LOCUS       NM_029077               3204 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tripartite motif-containing 14 (Trim14), mRNA.
ACCESSION   NM_029077 XM_131393
VERSION     NM_029077.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3204)
  AUTHORS   Schafer,A., Gralinski,L.E., Leist,S.R., Hampton,B.K., Mooney,M.A.,
            Jensen,K.L., Graham,R.L., Agnihothram,S., Jeng,S., Chamberlin,S.,
            Bell,T.A., Scobey,D.T., Linnertz,C.L., VanBlargan,L.A.,
            Thackray,L.B., Hock,P., Miller,D.R., Shaw,G.D., Diamond,M.S., de
            Villena,F.P.M., McWeeney,S.K., Heise,M.T., Menachery,V.D.,
            Ferris,M.T. and Baric,R.S.
  TITLE     Genetic loci regulate Sarbecovirus pathogenesis: A comparison
            across mice and humans
  JOURNAL   Virus Res 344, 199357 (2024)
   PUBMED   38508400
REFERENCE   2  (bases 1 to 3204)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3204)
  AUTHORS   Kuroda,M., Halfmann,P.J., Thackray,L.B., Diamond,M.S., Feldmann,H.,
            Marzi,A. and Kawaoka,Y.
  TITLE     An Antiviral Role for TRIM14 in Ebola Virus Infection
  JOURNAL   J Infect Dis 228 (Suppl 7), S514-S521 (2023)
   PUBMED   37562033
  REMARK    GeneRIF: An Antiviral Role for TRIM14 in Ebola Virus Infection.
REFERENCE   4  (bases 1 to 3204)
  AUTHORS   Hou,H., Chen,Y., Feng,X., Xu,G. and Yan,M.
  TITLE     Tripartite motif-containing 14 may aggravate cardiac hypertrophy
            via the AKT signalling pathway in neonatal rat cardiomyocytes and
            transgenic mice
  JOURNAL   Mol Med Rep 28 (3) (2023)
   PUBMED   37503784
  REMARK    GeneRIF: Tripartite motif-containing 14 may aggravate cardiac
            hypertrophy via the AKT signalling pathway in neonatal rat
            cardiomyocytes and transgenic mice.
REFERENCE   5  (bases 1 to 3204)
  AUTHORS   Liu,D., Zhao,Z., She,Y., Zhang,L., Chen,X., Ma,L. and Cui,J.
  TITLE     TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to
            epigenetically regulate inflammation
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35145029
  REMARK    GeneRIF: TRIM14 inhibits OPTN-mediated autophagic degradation of
            KDM4D to epigenetically regulate inflammation.
REFERENCE   6  (bases 1 to 3204)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   7  (bases 1 to 3204)
  AUTHORS   Harms,M.J., Ishibashi,J., Wang,W., Lim,H.W., Goyama,S., Sato,T.,
            Kurokawa,M., Won,K.J. and Seale,P.
  TITLE     Prdm16 is required for the maintenance of brown adipocyte identity
            and function in adult mice
  JOURNAL   Cell Metab 19 (4), 593-604 (2014)
   PUBMED   24703692
REFERENCE   8  (bases 1 to 3204)
  AUTHORS   Nenasheva,V.V., Kovaleva,G.V., Khaidarova,N.V., Novosadova,E.V.,
            Manuilova,E.S., Antonov,S.A. and Tarantul,V.Z.
  TITLE     Trim14 overexpression causes the same transcriptional changes in
            mouse embryonic stem cells and human HEK293 cells
  JOURNAL   In Vitro Cell Dev Biol Anim 50 (2), 121-128 (2014)
   PUBMED   24092016
  REMARK    GeneRIF: These results demonstrate the presence of the similar
            mechanism of trim14 gene action in different types of mammalian
            cells.
REFERENCE   9  (bases 1 to 3204)
  AUTHORS   Novosadova,E.V., Manuilova,E.S., Arsen'eva,E.L., Khaidarova,N.V.,
            Dolotov,O.V., Inozemtseva,L.S., Kozachenkov,K.Y., Tarantul,V.Z. and
            Grivennikov,I.A.
  TITLE     Different effects of enhanced and reduced expression of pub gene on
            the formation of embryoid bodies by cultured embryonic mouse stem
            cell
  JOURNAL   Bull Exp Biol Med 140 (1), 153-158 (2005)
   PUBMED   16254642
  REMARK    GeneRIF: Pub gene participates in early stages of differentiation
            of embryonic stem cells leading to the formation of embryoid
            bodies.
REFERENCE   10 (bases 1 to 3204)
  AUTHORS   Hirose,S., Nishizumi,H. and Sakano,H.
  TITLE     Pub, a novel PU.1 binding protein, regulates the transcriptional
            activity of PU.1
  JOURNAL   Biochem Biophys Res Commun 311 (2), 351-360 (2003)
   PUBMED   14592421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB117644.1, AK133220.1 and AV326753.1.
            
            On Dec 18, 2013 this sequence version replaced NM_029077.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172895.1, AK133220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1362              AB117644.1         12-1373
            1363-3197           AK133220.1         1286-3120
            3198-3204           AV326753.1         191-197
FEATURES             Location/Qualifiers
     source          1..3204
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.84 cM"
     gene            1..3204
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /note="tripartite motif-containing 14"
                     /db_xref="GeneID:74735"
                     /db_xref="MGI:MGI:1921985"
     exon            1..262
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1384
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /note="PU.1 binding protein Pub"
                     /codon_start=1
                     /product="tripartite motif-containing protein 14"
                     /protein_id="NP_083353.1"
                     /db_xref="CCDS:CCDS18153.1"
                     /db_xref="GeneID:74735"
                     /db_xref="MGI:MGI:1921985"
                     /translation="MASETTEARAPFQPDGAYGWRCPEHSERPAELFCRRCGRCVCAL
                     CPVLGAHRGHPVGLAEEEAVRVQKLIQDCLECLATKKRQHADNIAHLEDAGERLKVYA
                     DSSKAWLTQKFTELRLLLDEEEVLAKKFIDKSTQLTLQVYREQAETCGKQIEVMDDFS
                     TRVWGIGQEPNPVQLLQAYIATKTEMGQQMSPSELSHPVPLSFEPVKNFFKEFVEAIG
                     NTLQTPMDTRLKENINCQLSNSSSTKPGALLKTSPSPERALFLKYARTPTLDPDTMHA
                     RLRLSPDGLTVRCSLLGRLGPRPAPRFDALRQVLGRDGFAAGRHYWEVDVQEAGVGWW
                     VGAAYPSLRRRGASAAARLGCNRESWCVKRYDLEYWAFHDGQRSRLRPRRDPHRLGVF
                     LDYEAGILAFYDVAGGMSHLHTFHAAFQEPLYPALRLWEGPISIPRLP"
     exon            263..358
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /inference="alignment:Splign:2.1.0"
     exon            359..592
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /inference="alignment:Splign:2.1.0"
     exon            593..755
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /inference="alignment:Splign:2.1.0"
     exon            756..848
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /inference="alignment:Splign:2.1.0"
     exon            849..3204
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3172..3177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /note="hexamer: AATAAA"
     polyA_site      3199
                     /gene="Trim14"
                     /gene_synonym="5830400N10Rik; pub"
                     /note="major polyA site"
ORIGIN      
        1 tcgatttctg caccaaccca acccgaccac actgcacaga gaacagcggt tgccactgag
       61 aatggcgagc gagactaccg aggcgcgggc gccctttcag cccgacgggg cgtatggctg
      121 gcgctgtccg gagcacagcg aacgcccggc tgagctcttc tgtcgccgct gcggccgctg
      181 tgtgtgcgcg ctctgcccgg ttctgggtgc gcaccgcggc cacccggtgg gcctggccga
      241 ggaggaggct gtgcgtgtgc agaagctaat ccaggactgt ttagagtgtt tggcaaccaa
      301 gaagaggcaa catgcggaca acatagccca tttggaagac gccggggaaa ggctcaaggt
      361 ttacgcagac tcaagtaaag cctggctgac acagaaattc acagaactca gattactcct
      421 ggatgaagag gaagtactgg ccaaaaaatt cattgacaaa agcacacagc tcaccctcca
      481 ggtgtaccgg gagcaagccg agacttgtgg gaagcagatt gaggtcatgg atgacttctc
      541 taccagggtg tggggcattg gccaggagcc caaccctgtt cagctgctgc aggcatatat
      601 agccaccaag acagagatgg gacagcagat gagcccctcg gagctgagcc accctgtgcc
      661 cctgtccttc gagcctgtca agaacttctt taaggagttt gtggaagcca tcgggaacac
      721 gttgcagaca ccaatggaca ctcgcctgaa ggaaaacata aactgccagc tttcaaactc
      781 ctccagcacc aagccaggcg ccttgttgaa aaccagcccc tcgccagaga gagctctctt
      841 cttgaaatac gcccgtacgc caacgctgga cccggacacg atgcacgcgc gcctgcgcct
      901 gtcgccggac ggtctgacag tccgctgctc gctgctgggt cgcctggggc cgcgtcccgc
      961 gccgcggttc gacgcgctgc ggcaggtgct gggccgcgac ggcttcgcag ccggacgcca
     1021 ctactgggag gtggacgtgc aggaggccgg tgtgggctgg tgggtgggcg cggcgtaccc
     1081 gtcgctgcgc cgccgcggag cctccgccgc cgcccgcctg ggctgcaacc gcgagtcgtg
     1141 gtgcgtaaag cgttacgacc tagagtactg ggccttccat gacggccagc gaagtcgcct
     1201 gcggccccgc cgcgaccccc accggctcgg cgtcttcctg gactacgagg ccggcattct
     1261 ggccttctac gacgtggcgg gtggcatgag ccacttgcac accttccacg ccgccttcca
     1321 ggagccgctc tatccagccc tgcgcctctg ggaggggccc atcagcatcc ctaggttgcc
     1381 ctaagggaaa tcgggctttc ttttcctagg cttgtctcca gttgtcccct gtgcgccctg
     1441 ccccccaacg atgcctttat agtgcatatt cctgaaaggg gcaccccgct gcctgtgtct
     1501 gggagactat cgtgcagcgc ctagaacctc ctggcacaca gtaggcacac agtatcagtg
     1561 aatgtctccc agcaggggca agtagttccc ctacagtttc cgtttgagcc agctgctcta
     1621 cagccacttc agcttgtcca ggtcgccttg atccagagca cctgagaggg ttcttgtctg
     1681 agtctgcatc ctcttgcttc ttcatcttct acactaaaac cagggtgggc atcctgaaac
     1741 ttagcttggc ctcttgggat tagagggagg ctctgtaaga gctacaaaaa caacacggga
     1801 agcgcttttc ccatgtcaat ctttttcaga catgctccgg tcagaagcta gatcacagtt
     1861 gcacctttga accattgtgc ttcccaccat aaataggaaa accggctctc tgcctgtgtc
     1921 agttctcagg catatctgcc cccaagaaat tccctcccaa gcccccaaaa acaacagatt
     1981 gggcctgcaa atccctccac cacaccccct cagaaaacta ttaggcctgt aaatctggga
     2041 cctgtcactc cagttacttt ctaaggacat ccgtgtcctt ccctcccagg cacttcctgg
     2101 gtgatcagta ggtagactgc tacccacagg agagaaaact actgagatgg gttcaaaggg
     2161 caggacatac ctaacgggag atgctacatc ttcgtcattc acatgaccag agctttaacc
     2221 acaccctcca ctgcaggagg ggccaggcca ggcatctctt actaggtgct gttgaacata
     2281 gtcatacact acacacactt gacccttaca aactgttgta cccctggcag gattggtaca
     2341 cgtgaatcag ataacagaat cagtgtttca gtcaggatcc acactgcctg ccaggctgtg
     2401 ctgtggatgt gacagctctt ctccctcagt atttacctca gttttccttg gggcaaacct
     2461 gcttctagaa tgccttcatt ggtccctgaa atgaggtttc atacccttca ggctgaggga
     2521 tgaaatcgtt tgaggggatc ttagcttcct gtcagctgtg tggcccccat atgtaaaacg
     2581 tgggtcagtg ccaggtttaa acaagccaaa ttgccttaaa aactataatg tcgaatcagg
     2641 ctaggatttg ttagcacctc caatagattc tttctacctt gtcgcagtgc tggaccacag
     2701 atggccagca gctgggtggc agccaaggga gctagctgcc ttaatattct caggggagtc
     2761 tccttggcat ccatgctgtt gacagtacaa agcatacgtc ttcacgctcc tgactttgta
     2821 gaatttacct caaaggtaca caattgattt tcccggtgct tggtctagaa ccagtggcct
     2881 tgcacaagct gagcaagggc ttcaggccca acaggtgttt gtaagaaaaa ggcttagtca
     2941 aggccaggga agtggaggac agaaacctct gtgacaagtt ttctttttct tactttggtt
     3001 tttcgaaaca gggtttctct gtgtagccct ggctgtcctg gaactcactt tgtagaccat
     3061 gctggcctcg aactcagcaa tctgcctgcc tctgcctccc gagtgctggg attaaaggtg
     3121 tgcaccacca cacccagctc agacaacagc tttctaatac atgctttgtt taataaaata
     3181 ggaatactgt tccttgtaac tgtg
//
