LOCUS       NM_011907               1034 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus three prime repair exonuclease 2 (Trex2), mRNA.
ACCESSION   NM_011907
VERSION     NM_011907.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1034)
  AUTHORS   Cheng,H.L., Lin,C.T., Huang,K.W., Wang,S., Lin,Y.T., Toh,S.I. and
            Hsiao,Y.Y.
  TITLE     Structural insights into the duplex DNA processing of TREX2
  JOURNAL   Nucleic Acids Res 46 (22), 12166-12176 (2018)
   PUBMED   30357414
  REMARK    GeneRIF: Structural insights into the duplex DNA processing by
            TREX2 have been reported.
REFERENCE   2  (bases 1 to 1034)
  AUTHORS   Manils,J., Fischer,H., Climent,J., Casas,E., Garcia-Martinez,C.,
            Bas,J., Sukseree,S., Vavouri,T., Ciruela,F., de Anta,J.M.,
            Tschachler,E., Eckhart,L. and Soler,C.
  TITLE     Double deficiency of Trex2 and DNase1L2 nucleases leads to
            accumulation of DNA in lingual cornifying keratinocytes without
            activating inflammatory responses
  JOURNAL   Sci Rep 7 (1), 11902 (2017)
   PUBMED   28928425
  REMARK    GeneRIF: This study reports that lack of Trex2 results in the
            accumulation of DNA fragments in the cytoplasm of cornifying
            lingual keratinocytes and co-deletion of DNase1L2 and Trex2 causes
            massive accumulation of DNA fragments throughout the cornified
            layers of the tongue epithelium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1034)
  AUTHORS   Manils,J., Casas,E., Vina-Vilaseca,A., Lopez-Cano,M.,
            Diez-Villanueva,A., Gomez,D., Marruecos,L., Ferran,M., Benito,C.,
            Perrino,F.W., Vavouri,T., de Anta,J.M., Ciruela,F. and Soler,C.
  TITLE     The Exonuclease Trex2 Shapes Psoriatic Phenotype
  JOURNAL   J Invest Dermatol 136 (12), 2345-2355 (2016)
   PUBMED   27365293
  REMARK    GeneRIF: TREX2 acts as a critical factor in the pathogenesis of
            psoriasis.
REFERENCE   4  (bases 1 to 1034)
  AUTHORS   Dumitrache,L.C., Hu,L., Son,M.Y., Li,H., Wesevich,A., Scully,R.,
            Stark,J. and Hasty,P.
  TITLE     Trex2 enables spontaneous sister chromatid exchanges without
            facilitating DNA double-strand break repair
  JOURNAL   Genetics 188 (4), 787-797 (2011)
   PUBMED   21546543
REFERENCE   5  (bases 1 to 1034)
  AUTHORS   Parra,D., Manils,J., Castellana,B., Vina-Vilaseca,A.,
            Moran-Salvador,E., Vazquez-Villoldo,N., Tarancon,G., Borras,M.,
            Sancho,S., Benito,C., Ortega,S. and Soler,C.
  TITLE     Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout
            Mice
  JOURNAL   Cancer Res 69 (16), 6676-6684 (2009)
   PUBMED   19654293
  REMARK    GeneRIF: A tumor suppressor role for TREX2 in skin carcinogenesis
            through which it contributes to keratinocyte apoptosis under
            conditions of genotoxic stress.
REFERENCE   6  (bases 1 to 1034)
  AUTHORS   Dumitrache,L.C., Hu,L. and Hasty,P.
  TITLE     TREX2 exonuclease defective cells exhibit double-strand breaks and
            chromosomal fragments but not Robertsonian translocations
  JOURNAL   Mutat Res 662 (1-2), 84-87 (2009)
   PUBMED   19094998
  REMARK    GeneRIF: Trex2 deletion caused high levels of Robertsonian
            translocations (RbTs) showing Trex2 is important for chromosomal
            maintenance.
REFERENCE   7  (bases 1 to 1034)
  AUTHORS   Davies,W., Isles,A., Smith,R., Karunadasa,D., Burrmann,D.,
            Humby,T., Ojarikre,O., Biggin,C., Skuse,D., Burgoyne,P. and
            Wilkinson,L.
  TITLE     Xlr3b is a new imprinted candidate for X-linked parent-of-origin
            effects on cognitive function in mice
  JOURNAL   Nat Genet 37 (6), 625-629 (2005)
   PUBMED   15908950
REFERENCE   8  (bases 1 to 1034)
  AUTHORS   Schimenti,J.C.
  TITLE     ORFless, intronless, and mutant transcription units in the mouse t
            complex responder (Tcr) locus
  JOURNAL   Mamm Genome 10 (10), 969-976 (1999)
   PUBMED   10501965
REFERENCE   9  (bases 1 to 1034)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Identification and expression of the TREX1 and TREX2 cDNA sequences
            encoding mammalian 3'-->5' exonucleases
  JOURNAL   J Biol Chem 274 (28), 19655-19660 (1999)
   PUBMED   10391904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY714289.1 and AF151108.1.
            
            On Aug 31, 2007 this sequence version replaced NM_011907.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151108.1, BY714289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               BY714289.1         3-582
            581-1034            AF151108.1         568-1021
FEATURES             Location/Qualifiers
     source          1..1034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.31 cM"
     gene            1..1034
                     /gene="Trex2"
                     /note="three prime repair exonuclease 2"
                     /db_xref="GeneID:24102"
                     /db_xref="MGI:MGI:1346343"
     exon            1..47
                     /gene="Trex2"
                     /inference="alignment:Splign:2.1.0"
     exon            48..1016
                     /gene="Trex2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..792
                     /gene="Trex2"
                     /EC_number="3.1.11.2"
                     /note="3'-5' exonuclease TREX2"
                     /codon_start=1
                     /product="three prime repair exonuclease 2"
                     /protein_id="NP_036037.1"
                     /db_xref="CCDS:CCDS30201.1"
                     /db_xref="GeneID:24102"
                     /db_xref="MGI:MGI:1346343"
                     /translation="MSEPPRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPE
                     RDDSGSLVLPRVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQ
                     GFLSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGLDRAHSH
                     GTRAQGRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELLAWADEQARS
                     WAHIEPMYVPPDGPSLEA"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trex2"
                     /note="hexamer: AATAAA"
     polyA_site      1011
                     /gene="Trex2"
                     /note="major polyA site"
ORIGIN      
        1 gagacaggtg cccagcagtc caggaagcca gctgaagccc gccccagctc taggcctcat
       61 tgttcctgtg agaacatcag catgtctgag ccaccccggg ctgagacctt tgtattcctg
      121 gacctagaag ccactgggct cccaaacatg gatcctgaga ttgcagagat atcccttttt
      181 gctgttcacc gctcttccct ggagaaccca gaacgggatg attctggttc cttggtgctg
      241 ccccgtgttc tggacaagct cacactgtgc atgtgcccgg agcgcccctt tactgccaag
      301 gccagtgaga ttactggttt gagcagcgaa agcctgatgc actgcgggaa ggctggtttc
      361 aatggcgctg tggtaaggac actgcagggc ttcctaagcc gccaggaggg ccccatctgc
      421 cttgtggccc acaatggctt cgattatgac ttcccactgc tgtgcacgga gctacaacgt
      481 ctgggtgccc atctgcccca agacactgtc tgcctggaca cactgcctgc attgcggggc
      541 ctggaccgtg ctcacagcca cggcaccagg gctcaaggcc gcaaaagcta cagcctggcc
      601 agtctcttcc accgctactt ccaggctgaa cccagtgctg cccattcagc agaaggtgat
      661 gtgcacaccc tgcttctgat cttcctgcat cgtgctcctg agctgctcgc ctgggcagat
      721 gagcaggccc gcagctgggc tcatattgag cccatgtacg tgccacctga tggtccaagc
      781 ctcgaagcct gaatgccagt gccatccatt catccaggct ctgagctaca tctttgctct
      841 ctgtagcacc tttgtggcct tcctcagccc tgacctacct ggccatagga tcctacagcc
      901 ttctctgtac tccactatca gttgggcacc ttctggccag cctgtgagtt gctctttcag
      961 ggcttccatc tttcatccca tttctcaata aatatcacca actatttacc agctgaaaaa
     1021 aaaaaaaaaa aaaa
//
