      241 ctgcctggat cccatggtgg agcctatgag tatcgaatgt ggccattgct tttgcaagga
      301 atgcattttt gaagttggga agaatggggg cagttcatgt cccgagtgcc ggcaacagtt
      361 tctgctccga aacctcaggc ccaatagaca tatagccaac atggtggaaa accttaaaca
      421 gatagcccag aataccaaga agagtaccca ggaaacgcac tgcatgaagc atggagagaa
      481 gcttcaccta ttctgtgagg aagatgggca ggccctttgc tgggtgtgtg cccagtctgg
      541 gaaacaccgg gaccacacca gggtccctat tgaagaggct gctaaggtat accaggagaa
      601 gatccacgtg gctttagaaa aactgagaaa ggggaaagag ttggccgaga agatggaaat
      661 ggatctcacg atgcaaagaa cagactggaa gaggaacatt gacacccaga agtcgaggat
      721 tcacgcagag ttcgcacttc agaatagctt gctggctcag gaggagcaga ggcagctgca
      781 gaggctggag aaggatcaaa gggagtacct gagactcctg gggaagaagg aggctgagct
      841 ggctgagaag aaccaggccc tgcaggagct gatctcagag ctggagagga ggattcgtgg
      901 ttcagagctg gagctactgc aggaggtgag gatcatcctg gaaaggagtg gatcctggaa
      961 cctggacacg ttagatattg acgccccaga cctaacaagc acatgccctg tgccagggcg
     1021 gaagaagatg ctgaggacat gttgggttca tattactctg gatcgcaaca ccgccaactc
     1081 atggctcatc atctcaaagg atcggagaca agtgaggatg ggagacaccc atcagaacgt
     1141 gtctgacaat gaggagaggt ttagtaatta ccccatggtg ctaggtgccc agagattctc
     1201 ctctgggaag atgtactggg aggtagatgt gactcaaaag gaggcctggg atctgggggt
     1261 ttgcagagat tctgttcaga ggaaagggca gttttcactc agtcccgaga atggcttctg
     1321 gaccatttgg ttatggcaag acagctatga ggctggtacc agtcctcaga ccaccctcca
     1381 cattcaagta cctccatgcc aaattgggat ctttgtggac tatgaggctg gcgttgtctc
     1441 cttctacaac ataactgacc atggctccct catttacacc ttctcggagt gtgtttttgc
     1501 tggacctctg cgacctttct tcaatgttgg tttcaattat agtgggggaa atgcagcgcc
     1561 tctaaagctc tgtccactaa agatgtgatg gtcaggagcc agtgcctact gacggtactt
     1621 cccggacact tacctcctcc ctgtcctgat caagatccag tgactcctgg ggaccatttc
     1681 tggatactgc tgctcacttc ctgttggtgt tcttcagcca tgcacttggt cattttgacc
     1741 catctagttg gaactaccct aaaccctcat ctctttaaag gagtcagggt cccaggatga
     1801 aggtatcagc tggacataac tgaaagtcaa tgtcaaatga ccttcaccat caatatacct
     1861 gacatagatt ccgcaatgat tcctcaatga aacagactcc tcacattgga cccaaactca
     1921 tctaaaagac aaacaaacat ttctgccttt atgtgacttc ctttgttttc tctgtccttg
     1981 gttgttacct ttggctagat acctgtctac tcctatatct tttgtggctt gcagaaggac
     2041 ttcctagaaa ttgtgcttga actatcctgt tcagttatta ttggtaaaat atatatatat
     2101 atatatatat atatatatat atatgcatac atatgtctta acattataca tcttctggtt
     2161 tggtttgttg ttttgttgtt actgggggat tttagggttt tattgttcgt tgtttgtttg
     2221 ttttccctcc ctggaatgct ctatgcactt cttctgtaaa cccaggtcaa gaatatcttc
     2281 tatgggaaca aatgaaagcc aggataaagt agtgaaagtg gttcagacaa gagctgaatg
     2341 ttacactgac agtatgctca gtatccccag tgatagccaa agtctgggtg ctgtgctggg
     2401 tctggtcagt gaacccctgc tgttgactct cacaaggcta caacagctgt gctcagacac
     2461 tgcctgctgt cattttgtgg atatgttggt ttctgattcc attgccttga agaaagtgaa
     2521 attagtagct gaactagtat acaaatattt tgaaagcttc aaaaatacta cctggagatt
     2581 tatgttacat agttaataaa ccccttattc tccactgaat ggaattggga ggtttcatac
     2641 tatctcagct ttcccccata gccaataaca aatggtctgg atacaagtgt ctttgttaca
     2701 taaaagttac cttgagaaag atctccaagt attggttcca attctgaata atatgtcttt
     2761 taagatcaaa taaagcctgt tgattttcct
//
