LOCUS       NM_031172               3026 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 17 (Trim17), mRNA.
ACCESSION   NM_031172
VERSION     NM_031172.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Mojsa,B., Mora,S., Bossowski,J.P., Lassot,I. and Desagher,S.
  TITLE     Control of neuronal apoptosis by reciprocal regulation of NFATc3
            and Trim17
  JOURNAL   Cell Death Differ 22 (2), 274-286 (2015)
   PUBMED   25215946
  REMARK    GeneRIF: NFATc3 interacted in a SUMO-dependent manner with Trim17,
            an E3 ubiquitin ligase necessary for neuronal apoptosis
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Magiera,M.M., Mora,S., Mojsa,B., Robbins,I., Lassot,I. and
            Desagher,S.
  TITLE     Trim17-mediated ubiquitination and degradation of Mcl-1 initiate
            apoptosis in neurons
  JOURNAL   Cell Death Differ 20 (2), 281-292 (2013)
   PUBMED   22976837
  REMARK    GeneRIF: Trim17 contributes to the ubiquitination and the
            proteasomal degradation of Mcl-1 in neurons.
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Lassot,I., Robbins,I., Kristiansen,M., Rahmeh,R., Jaudon,F.,
            Magiera,M.M., Mora,S., Vanhille,L., Lipkin,A., Pettmann,B., Ham,J.
            and Desagher,S.
  TITLE     Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis
  JOURNAL   Cell Death Differ 17 (12), 1928-1941 (2010)
   PUBMED   20559321
  REMARK    GeneRIF: Overexpression and silencing data indicate that Trim17 is
            necessary and sufficient for inducing the Bax-dependent intrinsic
            pathway of neuronal apoptosis and that its pro-apoptotic effect
            depends on its E3 activity.
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Urano,T., Usui,T., Takeda,S., Ikeda,K., Okada,A., Ishida,Y.,
            Iwayanagi,T., Otomo,J., Ouchi,Y. and Inoue,S.
  TITLE     TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3
            ligase
  JOURNAL   Biochem Biophys Res Commun 383 (2), 263-268 (2009)
   PUBMED   19358823
  REMARK    GeneRIF: terf interacts with TRIM44;TRIM44 inhibited ubiquitination
            of terf, and thus stabilized the protein.
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Ogawa,S., Saito,T., Matsuda,Y., Seki,N., Hayashi,A., Orimo,A.,
            Hosoi,T., Ouchi,Y., Muramatsu,M., Hori,T. and Inoue,S.
  TITLE     Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes
            coding for testis RING finger protein (terf), a member of the RING
            finger family
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 56-58 (2000)
   PUBMED   10894938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC055112.1 and AL662809.14.
            
            On Jan 24, 2017 this sequence version replaced NM_031172.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055112.1, AK077212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1680              BC055112.1         1-1680
            1681-3026           AL662809.14        56202-57547
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.38 cM"
     gene            1..3026
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /note="tripartite motif-containing 17"
                     /db_xref="GeneID:56631"
                     /db_xref="MGI:MGI:1861440"
     exon            1..89
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            90..523
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1528
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 16; tripartite motif protein
                     17; tripartite motif-containing protein 17; tripartite
                     motif protein TRIM17; RING-type E3 ubiquitin transferase
                     TRIM17"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM17"
                     /protein_id="NP_112449.1"
                     /db_xref="CCDS:CCDS24756.1"
                     /db_xref="GeneID:56631"
                     /db_xref="MGI:MGI:1861440"
                     /translation="MDAVELARRLQEEATCSICLDYFTDPVMTACGHNFCRECIQMSW
                     EKGKVKKGKKKQKGSFPCPECREMSPQRNLRPNRLLTKVAEMARQHPGLQKRDLCQAH
                     QEPLKLFCQDDQSPICVVCREAQEHRMHRVLPLDEAAREYKLKLEEDIKYLREEMMKT
                     ETLQAKEEQTLTEWQERVKERRERILEEFQKVVLFLVEEERRILQVLKKEEEDTLGKL
                     QDSKASLDHQSRSLDLILLQLEERSQQEPLQMLQDVKDTLNRKESFSVQYPEVVLPAA
                     IKTLCRVPGQIEVLKSFQEDVMPDPSSAYPYLLLYESRQRRYLSPPPEGSAPYSKDRF
                     VAYPCAVGQKSFSSGRHYWEVGMNLTGDALWALGVCRDNVSRKDRVLKSPENGFWVVQ
                     LSKGKKQLSLLPNSTLVTLTEPPSHMGIFLDFQAGEVSFYSVNDGSHLHSFSQAAFPG
                     PLLPFFCLGAPKSGQMVISTVTMWVKG"
     exon            524..619
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            620..850
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            851..873
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            874..977
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /inference="alignment:Splign:2.1.0"
     exon            978..3026
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /note="hexamer: AATACA"
     polyA_site      1688
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /note="major polyA site"
     regulatory      2508..2513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /note="hexamer: AATAAA"
     polyA_site      2526
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
                     /note="hexamer: AATAAA"
     polyA_site      2922
                     /gene="Trim17"
                     /gene_synonym="Rnf16; terf"
ORIGIN      
        1 tcttccctag tgctgtagca caaacccagc ctttccccca tgcggcgcac ttgcccctgg
       61 cacctggcgc agtgcaaggc tccttccttg agccatggat gcggtggagc ttgccagacg
      121 gttacaagag gaggccacat gttccatctg ccttgactac tttactgatc ctgtgatgac
      181 tgcctgtggc cacaacttct gcagagagtg catccagatg agctgggaga aggggaaggt
      241 caagaaaggg aagaagaagc agaagggctc cttcccctgc cccgagtgca gggagatgtc
      301 ccctcagagg aacctgaggc ccaaccgcct cctgacaaaa gtggctgaga tggcccgcca
      361 gcaccctggg ctgcagaagc gagacctgtg ccaagcacac caagaacccc ttaagctgtt
      421 ctgccaggat gaccagagcc ccatttgtgt ggtctgcagg gaggcccagg agcaccggat
      481 gcacagggtg ctgcctctgg atgaggctgc aagggagtat aagctcaagt tggaggagga
      541 cataaaatat ctacgggagg agatgatgaa gacggagaca ctgcaagcca aggaggaaca
      601 gaccttaact gagtggcagg agagagtgaa agagcggaga gaacgcatcc tggaggagtt
      661 tcagaaggtg gtcttgtttc tggtggaaga agaacggagg atcctccagg tcctgaagaa
      721 ggaggaagag gacaccttag ggaagctgca ggacagcaag gcctccctgg accaccaaag
      781 ccgctccctg gacctgatcc tgttgcagct ggaggagcgg agccagcagg agcccctcca
      841 gatgctgcag gatgtgaagg acaccttgaa caggaaggag agcttcagcg tgcagtaccc
      901 agaggtggtc ctccccgcgg ctatcaagac cttgtgcaga gttccaggac agatagaggt
      961 gctcaaaagc ttccaagagg atgtgatgcc ggaccccagc tcagcatacc cctatctcct
     1021 cctctacgag agtcgccaga ggcggtactt gagcccaccg cccgagggca gcgcccccta
     1081 cagcaaggac cggttcgtgg cctacccgtg cgctgtgggg cagaagagct tttcctctgg
     1141 aaggcactac tgggaagtgg gcatgaatct caccggggat gcactctggg ccttgggggt
     1201 gtgcagggac aacgtgagtc ggaaggacag agtgcttaag tccccagaaa acggcttctg
     1261 ggtagtgcag ctgtccaagg ggaaaaaaca gctgtccctg ttacccaatt ccactctagt
     1321 cactctcaca gagcctccca gccacatggg gatcttcctg gacttccagg ctggagaggt
     1381 gtccttctac agcgtgaacg atgggtccca cttacacagc ttttcccagg ctgccttccc
     1441 tgggccgctg ctgccattct tctgcttggg ggctcccaag tcaggccaga tggtcatctc
     1501 cacagtgacc atgtgggtga agggatagag gcttgaagcc gggcagacac tgggtgtgcc
     1561 acagttcccc agaaggcagg gtgcttcacc accgtggcca cctacccagg cttccctggg
     1621 gcactaagag ttaatacctg tgctggcagg gtaactgaaa tacagtcaag attcaaatgc
     1681 tcaagtgaga ccgactacag ataagatgct aaatggggga actttggaaa gggtcctgct
     1741 tatctcagag tggactcaat tcttttctaa cacccttccc caagaacccc tcccacttcc
     1801 cattcctgtt aaaagttact agcatgccag gactcaagtg agatggtgaa ctggcatagc
     1861 acatgtttcc actgtgaccc ttctgtgccc atggtgtgac atgtatcttg tctcccattg
     1921 gggtcagtca accacagaca tgagggtggc actggaggct ctgagcaaca acaggtgctg
     1981 cgggctatga acacagagta aaagtgcaga gggaaaccac cgactccctt ggtcaccact
     2041 ctcagggttt tccatgtcct tgaggtcatc ctgcccatca gtagtactct gcatcctttt
     2101 ctgagccctg gagttacgca cttgtgcatg cttgtgtcta tcctcacagc ccctgctccc
     2161 aggataactc tgagactcag atatatttag atacctaggc cataaacctt ggctgttccc
     2221 taactagctc ataagctaat cttcccgtta ctctaaggtc tgccacatgg ttgataacct
     2281 ggtcctcagg ttttgctgct gtacatatca gcattcgggg gtcaatcttc cacctgtctc
     2341 tatcccagca tccccctcct gctctgtctg atgtcccatc taatttcctg cctcagctca
     2401 ttggccaata agccttttat tgacaggtga atgcttttac acagtgaaca agagtttctc
     2461 tctacatttc ccccttttag tccaagaaaa ggctcctttt cttacaaaat aaactatata
     2521 caataaccat tgtagtgctc agcccatatg ttccaaaact atagacatga caagttagct
     2581 gctttgacag tccctcagaa ttcctgtata atggtggaac ttcagtcttc agccctctgg
     2641 caccgtataa ctgacagact tttctgtgca gcaggaatga tgaaggactt agctatcttg
     2701 ttcttgcaaa gcttggcagt tgagttccct gcatcccagt ttgtccattc cggacagcat
     2761 tcagtcagca tttgaagcac ggacagtttc ttgcacagtg gcagtggcca catttgaaac
     2821 aaactccata gggagattct ttgatgctca actttctttg aagtagaaaa acgggtcctg
     2881 ttgccaaaaa gccttttaat aataaaacat ctttaaatgt catattctgt agatctctga
     2941 tgtttccaaa aaccatctat aactgaattg tctgtttcta gttagtcact atttgattat
     3001 tagtcttgaa aacatctact ggaggc
//
