LOCUS       NM_009426               1400 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus thyrotropin releasing hormone (Trh), mRNA.
ACCESSION   NM_009426
VERSION     NM_009426.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Zupancic,M., Keimpema,E., Tretiakov,E.O., Eder,S.J., Lev,I.,
            Englmaier,L., Bhandari,P., Fietz,S.A., Hartig,W., Renaux,E.,
            Villunger,A., Hokfelt,T., Zimmer,M., Clotman,F. and Harkany,T.
  TITLE     Concerted transcriptional regulation of the morphogenesis of
            hypothalamic neurons by ONECUT3
  JOURNAL   Nat Commun 15 (1), 8631 (2024)
   PUBMED   39366958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Grzelka,K., Wilhelms,H., Dodt,S., Dreisow,M.L., Madara,J.C.,
            Walker,S.J., Wu,C., Wang,D., Lowell,B.B. and Fenselau,H.
  TITLE     A synaptic amplifier of hunger for regaining body weight in the
            hypothalamus
  JOURNAL   Cell Metab 35 (5), 770-785 (2023)
   PUBMED   36965483
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Lu,C., Zhang,J., Wang,B., Gao,Q., Ma,K., Pei,S., Li,J. and Cui,S.
  TITLE     Casein kinase 1alpha is required to maintain murine hypothalamic
            pro-opiomelanocortin expression
  JOURNAL   iScience 26 (5), 106670 (2023)
   PUBMED   37168577
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Nillni,E.A.
  TITLE     Regulation of the hypothalamic thyrotropin releasing hormone (TRH)
            neuron by neuronal and peripheral inputs
  JOURNAL   Front Neuroendocrinol 31 (2), 134-156 (2010)
   PUBMED   20074584
  REMARK    Review article
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   O'Leary,R. and O'Connor,B.
  TITLE     Thyrotropin-releasing hormone
  JOURNAL   J Neurochem 65 (3), 953-963 (1995)
   PUBMED   7643125
  REMARK    Review article
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Satoh,T., Yamada,M., Monden,T., Iizuka,M. and Mori,M.
  TITLE     Cloning of the mouse hypothalamic preprothyrotropin-releasing
            hormone (TRH) cDNA and tissue distribution of its mRNA
  JOURNAL   Brain Res Mol Brain Res 14 (1-2), 131-135 (1992)
   PUBMED   1323011
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Foresti,V. and Ferrari,C.
  TITLE     Central hypothyroidism: isolated thyrotropin-releasing hormone
            deficiency or resistance of pituitary thyrotropes?
  JOURNAL   J Endocrinol Invest 8 (6), 577 (1985)
   PUBMED   3938792
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Katakami,H., Kato,Y., Inada,M. and Imura,H.
  TITLE     Hypothalamic hypothyroidism due to isolated thyrotropin-releasing
            hormone (TRH) deficiency
  JOURNAL   J Endocrinol Invest 7 (3), 231-233 (1984)
   PUBMED   6432893
  REMARK    GeneRIF: Reversal of hypothyroidism in female patient after
            treatment with thyrotropin releasing hormone.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC164642.3, AK010666.1,
            CF951860.1 and AI836004.1.
            
            On May 1, 2013 this sequence version replaced NM_009426.2.
            
            Summary: This gene encodes a member of the thyrotropin-releasing
            hormone family. Cleavage of the encoded proprotein releases mature
            thyrotropin-releasing hormone, which is a tripeptide hypothalamic
            regulatory hormone. The mouse proprotein contains five
            thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing
            hormone is involved in the regulation and release of
            thyroid-stimulating hormone, as well as prolactin. Disruption of
            this gene results in hypothyroidism, elevated thyroid-stimulating
            hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053493.1, AK010666.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN01164131,
                                           SAMN01164139 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC164642.3         142359-142360       c
            3-557               AK010666.1         2-556
            558-561             CF951860.1         546-549
            562-1113            AK010666.1         560-1111
            1114-1400           AI836004.1         1-287               c
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 41.03 cM"
     gene            1..1400
                     /gene="Trh"
                     /gene_synonym="Pro-TRH; Trf"
                     /note="thyrotropin releasing hormone"
                     /db_xref="GeneID:22044"
                     /db_xref="MGI:MGI:98823"
     exon            1..103
                     /gene="Trh"
                     /gene_synonym="Pro-TRH; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            104..319
                     /gene="Trh"
                     /gene_synonym="Pro-TRH; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            320..1384
                     /gene="Trh"
                     /gene_synonym="Pro-TRH; Trf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1365..1370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trh"
                     /gene_synonym="Pro-TRH; Trf"
                     /note="hexamer: AATAAA"
     polyA_site      1384
                     /gene="Trh"
                     /gene_synonym="Pro-TRH; Trf"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagtcga ctctggattc tggagccttg cagactctac ccagccagtt tgcactcttc
       61 ggctcagcat cttggaaagc tctgcagagt ctccaccttg cagactccaa gatgcaggga
      121 ccttggctga tgatggctct ggctttgatc ttcgtgctaa ctggtatccc caaatcctgc
      181 gccttgctgg aagcagccca ggaggaaggt gctgtgactc ctgaccttcc aggcctggag
      241 aaagtccagg tccggccaga acgtcgattc ttgaggaaag acctccagcg tgtgcgaggg
      301 gaccttggtg ctgccttaga ttcctggatc acaaaacgcc agcatccggg caaaagggag
      361 gagaaggagg aagacgttga agccgaagag aggggagatt tgggagaagt gggagcctgg
      421 agaccccaca aacgacagca ccctggccga cgtgccaacc aagacaagga ttcatggtca
      481 gatgaggggg acagtgactg gctgcccccg tcctggctac cagatttctt tctggattcc
      541 tggttctcag atgcccccca agtcaagcgg cagcaccctg gcaggcgatc cttcccctgg
      601 atggagtctg atgtcaccaa gaggcagcat ccaggccgga ggttcataga tcctgagctc
      661 caaagaagct gggaagaaac agagggagag gagggtggct taatgcctga gaaacgtcag
      721 catcctggca aaagggcagt gggtcaccct tgtgggcccc aggggatttg tggccaaaca
      781 ggcctgctcc agcttctagg tgacctgagt aggggccagg agaccctggc aaagcaaacc
      841 ccacaactgg aagcctgggt cagggaacct ctggaggagt aaggttagag tcaggcttta
      901 ggtctaggct gatgtaagcc ctgtgtatcc tatcccagtc ccttcactgg ttttcttctt
      961 agatgctaac cctgggccct ctgtacatag catccaccca aacccctccc ttacccactt
     1021 caggaacttc aaagagccaa tcaggaagtt aaaaccctac ttatcccttc aagcaaggag
     1081 gtgggggccc ctcttctctg acagccccac agtctctcac cccttccaca ctggccaaga
     1141 cggttcttcc acgcctccta agggacctcc tcagaaaggg taggattgaa aagtttgggt
     1201 gttaaaatcc aacttctgtc atctgcccca tatggcaaga ctgacctggt ataacttcag
     1261 cgcatcctcc aaggttgggg gccctaagca gtttggggga tattcagata tgttgggggg
     1321 ggtcacatct tgtatataac cctgctcttg ttaatctcaa tgacaataaa atatatccag
     1381 gtcaaaaaaa aaaaaaaaaa
//
