LOCUS       NM_001271727            7413 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 2 (Trim2), transcript
            variant 3, mRNA.
ACCESSION   NM_001271727
VERSION     NM_001271727.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7413)
  AUTHORS   Wong,N.K.P., Solly,E.L., Le,R., Nankivell,V.A., Mulangala,J.,
            Psaltis,P.J., Nicholls,S.J., Ng,M.K.C., Bursill,C.A. and Tan,J.T.M.
  TITLE     TRIM2 Selectively Regulates Inflammation-Driven Pathological
            Angiogenesis without Affecting Physiological Hypoxia-Mediated
            Angiogenesis
  JOURNAL   Int J Mol Sci 25 (6), 3343 (2024)
   PUBMED   38542330
  REMARK    GeneRIF: TRIM2 Selectively Regulates Inflammation-Driven
            Pathological Angiogenesis without Affecting Physiological
            Hypoxia-Mediated Angiogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7413)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7413)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7413)
  AUTHORS   Sarute,N., Cheng,H., Yan,Z., Salas-Briceno,K., Richner,J., Rong,L.
            and Ross,S.R.
  TITLE     Signal-regulatory protein alpha is an anti-viral entry factor
            targeting viruses using endocytic pathways
  JOURNAL   PLoS Pathog 17 (6), e1009662 (2021)
   PUBMED   34097709
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7413)
  AUTHORS   Khazaei,M.R., Bunk,E.C., Hillje,A.L., Jahn,H.M., Riegler,E.M.,
            Knoblich,J.A., Young,P. and Schwamborn,J.C.
  TITLE     The E3-ubiquitin ligase TRIM2 regulates neuronal polarization
  JOURNAL   J Neurochem 117 (1), 29-37 (2011)
   PUBMED   20796172
  REMARK    GeneRIF: Trim2 has an important function in the regulation of axon
            outgrowth during development.
REFERENCE   6  (bases 1 to 7413)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 7413)
  AUTHORS   Balastik,M., Ferraguti,F., Pires-da Silva,A., Lee,T.H.,
            Alvarez-Bolado,G., Lu,K.P. and Gruss,P.
  TITLE     Deficiency in ubiquitin ligase TRIM2 causes accumulation of
            neurofilament light chain and neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 12016-12021 (2008)
   PUBMED   18687884
  REMARK    GeneRIF: TRIM2 is an ubiquitin ligase and point to a mechanism
            regulating neurofilament light subunit metabolism through an
            ubiquitination pathway that, if deregulated, triggers
            neurodegeneration
REFERENCE   8  (bases 1 to 7413)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7413)
  AUTHORS   Ohkawa,N., Kokura,K., Matsu-Ura,T., Obinata,T., Konishi,Y. and
            Tamura,T.A.
  TITLE     Molecular cloning and characterization of neural activity-related
            RING finger protein (NARF): a new member of the RBCC family is a
            candidate for the partner of myosin V
  JOURNAL   J Neurochem 78 (1), 75-87 (2001)
   PUBMED   11432975
REFERENCE   10 (bases 1 to 7413)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ105472.1, AK147275.1 and CA751006.1.
            
            Transcript Variant: This variant (3) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting isoform (2) has a shorter N-terminus,
            compared to isoform 1. Variants 2, 3, and 5 encode the same isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147275.1, AK079415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-543               CJ105472.1         2-544
            544-6700            AK147275.1         452-6608
            6701-7413           CA751006.1         23-735
FEATURES             Location/Qualifiers
     source          1..7413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.48 cM"
     gene            1..7413
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /note="tripartite motif-containing 2"
                     /db_xref="GeneID:80890"
                     /db_xref="MGI:MGI:1933163"
     exon            1..455
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            456..637
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2738
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 3;
                     tripartite motif protein 2; E3 ubiquitin-protein ligase
                     TRIM2; tripartite motif protein TRIM2; neural
                     activity-related ring finger protein; tripartite
                     motif-containing protein 2; RING-type E3 ubiquitin
                     transferase TRIM2"
                     /codon_start=1
                     /product="tripartite motif-containing protein 2 isoform 2"
                     /protein_id="NP_001258656.1"
                     /db_xref="CCDS:CCDS71256.1"
                     /db_xref="GeneID:80890"
                     /db_xref="MGI:MGI:1933163"
                     /translation="MASEGASIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCE
                     RCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNGEDSS
                     ILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQ
                     HKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVR
                     KSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQ
                     MSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEG
                     LRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFL
                     YTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKA
                     VKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQ
                     CVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKF
                     KTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAG
                     PHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGN
                     IIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVY
                     RYLQ"
     exon            638..875
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1027
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1208
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1932
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2036
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2204
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2373
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2444
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2585
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..7396
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4066..4071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /note="hexamer: AAGAAA"
     polyA_site      4080
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /note="major polyA site"
     polyA_site      4084
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
     regulatory      7371..7376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
                     /note="hexamer: AATAAA"
     polyA_site      7396
                     /gene="Trim2"
                     /gene_synonym="mKIAA0517; narf"
ORIGIN      
        1 agtagacctg aaaacccagc cagccgcgga ttggcgcatc ccggctgcgg ccgcctgagt
       61 catccgaatc gttctggaac cgggcaccaa cttgcgtgtt tgtccgcggc tctttgtgcg
      121 cggatcagct gtaccgtggg ctctggcatc taatccagga tttgcctctg cgcgaggctt
      181 atggaaagca gatgtctcgc cgctctggga ctgagcacag aatggaagtg acccagagag
      241 gagctgtttg gtacagacga cacggaggga aggccccggc gcggcccgcg aggccagctc
      301 cgctcctcgc gtccgtcctc tctgccgagc ccgccgctca gatcgtgtcc cgcgagcgag
      361 ccgtgtgacc gtgaggccgc gtgcggcggg agccgggata ccggggtccg cggccgccag
      421 agatccgggt gcgagcagca gccgcgaggg tcgcgcagcg tgcagggtcg aggacagccg
      481 gccccccatg tcagtggtct aggatggcca gtgagggcgc cagcatccca agtcccgtgg
      541 tgcgccagat tgacaagcag tttctgatct gcagtatatg cctggaacgg tacaagaacc
      601 ccaaggtcct gccctgtctg cacactttct gcgagaggtg cctgcagaac tacatcccag
      661 cccacagttt aaccctctcc tgcccggtgt gtcgccagac atccatcctg cccgagaaag
      721 gggtggccgc acttcagaac aacttcttta tcacgaacct catggatgtg ctgcagcgga
      781 cgccaggcag caacggcgag gactcttcca tcctggagac ggtcaccgct gtggctgcag
      841 gaaagcctct ttcgtgccca aaccatgatg gaaatgtgat ggaattttac tgccagtcct
      901 gtgagaccgc catgtgtcgg gagtgcacgg agggggagca cgcggagcac cccacagtcc
      961 cgctgaagga tgtggtggag cagcacaagg cctcgctcca ggtccagctg gacgcagtca
     1021 acaaaagact cccagaaata gattctgctc ttcagttcat ctcagaaatc atccatcagt
     1081 taaccaacca aaaggccagc attgtggatg acatccactc cacctttgat gagctgcaga
     1141 agactttaaa tgttcgcaag agcgtgctgc tcatggagtt ggaggtcaac tatggtctca
     1201 aacacaaagt gctgcagtcg cagctggata ccctgctcca aggccaggaa agcattaaga
     1261 gctgcagcaa cttcacggct caggccctca accatggcac ggagacggag gtgctgctgg
     1321 tgaagaagca gatgagcgag aagctgaacg aactggcgga ccaggacttc ccactgcacc
     1381 cgcgcgagaa cgaccagctg gattttatcg tggaaacgga gggactgaag aagtctatcc
     1441 acaacctggg gaccatcctc accactaacg cggtcgcctc tgagacggtg gccacggggg
     1501 aggggctgcg gcagaccatc atcgggcagc ccatgtccgt tactataacc accaaggaca
     1561 aagacggaga gctgtgcaag acaggcaacg catacctcac cgctgagctc agcaccccgg
     1621 acggcagcgt ggccgacgga gagatcctgg acaacaagaa cggcacctac gagttcttgt
     1681 atactgtgca gaaggagggg gacttcaccc tgtccctcag gctctacgac cagcatatcc
     1741 gaggcagccc gtttaagctc aaggtcatcc gctctgccga cgtgtccccc accaccgagg
     1801 gcgtgaagcg acgagtcaag tccccgggga gcgggcacgt caagcagaag gctgtgaaga
     1861 gacctgccag catgtacagc accggcaagc gaaaagagaa ccccatcgag gacgacctga
     1921 tcttccgagt cggtaccaaa ggaagaaaca aaggagaatt tacaaacctg cagggtgtgg
     1981 ctgcatctac aagtggaaag atattaattg cagatagtaa caaccagtgt gtgcagatct
     2041 tttccaatga tggacagttc aaaagtcgtt tcggcatccg aggacgatca cccggacagc
     2101 tccagcggcc cacgggggta gcggtgcacc ccagtgggga catcatcatt gcagattatg
     2161 acaacaagtg ggttagcatt ttctccaatg atgggaagtt taagacaaaa attggatcag
     2221 gaaaactgat ggggcccaaa ggagtttctg tggaccgcaa tgggcacatt attgtggtgg
     2281 acaacaaggc gtgctgtgtg tttatcttcc agcccaacgg gaaaatagtc accaggtttg
     2341 gtagccgagg aaacggggac aggcagtttg caggtcccca ctttgcagct gtgaatagca
     2401 ataatgagat catcattaca gatttccata atcactctgt caaggtattt aatcaggaag
     2461 gagaattcat gttgaagttt ggctccaatg gagaaggaaa tgggcagttt aatgcaccaa
     2521 caggtgtggc cgtggactca aatgggaaca tcattgtggc tgactggggg aacagcagga
     2581 tccaggtttt tgatgggagt ggatcatttt tgtcctatat caacacatct gctgacccgc
     2641 tctatggccc ccagggcctg gctctcactt cagatggcca tgttgtggtt gcagactccg
     2701 gaaaccactg tttcaaggtc taccggtact tacagtaaca gtggacagct ctgtactgag
     2761 gtcttgcact agaaactgga atggagttct caaggtggga ccagactacg ataggacttt
     2821 tcatactagg aagaatcttc ggtgaacttc ccaaggttat ttctgaatgt aaccatttct
     2881 ttaaaaactg tctatccaat ttccgtaatt cacttttagg atttaaaaag aatcttcttc
     2941 tactgaatct atacaaactg cgaagtttta cacccatgaa ctatggctca taggacaggg
     3001 atttctgtag ttaaactaat tttgcaaatc agacgttaaa aagaattagc gtatctgttg
     3061 actggtgaat gaatgatagc ctttgcatag agcttccaag aacaaaactt gtagttgcct
     3121 attttattta acttcgatca caagacccaa gggaccttct aacctcactt ttacagtagg
     3181 tgttattatt ctggtgacat gtttttgctt atcaacaacc acatataaat taccttagaa
     3241 aaatccaagg ctgtcttgca agatcctttc agttcaactc aggccctgag ttgagcccat
     3301 cagaatcaat gcaaattccc caaatttcct gggtttgatc aaagatcgtt tccatgtgtt
     3361 ctcttcacct tctcatttct gctcaccttg catcagaaaa tgaaatatat tttcaggaaa
     3421 acctgaaatt cccgatgctt tggaaggcac gtagcaaaag caaggggact ctttggttac
     3481 tagcttcaga tcaacacact ggaatggaat caagagaagt cacattcatg tgccatgcgt
     3541 tcatgtgtct ttcctcttcc acatcacgaa agcgaaagct ttacctcctg caaaacgtca
     3601 gcacatgtag tcagacgcca gtgtcctagg acagagagcc ataagcagcc ctttggagga
     3661 tggatggtgt caaccaaagg catgtgattg attcatgatt tccccttaga gagcaagtgt
     3721 taccaaagtt ctgttgagca ttacaggtaa gggcatgttg tggttattta tcattgtcta
     3781 atgagtagta gaggcattaa gggggcaagt atacatggtt agggtaagat agaatgtatt
     3841 atacatatat atatatatat aaatatatag ctgagtcctt ggtgtgcggg aataggcagc
     3901 actctgaaag acagaagcat tgtccagcca tccttcagta cattccctgc ctgttgcagt
     3961 ctgaagccgt ccctggagag tgagccccac agcagctttc tgtgctgcca tttcctggca
     4021 tgatggtgat gtctggcttc cagtcaaatt accttctttg tgttcaagaa aaaaaagaaa
     4081 gaaaggaaga aaaaaaggaa gaaggggagg aagaaagaaa gaaagaaaga aagaaagaaa
     4141 gaaagaaaga aagaaagaaa gaaagagaaa gagagaaaga aagaaagaag tctttataac
     4201 attgagtttg agttaccttt catttaggta taaatgcatt tgagaaacat tacctgtcat
     4261 ggatactgta aactaagatg tgttctcttt ccactgattt tctactcagt tctaccaaat
     4321 aggaatgttg tgctttgcat gtttgatgat gacgctgtga tgtcattcac cgaaagcacc
     4381 ttagatatct actgtaaaag acatcttccc ttagatacaa atgatgatgt ttatggctta
     4441 ttatcttaaa attcaaatgt tcttgacata aattttttaa aaaaatttag aagggaaatc
     4501 tggctacttc cagtggtcta tttaattcat tatgcccaaa tcaacatctg ggtggaaaaa
     4561 ctttattttc agaagattta cattggtatt tagcttatta ttattttagt tctgtggggt
     4621 tttaaaatac acaagcctgt ctttactaga cataaaattt aataccaatt ttagaacgat
     4681 aaggtaagac tgcttctgaa tatcatgaaa taagtctttg atattttggt tgtaattttt
     4741 ttttcttggt gctggggatg gtactcacgg cctcagagat attcagcaag agccctacag
     4801 tcgggcagag cctgcagccc aaccctcagt atgaatgtca gtgtttctcc ctccaggctt
     4861 ccgaccaggg gccaggaatg catctaggca ctgggaccag agggatgctt agaagagaaa
     4921 ggcatctctg cccttgtaca gcttatactc tggaaaggag acatcgttgt gctttaatag
     4981 tctgcctgca ggactgtttc tgtttctggg ctacttaaaa gaaagctttt tttaaaaaaa
     5041 aatgagtaaa ttaattgtag aaattaaaaa tgtaaaagta gaaattttgt ttttgttttt
     5101 tgttttccaa gacggggttt ctcaatgtag ccctggctgt cttggaactc actctgtaga
     5161 ccaggttggc ctcgaatgca gaaatccacc tgcctctgac tcccaagtgc tgggattaat
     5221 ggcgtgtgcc accactgccc ggccagaaaa cattttttaa agaggctgcc atgggctgtt
     5281 tttggttggt tggttggttc tttgttttgt ggtgctggag atggaatcag ggctctgcaa
     5341 ctgagccaca cctccacgtt gcaactctta ttttgaaaat gaatttacca aatgagttct
     5401 cattttgtac aatgttgaga tatttgtgaa ctgagaaatt aattcgtaaa tgaatcagct
     5461 gcacatataa aatatcatgt caggcttgat agctcaataa gaaataacac aaattttttt
     5521 ttcttaacac acaaatattg gtatgaactg gaatgaaagg gtaatttaat ttagacctgt
     5581 tccaccattg gctactaaag cacctgctgt gggcactgca agaaacacta cattctacac
     5641 ctgggtacct gtgtgtgttc actgtatttc tttgtggtaa gcgaattggg ggttgggggt
     5701 ggagtgctgc tactaagata taaatagaca aggtctaaat ggaattttgt ctcatttggt
     5761 cagaatggtt tctggtaaac tgagaaggat tattacaata agtggctttt tttgttctag
     5821 gctactgtta ctgtccaatt gatcttcgtt gagtgtatag aacccgtcac acattcatga
     5881 tacgtagcac tgagaaagta agcgttcagc tttcccttgg gcactaagga caagcagtta
     5941 ggttttatag gttaacgata gtgtgtcttc tcccgccata aacctccctt gctggacaca
     6001 gggtggtagg gagtcacttt gactatccag aaacacacaa ttagaaagtt gttatgactg
     6061 tttgctggtg tttaaatgat gtgtaagatt ttgatgaaac tttagtctct gtaaccaaat
     6121 aagcccccga gtttcctaaa cttgacaaaa tttgaggcaa taagcacccc tggtccatgc
     6181 agctgttgca catctgctcc cactacatgt acagggtatg tatgtcctca cggggaatga
     6241 actggaatag cgggacgtaa ccaggtatat ggagcctcgc tctaaagggt tagcataaat
     6301 gctttggtaa tacctacgga ggaaattgga gagatcagat caacatcagg ccatctgtag
     6361 gtcacatcaa atgggaaaag tctctctatg catttgaact gtagatcacc ctctctgttc
     6421 accagcttct gaacagggaa gaggaatttc tgtttttggt gaatgctttt aaaacaagac
     6481 ctttttccaa gtaggatagc attgaagctg cctgatgcaa acctttctaa tttcccttaa
     6541 aatcaaaagt cctaatactg ttactttatg taaatgttgc agggtgttta aaattttaca
     6601 attattttaa tatttttgat aactaggaat ctagtattgc cataaaggaa actaagtgcc
     6661 cattaaatat ttgtttggta taaataaata cttttttttt tggttttgtt tcaaatgaca
     6721 gtaagctaca aatcatgacg ctaatcttca aaaacacttt ctaatgaact gtgtggtagt
     6781 tgattgtgtg gtctgtttgt ggagaatgta tggatgcgat tcattagtat tctagaagag
     6841 attaataatc agctatgttg ttccaatgaa tgtacagcac ttccattaac ttttgaaagc
     6901 aacacagcct taacctcatg cttttgcttt ataacgtggg acgttgtgct atcaacacag
     6961 taccctctgc taacgttctt tctcaccatt cctgactgca gccatcggag gctgcctacg
     7021 agaatggggg ttgtttgttc ccttttcgtt tctttgaaga ttttgtacat tccaccttga
     7081 cacatctgtc tcatacattt tgtgtacaga ccactggtct tgtgttttct gccattgata
     7141 atgatatagc ctcctcatat gttcttttat gaattgaaat gctgactgcc tgtttaaata
     7201 gaagaacgga cgccgtgcat cagtgtgttt gtatgttcgt agctacatcc gtaccacagt
     7261 attttggatg ctttagtcta taaaacttta aattaattct gtcttgaaac acaggagaaa
     7321 caagactcga gtgtatatcg ttaccatgca caaaagtctc agatcattat aataaagctt
     7381 gttctctcca cctgcaaaaa aaaaaaaaaa aaa
//
