LOCUS       NM_133202               2101 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus thyrotropin releasing hormone receptor 2 (Trhr2),
            mRNA.
ACCESSION   NM_133202 XM_011248319
VERSION     NM_133202.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Muller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V,
            Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S and
            Schwaninger M.
  TITLE     Tanycytes control the hormonal output of the
            hypothalamic-pituitary-thyroid axis
  JOURNAL   Nat Commun 8 (1), 484 (2017)
   PUBMED   28883467
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Thirunarayanan N, Nir EA, Raaka BM and Gershengorn MC.
  TITLE     Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2,
            primarily mediates taltirelin actions in the CNS of mice
  JOURNAL   Neuropsychopharmacology 38 (6), 950-956 (2013)
   PUBMED   23303050
  REMARK    GeneRIF: TRH-R2 does not mediate the central nervous system effects
            of taltirelin, but TRH-R1 does.
REFERENCE   3  (bases 1 to 2101)
  AUTHORS   Boutin A, Allen MD, Neumann S and Gershengorn MC.
  TITLE     Persistent signaling by thyrotropin-releasing hormone receptors
            correlates with G-protein and receptor levels
  JOURNAL   FASEB J 26 (8), 3473-3482 (2012)
   PUBMED   22593547
  REMARK    GeneRIF: We suggest that persistent signaling by TRHRs is exhibited
            when sufficient levels of agonist/receptor/G-protein complexes are
            established and maintained and that TRH-R2 forms and maintains
            these complexes more efficiently than TRH-R1.
REFERENCE   4  (bases 1 to 2101)
  AUTHORS   Sun Y, Zupan B, Raaka BM, Toth M and Gershengorn MC.
  TITLE     TRH-receptor-type-2-deficient mice are euthyroid and exhibit
            increased depression and reduced anxiety phenotypes
  JOURNAL   Neuropsychopharmacology 34 (6), 1601-1608 (2009)
   PUBMED   19078951
  REMARK    GeneRIF: data provide the first evidence for the involvement of the
            TRH/TRH-R system, specifically extrahypothalamic TRH/TRH-R2, in
            regulating mood and affect
REFERENCE   5  (bases 1 to 2101)
  AUTHORS   McKnight KD, Hou J and Hoodless PA.
  TITLE     Dynamic expression of thyrotropin-releasing hormone in the mouse
            definitive endoderm
  JOURNAL   Dev Dyn 236 (10), 2909-2917 (2007)
   PUBMED   17849455
REFERENCE   6  (bases 1 to 2101)
  AUTHORS   Harder S, Lu X, Wang W, Buck F, Gershengorn MC and Bruhn TO.
  TITLE     Regulator of G protein signaling 4 suppresses basal and thyrotropin
            releasing-hormone (TRH)-stimulated signaling by two mouse TRH
            receptors, TRH-R(1) and TRH-R(2)
  JOURNAL   Endocrinology 142 (3), 1188-1194 (2001)
   PUBMED   11181534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591003.16.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_133202.4.
            
            On or before Oct 25, 2017 this sequence version replaced
            XM_011248319.2, NM_133202.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.34874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL591003.16        130658-130685       c
            29-1167             AL591003.16        128198-129336       c
            1168-1561           AL591003.16        126348-126741       c
            1562-2101           AL591003.16        124824-125363       c
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.95 cM"
     gene            1..2101
                     /gene="Trhr2"
                     /gene_synonym="TRH-R2"
                     /note="thyrotropin releasing hormone receptor 2"
                     /db_xref="GeneID:170732"
                     /db_xref="MGI:MGI:2177284"
     exon            1..28
                     /gene="Trhr2"
                     /gene_synonym="TRH-R2"
                     /inference="alignment:Splign:2.1.0"
     exon            29..1167
                     /gene="Trhr2"
                     /gene_synonym="TRH-R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             809..1957
                     /gene="Trhr2"
                     /gene_synonym="TRH-R2"
                     /codon_start=1
                     /product="thyrotropin releasing hormone receptor 2"
                     /protein_id="NP_573465.1"
                     /db_xref="CCDS:CCDS22734.1"
                     /db_xref="GeneID:170732"
                     /db_xref="MGI:MGI:2177284"
                     /translation="MDGPSNVSLVHGDTTLGLPEYKVVSVLLVLLVCTVGIVGNAMVV
                     LVVLTSRDMHTPTNCYLVSLALADLIVLLAAGLPNVSDSLVGHWIYGHAGCLGITYFQ
                     YLGINVSSCSILAFTVERYIAICHPMRAQTVCTVARARRIIAGIWGVTSLYCLLWFFL
                     VDLNVRDNQRLECGYKVSRGLYLPIYLLDFAVFFIAPLLGTLVLYGFIGRILFQSPLS
                     QEAWQKERQSHGQSEGTPGNCSRSKSSMSSRKQATRMLAVIVLLFAVLWTPYRTLVLL
                     NSFLARPFLDPWVLLFCRTCVYTNSAINPVIYSLMSQKFRAAFLKLCWCRAAGSQRRA
                     ACAPTSNYSAAQETSLGTEKMQLGSREVSGPAAAASLRCQHEPHFSVL"
     exon            1168..1561
                     /gene="Trhr2"
                     /gene_synonym="TRH-R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..2101
                     /gene="Trhr2"
                     /gene_synonym="TRH-R2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggaaaat gcattgagtc ttcactagcc atcgccagga agctggtact ctgtggatct
       61 cagaacacac acccatctcc tcgtggttca tctgagtcta ctgggtcttg agcctcagac
      121 acttgcaggt gaacagaaga ttcagagtcc acgaggctca gggcctggct ctgttgctct
      181 gggcttcagg cttggcagct gagccctccc accctcagct gtgggctggg accatatcat
      241 gcactttgta ctatcatagg actgctgcgg cagctgctgt cccaagaacc atccatgccc
      301 ctgtgctgtt ggctgctcta tttccaccct tagccctgac tctagagccc tcctcgaagc
      361 ctgctgttct gcacctcagt ggagggtcca cagggcttta aactacagct tctcaactct
      421 caaatatgca tccacctgat ttctacgctg actcctttct tggccttcct atctgagccc
      481 tgtcccagca tcccccatgc cctatagact gccctgatgg catctccagc tgctcttcca
      541 gaggacctgg gttcaattcc cagcacctat atgacaactt acttatagat tggagtctgt
      601 aactccaatc cagggaatgc catctgatgc catcttttgg ccttcccagg cactaggtac
      661 acacacgata cacagacata cattcagtta aaatgcccat gcacataaaa ataaataaat
      721 aaaaaggaaa taattaaata ataaagaaca ggcacaggtc acttaccaag gtcaaggccg
      781 gcagggcatc acagaagacg ccagcaagat ggatggtccc agcaatgtct cactcgttca
      841 cggtgacacc acactgggcc tcccagagta caaagtagtc tcggtcctcc tggtcctcct
      901 ggtgtgcacc gtgggcatcg tgggcaatgc catggtggtc ctggtggtgc tgacctcacg
      961 tgacatgcac acacccacca actgctacct ggtcagcctg gctctcgctg acctcattgt
     1021 gctgctggct gcggggctgc ccaatgtctc tgacagcctg gtggggcact ggatctatgg
     1081 acatgctggc tgcttgggca tcacctactt ccagtaccta ggcatcaatg tctcctcctg
     1141 ctccatcctg gccttcactg tggagaggta catcgccatt tgccacccaa tgagagcaca
     1201 gaccgtgtgc actgtggccc gggccagacg gatcatcgca ggcatttggg gggtcacgtc
     1261 cctctattgc ttactctggt tctttctggt ggacctcaat gtccgtgaca accagcgcct
     1321 ggaatgtggc tacaaggtgt cccgaggcct ctacctgccc atctacctgc tggactttgc
     1381 tgtcttcttc attgcaccct tgctggggac cctcgtgctc tatgggttca ttggaaggat
     1441 cttatttcag agcccattgt cccaggaggc ctggcagaag gagaggcagt cccatgggca
     1501 gagcgagggt acaccaggca actgctctag gtccaagagc tcaatgtcct ccaggaagca
     1561 ggccaccagg atgctggccg tgattgtgtt gctctttgca gtgctctgga ccccctaccg
     1621 cacactggtg ctgctcaact ccttcctggc ccggcctttc ctggacccct gggtcctgct
     1681 gttctgccgc acctgcgtct acaccaacag tgccatcaac cctgtcatct acagcctcat
     1741 gtcgcagaaa ttccgggcag ccttcctgaa actgtgctgg tgccgggcag ctgggtccca
     1801 gagacgtgca gcatgcgccc ccaccagcaa ctacagtgct gcccaggaga cctccctagg
     1861 aactgagaag atgcaactgg gctcccgtga ggtctcaggt ccagcagcag ctgcttccct
     1921 gcgttgccag catgagcccc acttcagtgt gctctgagga ctcctgcctg gcccctgact
     1981 ccactcccct ggttggcatc tgttctgagc actggcgggc catcaggaga ggggcaggca
     2041 gctccttgct tctgggtctc cagagattcc tttaccatga agaaggacac tcgaacgctc
     2101 t
//
