LOCUS       NM_053168               2279 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus tripartite motif-containing 11 (Trim11), transcript
            variant 2, mRNA.
ACCESSION   NM_053168
VERSION     NM_053168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2279)
  AUTHORS   Wu,X. and Zhang,W.
  TITLE     TRIM11 expression levels was downregulated and prevents ferroptosis
            of cardiomyocyte by Dusp6 in acute myocardial infarction
  JOURNAL   Anticancer Drugs 35 (8), 720-731 (2024)
   PUBMED   38718254
  REMARK    GeneRIF: TRIM11 expression levels was downregulated and prevents
            ferroptosis of cardiomyocyte by Dusp6 in acute myocardial
            infarction.
REFERENCE   2  (bases 1 to 2279)
  AUTHORS   Yu,T., Yang,X., Fu,Q., Liang,J., Wu,X., Sheng,J., Chen,Y., Xiao,L.,
            Wu,Y., Nie,D., You,X., Mai,H., Chen,K. and Hu,S.
  TITLE     TRIM11 attenuates Treg cell differentiation by p62-selective
            autophagic degradation of AIM2
  JOURNAL   Cell Rep 42 (10), 113231 (2023)
   PUBMED   37804507
  REMARK    GeneRIF: TRIM11 attenuates Treg cell differentiation by
            p62-selective autophagic degradation of AIM2.
REFERENCE   3  (bases 1 to 2279)
  AUTHORS   Zhang,Z.Y., Harischandra,D.S., Wang,R., Ghaisas,S., Zhao,J.Y.,
            McMonagle,T.P., Zhu,G., Lacuarta,K.D., Song,J., Trojanowski,J.Q.,
            Xu,H., Lee,V.M. and Yang,X.
  TITLE     TRIM11 protects against tauopathies and is down-regulated in
            Alzheimer's disease
  JOURNAL   Science 381 (6656), eadd6696 (2023)
   PUBMED   37499037
REFERENCE   4  (bases 1 to 2279)
  AUTHORS   Xiao,Q., Wang,C.Y., Gao,C., Chen,J.D., Chen,J.J., Wang,Z., Ju,L.G.,
            Tang,S.B., Yao,J., Li,F., Li,L.Y. and Wu,M.
  TITLE     Regulation of KDM5C stability and enhancer reprogramming in breast
            cancer
  JOURNAL   Cell Death Dis 13 (10), 843 (2022)
   PUBMED   36192394
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2279)
  AUTHORS   Liu,T., Tang,Q., Liu,K., Xie,W., Liu,X., Wang,H., Wang,R.F. and
            Cui,J.
  TITLE     TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via
            p62-Dependent Selective Autophagy
  JOURNAL   Cell Rep 16 (7), 1988-2002 (2016)
   PUBMED   27498865
  REMARK    GeneRIF: TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via
            p62-dependent selective autophagy.
REFERENCE   6  (bases 1 to 2279)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   7  (bases 1 to 2279)
  AUTHORS   Cooper,S.T. and Hanson,I.M.
  TITLE     A screen for proteins that interact with PAX6: C-terminal mutations
            disrupt interaction with HOMER3, DNCL1 and TRIM11
  JOURNAL   BMC Genet 6, 43 (2005)
   PUBMED   16098226
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2279)
  AUTHORS   Niikura,T., Hashimoto,Y., Tajima,H., Ishizaka,M., Yamagishi,Y.,
            Kawasumi,M., Nawa,M., Terashita,K., Aiso,S. and Nishimoto,I.
  TITLE     A tripartite motif protein TRIM11 binds and destabilizes Humanin, a
            neuroprotective peptide against Alzheimer's disease-relevant
            insults
  JOURNAL   Eur J Neurosci 17 (6), 1150-1158 (2003)
   PUBMED   12670303
  REMARK    GeneRIF: The results suggest that TRIM11 plays a role in the
            regulation of intracellular humanin level through
            ubiquitin-mediated protein degradation pathways.
REFERENCE   9  (bases 1 to 2279)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2279)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040618.1, AK139477.1 and AL662809.14.
            
            On Mar 21, 2014 this sequence version replaced NM_053168.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon,
            compared to variant 1. The encoded isoform (2) is shorter, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF220124.1, AK139477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK040618.1         2-16
            16-2274             AK139477.1         1-2259
            2275-2279           AL662809.14        75930-75934
FEATURES             Location/Qualifiers
     source          1..2279
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.4 cM"
     gene            1..2279
                     /gene="Trim11"
                     /note="tripartite motif-containing 11"
                     /db_xref="GeneID:94091"
                     /db_xref="MGI:MGI:2137355"
     exon            1..552
                     /gene="Trim11"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1551
                     /gene="Trim11"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif-containing protein 11; E3
                     ubiquitin-protein ligase TRIM11; RING-type E3 ubiquitin
                     transferase TRIM11"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM11 isoform 2"
                     /protein_id="NP_444398.1"
                     /db_xref="CCDS:CCDS36168.1"
                     /db_xref="GeneID:94091"
                     /db_xref="MGI:MGI:2137355"
                     /translation="MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW
                     GQPEGPYACPECRELSAQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCAAHREPLTTF
                     CGDDLSLLCPICERSEHWTHRVRPLQEAADDLKGRLEKSLEHLRKQMEDAMLFQAQAE
                     ETCALWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQKLEEEELEVLPRLREGAARLG
                     QQSTQLAALISELESRCQLPALGLLQDIKDALCRVQDVKLQPPAVVPMELRTVCRVPG
                     LVETLRRFRGDITLDPDTANPELVLSEDRRSVQRGEQRQALPDNPERFDPGPCVLGQE
                     RITSGRHYWEVEVGDQTSWALGVCKETANRKEKGELSAGNGFWILVFLGSFYNSNEPA
                     FSPLRDPPKRVGIFLDYEAGHLSFYSATDGSLLFIFPETLFSGTLRPLFSPLSSSPTP
                     MTICRLIGVSGDTLGPQ"
     exon            553..648
                     /gene="Trim11"
                     /inference="alignment:Splign:2.1.0"
     exon            649..879
                     /gene="Trim11"
                     /inference="alignment:Splign:2.1.0"
     exon            880..902
                     /gene="Trim11"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1003
                     /gene="Trim11"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..2279
                     /gene="Trim11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2256..2261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trim11"
                     /note="hexamer: AATAAA"
     polyA_site      2275
                     /gene="Trim11"
                     /note="major polyA site"
ORIGIN      
        1 gagagcttag tgccggatgt acccactacc caggaggctg agagtgccgc tacctgctcc
       61 tggcccgttc ccactgcgct ctcgcggcgg agttgcccga tcccggtgca ccacgaaaag
      121 ctcgatccag gcgcagacgc cagcaccatg gctgccccag acttgtccac caacctccag
      181 gaggaggcca cctgcgccat ctgcctggat tacttcaccg acccggtgat gaccgactgc
      241 ggccacaact tctgccgcga gtgcatccga cgttgctggg gccagcccga gggcccatac
      301 gcgtgccccg agtgtcgcga gctgtcggcg cagaggaacc tacggcccaa ccgcccgctc
      361 gccaaaatgg cagaaatggc acgacgcctg cacccgcctt ctccggtccc gcagggcgtc
      421 tgtgcggcgc accgcgagcc gctgaccacc ttctgcggcg acgacctcag cctgctgtgc
      481 cccatctgcg agcgttcgga gcactggact caccgggtga gaccgctgca ggaggcggcg
      541 gacgacctca aggggaggct ggagaagtca ctggagcacc tacggaaaca aatggaggac
      601 gcaatgctgt tccaagccca ggctgaggaa acctgtgcct tgtggcagaa gatggtggag
      661 agccagcggc agaatgtgct gggcgagttt gagaggctgc gccgcctgtt ggcagaggag
      721 gagcaacagc tgctgcagaa gctggaggag gaagagctgg aggttctgcc gcgcctgcgt
      781 gaaggcgctg cgaggcttgg ccagcaaagc acgcagctgg cagccctcat ctccgagctt
      841 gagagccgct gccagctgcc agccctgggt ttactgcagg acattaagga cgccctgtgc
      901 agggtgcagg atgtgaagct gcagcctcca gcagtggtgc ccatggagct gaggaccgtg
      961 tgccgggtcc cagggctggt ggagaccctg cggaggttcc gaggggacat aaccctggac
     1021 ccagacaccg ccaaccctga gctggtctta tctgaggacc ggaggagtgt gcagcgtggt
     1081 gaacagcggc aggccctgcc tgacaaccca gagcggttcg accccggccc ttgcgtgctg
     1141 ggccaggagc gcattacctc tggccgccac tactgggagg tggaagtcgg ggaccagacc
     1201 agctgggcac tcggcgtgtg taaagaaact gccaacagga aggagaaggg ggagctgtcg
     1261 gctggcaatg ggttctggat cctggtgttc ctggggagtt tctataattc caatgagccg
     1321 gccttctccc cactgcggga ccctcccaag cgtgtgggga tttttctgga ctatgaagct
     1381 ggccatctct cattctacag tgccacggat gggtcgctgc tgtttatctt ccccgagacc
     1441 ctgttctcag ggacactccg gcccctcttc tcacctctgt caagcagccc gacccctatg
     1501 actatctgca ggctgatagg tgtatctggg gacacccttg gcccgcagtg acccaaacct
     1561 tctaagaaag tcccttcacc tttcctggtc ctttgtcctg gccatacaga gacccaggag
     1621 ccagctgaca tcctgtgcgc attaggagga gcacacagtg cctttctgac cacacgtggg
     1681 aaacacaagt tctctgtctc agagacagta tgtgtgagag tacactgggc tgggctctgt
     1741 cctcatcctg gggatcctcc ccgccccccg atgccactta gtgccgaaag ctctcaccaa
     1801 agcactaagt cccatgtgtc accagcacct cagattctga gttcctgggc tgcctgccaa
     1861 gcatgccaca cagtccctgg agtgataggg attaggtagg gagacagctt caagcatctc
     1921 tggatttggt ctgataaacg ggaaggctgc tcagagtcct gaccttgctg ggcgtggcta
     1981 caaagaggac ggtagcgtgg ccccagagat gaagcaatct agtaggggct gaatcctaca
     2041 ggagtattca acatttgtat tcggcacata aggggcctag aagtagaacg cagaaatgac
     2101 acttgaacac acccttctgt cctgagactt gtctggtggc tggctgtggt acactgcccc
     2161 tggttgcaga ctgagctgca caggagtcag tagtgactgc ttttgtatta aactttggga
     2221 gttttatctt ctatttattg aaagggaaac atttaaataa actcatttga agtcatgtt
//
