LOCUS       NM_023233               1578 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 13 (Trim13), transcript
            variant 2, mRNA.
ACCESSION   NM_023233
VERSION     NM_023233.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Govatati,S., Kumar,R., Boro,M., Traylor,J.G. Jr., Orr,A.W.,
            Lusis,A.J. and Rao,G.N.
  TITLE     TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake
            leading to foam cell formation and atherosclerosis
  JOURNAL   J Biol Chem 300 (5), 107224 (2024)
   PUBMED   38537695
  REMARK    GeneRIF: TRIM13 reduces cholesterol efflux and increases oxidized
            LDL uptake leading to foam cell formation and atherosclerosis.
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   Dean,S.T., Ishikawa,C., Zhu,X., Walulik,S., Nixon,T., Jordan,J.K.,
            Henderson,S., Wyder,M., Salomonis,N., Wunderlich,M., Greis,K.D.,
            Starczynowski,D.T. and Volk,A.G.
  TITLE     Repression of TRIM13 by chromatin assembly factor CHAF1B is
            critical for AML development
  JOURNAL   Blood Adv 7 (17), 4822-4837 (2023)
   PUBMED   37205848
  REMARK    GeneRIF: Repression of TRIM13 by chromatin assembly factor CHAF1B
            is critical for AML development.
REFERENCE   4  (bases 1 to 1578)
  AUTHORS   Li,X., Yu,Z., Fang,Q., Yang,M., Huang,J., Li,Z., Wang,J. and
            Chen,T.
  TITLE     The transmembrane endoplasmic reticulum-associated E3 ubiquitin
            ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory
            response
  JOURNAL   Sci Adv 8 (4), eabh0496 (2022)
   PUBMED   35080984
  REMARK    GeneRIF: The transmembrane endoplasmic reticulum-associated E3
            ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered
            inflammatory response.
REFERENCE   5  (bases 1 to 1578)
  AUTHORS   Qian,Y., Lei,G. and Wen,L.
  TITLE     Brain-specific deletion of TRIM13 promotes metabolic
            stress-triggered insulin resistance, glucose intolerance, and
            neuroinflammation
  JOURNAL   Biochem Biophys Res Commun 527 (1), 138-145 (2020)
   PUBMED   32446357
  REMARK    GeneRIF: Brain-specific deletion of TRIM13 promotes metabolic
            stress-triggered insulin resistance, glucose intolerance, and
            neuroinflammation.
REFERENCE   6  (bases 1 to 1578)
  AUTHORS   Raveche,E.S., Salerno,E., Scaglione,B.J., Manohar,V., Abbasi,F.,
            Lin,Y.C., Fredrickson,T., Landgraf,P., Ramachandra,S., Huppi,K.,
            Toro,J.R., Zenger,V.E., Metcalf,R.A. and Marti,G.E.
  TITLE     Abnormal microRNA-16 locus with synteny to human 13q14 linked to
            CLL in NZB mice
  JOURNAL   Blood 109 (12), 5079-5086 (2007)
   PUBMED   17351108
REFERENCE   7  (bases 1 to 1578)
  AUTHORS   Corcoran,M.M., Hammarsund,M., Zhu,C., Lerner,M., Kapanadze,B.,
            Wilson,B., Larsson,C., Forsberg,L., Ibbotson,R.E., Einhorn,S.,
            Oscier,D.G., Grander,D. and Sangfelt,O.
  TITLE     DLEU2 encodes an antisense RNA for the putative bicistronic
            RFP2/LEU5 gene in humans and mouse
  JOURNAL   Genes Chromosomes Cancer 40 (4), 285-297 (2004)
   PUBMED   15188451
REFERENCE   8  (bases 1 to 1578)
  AUTHORS   Baranova,A., Hammarsund,M., Ivanov,D., Skoblov,M., Sangfelt,O.,
            Corcoran,M., Borodina,T., Makeeva,N., Pestova,A., Tyazhelova,T.,
            Nazarenko,S., Gorreta,F., Alsheddi,T., Schlauch,K., Nikitin,E.,
            Kapanadze,B., Shagin,D., Poltaraus,A., Ivanovich Vorobiev,A.,
            Zabarovsky,E., Lukianov,S., Chandhoke,V., Ibbotson,R., Oscier,D.,
            Einhorn,S., Grander,D. and Yankovsky,N.
  TITLE     Distinct organization of the candidate tumor suppressor gene RFP2
            in human and mouse: multiple mRNA isoforms in both species- and
            human-specific antisense transcript RFP2OS
  JOURNAL   Gene 321, 103-112 (2003)
   PUBMED   14636997
REFERENCE   9  (bases 1 to 1578)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 1578)
  AUTHORS   Kapanadze,B., Makeeva,N., Corcoran,M., Jareborg,N., Hammarsund,M.,
            Baranova,A., Zabarovsky,E., Vorontsova,O., Merup,M., Gahrton,G.,
            Jansson,M., Yankovsky,N., Einhorn,S., Oscier,D., Grander,D. and
            Sangfelt,O.
  TITLE     Comparative sequence analysis of a region on human chromosome
            13q14, frequently deleted in B-cell chronic lymphocytic leukemia,
            and its homologous region on mouse chromosome 14
  JOURNAL   Genomics 70 (3), 327-334 (2000)
   PUBMED   11161783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM933374.1, AK013959.2 and BE136192.1.
            
            On Aug 15, 2009 this sequence version replaced NM_023233.2.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 1. Both variants 1 and 2
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM939618.1, AK013959.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               BM933374.1         1-560
            561-1575            AK013959.2         533-1547
            1576-1578           BE136192.1         1-3                 c
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.16 cM"
     gene            1..1578
                     /gene="Trim13"
                     /gene_synonym="3110001L12Rik; CAR; LEU5; Rfp2; RNF77"
                     /note="tripartite motif-containing 13"
                     /db_xref="GeneID:66597"
                     /db_xref="MGI:MGI:1913847"
     exon            1..59
                     /gene="Trim13"
                     /gene_synonym="3110001L12Rik; CAR; LEU5; Rfp2; RNF77"
                     /inference="alignment:Splign:2.1.0"
     exon            60..161
                     /gene="Trim13"
                     /gene_synonym="3110001L12Rik; CAR; LEU5; Rfp2; RNF77"
                     /inference="alignment:Splign:2.1.0"
     exon            162..1578
                     /gene="Trim13"
                     /gene_synonym="3110001L12Rik; CAR; LEU5; Rfp2; RNF77"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1391
                     /gene="Trim13"
                     /gene_synonym="3110001L12Rik; CAR; LEU5; Rfp2; RNF77"
                     /EC_number="2.3.2.27"
                     /note="ret finger protein 2; tripartite motif protein 13;
                     tripartite motif-containing protein 13; putative tumor
                     suppressor RFP2; RING-type E3 ubiquitin transferase
                     TRIM13"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM13"
                     /protein_id="NP_075722.1"
                     /db_xref="CCDS:CCDS27186.1"
                     /db_xref="GeneID:66597"
                     /db_xref="MGI:MGI:1913847"
                     /translation="MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGLLEGNVRN
                     SLWRPSPFKCPTCRKETSATGVNSLQVNYSLKGIVEKYNKIKISPKMPVCKGHLGQPL
                     NIFCVTDMQLICGICATRGEHTKHVFSSIEDAYAREKNAFESLFQSFETWRRGDALSR
                     LDTLETNKRKALQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQTYDPE
                     INKINTILQEQRMAFNIAEAFKDVSEPIIFLQQMQEFREKIKVIKETPLPHSNLPTSP
                     LMKNFDTSQWGDIKLVDVDKLSLPQDTGVFTSKIPWYPYLLLMMVVLLGLLIFFGPTV
                     FLEWSPLDELATWKDYLSSFNSYLTKSADFIEQSVFYWEQMTDGFFIFGERVKNVSLV
                     ALNNVAEFICKYKLL"
     regulatory      1558..1563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim13"
                     /gene_synonym="3110001L12Rik; CAR; LEU5; Rfp2; RNF77"
                     /note="hexamer: AATAAA"
     polyA_site      1578
                     /gene="Trim13"
                     /gene_synonym="3110001L12Rik; CAR; LEU5; Rfp2; RNF77"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtggtcg ccgtgtccat tttgcaccgg cgcagcccgg ccccagttgg ctggtggagt
       61 gttctccagt tttaccgtca aaacgtgagg gaaaacgaac tggctctctc cacagaaaat
      121 atagtaagct tgccaaaagc atatacttgc ctggaacaaa ggatgtaatg gagctgcttg
      181 aagaagacct cacatgccca atttgctgca gtttgtttga tgacccccga gtgttgccct
      241 gctcacacaa cttctgcaaa aaatgcttag aagggctctt agaggggaat gtgcggaatt
      301 ccctgtggag accatctccc ttcaagtgtc ctacctgccg taaggaaacc tcagctactg
      361 gagtcaacag tctgcaggtc aattactccc taaagggtat cgtggagaaa tacaacaaaa
      421 tcaagatttc tcccaagatg ccagtgtgca aaggacattt ggggcagcct ctcaacatct
      481 tctgcgtaac tgatatgcag ctgatttgtg ggatctgtgc tactcgaggc gagcacacca
      541 agcatgtctt ctcttctatt gaagatgcct acgctcgaga aaagaatgcc tttgagtccc
      601 tctttcagag tttcgagact tggcgccggg gagatgctct ttcccgcttg gatactttgg
      661 aaacaaacaa gaggaaagcc ctccagttac tcacgaagga ttcagataaa gtaaaggagt
      721 tttttgagaa gttacagcac accttggatc aaaagaagaa tgaaatcctg tctgactttg
      781 aaactatgaa gcttgcagtt atgcaaacct atgacccgga gatcaacaaa atcaacacta
      841 ttttacagga gcagcggatg gccttcaaca ttgctgaggc tttcaaagat gtctcagaac
      901 ctattatatt tttgcaacag atgcaagagt tcagggagaa aatcaaagta atcaaggaaa
      961 ctcctttgcc acactctaat ttgcccacaa gccctttaat gaagaacttt gataccagtc
     1021 agtggggaga cattaaacta gttgatgtgg ataaactgtc tttgccgcaa gacacaggtg
     1081 tgttcactag caagattccc tggtacccct atctgctgct catgatggta gttctgctgg
     1141 gtctcctcat attctttggc cccactgtat tcctggaatg gtctccactt gatgaattgg
     1201 caacttggaa agactatctt tcaagcttca attcttacct gactaagtct gctgatttta
     1261 tagaacaatc tgttttttac tgggaacaga tgacagatgg gtttttcatt tttggtgaaa
     1321 gagtaaaaaa tgttagtttg gtggcactga acaatgtggc agagtttata tgcaaataca
     1381 aactattata aagtctttca attacacagt tctgcttctt gatgggattg ttggagaaca
     1441 caggaataat tcagatctga tcaagatttc agtctgtttc tttttaaagt atttcttcaa
     1501 tgtcatttga agtttagtag tcctaaacct tcccttcctt cttaaagaca gttttaaaat
     1561 aaatactgtt tctctaaa
//
