LOCUS       NM_053169               3896 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tripartite motif-containing 16 (Trim16), mRNA.
ACCESSION   NM_053169
VERSION     NM_053169.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3896)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3896)
  AUTHORS   Shi,M., Su,F., Dong,Z., Shi,Y., Tian,X., Cui,Z. and Li,J.
  TITLE     TRIM16 exerts protective function on myocardial
            ischemia/reperfusion injury through reducing pyroptosis and
            inflammation via NLRP3 signaling
  JOURNAL   Biochem Biophys Res Commun 632, 122-128 (2022)
   PUBMED   36208489
  REMARK    GeneRIF: TRIM16 exerts protective function on myocardial
            ischemia/reperfusion injury through reducing pyroptosis and
            inflammation via NLRP3 signaling.
REFERENCE   3  (bases 1 to 3896)
  AUTHORS   Liu,J., Li,W., Deng,K.Q., Tian,S., Liu,H., Shi,H., Fang,Q., Liu,Z.,
            Chen,Z., Tian,T., Gan,S., Hu,F., Hu,M., Cheng,X., Ji,Y.X.,
            Zhang,P., She,Z.G., Zhang,X.J., Chen,S., Cai,J. and Li,H.
  TITLE     The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac
            Hypertrophy
  JOURNAL   Circ Res 130 (10), 1586-1600 (2022)
   PUBMED   35437018
  REMARK    GeneRIF: The E3 Ligase TRIM16 Is a Key Suppressor of Pathological
            Cardiac Hypertrophy.
REFERENCE   4  (bases 1 to 3896)
  AUTHORS   Wang,L., Zhang,X., Lin,Z.B., Yang,P.J., Xu,H., Duan,J.L., Ruan,B.,
            Song,P., Liu,J.J., Yue,Z.S., Fang,Z.Q., Hu,H., Liu,Z., Huang,X.L.,
            Yang,L., Tian,S., Tao,K.S., Han,H. and Dou,K.F.
  TITLE     Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by
            promoting the degradation of phospho-TAK1
  JOURNAL   Cell Metab 33 (7), 1372-1388 (2021)
   PUBMED   34146477
  REMARK    GeneRIF: Tripartite motif 16 ameliorates nonalcoholic
            steatohepatitis by promoting the degradation of phospho-TAK1.
REFERENCE   5  (bases 1 to 3896)
  AUTHORS   Ren,X., Yu,J., Guo,L. and Ma,H.
  TITLE     TRIM16 protects from OGD/R-induced oxidative stress in cultured
            hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via
            downregulation of Keap1
  JOURNAL   Exp Cell Res 391 (1), 111988 (2020)
   PUBMED   32251645
  REMARK    GeneRIF: TRIM16 protects from OGD/R-induced oxidative stress in
            cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant
            signaling via downregulation of Keap1.
REFERENCE   6  (bases 1 to 3896)
  AUTHORS   Stefanov,A.N., Fox,J., Depault,F. and Haston,C.K.
  TITLE     Positional cloning reveals strain-dependent expression of Trim16 to
            alter susceptibility to bleomycin-induced pulmonary fibrosis in
            mice
  JOURNAL   PLoS Genet 9 (1), e1003203 (2013)
   PUBMED   23341783
  REMARK    GeneRIF: we demonstrate that genetic variation in Trim16 leads to
            its strain-dependent expression, which alters susceptibility to
            bleomycin-induced pulmonary fibrosis in mice.
            Erratum:[PLoS Genet. 2013 Oct;9(10).
            doi:10.1371/annotation/f184e509-5c53-48da-b94a-b7517f591b3e.
            Depault, Francois [added]]
REFERENCE   7  (bases 1 to 3896)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3896)
  AUTHORS   Haston,C.K., Tomko,T.G., Godin,N., Kerckhoff,L. and Hallett,M.T.
  TITLE     Murine candidate bleomycin induced pulmonary fibrosis
            susceptibility genes identified by gene expression and sequence
            analysis of linkage regions
  JOURNAL   J Med Genet 42 (6), 464-473 (2005)
   PUBMED   15937080
REFERENCE   9  (bases 1 to 3896)
  AUTHORS   Beer,H.D., Munding,C., Dubois,N., Mamie,C., Hohl,D. and Werner,S.
  TITLE     The estrogen-responsive B box protein: a novel regulator of
            keratinocyte differentiation
  JOURNAL   J Biol Chem 277 (23), 20740-20749 (2002)
   PUBMED   11919186
REFERENCE   10 (bases 1 to 3896)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087112.1, AK053139.1 and BB033733.2.
            
            On Jul 13, 2005 this sequence version replaced NM_053169.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053139.1, AF449496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1339              AK087112.1         2-1340
            1340-3533           AK053139.1         1154-3347
            3534-3896           BB033733.2         333-695
FEATURES             Location/Qualifiers
     source          1..3896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.75 cM"
     gene            1..3896
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /note="tripartite motif-containing 16"
                     /db_xref="GeneID:94092"
                     /db_xref="MGI:MGI:2137356"
     exon            1..747
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1923
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /EC_number="2.3.2.27"
                     /note="estrogen-responsive B box protein; tripartite motif
                     protein 16; E3 ubiquitin-protein ligase TRIM16"
                     /codon_start=1
                     /product="tripartite motif-containing protein 16"
                     /protein_id="NP_444399.2"
                     /db_xref="CCDS:CCDS24832.1"
                     /db_xref="GeneID:94092"
                     /db_xref="MGI:MGI:2137356"
                     /translation="MAELDLIAPGPLTGVTAHPLAPLGPDPVSAIPAEKEDADPLSKS
                     GEETQEQGHDPAEVGAPGEEDQILCDFCLGASRVRAVKSCLTCMVNYCEEHLRPHQEN
                     SKLHSHQLTEPAKDQDLRTCPAHHSPLVSFCHTHQQCICQECGEGEHRGDSTVSLDAA
                     RRNKEVDLRCMQLDLEQKLKLNENAIARLQANHKSVLVSVSEVKVVAEEKFGELLAAV
                     RKAQADVMVFLEEKEQAALNQVNSIKTHLEHRSLEMEKSKQELERLAAISNTVLFLEE
                     YCKLKKTEDTASPSIYIGLKDKLSGIRKVITDSTLNLIQLLESYKEKLQEFSREEEYD
                     IRTQVSAIVQRKYRTSKPEPRTRDEFLQYACDITFDPDTAHRYLRLQEDNRKVTNTTP
                     WEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVELSGGGTYVGLTCKGIDRKGEERNS
                     CISGNSFSWSIHWNGKEFTAWHSDTETPLKVSPFRRLGIYVNFPGGILSFYGVEYDAM
                     TLIHKFDCKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAGSSVEAAP"
     exon            748..843
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1077
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1243
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1339
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..3896
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2222..2227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /note="hexamer: AATAAA"
     polyA_site      2262
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
     regulatory      3864..3869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /note="hexamer: AATAAA"
     polyA_site      3884
                     /gene="Trim16"
                     /gene_synonym="9130006M08Rik; EBBP"
                     /note="major polyA site"
ORIGIN      
        1 ggaacagaca caggagccaa gtggcaaggc agttctgagc cttgtcactg tggctggcta
       61 ctagccaatc tggaggagcc tcgtcctgtc tgagtaactg agcttcctcg ggagggagga
      121 aacagttaat gtctcagggc agctgcaatc tgctaggcgt ggctctctgg tttgacttgg
      181 gctactcaga tcctgagcca agggaccgcg aggaaggacg ccttagtcct tagtccgcag
      241 agcctccacc agatggctga attggatctg attgccccgg ggcctctgac cggggtcact
      301 gctcaccctt tggcccctct cggcccagac cctgtgtcag ctatcccagc agaaaaagaa
      361 gatgcggacc ctctcagcaa gtcaggtgag gaaacccagg agcagggtca tgaccccgca
      421 gaggtcgggg ctcctggtga agaggatcag atcttgtgtg acttctgtct tggggccagc
      481 agagtaaggg cagtgaaatc ctgtctgacc tgcatggtga actactgtga ggagcacctg
      541 cggccacacc aggagaacag caaactgcac agccaccagc taaccgaacc cgcaaaggac
      601 caggatctac gcacctgccc tgcccaccac agccctttgg tttccttctg ccacacgcac
      661 cagcagtgta tctgccagga atgcggggag ggtgaacaca gaggcgacag tactgtctcc
      721 ctggatgcag cccgcaggaa caaagaggtg gaccttcggt gtatgcagtt ggacctggag
      781 cagaagctta agttgaatga aaatgccatt gccaggctcc aagctaacca taagtctgtt
      841 ttggtgtcgg tgtcagaggt gaaggtggta gctgaagaga agtttgggga actcctcgca
      901 gctgtacgga aggcccaggc agatgtgatg gtcttcctag aggagaaaga acaggctgca
      961 ctgaatcaag tcaacagcat caaaacccat ctggagcaca ggagcctcga gatggagaaa
     1021 agcaagcagg agctggagag gctggccgcc atcagcaaca ctgtgctgtt cctggaggag
     1081 tactgcaagc tcaagaagac agaggacact gcctccccta gcatttacat agggctgaag
     1141 gacaaactct caggcatccg caaggtcatc acagattcaa ctctgaactt gatccaattg
     1201 ctagaaagct ataaggaaaa gctccaggaa ttttccaggg aagaggaata tgacatcaga
     1261 actcaagtgt ctgccattgt ccagcgcaag tataggacct cgaaacctga gcccagaacc
     1321 cgggatgagt ttcttcaata tgcctgtgac atcacgtttg acccagacac agcacacagg
     1381 taccttcgcc tgcaggagga caaccgcaag gtcaccaaca ccacgccctg ggaacacccc
     1441 tacccggacc tccccagtag gtttctgcac tggcggcagg tgctgtccca acagagcctg
     1501 tacctgcaca gatattattt tgaggtggag ctctctggag gtggcaccta tgttggcctg
     1561 acctgcaaag gcattgaccg taagggggaa gaacggaaca gctgcatttc tggaaatagc
     1621 ttctcctgga gcatccattg gaatgggaag gagttcacag cctggcacag tgacacagag
     1681 accccgctca aggtcagccc cttcagaagg ctcggtatct atgtaaactt cccaggagga
     1741 atcctttcct tctatggtgt agagtatgat gctatgactc tgattcacaa gtttgactgc
     1801 aagttctcag agccggtcta tgctgctttc tggctgtcta agaaagaaaa cgccatccgg
     1861 attgtggatc tgggagagga gcccgagaag ccagctgggt cctctgtgga ggctgctccc
     1921 tagattctag gatctacctc ccaggggttg ctaactgtga caactgggca gcagctggta
     1981 ttttaaggta gacagaaata cctgctgatg gtagttggct ttagaaactg tgtgggtcct
     2041 gaatgaactt tcccgcctgc ttctcaagac agttcttgca tgaatgcaga aactctaagg
     2101 cacaaaagcc tctcctcaca tcttctagtg agggtctcct gtctgctcag gtgactgtca
     2161 ccgtcatcca gaatttccaa ctagggatct tcaaaccata acaagactgc acagggatca
     2221 taataaatcg caaacacatc gctgtgtgtt tcttacacac tctccagcgt ttggagtgct
     2281 ttctctttgt tagttcatct ttatggggta aatgtttaca ttgtcttcat gatacacatt
     2341 aggggatggt ggccaggttg gtcagctaac ttgtctggtc acccaataaa tggggggcag
     2401 atctgggatt caagtctgtt gttgaacttg tggctacatg ttatgcttac ctcattagat
     2461 catgaaagtt atgcctgagg ggtaaaccac acactaaacc gcatagccca cagtcttgag
     2521 cattcctctt aagagtttgg tttttttttc tgcatgtgcc aggctcaact tggtcatcca
     2581 gccttgcacc atctgagcat gccctcatcc ctgacacagc agcagcagca gcagcggcag
     2641 gatcaccatt aatcagcagc acatgatagt tttgaacagc aagatttaga ataaatgttt
     2701 tagcgaggtc cttttgagag gagtagtcat cctctctgct aaggtcaccc agacttcatg
     2761 gacttgtcta ttttcttgcc caaagggata gttcctcagg tatttgggga cagcgttcac
     2821 ctctcgcagg agctatgcct gtttgtttgt gctaagttga tactttctgc gatgatctca
     2881 cttccccccg acaccctgtt gatgacttca ttctccttta gacagacgat gaacatccat
     2941 caagccttta tgcacaccat cttaaaatgg atttctattg ccctagcctg aagtccctgg
     3001 tgggctttat cacaaatatt acttccgtgt cttttcccac gacctgtgtc aaggcaaatc
     3061 ttcttgttca atcagtcccg tgatcctgtc tcaactgtgt gttgctttag acttatttga
     3121 cttgattcta agactccgca tctttgcctc taagaactta aatactttcc acctgcttcc
     3181 tcatgtcact gccctgcact gagatacttt catgatctag tgcattgcct ctccttccag
     3241 cagaaatagt ttccctgcag agtcaacggc cttctctcaa gtctaaatcc tggtccagag
     3301 ttactgagac tatgagggcc aacacatgct agcttctcag tagaactgtg cagggcaggg
     3361 ttcactggtc gcctcccttt cccactgaac aagatcaaag agcttttctt ctcttctctt
     3421 tttttctttt ctttttattt gggatagggc ttcacaacgt ggcccaagct ggcctgggat
     3481 acactatgta ttctcgtctg gcctcagact cagttctctc ttcttagctt ccaaatgctc
     3541 aggttacaag catgagctac ctatgctcag ctcagctccg caaaggacct cttcaatggc
     3601 agaaatcaat gtgaatttct tggatccagc aggtaaagaa tactcttcaa aagagaaagg
     3661 cgtgtttccc tggcctgccc tttcttcttt tctttttttt ttttgtctta tttttaattg
     3721 acacacaata acagtatact tatggaattc agtgtggctt ttcagtgtcg taataaccaa
     3781 gtaagaacat atacttatcc ctataccaaa gactatttat ttattgtaag aacactccaa
     3841 atcctgtctt ccaattgttt tgaaataaac ctgctttaaa aatatatttt tttgct
//
