LOCUS       NM_144549               4026 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus tribbles pseudokinase 1 (Trib1), mRNA.
ACCESSION   NM_144549
VERSION     NM_144549.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4026)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4026)
  AUTHORS   McClory,S.E., Bardhan,O., Rome,K.S., Giles,J.R., Baxter,A.E.,
            Xu,L., Gimotty,P.A., Faryabi,R.B., Wherry,E.J., Pear,W.S. and
            Jordan,M.S.
  TITLE     The pseudokinase Trib1 regulates the transition of exhausted T
            cells to a KLR+ CD8+ effector state, and its deletion improves
            checkpoint blockade
  JOURNAL   Cell Rep 42 (8), 112905 (2023)
   PUBMED   37527035
  REMARK    GeneRIF: The pseudokinase Trib1 regulates the transition of
            exhausted T cells to a KLR[+] CD8[+] effector state, and its
            deletion improves checkpoint blockade.
REFERENCE   3  (bases 1 to 4026)
  AUTHORS   Sun,X., Wang,S., Miao,X., Zeng,S., Guo,Y., Zhou,A., Chen,Y.,
            Chen,Y., Lv,F., Fan,Z., Wang,Y., Xu,Y. and Li,Z.
  TITLE     TRIB1 regulates liver regeneration by antagonizing the
            NRF2-mediated antioxidant response
  JOURNAL   Cell Death Dis 14 (6), 372 (2023)
   PUBMED   37355685
  REMARK    GeneRIF: TRIB1 regulates liver regeneration by antagonizing the
            NRF2-mediated antioxidant response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4026)
  AUTHORS   Arndt,L., Hernandez-Resendiz,I., Moos,D., Dokas,J., Muller,S.,
            Jeromin,F., Wagner,R., Ceglarek,U., Heid,I.M., Horing,M.,
            Liebisch,G., Stadler,S.C. and Burkhardt,R.
  TITLE     Trib1 Deficiency Promotes Hyperlipidemia, Inflammation, and
            Atherosclerosis in LDL Receptor Knockout Mice
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (6), 979-994 (2023)
   PUBMED   37078290
  REMARK    GeneRIF: Trib1 Deficiency Promotes Hyperlipidemia, Inflammation,
            and Atherosclerosis in LDL Receptor Knockout Mice.
REFERENCE   5  (bases 1 to 4026)
  AUTHORS   Chen,Q., Song,Y., Yang,N., Ai,X., Pu,L. and Kong,L.
  TITLE     Aging deteriorated liver Ischemia and reperfusion injury by
            suppressing Tribble's proteins 1 mediated macrophage polarization
  JOURNAL   Bioengineered 13 (6), 14519-14533 (2022)
   PUBMED   36694470
  REMARK    GeneRIF: Aging deteriorated liver Ischemia and reperfusion injury
            by suppressing Tribble's proteins 1 mediated macrophage
            polarization.
REFERENCE   6  (bases 1 to 4026)
  AUTHORS   Dedhia,P.H., Keeshan,K., Uljon,S., Xu,L., Vega,M.E., Shestova,O.,
            Zaks-Zilberman,M., Romany,C., Blacklow,S.C. and Pear,W.S.
  TITLE     Differential ability of Tribbles family members to promote
            degradation of C/EBPalpha and induce acute myelogenous leukemia
  JOURNAL   Blood 116 (8), 1321-1328 (2010)
   PUBMED   20410507
  REMARK    GeneRIF: Trib1 transduced hematopoietic stem cells developed acute
            myeloid leukemia.
REFERENCE   7  (bases 1 to 4026)
  AUTHORS   Takasato,M., Kobayashi,C., Okabayashi,K., Kiyonari,H., Oshima,N.,
            Asashima,M. and Nishinakamura,R.
  TITLE     Trb2, a mouse homolog of tribbles, is dispensable for kidney and
            mouse development
  JOURNAL   Biochem Biophys Res Commun 373 (4), 648-652 (2008)
   PUBMED   18593568
REFERENCE   8  (bases 1 to 4026)
  AUTHORS   Yamamoto,M., Uematsu,S., Okamoto,T., Matsuura,Y., Sato,S.,
            Kumar,H., Satoh,T., Saitoh,T., Takeda,K., Ishii,K.J., Takeuchi,O.,
            Kawai,T. and Akira,S.
  TITLE     Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1
            deficiency
  JOURNAL   J Exp Med 204 (9), 2233-2239 (2007)
   PUBMED   17724128
  REMARK    GeneRIF: These results demonstrate that Trib1 is a negative
            regulator of NF-IL6 protein expression and modulates
            NF-IL6-dependent gene expression in toll-like receptors-mediated
            signaling.
REFERENCE   9  (bases 1 to 4026)
  AUTHORS   Naiki,T., Saijou,E., Miyaoka,Y., Sekine,K. and Miyajima,A.
  TITLE     TRB2, a mouse Tribbles ortholog, suppresses adipocyte
            differentiation by inhibiting AKT and C/EBPbeta
  JOURNAL   J Biol Chem 282 (33), 24075-24082 (2007)
   PUBMED   17576771
  REMARK    GeneRIF: describe suppression of adipocyte differentiation by TRBs
            Trib1, Trib2, Trib3
REFERENCE   10 (bases 1 to 4026)
  AUTHORS   Kiss-Toth,E., Bagstaff,S.M., Sung,H.Y., Jozsa,V., Dempsey,C.,
            Caunt,J.C., Oxley,K.M., Wyllie,D.H., Polgar,T., Harte,M.,
            O'neill,L.A., Qwarnstrom,E.E. and Dower,S.K.
  TITLE     Human tribbles, a protein family controlling mitogen-activated
            protein kinase cascades
  JOURNAL   J Biol Chem 279 (41), 42703-42708 (2004)
   PUBMED   15299019
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161172.4.
            
            On May 1, 2007 this sequence version replaced NM_144549.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028626.1, AK162876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-869               AC161172.4         87740-88608         c
            870-1162            AC161172.4         85491-85783         c
            1163-4026           AC161172.4         80163-83026         c
FEATURES             Location/Qualifiers
     source          1..4026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 25.41 cM"
     gene            1..4026
                     /gene="Trib1"
                     /gene_synonym="A530090O15Rik; TRB-1; Trb1"
                     /note="tribbles pseudokinase 1"
                     /db_xref="GeneID:211770"
                     /db_xref="MGI:MGI:2443397"
     exon            1..869
                     /gene="Trib1"
                     /gene_synonym="A530090O15Rik; TRB-1; Trb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             510..1628
                     /gene="Trib1"
                     /gene_synonym="A530090O15Rik; TRB-1; Trb1"
                     /codon_start=1
                     /product="tribbles homolog 1"
                     /protein_id="NP_653132.1"
                     /db_xref="CCDS:CCDS27499.1"
                     /db_xref="GeneID:211770"
                     /db_xref="MGI:MGI:2443397"
                     /translation="MRVGPVRFALSGASQPRGPGLLFPAARGTPAKRLLDTDDAGAVA
                     AKCPRLSECSSPPDYLSPPGSPCSPQPPPSTQGTGGSCVSSPGPSRIADYLLLPLAER
                     EHVSRALCIHTGRELRCKEFPIKHYQDKIRPYIQLPSHSNITGIVEVLLGESKAYVFF
                     EKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEER
                     TQLRLESLEDTHIIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT
                     LLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPQILL
                     HPWFEYVLEPGYVDSEIGTSDQIVPEYQEDSDISSFFC"
     exon            870..1162
                     /gene="Trib1"
                     /gene_synonym="A530090O15Rik; TRB-1; Trb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..4026
                     /gene="Trib1"
                     /gene_synonym="A530090O15Rik; TRB-1; Trb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3454..3459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trib1"
                     /gene_synonym="A530090O15Rik; TRB-1; Trb1"
                     /note="hexamer: AATAAA"
     polyA_site      3477
                     /gene="Trib1"
                     /gene_synonym="A530090O15Rik; TRB-1; Trb1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggcac acacactcat agtcggtcac tctctctctc tctcctggag cgcgtctcgc
       61 tcgctcacac gcctggagcc caggagcgcg caggattccg agcggcgcgg aaaagttgta
      121 ccggctttta cgccagacta attgctttgg gaagtgcgtt tgctcggaga agccgaggag
      181 cctgtggaat cctgtcctcg aggctcaaca cccgggaact cgggccgtct ccacgtcccg
      241 gactatccac agcctcggca acaatagcgg cggccaccgc caacgaggcg cccagacctg
      301 gtgcctgtgg gggtctggag accttagccg gcctcccacc cttggacgcg tggccaacgt
      361 ggttctggtg gacaacgcca gcgtcctgga acggctcctc ttggggaccg atccaagctc
      421 tatctgcaaa ctccatcccg ccgactggaa gaagtcacag cgcagatcca gggatttaca
      481 aagccggggc cgctccggcc agggccgcga tgcgggtcgg tcccgtgcgt tttgccctga
      541 gcggcgcctc gcagccccgc ggtccgggtc tactgtttcc ggctgcccgg ggaaccccgg
      601 ccaaacgcct gctggacacg gacgacgcgg gggcagtggc ggccaagtgt ccgcgcctct
      661 ctgagtgctc gagtcccccc gactacctca gtccccctgg ctcgccctgc agccctcagc
      721 ctccgccctc cacgcagggg accggcggca gctgtgtgag ctcacccggg cccagccgaa
      781 tcgccgacta cctgctgcta cccctagctg agcgcgagca tgtgtcccgg gcactgtgca
      841 tccacaccgg ccgcgagctg cgctgcaagg aattccccat taaacactac caggacaaaa
      901 tcaggcctta catccagctg ccgtcccata gcaacatcac tggcattgtg gaggtgctcc
      961 ttggtgagag caaggcctac gtcttcttcg agaaggactt tggagacatg cactcctatg
     1021 tgcggagccg aaaacggctt cgggaagagg aggccgctcg gctcttcaag cagattgttt
     1081 ccgccgtcgc ccactgccac cagtcggcca tcgtgctggg ggacctgaag ctcaggaagt
     1141 tcgtcttctc caccgaggag agaacccagc ttagactgga aagcctggaa gatactcaca
     1201 tcattaaggg tgaagatgat gcgctgtcag ataaacatgg ctgcccagcc tacgtgagcc
     1261 ccgagatcct caacactact gggacctact ctggaaaggc ggcggacgtc tggagcctcg
     1321 gggtgatgct ctatacgctt ttggtcggac gatacccctt tcatgactca gatccgagtg
     1381 cccttttttc caaaatccgc cgtggacagt tctgcattcc tgagcacgtc tcccccaaag
     1441 ccaggtgcct catccgaagc ctcctaagac gagaaccttc tgagagactc acagctcctc
     1501 agatcttact ccatccctgg ttcgagtatg tcttggaacc gggctatgtt gactcagaaa
     1561 taggaacttc agaccagatt gttcctgagt accaggagga cagtgacata agttccttct
     1621 tctgctagtc ccccccaaaa aacctcagaa acctcataat tctcacacat ggcatttcta
     1681 atgacaggca ggccctcttc catggtgccg gccagatttg gggacggagc accattgtcc
     1741 ctgtggggct caatgtggtg tcgcctctct gggctgagtg acttgatttg accagcatgc
     1801 actcagatta gctgctcgac agaggtgtcc ccttttcaat gaaccatcat gactgtccca
     1861 gtgtcggatg caagggtgcc acgggctctg aagctaacgg gcatcccacg cggtcaggtg
     1921 tagtagtgaa cttgaacatt tgaatgggaa ggaagcactt cgcacaatgg catttgaaca
     1981 aggtggcaat cggttggagt aacaaactcc cccttgctgc tgcagtttct cctaccagaa
     2041 gtttttcttt tcttttttta acccttactc tccctgcaga ctcaaccatg actgttctgc
     2101 gttggaacag atggagtgag aaaccctaca gcctgcccga acccagactc tcccccaaag
     2161 ccaagacctc ctatgcaata atgcccccct ccaaccccac ccaccccacc ttgggaccta
     2221 tcccctgcag ctatgaaagc agtcaccagc taattgtgga aaagtatcag gagattcaaa
     2281 ttcttggctg tttcagaact cttgagctca gtcaggcagg gatgttttta aagaaatgaa
     2341 tttgatcatg tggaatctgt tagctcttaa ggctctcctc gaatatggca gcatttggcc
     2401 gccactccct acgcccacca ttaggaccat ctctgggtgg aacattttgt gtgtgcagac
     2461 aagggtgagg agactcgcca gcctgctctc tcaggagcac gtgtgaaccg tcttcgtgct
     2521 tcagcgaaag cgagtttgag gcagtcttgc aagattctca gactaatttc caaaaggaaa
     2581 ccggatgcca acttcccacg ggtttactgt gcctctggca tccagggtct tcagtttccc
     2641 gtgcttggct ctttggggtt catgtgtcat gttgcttatg accctatctg tgaagccggc
     2701 tctggagtga cagagagaac ctcaaaaatg tagctggaaa ggactttaaa actcatccaa
     2761 tgcagagtct cgctcctagc tgcctacccg agatcccttg cttcaacctc cccaggtggg
     2821 ggacctggcc tctgcctaaa tgcttctgga gacggaaaca tattccctac agggaatgaa
     2881 gcttctcaga gaaactgccg aaagttgcat taaaaaaaat aaaaagtaca gaagaaatag
     2941 ttgccactgt ctaggacagt gctgaagcta ggtggttaaa cgggtaacag aaatactgta
     3001 ttgtgagaaa tgacacaaca aaagccggca ggcatcttta agggctatgc ctagggagac
     3061 tactaacatg gagagaatgc cgtgtatacc tcacgtactg tgtgctttat atttgtatat
     3121 acattttacc ttttatacag atgtccgatt gttgtcattt ggctctgcag cttgttttgt
     3181 cgtctgtgtc tgtctgagga acctgtgtgt ccagagccac atgaaatgtg aatgattgtt
     3241 ggcaatataa tcttgagagg ctggtgggac ttggggaagg agcagggaca gacatctgtt
     3301 ggtattgccc agctcctgta tctgtgatac attccctggc tgaggactcg gggctggcct
     3361 gggcatttgc ctggactgct ggaaacacta ggtctcctgt gcgtgtgtgg aaaggtaata
     3421 gtggcacaat gttgctaact ttagacaact tttaataaat atggtttcgt aaagaaatac
     3481 agtgagtttc ctttgtgtgc acgctgcctt cctgtgactg tccctggcta cagtgagata
     3541 ccctttgact ttctggctgc attggctcaa ggacacaata gagtcagaca ggtggttggc
     3601 tactttattt tttttcgttt tatatagtcc tgcttagcat taaatcgcta tgtagaccag
     3661 gccggtcttg aactcacaga ggtctttgtg cctctggaat taaaggcatg agtgattatg
     3721 cctgcctgga atctgccctt ttttgtgtgt gtctgaacat gtgttcttta atgggcaagg
     3781 ctcatatgca gaatgaggtg ggtgggtggg tgctgtggtc tgggttggaa gcattggagg
     3841 gcagtgtaac atggattttt gagtttaaga gttgaagaat tggctgcctt ttgacaggct
     3901 tggatggttc acccctgcct tggctttctg atactgtgga agctgagaca ggtacatcaa
     3961 gagttcaaga ccagcttggg ctatatagca agtctgtttc aaaaacaata aaatgaattc
     4021 tctggc
//
