LOCUS       NM_175093               2051 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus tribbles pseudokinase 3 (Trib3), mRNA.
ACCESSION   NM_175093
VERSION     NM_175093.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Kong,L., Kong,L., Li,P., Gao,L., Ma,H. and Shi,B.
  TITLE     Tribbles pseudokinase 3 promoted renal fibrosis by regulating the
            expression of DNA damage-inducible transcript 3 in diabetic
            nephropathy
  JOURNAL   Biomol Biomed 24 (6), 1559-1570 (2024)
   PUBMED   38733632
  REMARK    GeneRIF: Tribbles pseudokinase 3 promoted renal fibrosis by
            regulating the expression of DNA damage-inducible transcript 3 in
            diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Li,J., Huang,Y., Yang,X., Cai,Y., Wang,Y., Dai,W., Jiang,L.,
            Wang,C. and Wen,Z.
  TITLE     Tyrosine-phosphorylated DNER sensitizes insulin signaling in
            hepatic gluconeogenesis by inducing proteasomal degradation of TRB3
  JOURNAL   Mol Metab 83, 101927 (2024)
   PUBMED   38553003
  REMARK    GeneRIF: Tyrosine-phosphorylated DNER sensitizes insulin signaling
            in hepatic gluconeogenesis by inducing proteasomal degradation of
            TRB3.
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Ohoka,N., Yoshii,S., Hattori,T., Onozaki,K. and Hayashi,H.
  TITLE     TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP
            pathway and is involved in cell death
  JOURNAL   EMBO J 24 (6), 1243-1255 (2005)
   PUBMED   15775988
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Koo,S.H., Satoh,H., Herzig,S., Lee,C.H., Hedrick,S., Kulkarni,R.,
            Evans,R.M., Olefsky,J. and Montminy,M.
  TITLE     PGC-1 promotes insulin resistance in liver through
            PPAR-alpha-dependent induction of TRB-3
  JOURNAL   Nat Med 10 (5), 530-534 (2004)
   PUBMED   15107844
  REMARK    GeneRIF: Knockdown of hepatic TRB-3 expression improved glucose
            tolerance, whereas hepatic overexpression of TRB-3 reversed the
            insulin-sensitive phenotype of PGC-1-deficient mice.
            Erratum:[Nat Med. 2004 Jul;7(10):755]
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Ord,D. and Ord,T.
  TITLE     Mouse NIPK interacts with ATF4 and affects its transcriptional
            activity
  JOURNAL   Exp Cell Res 286 (2), 308-320 (2003)
   PUBMED   12749859
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Du,K., Herzig,S., Kulkarni,R.N. and Montminy,M.
  TITLE     TRB3: a tribbles homolog that inhibits Akt/PKB activation by
            insulin in liver
  JOURNAL   Science 300 (5625), 1574-1577 (2003)
   PUBMED   12791994
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY010029.1 and AK132257.1.
            
            On Nov 3, 2006 this sequence version replaced NM_175093.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132257.1, AK160099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY010029.1         2-63
            63-2051             AK132257.1         2-1990
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..2051
                     /gene="Trib3"
                     /gene_synonym="Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3"
                     /note="tribbles pseudokinase 3"
                     /db_xref="GeneID:228775"
                     /db_xref="MGI:MGI:1345675"
     exon            1..204
                     /gene="Trib3"
                     /gene_synonym="Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1269
                     /gene="Trib3"
                     /gene_synonym="Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3"
                     /note="induced in fatty liver dystrophy 2; neuronal cell
                     death-inducible putative kinase"
                     /codon_start=1
                     /product="tribbles homolog 3"
                     /protein_id="NP_780302.2"
                     /db_xref="CCDS:CCDS16881.1"
                     /db_xref="GeneID:228775"
                     /db_xref="MGI:MGI:1345675"
                     /translation="MRATPLAASADVSCRKKPLEFDDNIDAKCPVLKRVRDEPEPGPL
                     PSLLPPSPPPASDLSPAVAPATRLGPYILLEREQGSCSYRALHCPTGTEYTCKVYPAS
                     EAQAVLAPYARLPTHQHVARPTEVLLGSRLLYIFFTKTHGDLHSLVRSRRGIPESEAA
                     GLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWD
                     KHACPAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRG
                     TFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWLREDHGRVSPPQSDRREMDQ
                     VVPDGPQLEEAEEGEVGLYG"
     exon            205..495
                     /gene="Trib3"
                     /gene_synonym="Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..788
                     /gene="Trib3"
                     /gene_synonym="Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..2051
                     /gene="Trib3"
                     /gene_synonym="Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattagctc aggtttacat cagccgggcg gggatccgag cccgcgtccc ggtgccgcag
       61 cactttagca gcggaagagg ctgctgccga gtacgtgacg gctggggtct ggcactagcg
      121 tgcaggagac tccgagagct gctcagttag gctggcggcg gtccacgggc gtgggcgcag
      181 gcggctctga ggctccagga caagatgcga gctacacctc tggctgcttc tgctgatgtt
      241 tcctgcagga agaaaccgtt ggagtttgat gacaatattg atgccaagtg tccagtccta
      301 aaacgagtga gagatgagcc tgagcccgga ccactcccca gcctgctgcc ccccagccca
      361 cctcccgcct cagacttgtc acctgctgtg gcccctgcaa ctcgactggg gccttatatc
      421 cttttggaac gagagcaagg cagctgcagc tatcgagccc tgcactgccc cacaggcaca
      481 gagtacacct gcaaggtgta ccctgccagc gaggcccagg cggtgctggc accttatgcc
      541 cggctgccta cccaccagca tgtggcccgt cccacagagg tcctgctggg ctctcggctc
      601 ctttacatct ttttcacgaa gacccatggg gacttgcaca gcctggtgcg cagccgccgc
      661 ggtatcccag agtccgaggc tgccgggctc ttccggcaga tggctagtgc cgtggcacac
      721 tgccacaagc acgggcttgt cttgcgcgac ctcaagctgc gtcgctttgt cttcagcaac
      781 tgtgagagga cgaagctggt gctggagaac ctggaagatg cctgcgtgat gactggatca
      841 gatgactctc tgtgggacaa gcatgcgtgc cctgcctacg tgggaccaga gatactcagc
      901 tcccggccat cctactctgg caaagcggct gatgtctgga gcctgggtgt ggcgctcttc
      961 accatgctgg ctggcagata cccattccac gactctgagc cagtcctgct ctttggcaag
     1021 atccgtagag ggacctttgc cctgcctgag ggcctatcag ccccagcccg ctgtctgatc
     1081 cgctgtctcc tccgcaagga accttcagag cgacttgtgg ccctgggaat cctcttgcat
     1141 ccctggttga gagaggatca cggccgagtc tctcctccac agtctgaccg aagggagatg
     1201 gaccaggtgg tcccagatgg gccacagctg gaggaggctg aggaagggga ggtggggctg
     1261 tacggctagg gccaccttac tggcccctca gctccaaggt gtgagttgag tacctgagtc
     1321 tcagctttct cctgactttt tgggccaagc taaaccttaa gtgcctttct ggaggaagaa
     1381 acagccggcg tgccttattc gttcctgtgc ctagtggggt gatgctccct gagtgccacg
     1441 ccctgctcta ggtgctgtga acagcaaagg aaaaagaggg agaaatatac cttgctggcc
     1501 aagttgccac agtgccgcat gctctccggc cagcccctgc cttgggcacg tttcctaccg
     1561 gggctgtctt ctctggtgct ggttcatggg acagtccctt ttatcagtgc cccagctgcc
     1621 ttctgtcttg tgcctttaaa caaaggaaac atctctgtgc caaagaccaa agtcctcact
     1681 caccatgtgc ctcaggacca caaatcaggc cgggctggga ttgtggcctc caggcaggag
     1741 aacctgtttg aagaagactt ggctgtggga ttcaagccaa aaggatgaga ctccaataaa
     1801 gaggcatctg actcaaggaa tagtctggaa taaggatccg ggtctgttta ccctggtagc
     1861 ctccggctga agcaccaaag ttggaggggg aggaccaggc agggtctgtc ctactgccta
     1921 cagacaatct caggccctgt tctggggact tttagtaccc aggcccacag tcagtttgat
     1981 gactttggtc tggttaagtg tgtattttca tcatgtgccc aataaaagag agctgtgtgg
     2041 tttgatatgt g
//
