LOCUS       NM_025817               5377 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus TLR4 interactor with leucine-rich repeats (Tril),
            mRNA.
ACCESSION   NM_025817
VERSION     NM_025817.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5377)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   2  (bases 1 to 5377)
  AUTHORS   Moura-Assis,A., Nogueira,P.A.S., de-Lima-Junior,J.C.,
            Simabuco,F.M., Gaspar,J.M., Donato,J. Jr. and Velloso,L.A.
  TITLE     TLR4-interactor with leucine-rich repeats (TRIL) is involved in
            diet-induced hypothalamic inflammation
  JOURNAL   Sci Rep 11 (1), 18015 (2021)
   PUBMED   34504172
  REMARK    GeneRIF: TLR4-interactor with leucine-rich repeats (TRIL) is
            involved in diet-induced hypothalamic inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5377)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5377)
  AUTHORS   Xiang,C., Frietze,K.K., Bi,Y., Li,Y., Dal Pozzo,V., Pal,S.,
            Alexander,N., Baubet,V., D'Acunto,V., Mason,C.E., Davuluri,R.V. and
            Dahmane,N.
  TITLE     RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell
            Identity and Glioblastoma Subtypes in Developing Neurons
  JOURNAL   Mol Cell Biol 41 (7), e0052620 (2021)
   PUBMED   33903225
REFERENCE   5  (bases 1 to 5377)
  AUTHORS   Wochal,P., Rathinam,V.A., Dunne,A., Carlson,T., Kuang,W.,
            Seidl,K.J., Hall,J.P., Lin,L.L., Collins,M., Schattgen,S.A.,
            MacKay,C.R., Fagundes,C.T., Carpenter,S., Fitzgerald,K.A. and
            O'Neill,L.A.
  TITLE     TRIL is involved in cytokine production in the brain following
            Escherichia coli infection
  JOURNAL   J Immunol 193 (4), 1911-1919 (2014)
   PUBMED   25015823
  REMARK    GeneRIF: these data uncover TRIL as a mediator of innate immune
            responses within the brain, where it enhances neuronal cytokine
            responses to infection.
REFERENCE   6  (bases 1 to 5377)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   7  (bases 1 to 5377)
  AUTHORS   Carpenter,S., Carlson,T., Dellacasagrande,J., Garcia,A.,
            Gibbons,S., Hertzog,P., Lyons,A., Lin,L.L., Lynch,M., Monie,T.,
            Murphy,C., Seidl,K.J., Wells,C., Dunne,A. and O'Neill,L.A.
  TITLE     TRIL, a functional component of the TLR4 signaling complex, highly
            expressed in brain
  JOURNAL   J Immunol 183 (6), 3989-3995 (2009)
   PUBMED   19710467
  REMARK    GeneRIF: TRIL is a novel component of the TLR4 complex which may
            have particular relevance for the functional role of TLR4 in the
            brain
REFERENCE   8  (bases 1 to 5377)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   9  (bases 1 to 5377)
  AUTHORS   Lehoczky,J.A., Williams,M.E. and Innis,J.W.
  TITLE     Conserved expression domains for genes upstream and within the HoxA
            and HoxD clusters suggests a long-range enhancer existed before
            cluster duplication
  JOURNAL   Evol Dev 6 (6), 423-430 (2004)
   PUBMED   15509224
REFERENCE   10 (bases 1 to 5377)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291576.1, BC059224.1 and AC079130.4.
            
            On Dec 23, 2009 this sequence version replaced NM_025817.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC059224.1, AK051421.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               BY291576.1         2-132
            132-3801            BC059224.1         1-3670
            3802-3802           AC079130.4         149850-149850       c
            3803-5377           BC059224.1         3671-5245
FEATURES             Location/Qualifiers
     source          1..5377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 26.07 cM"
     gene            1..5377
                     /gene="Tril"
                     /gene_synonym="1200009O22Rik; mKIAA0644"
                     /note="TLR4 interactor with leucine-rich repeats"
                     /db_xref="GeneID:66873"
                     /db_xref="MGI:MGI:1914123"
     exon            1..5358
                     /gene="Tril"
                     /gene_synonym="1200009O22Rik; mKIAA0644"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..3020
                     /gene="Tril"
                     /gene_synonym="1200009O22Rik; mKIAA0644"
                     /codon_start=1
                     /product="TLR4 interactor with leucine rich repeats
                     precursor"
                     /protein_id="NP_080093.1"
                     /db_xref="CCDS:CCDS51776.1"
                     /db_xref="GeneID:66873"
                     /db_xref="MGI:MGI:1914123"
                     /translation="MEGVGAVRFWLVVCGCLAFPPRAESVCPERCDCQHPQHLLCTNR
                     GLRAVPKTSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKT
                     FEKLSRLEELYLGNNLLQALVPGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKL
                     RLDGNVLGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFSQLGKLRFLNLSANELQPS
                     LRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGL
                     EALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRD
                     NALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVFVQCRH
                     PPALRGKYLDYLDDQLLQNGSCVDPSPSPTAGSRQWPLPTSSEEGMTPPAGLSQELPL
                     QPQPQPQQRGRLLPGVAWGGAAKELVGNRSALRLSRRGPGPHQGPSAAAPGSAPQSLD
                     LHEKPGRGRHTRANLSQTEPTPTSEPASGTPSARDSWQRAAKQRLASEQQESAVQSVS
                     GVGLPPLVSDPCDFNKFILCNLTVEAVSANSASVRWAVREHRSPRPQGGARFRLLFDR
                     FGQQPKFQRFVYLPERSDSATLHELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTL
                     PEAGGRGGVDYQLLTLVLLAVNALLVLLALAAWGSRWLRRKLRARRKGGAPVHVRHMY
                     STRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSTGGGTSGSLR
                     REDHLLQRFAD"
     regulatory      3633..3638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tril"
                     /gene_synonym="1200009O22Rik; mKIAA0644"
                     /note="hexamer: AATAAA"
     polyA_site      3658
                     /gene="Tril"
                     /gene_synonym="1200009O22Rik; mKIAA0644"
                     /note="major polyA site"
     regulatory      4404..4409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tril"
                     /gene_synonym="1200009O22Rik; mKIAA0644"
                     /note="hexamer: ATTAAA"
     polyA_site      4427
                     /gene="Tril"
                     /gene_synonym="1200009O22Rik; mKIAA0644"
ORIGIN      
        1 gtgggaagaa cgaatttccg ccggtttgct cgctccacgc cgacatgggt cccttccgga
       61 cgctgcttgc gcgtccccca ggctgctcac tccggctgca ctcccaatcc ccccggatcg
      121 cgagcgggca ggcgccggag acgtgggcct agcggccggt actctgcagc caagccgcac
      181 cccagcagct cttggaaggg atcccgcctg cagcggggga atccgtttgg cggggagaat
      241 ccgcgccagg gaatccagct ctccggactc cagagcaaac aaaaagcacc aactcttgct
      301 cgctcctccc gcccccgacg ctcacccgaa gaaacagttt tctgcagaaa tgcaacaagt
      361 agcaccccag attcgccgag cgcccagcgc cttctgattt ggctccgcga acttggcctg
      421 cggagacccg ggcgagccac cgggacaaag aggaagggct ggacggagca ccagcgaagt
      481 acgaaagagg cctttttagc gactcaggcc cggccgaggg gaatgcagag gagacacaga
      541 gccggccggc ccagaagacg atccggccgc agcgcgctgg gcgggcggcg atggagggtg
      601 tgggtgccgt gcgcttctgg ctcgtggtgt gcggctgcct ggcgttcccg ccgcgggccg
      661 agtccgtgtg cccggagcgc tgcgactgcc agcaccccca acatctccta tgcaccaaca
      721 ggggacttcg cgctgtaccc aagaccagct cgctgcctag tccccaggac gtgctcacct
      781 acagcctagg cggcaacttc atcaccaaca tcaccgcctt cgacttccac cgtctggggc
      841 agctcagacg gctggatctg cagtacaacc agatccgttc tctccacccc aagaccttcg
      901 agaagctctc acgactagag gagctgtacc tggggaacaa cctcttgcag gcgctcgttc
      961 ctggcacgtt ggctccgctg cgcaagttgc gcatccttta cgccaacggc aacgagattg
     1021 gacgcctgag tcgcgggtcc ttcgagggcc tggagagttt ggtcaagcta cggctggacg
     1081 ggaacgtgct gggagcgctg ccggacgcgg tcttcgctcc cctgggcaac ctgctctacc
     1141 tacacctgga atctaaccgg atccgttttt tgggcaagaa cgccttcagc cagctgggta
     1201 agcttcgatt cctcaatctc tcggccaacg agctgcaacc ctctctgcgc cacgcggcca
     1261 cctttgtccc tctgcgctcc ctctctactc tcatcctctc agccaacagc ctacagcacc
     1321 tcggcccccg cgtcttccag cacctgccac gcctaggcct gctctccctc agtggaaacc
     1381 agctcacgca cctcgcccca gaggcctttt ggggactgga ggccctacgt gagctgcgcc
     1441 tggaaggtaa ccggctgaac cagctccccc tgacactgct ggagcctctg cacagcttgg
     1501 aggcactaga cctgagtggc aatgagcttt ctgctctgca ccctgccacc tttggccacc
     1561 agggccggct ccgtgagctc agcctgcgcg acaacgcgct cagcgccctt tctggggaca
     1621 tctttgccgc cagtccggct ctctaccggc tggatctaga cggcaatggt tggacctgcg
     1681 actgccggtt gcggggtctg aaacgctgga tgggcaactg gcattctcag ggtcgcctcc
     1741 ttacggtctt cgtgcagtgt cgccaccccc cggccctgcg gggcaagtac ctggattacc
     1801 tggatgacca actgctgcag aatgggtctt gcgtggatcc ctcaccttcc cctacagcag
     1861 gcagtaggca gtggccgcta cccacatcgt cagaagaggg gatgacgccc cctgcaggcc
     1921 tctcgcagga gctaccactg cagccgcagc cgcagcccca gcagcgggga agacttctac
     1981 caggagtggc ctggggtggg gctgccaagg aactggtggg caaccgcagc gcattaaggt
     2041 tgagccggcg gggaccaggt ccccatcagg gcccctctgc tgcggctccg ggctctgccc
     2101 cacagtcctt ggacctgcac gagaagccgg ggagaggacg tcacacccga gccaatctct
     2161 cccagacgga gcccaccccg acgtctgagc ccgcctctgg gacaccatct gccagagaca
     2221 gctggcagcg cgcagcaaag cagcgcctag cgtccgagca gcaagagagc gcagtccagt
     2281 ccgttagtgg ggttggtttg ccacctctgg tgtctgaccc ctgtgacttc aacaaattca
     2341 ttctgtgcaa cctgacagta gaggcggtga gcgccaacag cgcctcggtg cgctgggcgg
     2401 ttcgcgaaca ccgcagtccc cggccgcagg gcggcgcacg cttccgcctg cttttcgacc
     2461 gctttggcca gcagcccaag ttccagcgct tcgtctacct gccggagcgc agcgactcgg
     2521 ccacgctgca cgagctgcgc ggagacaccc cctacctagt atgcgtggag ggtgtgctcg
     2581 ggggtcgcgt ttgccccgtg gccccccgag accactgcgc agggttagta accctgccag
     2641 aggcaggagg tcgaggtggc gtcgactacc agctcctgac cttggtcttg ctggctgtca
     2701 acgcgcttct ggtgctcctg gcactggcag cctggggatc gcgatggctg cggaggaagc
     2761 tgcgtgccag gcggaaggga ggggccccgg tccacgttcg ccacatgtac tccacccgac
     2821 ggccactgcg ctccatgggc actggtgtgt ccgcggactt ctcaggcttc cagtcgcacc
     2881 gtccccgcac caccgtgtgc gcgctcagcg aggccgacct cattgagttc ccctgcgacc
     2941 gcttcatgga cagcaccggc ggtggtacca gtggcagctt gaggcgggag gatcacctct
     3001 tgcaaagatt cgctgactag gcaatgcctt gggatctcac aggccttaag gagccactct
     3061 ccgtggtccc atgccttctc agaggaagaa ctagttttat tagacttgtt ctttctccct
     3121 tttgtgcatt tgccaagtga aatctagatg tgaaagtgaa tctagatgcc atccatcacg
     3181 tcctggtaat cacaaagcaa atggatggtt cttggtggtc taacccaaga gtggggacaa
     3241 atgaataatg gcgtaaaagt gggaaacctt gacacactta gctcatggct cctgtgactt
     3301 tcagcacagt agcctgctga ccttgggcta gaaagggtgc tttacgctcc cagcatgacc
     3361 agaacgctct ggtgtgtata cacactcctt tgctctatgg caaactgagt tctgtttcta
     3421 gttaagaaaa gggggacttg ccaccatcac agtgatcccc atcagcaact gaccccactg
     3481 atctggtggg ttctgccaag accggcaggg taaacaaaca ggtaccactc tctcccggga
     3541 accctttctt ctgttgtctg ggagagcatc taggaagcct taaggaaaag ctacctgtgt
     3601 caacaatatg aagaggattt aacaagctga ccaataaact cagactcttt tgataggact
     3661 ggacctcctc tctatcgttt tatcagttag ggaaatgacc ttttgctgac ctttgggtaa
     3721 ctgataatat cctcaggaga aggcagcatt taatacttct ccaccaggct tgcgcctgtg
     3781 gttttacctt attttttttt ttaaatctat acatgggaaa aaatcgaatg ccagatttga
     3841 tcttttaaaa agaaaaaaga atgcgatatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3901 taaccagtga ctccctaggg cactgcagcc ttccagttcg cttaccacat ttctgatagc
     3961 atgcctagac gggtgtgaat gtgacctaca tcttacgaca gttcagcagt gtcccccatc
     4021 cccttcttga cagcacccat ttctgagttg cacggttagg cattaagcgt aaggtaattg
     4081 tcaggcttgg ggcagggggc agtgagctca gtggtggagc ttgcttgtgg ggctctgagt
     4141 ttgtcccaaa caaacaaagc aatgggtgaa ttgtctgtaa tctctgacca catcactgtc
     4201 gctctttata agaaatagaa caggagaaga aaactgtagg gaacaaatgt gaaaacaaac
     4261 aaacaaacaa aaaaacaaaa aacccacagt agcgaatatg tgtttctact aaacccagaa
     4321 gaacatgtgc attcaactgt cactgtgaaa taattatata ttttacaaat taattattcc
     4381 aatagccagt atcttactgt gttattaaac cttatctttt agtagtagat gcagtatttc
     4441 ttttcttttt atgttttatt tttaatttag gattagcctc ttgtatttgt ttagttgtgt
     4501 ttttagctat ttgggatact tttctccctt gatatttatg aagtccacgt ttatgattaa
     4561 atatagtggc tgggttcaca ttaataattc gtgtgtggtc cacatacacg tgctaagagg
     4621 atgtacactg tggtatagtc accgtggtta tggatttatt ggcagtgggg gactgtgcag
     4681 tgcaggtcag ccagttctat ggctaacagt gactcttctg ttccaggcct caggcccctg
     4741 agggtcccaa tgactcaggg aacccatcac agtccagggc ccttcaccac gatcactctt
     4801 tatgtttggc ctacgtgagc catgctgcct tgtctcagca gctgaagacc tgggggtcta
     4861 aatgagccgg tctttgttta tgtccagcat gagtaaaatg tccagaccac ttaagccaca
     4921 gctgcttttc tggcagtctt atctgcaggg acgaaactta ataaaccaca ggaaataaga
     4981 ctgtcattcc gtgtttgctg ccaggccttg ttttacatcc acagtgcatg gtgcatggga
     5041 gctggggctg ttcgctctta gtttcaaccc acaggctatc tggcacctcc tgtagaactc
     5101 gcaatttttc atgcacagca cagttgcctc tcttagctgt ttcatttaca cagtgtaaaa
     5161 ctgagacccg ttgaaagtat ggaaaagacc actgattctg tttaccatct gccttgccca
     5221 actgtagact gtcaccaaaa ccctttaatg cctggactta aaaaaaacag tctcactgaa
     5281 aagtcttttc agtgagaaat ggataaatgt tatacattgt tacattcaat tatgtcaata
     5341 aacccacata ctgatagaaa aaaaaaaaaa aaaaaaa
//
