LOCUS       NM_013696               3976 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus thyrotropin releasing hormone receptor (Trhr), mRNA.
ACCESSION   NM_013696
VERSION     NM_013696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3976)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   2  (bases 1 to 3976)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3976)
  AUTHORS   Kwon,J.T., Ryu,C., Lee,H., Sheffield,A., Fan,J., Cho,D.H.,
            Bigler,S., Sullivan,H.A., Choe,H.K., Wickersham,I.R., Heiman,M. and
            Choi,G.B.
  TITLE     An amygdala circuit that suppresses social engagement
  JOURNAL   Nature 593 (7857), 114-118 (2021)
   PUBMED   33790466
REFERENCE   4  (bases 1 to 3976)
  AUTHORS   Rattner,A., Terrillion,C.E., Jou,C., Kleven,T., Hu,S.F.,
            Williams,J., Hou,Z., Aggarwal,M., Mori,S., Shin,G., Goff,L.A.,
            Witter,M.P., Pletnikov,M., Fenton,A.A. and Nathans,J.
  TITLE     Developmental, cellular, and behavioral phenotypes in a mouse model
            of congenital hypoplasia of the dentate gyrus
  JOURNAL   Elife 9, e62766 (2020)
   PUBMED   33084572
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3976)
  AUTHORS   Seifinejad,A., Li,S., Mikhail,C., Vassalli,A., Pradervand,S.,
            Arribat,Y., Pezeshgi Modarres,H., Allen,B., John,R.M., Amati,F. and
            Tafti,M.
  TITLE     Molecular codes and in vitro generation of hypocretin and melanin
            concentrating hormone neurons
  JOURNAL   Proc Natl Acad Sci U S A 116 (34), 17061-17070 (2019)
   PUBMED   31375626
REFERENCE   6  (bases 1 to 3976)
  AUTHORS   Duthie,S.M., Taylor,P.L. and Eidne,K.A.
  TITLE     Characterization of the mouse thyrotrophin-releasing hormone
            receptor gene: an exon corresponds to a deletion in the rat cDNA
  JOURNAL   J Mol Endocrinol 11 (2), 141-149 (1993)
   PUBMED   8297470
REFERENCE   7  (bases 1 to 3976)
  AUTHORS   Duthie,S.M., Taylor,P.L., Anderson,L., Cook,J. and Eidne,K.A.
  TITLE     Cloning and functional characterisation of the human TRH receptor
  JOURNAL   Mol Cell Endocrinol 95 (1-2), R11-R15 (1993)
   PUBMED   8243797
REFERENCE   8  (bases 1 to 3976)
  AUTHORS   Lossie,A.C., Gordon,D.F. and Camper,S.A.
  TITLE     Localization of thyrotropin-releasing hormone receptor and
            thyrotroph embryonic factor on mouse chromosome 15
  JOURNAL   Mamm Genome 4 (10), 621-623 (1993)
   PUBMED   7903570
REFERENCE   9  (bases 1 to 3976)
  AUTHORS   Narayanan,C.S., Fujimoto,J., Geras-Raaka,E. and Gershengorn,M.C.
  TITLE     Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor
            mRNA degradation in rat pituitary GH3 cells
  JOURNAL   J Biol Chem 267 (24), 17296-17303 (1992)
   PUBMED   1324930
REFERENCE   10 (bases 1 to 3976)
  AUTHORS   Straub,R.E., Frech,G.C., Joho,R.H. and Gershengorn,M.C.
  TITLE     Expression cloning of a cDNA encoding the mouse pituitary
            thyrotropin-releasing hormone receptor
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9514-9518 (1990)
   PUBMED   2175902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB653069.1, BC128269.1 and AC132870.10.
            
            On Mar 22, 2007 this sequence version replaced NM_013696.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by mRNA and EST alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.70069.1, BC109005.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               BB653069.1         2-582
            582-1889            BC128269.1         467-1774
            1890-3976           AC132870.10        18193-20279         c
FEATURES             Location/Qualifiers
     source          1..3976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.82 cM"
     gene            1..3976
                     /gene="Trhr"
                     /gene_synonym="TRH-R1"
                     /note="thyrotropin releasing hormone receptor"
                     /db_xref="GeneID:22045"
                     /db_xref="MGI:MGI:98824"
     exon            1..254
                     /gene="Trhr"
                     /gene_synonym="TRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..1138
                     /gene="Trhr"
                     /gene_synonym="TRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1525
                     /gene="Trhr"
                     /gene_synonym="TRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..3976
                     /gene="Trhr"
                     /gene_synonym="TRH-R1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3960..3965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trhr"
                     /gene_synonym="TRH-R1"
     polyA_site      3976
                     /gene="Trhr"
                     /gene_synonym="TRH-R1"
ORIGIN      
        1 attaagggac gatctatggt ttgacagcct cggtgctgcg cctgctgctg cttcagttac
       61 tgcggctgtg tggtctgtca tgagttgaaa agggatgtga gggtttagag gaactgccgc
      121 tctgaagact gagcctctgc taagtgatct tcctgccaga cagactggac aagatttctt
      181 ctgcacgatt ggaaacttgg acctattagc acttcatcta cacagagaaa caggcagcgt
      241 gacagagtga agaggggaaa gaactactgc aaaaacaaac agacagaaag gtgaaggctg
      301 gaaagatgtt ttagagtccc cgtgtcagag aagcttcaag ccactgaaga tggagaatga
      361 tactgtcagt gaaatgaacc aaaccgagct ccagccacaa gcagctgtgg ccctcgagta
      421 ccaggtggtt accatcttac ttgtggtcat tatttgtgga ctgggcattg tgggcaacat
      481 catggtagtc ctggtggtca tgagaacaaa gcacatgaga acccctacaa actgttacct
      541 ggtaagtctg gctgtggcag atctcatggt tctggtggct gcaggcctcc ccaacataac
      601 cgacagtatc tatggttcct gggtctatgg ctatgttggc tgcctctgca ttacatatct
      661 ccagtaccta ggcattaatg catcttcatg ttcaataacg gcctttacca ttgaaaggta
      721 catagcaatc tgtcacccca tcaaagccca gtttctctgc acgttttcca gagccaaaaa
      781 aatcatcatc tttgtctggg ccttcacatc catttactgt atgctctggt tcttcctgct
      841 ggatctcaac atcagcacct acaaaaacgc tgttgtggtt tcctgtggct acaagatctc
      901 caggaactac tactcaccta tttacctaat ggactttggt gtcttttatg ttgtgccaat
      961 gatcctggcc actgtgcttt atggatttat agctagaatc ctcttcttaa accccattcc
     1021 ttcagaccct aaagaaaact ctaagatgtg gaaaaatgac tcaatccatc agaacaagaa
     1081 tttgaattta aatgccacca acagatgctt caacagcact gtatcttcca ggaagcaggt
     1141 caccaagatg ctcgcagtgg ttgtaattct gtttgccctt ttatggatgc cctacaggac
     1201 tcttgtggtt gtcaactcat ttctctccag ccctttccag gaaaattggt tcttgctctt
     1261 ttgcagaatt tgcatttatc tcaacagtgc catcaaccca gtgatttaca acctcatgtc
     1321 tcagaaattt cgtgcagcct tcaggaagct ctgcaattgc aagcagaagc ccacagaaaa
     1381 agctgctaac tacagtgtgg ccctaaatta cagtgtcatc aaggagtcag accgcttcag
     1441 cacagagcta gaagatatca ccgtcaccga tacgtatgtg tcaaccacaa aagtgtcctt
     1501 tgatgacacc tgcttggcct ctgagaacta aagaaggcca taaagaaccc tataatgttc
     1561 ttcatgtata tttatttcat aattatgatc tcaaataatt cagcaacaga tgtcttcagg
     1621 caagttacat actgggaagc agttcactat taagattttc agcaacttac ggactacatc
     1681 aagtgacaag tttaacctat ggtgtgctta attcaaaact caaataatct tctttgacaa
     1741 gagtgatcat ggatgtgcgt actcaaagtt gtcatgtcaa aaatatgtaa atagcattct
     1801 tttataccaa gcaaattcat gctaaccaaa taaaatatgt ttatttcata ttttaagaat
     1861 tatacctaga aaactgaaaa aggctgaaat atgtaatacc agttaagatg atacattgtc
     1921 taaaactatc aaatctggat gtagcaagac aagaatttag tgaccaataa accacatagt
     1981 caaataatga ctgtaagcct tgatggaggt tcacactgta gagtctcaac tggaataatg
     2041 ggaatgtgaa gcatattgac agttatgcta agagaatggg gtaatcagta ctgttggcta
     2101 gcatcattgc aagcttgcaa gtgactctct ctttatagaa aaatggactc agttcttgtg
     2161 catatagctt ttctttgact gccaaacaag agcgaatatg aacttcttca agaacatctt
     2221 gaactggtat tactaaaatg aaatcttttt aaaaattcaa tatgactcag aacaggatgg
     2281 tttcaactga ccaaaggtct tccttcagaa gtcagtaaga acatcgtggt actgaaatga
     2341 tacaggatgg tacaataagg aagcaaaatt taatccctag ccatgaggac aagccattct
     2401 tggtttgata tatacaaaaa ttactggcat gtcttttctt aatatgtctc aaaaaattgt
     2461 catttgctgg atgatgctga acacattctg aaaatcaatt tgttctgagc ctctacatat
     2521 atgcttcaag acccttgaat aaccaataac tctaaatagg caaataaaca gaaaacccca
     2581 tgtaggacaa gctcatttca tgtttgtatc ccacaaatta aactaagatg atgagcctga
     2641 cattgacttt ctgttgaatg agtgaatgaa tgaatgaatg aatgaatgaa taagtaaatt
     2701 gatgaatctc caactaagaa atataaccta aaatttttgt gactcctgat tttcccatag
     2761 atttctttac tattataaaa ctttattgtt tttttcatca ttttaaacca ttctcctggc
     2821 tcattaaaat gtactatatt gtgtcagaga gtggtcacaa ctatccctgt gtatatattg
     2881 tgagtgcaaa gttcaatagt actctcacat atctcaccta atttaataat gatcaagatt
     2941 atcacatata ctttcagaga atgacaacat attatcactg acatgtgaat agaatgtgca
     3001 gagtatatga tagagagaga agttgcataa tttcagacta caaacattag aattcctcat
     3061 agggaaaaga atatcagggg gtgatagagt aattagaaca acctgttagg gaagcttgaa
     3121 agttctttta agattagacc tggtttagat agttaggaaa agccaactga tgtaagaaaa
     3181 gaaagatgag gaggtgtagg gtgaaaagaa aaaactccag gtgttatggg tatgtgtcca
     3241 gtacagtgtg attcatcaga gattgattaa cgcaagcaac taggagaaag gaaaggaagg
     3301 gaggtaaagt acttcctagt gcttatattt gatgaggaaa tattcatcca gacacagtaa
     3361 atagatgtgt atattagtaa gctgtcatgt attttctgaa cattgtgaat ttcacttatc
     3421 tataaaaaat atagaatgct atttgtctcc taagtgttat aattctgtaa gtatcctaaa
     3481 gtcataattt tccaagtaaa aactgtgctg tatatgtata tatcttttct atattacatt
     3541 gtcgttgtat atggggcata tttatttatg tatatatgat tcagaggccc ataatagcca
     3601 cgaagttatc cagttatgct aaccatagag atccaagata gctcataggt ccttcataag
     3661 cctaagcatc cgtattaaat gtgaaactga taagcagtga aactccttag cttctaaccc
     3721 cttctacctg ttgacttgca tgttgcttct attgtgctcc tgaatgattg atttcttaca
     3781 acatgcctct gaatggtttg gtttcctttc accagttgta gaaagctgta tgctgactca
     3841 tctcattgct gggagattaa ccattgtgtc cacatgaaca aagaatcttc tttaagaaag
     3901 tgcgatatta tgtgttctct ctgcagtgtg aaactgtttt tgtatgtgta tgtatgagca
     3961 ataaagtatc aaactg
//
