LOCUS       NM_001012236            1060 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus three prime repair exonuclease 1 (Trex1), transcript
            variant 2, mRNA.
ACCESSION   NM_001012236
VERSION     NM_001012236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Li,H., Liu,C., Li,R., Zhou,L., Ran,Y., Yang,Q., Huang,H., Lu,H.,
            Song,H., Yang,B., Ru,H., Lin,S. and Zhang,L.
  TITLE     AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine
            lactyltransferases
  JOURNAL   Nature 634 (8036), 1229-1237 (2024)
   PUBMED   39322678
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Li,T., Yum,S., Wu,J., Li,M., Deng,Y., Sun,L., Zuo,X. and Chen,Z.J.
  TITLE     cGAS activation in classical dendritic cells causes autoimmunity in
            TREX1-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (38), e2411747121 (2024)
   PUBMED   39254994
  REMARK    GeneRIF: cGAS activation in classical dendritic cells causes
            autoimmunity in TREX1-deficient mice.
REFERENCE   3  (bases 1 to 1060)
  AUTHORS   Lim,J., Rodriguez,R., Williams,K., Silva,J., Gutierrez,A.G.,
            Tyler,P., Baharom,F., Sun,T., Lin,E., Martin,S., Kayser,B.D.,
            Johnston,R.J., Mellman,I., Delamarre,L., West,N.R., Muller,S.,
            Qu,Y. and Heger,K.
  TITLE     The Exonuclease TREX1 Constitutes an Innate Immune Checkpoint
            Limiting cGAS/STING-Mediated Antitumor Immunity
  JOURNAL   Cancer Immunol Res 12 (6), 663-672 (2024)
   PUBMED   38489753
  REMARK    GeneRIF: The Exonuclease TREX1 Constitutes an Innate Immune
            Checkpoint Limiting cGAS/STING-Mediated Antitumor Immunity.
REFERENCE   4  (bases 1 to 1060)
  AUTHORS   Chauvin,S.D., Ando,S., Holley,J.A., Sugie,A., Zhao,F.R., Poddar,S.,
            Kato,R., Miner,C.A., Nitta,Y., Krishnamurthy,S.R., Saito,R.,
            Ning,Y., Hatano,Y., Kitahara,S., Koide,S., Stinson,W.A., Fu,J.,
            Surve,N., Kumble,L., Qian,W., Polishchuk,O., Andhey,P.S.,
            Chiang,C., Liu,G., Colombeau,L., Rodriguez,R., Manel,N., Kakita,A.,
            Artyomov,M.N., Schultz,D.C., Coates,P.T., Roberson,E.D.O.,
            Belkaid,Y., Greenberg,R.A., Cherry,S., Gack,M.U., Hardy,T.,
            Onodera,O., Kato,T. and Miner,J.J.
  TITLE     Inherited C-terminal TREX1 variants disrupt homology-directed
            repair to cause senescence and DNA damage phenotypes in Drosophila,
            mice, and humans
  JOURNAL   Nat Commun 15 (1), 4696 (2024)
   PUBMED   38824133
  REMARK    GeneRIF: Inherited C-terminal TREX1 variants disrupt
            homology-directed repair to cause senescence and DNA damage
            phenotypes in Drosophila, mice, and humans.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1060)
  AUTHORS   Luca,D., Lee,S., Hirota,K., Okabe,Y., Uehori,J., Izawa,K.,
            Lanz,A.L., Schutte,V., Sivri,B., Tsukamoto,Y., Hauck,F.,
            Behrendt,R., Roers,A., Fujita,T., Nishikomori,R., Lee-Kirsch,M.A.
            and Kato,H.
  TITLE     Aberrant RNA sensing in regulatory T cells causes systemic
            autoimmunity
  JOURNAL   Sci Adv 10 (9), eadk0820 (2024)
   PUBMED   38427731
REFERENCE   6  (bases 1 to 1060)
  AUTHORS   Morita,M., Stamp,G., Robins,P., Dulic,A., Rosewell,I., Hrivnak,G.,
            Daly,G., Lindahl,T. and Barnes,D.E.
  TITLE     Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA
            exonuclease develop inflammatory myocarditis
  JOURNAL   Mol Cell Biol 24 (15), 6719-6727 (2004)
   PUBMED   15254239
  REMARK    GeneRIF: Trex1(-/-) mice exhibit a dramatically reduced survival
            and develop inflammatory myocarditis leading to progressive, often
            dilated, cardiomyopathy and circulatory failure
REFERENCE   7  (bases 1 to 1060)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases.
            Characterization of the recombinant proteins
  JOURNAL   J Biol Chem 276 (20), 17022-17029 (2001)
   PUBMED   11279105
REFERENCE   8  (bases 1 to 1060)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Structure and expression of the TREX1 and TREX2 3' --> 5'
            exonuclease genes
  JOURNAL   J Biol Chem 276 (18), 14718-14727 (2001)
   PUBMED   11278605
REFERENCE   9  (bases 1 to 1060)
  AUTHORS   Schimenti,J.C.
  TITLE     ORFless, intronless, and mutant transcription units in the mouse t
            complex responder (Tcr) locus
  JOURNAL   Mamm Genome 10 (10), 969-976 (1999)
   PUBMED   10501965
REFERENCE   10 (bases 1 to 1060)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Identification and expression of the TREX1 and TREX2 cDNA sequences
            encoding mammalian 3'-->5' exonucleases
  JOURNAL   J Biol Chem 274 (28), 19655-19660 (1999)
   PUBMED   10391904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087832.1 and AU041952.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009899.1, AK087832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1054              AK087832.1         2-1055
            1055-1060           AU041952.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..1060
                     /gene="Trex1"
                     /note="three prime repair exonuclease 1"
                     /db_xref="GeneID:22040"
                     /db_xref="MGI:MGI:1328317"
     exon            1..63
                     /gene="Trex1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..1060
                     /gene="Trex1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trex1"
                     /note="hexamer: AATAAA"
     polyA_site      1055
                     /gene="Trex1"
                     /note="major polyA site"
ORIGIN      
        1 acttcctcag ccacactgct gccagcagca gacccagcgg agtgccttgc tgcctgcttc
       61 tcggttcagc atgggctcac agaccctgcc ccatggtcac atgcagaccc tcatcttctt
      121 agacctggaa gccactggcc tgccttcgtc tcggcccgaa gtcacagagc tgtgcctgct
      181 ggctgtccac agacgtgctc tggagaacac ttccatttct cagggacatc cacctccagt
      241 gcccagaccg ccccgtgtgg tggacaagct ctctctgtgc attgctccag ggaaagcctg
      301 tagccctggg gccagtgaga tcacaggtct gagcaaagct gagctggaag tacaggggcg
      361 tcaacgcttc gatgacaacc tggccatcct gctccgagcc ttcctgcagc gccagccaca
      421 gccttgctgc cttgtggcac acaacggtga ccgctatgac tttcctctgc tccagacaga
      481 gcttgctagg ctgagcactc ccagtcccct agatggtacc ttctgtgtgg acagcatcgc
      541 tgccctaaag gccttggaac aagctagcag cccctcaggg aatggttcga ggaaaagcta
      601 cagcctgggc agcatctaca cccgcctgta ctggcaagca ccgacagact cacatactgc
      661 tgaaggtgat gttctaaccc tgctcagcat ctgtcagtgg aagccacagg ccctactgca
      721 gtgggtggac gaacatgccc ggccctttag caccgtcaag cccatgtacg gcactccggc
      781 taccactgga acaaccaacc taaggccaca tgctgccaca gctactacac ccctggccac
      841 agccaatgga agtcccagca atggcaggag caggcgacct aagagtcctc ctccagagaa
      901 ggtcccagaa gccccatcac aggaggggct gctggcccca ctgagcctgc tgaccctcct
      961 gaccttggca atagccactc tgtatggact cttcctggcc tcacctgggc agtaagtcaa
     1021 gaggggaaat atgatgaata aagacttcca tagcactgac
//
