LOCUS       NM_172623               1742 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus triggering receptor expressed on myeloid cells-like 4
            (Treml4), transcript variant 2, mRNA.
ACCESSION   NM_172623
VERSION     NM_172623.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Nedeva,C., Menassa,J., Duan,M., Liu,C., Doerflinger,M., Kueh,A.J.,
            Herold,M.J., Fonseka,P., Phan,T.K., Faou,P., Rajapaksha,H.,
            Chen,W., Hulett,M.D. and Puthalakath,H.
  TITLE     TREML4 receptor regulates inflammation and innate immune cell death
            during polymicrobial sepsis
  JOURNAL   Nat Immunol 21 (12), 1585-1596 (2020)
   PUBMED   33020659
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Gonzalez-Cotto,M., Guo,L., Karwan,M., Sen,S.K., Barb,J.,
            Collado,C.J., Elloumi,F., Palmieri,E.M., Boelte,K., Kolodgie,F.D.,
            Finn,A.V., Biesecker,L.G. and McVicar,D.W.
  TITLE     TREML4 Promotes Inflammatory Programs in Human and Murine
            Macrophages and Alters Atherosclerosis Lesion Composition in the
            Apolipoprotein E Deficient Mouse
  JOURNAL   Front Immunol 11, 397 (2020)
   PUBMED   32292401
  REMARK    GeneRIF: TREML4 Promotes Inflammatory Programs in Human and Murine
            Macrophages and Alters Atherosclerosis Lesion Composition in the
            Apolipoprotein E Deficient Mouse.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Ramirez-Ortiz,Z.G., Prasad,A., Griffith,J.W., Pendergraft,W.F. 3rd,
            Cowley,G.S., Root,D.E., Tai,M., Luster,A.D., El Khoury,J.,
            Hacohen,N. and Means,T.K.
  TITLE     The receptor TREML4 amplifies TLR7-mediated signaling during
            antiviral responses and autoimmunity
  JOURNAL   Nat Immunol 16 (5), 495-504 (2015)
   PUBMED   25848864
  REMARK    GeneRIF: positive regulator of TLR7 signaling that controls
            antiviral immunity and the development of autoimmunity
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Hemmi,H., Zaidi,N., Wang,B., Matos,I., Fiorese,C., Lubkin,A.,
            Zbytnuik,L., Suda,K., Zhang,K., Noda,M., Kaisho,T., Steinman,R.M.
            and Idoyaga,J.
  TITLE     Treml4, an Ig superfamily member, mediates presentation of several
            antigens to T cells in vivo, including protective immunity to HER2
            protein
  JOURNAL   J Immunol 188 (3), 1147-1155 (2012)
   PUBMED   22210914
  REMARK    GeneRIF: Treml4 participates in Ag presentation in vivo
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Hemmi,H., Idoyaga,J., Suda,K., Suda,N., Kennedy,K., Noda,M.,
            Aderem,A. and Steinman,R.M.
  TITLE     A new triggering receptor expressed on myeloid cells (Trem) family
            member, Trem-like 4, binds to dead cells and is a DNAX activation
            protein 12-linked marker for subsets of mouse macrophages and
            dendritic cells
  JOURNAL   J Immunol 182 (3), 1278-1286 (2009)
   PUBMED   19155473
  REMARK    GeneRIF: Treml4 associates with adaptor molecule DNAX activation
            protein 12 kDa (DAP12) and serves as a marker for select groups of
            both dendritic cells and macrophages.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077228.1, AC241601.3 and BC117091.1.
            
            On Aug 1, 2009 this sequence version replaced NM_172623.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 3. The
            resulting isoform (2) has the same N- and C-termini but is 1 aa
            shorter compared to isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077228.1, AK156085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK077228.1         1-10
            11-11               AC241601.3         44689-44689         c
            12-313              AK077228.1         12-313
            314-963             BC117091.1         289-938
            964-1742            AK077228.1         964-1742
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..1742
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /note="triggering receptor expressed on myeloid cells-like
                     4"
                     /db_xref="GeneID:224840"
                     /db_xref="MGI:MGI:1923239"
     exon            1..146
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..877
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; IG-like domain containing protein IDCP1c;
                     triggering receptor expressed on myeloid cells-like 3;
                     triggering receptor expressed on myeloid cells-like 3b;
                     triggering receptor expressed on myeloid cells-like
                     protein 3; triggering receptor expressed on myeloid
                     cells-like protein 4; trem-like transcript 4 protein"
                     /codon_start=1
                     /product="trem-like transcript 4 protein isoform 2
                     precursor"
                     /protein_id="NP_766211.2"
                     /db_xref="CCDS:CCDS28862.1"
                     /db_xref="GeneID:224840"
                     /db_xref="MGI:MGI:1923239"
                     /translation="MAWRYSQLLLVPVQLVFLASVCCPGVWGSTVSEELHRMVGQSLS
                     VQCQYKPKEESYVLKTWCRQTAPSKCTRVVTTSEPRKAARELQHTIWDDPEAGFFNIT
                     MTQLTEDDSAFYWCGPYYPSLREVTVLRNISLVVSPAPSTLPSQTIAPLPESTATIFM
                     PFPVLTTSPEETTDSSINGTGHRNQSSSSPGWTSPGLLVSVQYGLLLLKALMLSVFCV
                     LLCWRSGQGREYMAETMELSKLPHISKSLDTVSHISGYEKKANWY"
     exon            147..500
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..551
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..633
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..763
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1742
                     /gene="Treml4"
                     /gene_synonym="5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgatgag acttagggga agacttgcct agttcagagg tctcctcctt ttctcctctc
       61 ctctactgac agaatctgga ctggtatggc ctggaggtac tcacaactgc tcctggtccc
      121 tgtgcagctg gtgttcctgg cctcagtttg ttgtccaggt gtctgggggt ccacagtatc
      181 tgaagagctt catagaatgg taggacagag cctctccgtg cagtgccaat acaagcctaa
      241 ggaggagtcc tatgtgctga aaacgtggtg tcggcaaaca gccccaagta aatgtacgag
      301 agtggtcact acctctgagc ctcggaaagc agccagggaa ttacagcaca caatctggga
      361 tgatcctgaa gctggcttct tcaacatcac catgactcaa ctaacagagg atgactcagc
      421 gttctactgg tgtggtccat attatccttc cctcagagaa gtaactgttc tcagaaacat
      481 cagcctggtg gtgtcgccag ccccatcaac ccttccttcg cagacgattg ctccgctccc
      541 agaaagcaca gccaccatct ttatgccctt cccagttctg actacctctc ccgaggagac
      601 cactgactct tccatcaatg gcactgggca cagaaaccaa agttcctcct ctcctggctg
      661 gacctccccg gggcttctgg tctctgtgca atatggactc ctcctgctca aggccctgat
      721 gctgtcagtt ttctgtgtgc ttctttgctg gaggagtggc cagggacgag agtacatggc
      781 agagacgatg gagctttcaa aactacctca catctccaag tccttggaca cggttagcca
      841 catctcaggg tatgagaaga aggctaactg gtactaaggc agaacaggcc aaacttccgc
      901 tctaccgaag ccatcaggca agcccacgag agacaacagc cagacctgca tctcaaatcg
      961 ccagggctaa ttgacactcc agtatcgagc accctcagag ctgtataccc cgtagcccag
     1021 acctccgcca agatgaccaa ccacggggca gttcatctgc aacacccagc tcaagtgctt
     1081 tcccagatcc ccagccccgg gcctttctca ctctctctcc tgcctccctt ggcatcacaa
     1141 gcctcacagg ctctgtttcc caagtgagct actcacaagg cccatgcctg tccactctac
     1201 tcacgttcac aagctcacct tcttggtttg ctctagattt cctaaaatga gggggaaact
     1261 aacttaaagg ctaacacggg gagccaagaa aggctgtgtg ctgcggacca caaaccgaga
     1321 aagtccagaa gttaaagggg ggaaaaaagt gttttaaaca agaccaaaac ctccccaaac
     1381 tgacccttca tgcacatcat gctgacttca tgcacatcag agctgaccac caggggtcag
     1441 tattgtgctg gtttacccag tgatgcaatt tcatctgcac aaagtctgct tatacaaaga
     1501 ggatggttgg ctgatgggag gagccgggga gaatccctta gggaacaaaa agaatgtcac
     1561 atctgtaaaa caagaagagt ccagagtgac gttcaggaga gcctggatac tggcatacgc
     1621 tactaacaac atgctgaatg tagccacagc cttgtaacca taaaaaggcc actatgacgg
     1681 ggtcacattt tattcctttt ttatgttatg tgtgggagaa taaaatatag atgtttcttc
     1741 at
//
