LOCUS       NM_144551               4272 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus tribbles pseudokinase 2 (Trib2), transcript variant 1,
            mRNA.
ACCESSION   NM_144551 XM_001474232 XM_001480364
VERSION     NM_144551.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4272)
  AUTHORS   Wang,D., Kang,X., Zhang,L., Guo,Y., Zhang,Z., Ren,H. and Yuan,G.
  TITLE     TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin
            Resistance
  JOURNAL   Diabetes 73 (8), 1199-1214 (2024)
   PUBMED   38394623
  REMARK    GeneRIF: TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin
            Resistance.
REFERENCE   2  (bases 1 to 4272)
  AUTHORS   Wirth,S., Schlosser,A., Beiersdorfer,A., Schweizer,M., Woo,M.S.,
            Friese,M.A., Lohr,C. and Grochowska,K.M.
  TITLE     Astrocytic uptake of posttranslationally modified amyloid-beta
            leads to endolysosomal system disruption and induction of
            pro-inflammatory signaling
  JOURNAL   Glia 72 (8), 1451-1468 (2024)
   PUBMED   38629411
REFERENCE   3  (bases 1 to 4272)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4272)
  AUTHORS   Cao,W., Sturmlechner,I., Zhang,H., Jin,J., Hu,B., Jadhav,R.R.,
            Fang,F., Weyand,C.M. and Goronzy,J.J.
  TITLE     TRIB2 safeguards naive T cell homeostasis during aging
  JOURNAL   Cell Rep 42 (3), 112195 (2023)
   PUBMED   36884349
  REMARK    GeneRIF: TRIB2 safeguards naive T cell homeostasis during aging.
REFERENCE   5  (bases 1 to 4272)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   6  (bases 1 to 4272)
  AUTHORS   Keeshan,K., Shestova,O., Ussin,L. and Pear,W.S.
  TITLE     Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute
            myelogenous leukemia
  JOURNAL   Blood Cells Mol Dis 40 (1), 119-121 (2008)
   PUBMED   17988908
  REMARK    GeneRIF: Mice reconstituted with HSC cotransduced with HoxA9 and
            Trib2 had accelerated onset of AML compared to either gene alone
REFERENCE   7  (bases 1 to 4272)
  AUTHORS   Naiki,T., Saijou,E., Miyaoka,Y., Sekine,K. and Miyajima,A.
  TITLE     TRB2, a mouse Tribbles ortholog, suppresses adipocyte
            differentiation by inhibiting AKT and C/EBPbeta
  JOURNAL   J Biol Chem 282 (33), 24075-24082 (2007)
   PUBMED   17576771
  REMARK    GeneRIF: describe suppression of adipocyte differentiation by TRBs
            Trib1, Trib2, Trib3
REFERENCE   8  (bases 1 to 4272)
  AUTHORS   Lin,K.R., Lee,S.F., Hung,C.M., Li,C.L., Yang-Yen,H.F. and Yen,J.J.
  TITLE     Survival factor withdrawal-induced apoptosis of TF-1 cells involves
            a TRB2-Mcl-1 axis-dependent pathway
  JOURNAL   J Biol Chem 282 (30), 21962-21972 (2007)
   PUBMED   17545167
REFERENCE   9  (bases 1 to 4272)
  AUTHORS   Keeshan,K., He,Y., Wouters,B.J., Shestova,O., Xu,L., Sai,H.,
            Rodriguez,C.G., Maillard,I., Tobias,J.W., Valk,P., Carroll,M.,
            Aster,J.C., Delwel,R. and Pear,W.S.
  TITLE     Tribbles homolog 2 inactivates C/EBPalpha and causes acute
            myelogenous leukemia
  JOURNAL   Cancer Cell 10 (5), 401-411 (2006)
   PUBMED   17097562
  REMARK    GeneRIF: Data identify Tribbles homolog 2 as an oncogene that
            induces acute myelogenous leukemia through a mechanism involving
            inactivation of C/EBPalpha.
REFERENCE   10 (bases 1 to 4272)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159643.2.
            
            On Feb 9, 2022 this sequence version replaced NM_144551.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037387.1, AK144192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1627              AC159643.2         14531-16157
            1628-1920           AC159643.2         21400-21692
            1921-4272           AC159643.2         37312-39663
FEATURES             Location/Qualifiers
     source          1..4272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 7.25 cM"
     gene            1..4272
                     /gene="Trib2"
                     /gene_synonym="TRB-2; TRB2"
                     /note="tribbles pseudokinase 2"
                     /db_xref="GeneID:217410"
                     /db_xref="MGI:MGI:2145021"
     exon            1..1627
                     /gene="Trib2"
                     /gene_synonym="TRB-2; TRB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1358..2389
                     /gene="Trib2"
                     /gene_synonym="TRB-2; TRB2"
                     /codon_start=1
                     /product="tribbles homolog 2"
                     /protein_id="NP_653134.2"
                     /db_xref="CCDS:CCDS25821.1"
                     /db_xref="GeneID:217410"
                     /db_xref="MGI:MGI:2145021"
                     /translation="MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLG
                     SPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFEISCYQESLA
                     PCFCLSAHSNINQITEILLGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIA
                     SAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAY
                     VSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPET
                     LSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSGFGAKEACDQLVPDVNM
                     EENLDPFFN"
     exon            1628..1920
                     /gene="Trib2"
                     /gene_synonym="TRB-2; TRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..4272
                     /gene="Trib2"
                     /gene_synonym="TRB-2; TRB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4246..4251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trib2"
                     /gene_synonym="TRB-2; TRB2"
                     /note="hexamer: AATAAA"
     polyA_site      4272
                     /gene="Trib2"
                     /gene_synonym="TRB-2; TRB2"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcgagc aagcgaggcg cgcgcgcaca catacgcgca cacacagccg ggctcgctcc
       61 gagatccccg gccacgtaag taactattaa taccgcctcg cccggggatg cgggcgtgct
      121 tgagcgccgg gattggccta gggcgccgtg gccatcccct ttaattttta aatacacggt
      181 cctctcctac ttctgggtgg caagaaaaaa aaaataataa gaaaagaaga caagccgtcg
      241 atttttattt ttcctgcaga gcaaaccccg ccgtgcaatt tggtcgcaag gcatcgggag
      301 acaagagtgg tttgcaaatt gtttcaaggc tcaagaccca gttgtgcagc ggaaaaggaa
      361 cgccgcgggt tgacggagtc cggggagcat ctgctggcag ctcctgcagg acccccggaa
      421 agctcctgct gctggtaccc cccaggtcac cgcccgcact tcttgcttca tcggaggagg
      481 atctgggacg tgagcagcga cagcaagagc tagtgctgac cgcgcgggct ctgccttggg
      541 ctttgtcgcg gtacctgtgc ctgccctact ccgcgcactc cctactcagc ttttgcaatc
      601 ttttgttgcc actgctgacc gccccaagtt aaaagcgcct ttgcaatttt ttttttctgt
      661 cttttttttt ttttcttgag agagacagct ctgcgatttt ttggaaaagc ctcagacgcc
      721 atctacagtt aagacttagg taactgccct ctctagcacc ccccttacac gccccccacc
      781 ctttccacca aaaagagggg ggtgcagcgc ggattctggc tgccgcgcgg cgtgagccgg
      841 tagacccgag cttatttcct ttttcttttt gtttggtttc taacgcgtgg agggcgagcc
      901 ggcgccgcgc gctccctgaa gactgcacaa actccacgca gggcttctcc gcccggtctg
      961 cggatcctca gctggggatc gctcagaagc ccggcgctgc agctcctcac cccagaggca
     1021 cgctcactcg tccagatcca cgctgcgaac agagacccac tgagtccagc gtgcggttct
     1081 gcaccgcgct ggcagcttct gggtaacaaa aggacccgag ttgtccgcag agcgagcacc
     1141 cccgggagcg gggctcgcag ccggggacca gccctgcagc gcccatctgg gggctagttc
     1201 ttaactcttc ctccacggag ccccagacgg gtcccctccc ttcttgatcc ttttaagtcg
     1261 gtagcaccga ggcgcctgca ccggcgcggc tcatccatct ctccagaggg gttttttggt
     1321 ttgtttgttt gttttgtcgt gtgcgatcct cacactcatg aacatacaca ggtctacccc
     1381 tatcacaata gcgagatatg ggagatcgcg gaacaaaacc caggatttcg aagagctgtc
     1441 gtctataagg tccgctgagc ccagccagag tttcagcccg aaccttggct ctccgagccc
     1501 gcccgagact ccgaacttgt cgcattgcgt ttcttgcatc gggaaatact tactgttgga
     1561 gcctctggag ggagaccacg ttttccgcgc tgtgcatctg cacagcggag aggagctggt
     1621 ttgcaaggtg tttgagatca gctgctacca ggagtccctg gccccctgct tctgcctgtc
     1681 tgcccatagc aacatcaacc aaatcacgga aatcctcctg ggagagacca aagcctatgt
     1741 gttctttgag cgaagctatg gagacatgca ttcctttgtc cgcacttgta agaagctgag
     1801 ggaggaggag gcagcccgac tgttctacca gattgcctca gctgtggccc attgccacga
     1861 tggaggcctg gtgctgcgtg acctcaagct gcggaaattt atcttcaagg atgaagagag
     1921 gactcgtgtc aagctggaga gtttggaaga cgcttacatt ctccggggtg atgatgactc
     1981 actctctgac aagcatggct gcccagcgta tgtcagccca gagatcttga acaccagcgg
     2041 cagttattcg ggcaaggcag cggacgtgtg gagcctgggg gtaatgctgt acaccatgtt
     2101 ggtggggcgt taccctttcc atgacattga gcctagttct cttttcagta agatccgcag
     2161 gggccagttc aacattccag aaactctgtc tcccaaggcc aagtgcctca tccgaagcat
     2221 cctgcgacgg gagccgtcag agcggctgac ctcgcaggaa attctggacc atccttggtt
     2281 ttctacagat tttagtgtct caaattcggg atttggtgct aaagaggcgt gtgaccagct
     2341 ggtgccagac gtcaacatgg aggagaactt ggaccctttc tttaactgag ctcaaggccc
     2401 agggacacat agcaggtacc aggagcaaga gagagcccca gaaaggagtt ctgggacaca
     2461 ggtggcctgg ctgagaagca agacggacat tcatatttac acatttcttg gttcagagaa
     2521 ggaatatgtt ctaggagctg acggaacacg tagcatggga acaagacgtg tgggatgggg
     2581 gttgggttca gatggacggg agcccctccc ctaagcttct cttccctggg gtagcctgag
     2641 agtccccctt accagtaggg ctattctacc ccacttttca ttttgttcag aaatagttgc
     2701 agatctcgat agaatccaaa ctcttctgcc tcaaacacct accttggcat tgcactgtta
     2761 gcatttaact tcttgttacg attcagggaa gggacaattg atcgaagatt tttttttttt
     2821 ttttggaaca gaccaaccac ctatgtaata attaataaga ttcacctaaa aataataata
     2881 attcggtgca cacagactga cctgaaacct gggtgctaaa ctaaaagaaa acaaaagttc
     2941 cagttgtcgt ctctcattcg cactttccaa ttcatttctt ctaaataaac gatgtcctat
     3001 tctggttagg aagtaacaca ttaacgcttt gctccctgaa cggggagggg gagtctgttc
     3061 ctccacagac atttctgttt tgtatcagct ggtttttgta gcaggaaact atcagaagtc
     3121 aaacttccag atgtattatc acagttcagg ggaagaagaa aggaaaagaa gaaaaatcca
     3181 actcctttct ggtttttgtt cttttgaagg aagagggttc acattgtaga cattgctctc
     3241 tgctccaaat tcagtgaggg gctcccagag ggcaggcgcc tcctggagtc agatcttttt
     3301 gatgatgctg atctcaacgt tttgtttttg ctttatggga aactagtaaa acgagacagg
     3361 ttgtcccatg tgtataaaat acagggcagc tatttccttt tctttgctaa gaatgatcct
     3421 ttgggcttgg aaaggccctc tggtttgaac agaaagagta aacgggcaat aagccaaaag
     3481 ccaggatgat atacatacaa acagctctct gtcccaatac gcaccttgta tttattaagg
     3541 aaaatgtcac attgtgatgt attaagccag tacttcaatt acgggtcaac gggatgacat
     3601 gttacatgct gtagtttaac atttataatt ttgttcccct gttttgagta tttctgtccc
     3661 tggaataacc ttttatttgg ctttctctag atagccttat ttgattttga gtggcaaaat
     3721 gtttttcctt ttgtactctg gcttttctat tgctgtatga tacagaactc ttttggcata
     3781 aatatttgtg ttcccagtac ctcagtcgtt tgggttttcc tgcctgcatc tgttttgtga
     3841 aatggtcctg tttttgggta ggtgacacgt ggactctagt gtgtaaatgt tacttgaatc
     3901 tgtgcttcac tctagtatgt ggcatgtgtg tgcggactct tggatgcttc acgcctactc
     3961 cactggagcc cctgtcccca ggaggacagc ttccccactg ataatcagga gaccaagctg
     4021 ccatggattt acccttgatt ctattttgat aatggaagat acagagagag ggtttttaca
     4081 ttcagaagat ggtgctgtgg caagaaggac cttttatctt ccctctcccc tgtttttaaa
     4141 gtcctcggtg ggaggaaaga ttggaaacat gcatgatggg gactaatggc ctctggtgct
     4201 ttgtcctgta tttggtttaa tgtttttgtc ctaatctctt caatcaataa aattgtgcgt
     4261 atttaactaa aa
//
