LOCUS       NM_001146007            3736 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus tripartite motif-containing 12C (Trim12c), transcript
            variant 1, mRNA.
ACCESSION   NM_001146007
VERSION     NM_001146007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3736)
  AUTHORS   Schafer,A., Marzi,A., Furuyama,W., Catanzaro,N.J., Nguyen,C.,
            Haddock,E., Feldmann,F., Meade-White,K., Thomas,T., Hubbard,M.L.,
            Gully,K.L., Leist,S.R., Hock,P., Bell,T.A., De la Cruz,G.E.,
            Midkiff,B.R., Martinez,D.R., Shaw,G.D., Miller,D.R., Vernon,M.J.,
            Graham,R.L., Cowley,D.O., Montgomery,S.A., Schughart,K., de
            Villena,F.P.M., Wilkerson,G.K., Ferris,M.T., Feldmann,H. and
            Baric,R.S.
  TITLE     Mapping of susceptibility loci for Ebola virus pathogenesis in mice
  JOURNAL   Cell Rep 43 (5), 114127 (2024)
   PUBMED   38652660
REFERENCE   2  (bases 1 to 3736)
  AUTHORS   Chang,T.H., Yoshimi,R. and Ozato,K.
  TITLE     Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a
            Ubiquitin Ligase That Stimulates Type I IFN and NF-kappaB Pathways
            along with TNFR-Associated Factor 6
  JOURNAL   J Immunol 195 (11), 5367-5379 (2015)
   PUBMED   26503954
  REMARK    GeneRIF: This study identifies TRIM12c as a mouse TRIM5 equivalent,
            critical for host innate immunity.
REFERENCE   3  (bases 1 to 3736)
  AUTHORS   Tareen,S.U., Sawyer,S.L., Malik,H.S. and Emerman,M.
  TITLE     An expanded clade of rodent Trim5 genes
  JOURNAL   Virology 385 (2), 473-483 (2009)
   PUBMED   19147168
  REMARK    GeneRIF: describe an expanded paralogous cluster of at least eight
            Trim5-like genes in mice
REFERENCE   4  (bases 1 to 3736)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050485.1 and AC142110.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033764.1, AK146437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1423              AK050485.1         6-1428
            1424-3736           AC142110.4         87760-90072         c
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.69 cM"
     gene            1..3736
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /note="tripartite motif-containing 12C"
                     /db_xref="GeneID:319236"
                     /db_xref="MGI:MGI:4821183"
     exon            1..165
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     exon            166..641
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1715
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /codon_start=1
                     /product="tripartite motif-containing 12C"
                     /protein_id="NP_001139479.1"
                     /db_xref="CCDS:CCDS52344.1"
                     /db_xref="GeneID:319236"
                     /db_xref="MGI:MGI:4821183"
                     /translation="MASQFMKNLKEEVTCPLCLNLMVKPVSADCGHSFCQGCITVYFE
                     STKCDKEMFSCPVCRLSYQSSNLRPNLHVANIVERLKEFKPSPEEEQKVFNCARHGEK
                     LQLFCRKDMMAICWLCERSQEHRGHKTALIEEVAQEYKEQLQVVLQRLMADKKEFENW
                     KDDLQKDRTYWENQIQKDVENVQSEFKRMRDIMNSEEKKELQKLKQEKENIINKLAES
                     ENEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIKRSHTFSMKKPKAIAREQRKF
                     RAPDLQGMLQVLQEVTEAQRYWVQVTLVQNNNPNIAITDDKRQIRYEDLQARNLEHGC
                     ENSHEGVLGHPVIQSGKHYWEVDVSGKGAWVLGLSDGSYLFNPIFRSNAERNPLFRRG
                     IKNDSHYQPKYGFWVIGLWKKSVYNAFEECPFTGKPSVLTLSLMVPPCRVGVFLDYAA
                     GTLSFYNISNNGTLIYRFCTASFPDRVFPYFNPMGSSEPMTICWPDS"
     exon            642..737
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..968
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..991
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1089
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1116
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..3736
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3717..3722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /note="hexamer: AATAAA"
     polyA_site      3736
                     /gene="Trim12c"
                     /gene_synonym="9230105E10Rik; Trim12-2"
                     /note="major polyA site"
ORIGIN      
        1 ctcaaacttt cgtttctcta gcttcgagtc ggaaatacct tgaagttctg gattggttag
       61 ttaattctcc ctggtttaca actttctggc gtctgataac gggctgagca attttagggg
      121 gcagactttt gaagactttg aaaggagaac attgcttttg cttgggcacc tgagcagaag
      181 tgcgaggagt caggacagtc atacacagga tcacagcaac tatggcttca caattcatga
      241 agaatttaaa ggaggaagtg acctgtcctc tctgtctgaa cctgatggtg aaacctgtga
      301 gtgcagattg tggtcacagc ttctgccaag gctgcatcac ggtgtacttt gaatccacca
      361 aatgcgataa ggaaatgttc agttgccctg tgtgccgact tagttaccag tctagcaatc
      421 tgaggcctaa tctacatgtg gccaacatag tagagaggct caaagagttc aagcctagcc
      481 cagaagagga gcagaaagtg tttaactgtg caagacatgg agagaaactc cagctcttct
      541 gtaggaagga catgatggcc atctgctggc tttgtgagcg atctcaggag caccggggcc
      601 acaaaacagc tctcattgaa gaggtggccc aggagtacaa ggagcagctg caggtagttc
      661 tgcaaaggct gatggcagac aagaaagaat ttgaaaactg gaaagatgac cttcagaagg
      721 atagaactta ctgggagaat caaatacaga aagatgtgga gaatgttcag tcagagttta
      781 aacgaatgag ggatatcatg aactctgaag agaagaagga attgcagaag ctgaagcaag
      841 agaaggaaaa cattatcaac aaactggcag agtctgaaaa tgagcatgct cagcagagca
      901 agttgctaga agacttcatt tcagatgtgg aacatcagtt acagtgctca gacatagaaa
      961 tactgcaggg tgtggagaac atcataaaac ggagtcatac tttttcgatg aagaagccca
     1021 aagccatcgc cagggaacaa agaaagttcc gagcccctga cctgcaaggc atgctgcaag
     1081 tgctgcaaga ggtcacagag gctcaacgct actgggttca ggtgacgctg gttcaaaaca
     1141 acaatccaaa cattgccatt actgatgaca aaaggcaaat acgatatgaa gacctccaag
     1201 caaggaatct tgaacatggc tgtgaaaact ctcatgaagg tgtcctggga cacccagtta
     1261 tccaatcagg aaaacattac tgggaagtag atgtgtctgg aaaaggtgct tgggttctgg
     1321 ggttaagtga tggaagctac ctcttcaatc caatatttcg ttcaaatgct gaaagaaacc
     1381 ctttatttcg cagggggatt aagaatgatt cacattatca accaaaatat ggcttctggg
     1441 ttatagggct gtggaaaaag tctgtgtata atgcttttga ggagtgtcct ttcacaggca
     1501 agcccagtgt cttgaccctg tctctgatgg tcccgccctg tcgtgttggt gttttccttg
     1561 actatgcagc tgggactctc tcattttaca atatttccaa caatgggact cttatctaca
     1621 gattctgtac agcttccttt cctgataggg tttttccata ttttaatccc atgggaagtt
     1681 cagagcccat gacaatttgc tggccagact cttaacattt gcctgtttac ttgcagggtc
     1741 tctggctctg atatgtatgt ccatttgcct gagctcatcg taccattttc tctctctttt
     1801 tttttttcct gactctagtc tttctgtgtg aatgtctttc attggtaaaa aaggatatat
     1861 tcatttctct aggtcagatt cttctcagtt tctttcagtt ttgttttgtt ttagatgaga
     1921 atagtaaatc acttcccatt tggtcaagga aaagtgcctg agtgctcatt gtgtaagata
     1981 acactgctgc aaagttctct tattcttcat gccagaggtg gaagccaagg ccttgtgcat
     2041 ggtgaggagg tgctccaccc ctgaggaggt gctccaccac tgagctaatt acctcagctc
     2101 tgtcagttct ctataacttc atcctgcata tcaatgaaag aagattaaag aaagttcaac
     2161 aacttgtcca ttcattctga aaattatagg taggaatctg tggttaagaa atgcaccctt
     2221 agctgtaggc cagttttacc aggatgcatc ttcatcaaag aatgaaggag aagcatcaca
     2281 atgaggcaca ctgtgttctt gctcaggcgt catgtgttcc caaagtagaa tgatcaggga
     2341 atgttaatat ggcccctgct catagatgac atgcgagttt atgaagcatt ccatattttt
     2401 gaagagcatt gatagtctaa atcatgttag agaggaggga agggaaggga agggaaggga
     2461 agggaaggga agggaaggga agggaaggga agggaaggga agggaaggga agggaaggaa
     2521 aggaaaggaa aggaagaaag aaagaaagct aaagaagata ctgtgttcgg aagggaaggg
     2581 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga
     2641 aaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa
     2701 gaaagaaagc taaagaagat actgtgttca gagtatctga gctccagtca tagttccaaa
     2761 cgtgtcagca gtggcagtgt gactatgctt attttcgtac tctgcctcaa gccagtatga
     2821 gaaatgggcc agtgggaaat agtccttgtc aacaagcctg agcacttgag ttcaattccc
     2881 tgcacctgac ttccacacat atgttgtagc atgtagaggc ccagacatgt acacaaacac
     2941 aaattgtgta aatataattt ttttcatgaa aagaaactag gtaagggtag agcatccact
     3001 gaattatatc agtgtttatt ctgttaatta ctgtgagata catgctgtgt tatagtgtcc
     3061 catgaaacca tgggaaaata aacaagggtt agctttcctg aagtcttatt actagtccct
     3121 taaataacaa ttatcattac ctgaccattc cgctttttta tggaggggtg tgtgtgtatt
     3181 cttagtgatc actttcttta gtcacaataa agaccccaaa tgaataaggt accatgtgtg
     3241 tatatatata cacatatata cacacacaca tatatatatc aactactaaa ttgttatatt
     3301 cattttattt ttagtaataa tggcagtaat aaatttatct tttggtatat tgtaaaacat
     3361 aaataagagt tattactaag atttacattg tttcaggcat gtgactggca gtccagtatg
     3421 gtgtcttatt cctttgggaa accttatcac tgtgactaaa ttaaatgatc attaagaccc
     3481 tgtatcagaa ccttgcatgg gagctcatac ctgccgtgct gcatctggga agttgtggca
     3541 ggaagattgc tctgtatttg aagccaacct tgtatacaga gtaagaccct gtttaacata
     3601 ataaagaata tatattggtt tattactcca ttatgtttta agaaatggaa tgactatatt
     3661 gcagaactgc aggtttttga ttgtttttac aatttataat tcttttgtct actacaaata
     3721 aatgctcgta acttca
//
