LOCUS       NM_133977               2332 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transferrin (Trf), mRNA.
ACCESSION   NM_133977
VERSION     NM_133977.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2332)
  AUTHORS   Powers,M., Minchella,D., Gonzalez-Acevedo,M., Escutia-Plaza,D.,
            Wu,J., Heger,C., Milne,G., Aschner,M. and Liu,Z.
  TITLE     Loss of hepatic manganese transporter ZIP8 disrupts serum
            transferrin glycosylation and the glutamate-glutamine cycle
  JOURNAL   J Trace Elem Med Biol 78, 127184 (2023)
   PUBMED   37163821
  REMARK    GeneRIF: Loss of hepatic manganese transporter ZIP8 disrupts serum
            transferrin glycosylation and the glutamate-glutamine cycle.
REFERENCE   3  (bases 1 to 2332)
  AUTHORS   Sukhbaatar,N., Scholler,M., Fritsch,S.D., Linke,M., Horer,S.,
            Trager,M., Mazic,M., Forisch,S., Gonzales,K., Kahler,J.P.,
            Binder,C., Lassnig,C., Strobl,B., Muller,M., Scheiber-Mojdehkar,B.,
            Gundacker,C., Dabsch,S., Kain,R., Hengstschlager,M.,
            Verhelst,S.H.L., Weiss,G., Theurl,I. and Weichhart,T.
  TITLE     Duodenal macrophages control dietary iron absorption via local
            degradation of transferrin
  JOURNAL   Blood 141 (23), 2878-2890 (2023)
   PUBMED   37018657
  REMARK    GeneRIF: Duodenal macrophages control dietary iron absorption via
            local degradation of transferrin.
REFERENCE   4  (bases 1 to 2332)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2332)
  AUTHORS   FitzGerald,F.G., Rodriguez Benavente,M.C., Garcia,C., Rivero,Y.,
            Singh,Y., Wang,H., Fields,G.B. and Cudic,M.
  TITLE     TF-containing MUC1 glycopeptides fail to entice Galectin-1
            recognition of tumor-associated Thomsen-Freidenreich (TF) antigen
            (CD176) in solution
  JOURNAL   Glycoconj J 37 (6), 657-666 (2020)
   PUBMED   33001366
  REMARK    GeneRIF: TF-containing MUC1 glycopeptides fail to entice Galectin-1
            recognition of tumor-associated Thomsen-Freidenreich (TF) antigen
            (CD176) in solution.
REFERENCE   6  (bases 1 to 2332)
  AUTHORS   Simpson,R.J., Cooper,C.E., Raja,K.B., Halliwell,B., Evans,P.J.,
            Aruoma,O.I., Singh,S. and Konijn,A.M.
  TITLE     Non-transferrin-bound iron species in the serum of
            hypotransferrinaemic mice
  JOURNAL   Biochim Biophys Acta 1156 (1), 19-26 (1992)
   PUBMED   1335284
REFERENCE   7  (bases 1 to 2332)
  AUTHORS   Degen,S.J., Gilbert,D.J., Jenkins,N.A. and Copeland,N.G.
  TITLE     Assignment of the gene coding for hepatocyte growth factor-like
            protein to mouse chromosome 9
  JOURNAL   Genomics 13 (4), 1368-1369 (1992)
   PUBMED   1354648
REFERENCE   8  (bases 1 to 2332)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 2332)
  AUTHORS   Groen,A.
  TITLE     Identification and genetic monitoring of mouse inbred strains using
            biochemical polymorphisms
  JOURNAL   Lab Anim 11 (4), 209-214 (1977)
   PUBMED   926748
REFERENCE   10 (bases 1 to 2332)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC156633.2.
            
            On Nov 17, 2006 this sequence version replaced NM_133977.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012313.1, AK168938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC156633.2         166242-166354       c
            114-286             AC156633.2         163964-164136       c
            287-395             AC156633.2         162906-163014       c
            396-572             AC156633.2         162029-162205       c
            573-705             AC156633.2         161111-161243       c
            706-761             AC156633.2         159652-159707       c
            762-940             AC156633.2         159003-159181       c
            941-1118            AC156633.2         158119-158296       c
            1119-1270           AC156633.2         156961-157112       c
            1271-1361           AC156633.2         155870-155960       c
            1362-1394           AC156633.2         155291-155323       c
            1395-1565           AC156633.2         153431-153601       c
            1566-1695           AC156633.2         151882-152011       c
            1696-1760           AC156633.2         151261-151325       c
            1761-1945           AC156633.2         147880-148064       c
            1946-2129           AC156633.2         146563-146746       c
            2130-2332           AC156633.2         144944-145146       c
FEATURES             Location/Qualifiers
     source          1..2332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 55.03 cM"
     gene            1..2332
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /note="transferrin"
                     /db_xref="GeneID:22041"
                     /db_xref="MGI:MGI:98821"
     exon            1..113
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2164
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /note="serotransferrin; siderophilin; beta-1 metal-binding
                     globulin; hypotransferrinemia with hemochromatosis"
                     /codon_start=1
                     /product="serotransferrin precursor"
                     /protein_id="NP_598738.1"
                     /db_xref="CCDS:CCDS23451.1"
                     /db_xref="GeneID:22041"
                     /db_xref="MGI:MGI:98821"
                     /translation="MRLTVGALLACAALGLCLAVPDKTVKWCAVSEHENTKCISFRDH
                     MKTVLPPDGPRLACVKKTSYPDCIKAISASEADAMTLDGGWVYDAGLTPNNLKPVAAE
                     FYGSVEHPQTYYYAVAVVKKGTDFQLNQLEGKKSCHTGLGRSAGWVIPIGLLFCKLSE
                     PRSPLEKAVSSFFSGSCVPCADPVAFPKLCQLCPGCGCSSTQPFFGYVGAFKCLKDGG
                     GDVAFVKHTTIFEVLPEKADRDQYELLCLDNTRKPVDQYEDCYLARIPSHAVVARKNN
                     GKEDLIWEILKVAQEHFGKGKSKDFQLFSSPLGKDLLFKDSAFGLLRVPPRMDYRLYL
                     GHNYVTAIRNQQEGVCPEGSIDNSPVKWCALSHLERTKCDEWSIISEGKIECESAETT
                     EDCIEKIVNGEADAMTLDGGHAYIAGQCGLVPVMAEYYESSNCAIPSQQGIFPKGYYA
                     VAVVKASDTSITWNNLKGKKSCHTGVDRTAGWNIPMGMLYNRINHCKFDEFFSQGCAP
                     GYEKNSTLCDLCIGPLKCAPNNKEEYNGYTGAFRCLVEKGDVAFVKHQTVLDNTEGKN
                     PAEWAKNLKQEDFELLCPDGTRKPVKDFASCHLAQAPNHVVVSRKEKAARVKAVLTSQ
                     ETLFGGSDCTGNFCLFKSTTKDLLFRDDTKCFVKLPEGTTPEKYLGAEYMQSVGNMRK
                     CSTSRLLEACTFHKH"
     exon            114..286
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            287..395
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            396..572
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            573..705
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            706..761
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            762..940
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1118
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1270
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1361
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1394
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1565
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1695
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1760
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1945
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2129
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2332
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /note="hexamer: AATAAA"
     polyA_site      2332
                     /gene="Trf"
                     /gene_synonym="Cd176; HP; hpx; Tf; Tfn"
                     /note="major polyA site"
ORIGIN      
        1 gccacgggca ggcggcgcag aagcgggtcg gtctgtactc cccgctcctc gccacacaca
       61 caccgagagg atgaggctca ccgtgggtgc cctgctggcc tgcgctgccc tggggctgtg
      121 tctggctgtc cctgacaaaa cggtcaaatg gtgcgcagtg tcagagcacg agaataccaa
      181 gtgcatcagc ttccgtgacc acatgaagac cgtccttccg cctgatggcc cccggcttgc
      241 ctgtgtgaag aaaacctcct atccggattg catcaaggcc atttctgcaa gtgaagccga
      301 tgctatgacc ttggatgggg gttgggtgta cgatgccggc ctgactccga acaacctgaa
      361 gcccgtggcg gcggagtttt atggatcagt ggaacatcca cagacctact actacgctgt
      421 ggctgtggta aagaagggaa cagacttcca gctgaaccag ctcgaaggca agaagtcctg
      481 ccacacaggc ctgggaaggt ctgcaggctg ggtcatcccc attggcttgc tcttctgtaa
      541 gctgtcggag ccccgcagtc ctcttgagaa agctgtgtcc agtttcttct cgggcagttg
      601 tgtcccctgt gcagatccag tggccttccc caaactgtgt caactgtgcc caggctgtgg
      661 ctgctcctcc actcaaccat tctttggcta cgtaggcgca ttcaagtgtc tgaaagatgg
      721 cggtggggat gtggcctttg tcaagcacac aaccatattt gaggtcttgc cggagaaggc
      781 tgacagggac caatatgaac tgctctgcct tgacaatacc cgcaagccag tggatcagta
      841 tgaggattgc tacctggctc ggatcccttc tcatgctgtt gtggctcgaa aaaacaatgg
      901 caaggaagac ttgatctggg agattctcaa agtggcacag gaacactttg gcaaaggcaa
      961 atcaaaagac ttccaactgt tcagctctcc tcttgggaaa gacctgctgt ttaaagattc
     1021 tgcctttggg ctgttaaggg tccccccaag gatggactac aggctgtacc ttggccataa
     1081 ctatgtcact gccattcgga atcagcagga aggcgtgtgc ccggagggct cgatcgacaa
     1141 ctcgccagtg aagtggtgtg cactgagtca cctggagaga accaagtgtg acgagtggag
     1201 catcatcagt gagggaaaga tagagtgtga gtcagcagag accactgagg actgcattga
     1261 aaagattgtg aacggagaag cggacgccat gactttggat ggaggacatg cctacattgc
     1321 aggccagtgt ggtctagtgc ctgtcatggc agagtactac gagagctcta attgtgccat
     1381 cccatcacaa caaggtatct ttcctaaagg gtattatgcc gtggctgtgg tgaaggcatc
     1441 ggacactagc atcacctgga acaacctgaa aggcaagaag tcctgccaca ctggggtaga
     1501 cagaaccgct ggttggaaca tccctatggg catgctgtac aacaggatca accactgcaa
     1561 attcgatgaa tttttcagtc aaggctgcgc tcccgggtat gagaagaatt ccaccctctg
     1621 tgacctgtgt attggcccac tcaaatgtgc tccgaacaac aaagaggaat ataatggtta
     1681 cacaggggct ttcaggtgtc tcgttgagaa aggagatgta gcctttgtga aacaccagac
     1741 tgtcctggat aacaccgaag gaaagaaccc tgccgaatgg gctaagaatc tgaagcagga
     1801 agacttcgag ttgctctgcc ctgatggcac caggaagcct gtgaaagatt ttgccagctg
     1861 ccacctggcc caagctccaa accatgttgt ggtctcacga aaagagaagg cagcccgggt
     1921 taaggctgta ctgactagcc aggagacttt atttggggga agtgactgca ccggcaattt
     1981 ctgtttgttc aagtccacca ccaaggacct tctgttcagg gatgacacca aatgtttcgt
     2041 taaacttcca gagggtacca cacctgaaaa atacttagga gcggagtaca tgcaatctgt
     2101 cggtaacatg aggaagtgct caacctcacg actcctggaa gcctgcactt tccacaaaca
     2161 ttaaaatcca agaggtgggt tgccactgtg gtggagacag atgctccctc ccgtggccca
     2221 tgggcttctc ttggtcttca tgccctgagg ggttggggct aactggtgta gtcttcgctg
     2281 ctgtgcctta ccacatacac agagcacaaa ataaaaacga ctgctgactt ta
//
