LOCUS       NM_001289457            1241 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus triggering receptor expressed on myeloid cells-like 1
            (Treml1), transcript variant 3, mRNA.
ACCESSION   NM_001289457
VERSION     NM_001289457.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1241)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1241)
  AUTHORS   Pena-Garcia,P.E., Morales-Ortiz,J., Marrero-Polanco,J.,
            Virgillio,A., Finette,B.A., Washington,A.V. and Bonney,E.A.
  TITLE     Decreased level of TREM like Transcript 1 (TLT-1) is associated
            with prematurity and promotes the in-utero inflammatory response to
            maternal lipopolysaccharide (LPS) exposure
  JOURNAL   Am J Reprod Immunol 90 (4), e13772 (2023)
   PUBMED   37766406
  REMARK    GeneRIF: Decreased level of TREM like Transcript 1 (TLT-1) is
            associated with prematurity and promotes the in-utero inflammatory
            response to maternal lipopolysaccharide (LPS) exposure.
REFERENCE   3  (bases 1 to 1241)
  AUTHORS   Chang,C.M., Cheng,K.H., Wei,T.Y., Lu,M.P., Chen,Y.C. and Lu,Y.T.
  TITLE     Soluble TREM-like Transcript-1 Acts as a Damage-Associated
            Molecular Pattern through the TLR4/MD2 Pathway Contributing to
            Immune Dysregulation during Sepsis
  JOURNAL   J Immunol 210 (9), 1351-1362 (2023)
   PUBMED   36961438
  REMARK    GeneRIF: Soluble TREM-like Transcript-1 Acts as a Damage-Associated
            Molecular Pattern through the TLR4/MD2 Pathway Contributing to
            Immune Dysregulation during Sepsis.
REFERENCE   4  (bases 1 to 1241)
  AUTHORS   Das,A.A., Chakravarty,D., Bhunia,D., Ghosh,S., Mandal,P.C.,
            Siddiqui,K.N. and Bandyopadhyay,A.
  TITLE     Elevated level of circulatory sTLT1 induces inflammation through
            SYK/MEK/ERK signalling in coronary artery disease
  JOURNAL   Clin Sci (Lond) 133 (22), 2283-2299 (2019)
   PUBMED   31713591
  REMARK    GeneRIF: high levels in atherosclerotic apoE-/- mice
REFERENCE   5  (bases 1 to 1241)
  AUTHORS   Morales-Ortiz,J., Deal,V., Reyes,F., Maldonado-Martinez,G.,
            Ledesma,N., Staback,F., Croft,C., Pacheco,A., Ortiz-Zuazaga,H.,
            Yost,C.C., Rowley,J.W., Madera,B., John,A.S., Chen,J., Lopez,J.,
            Rondina,M.T., Hunter,R., Gibson,A. and Washington,A.V.
  TITLE     Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and
            prevents tissue damage in the lungs in a mouse model
  JOURNAL   Blood 132 (23), 2495-2505 (2018)
   PUBMED   30282800
  REMARK    GeneRIF: findings suggest that TLT-1 uses fibrinogen to govern the
            transition between inflammation and hemostasis and facilitate
            controlled leukocyte transmigration during the progression of ARDS.
REFERENCE   6  (bases 1 to 1241)
  AUTHORS   Washington,A.V., Gibot,S., Acevedo,I., Gattis,J., Quigley,L.,
            Feltz,R., De La Mota,A., Schubert,R.L., Gomez-Rodriguez,J.,
            Cheng,J., Dutra,A., Pak,E., Chertov,O., Rivera,L., Morales,J.,
            Lubkowski,J., Hunter,R., Schwartzberg,P.L. and McVicar,D.W.
  TITLE     TREM-like transcript-1 protects against inflammation-associated
            hemorrhage by facilitating platelet aggregation in mice and humans
  JOURNAL   J Clin Invest 119 (6), 1489-1501 (2009)
   PUBMED   19436112
  REMARK    GeneRIF: TLT-1 plays a protective role during inflammation by
            dampening the inflammatory response and facilitating platelet
            aggregation at sites of vascular injury
REFERENCE   7  (bases 1 to 1241)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   8  (bases 1 to 1241)
  AUTHORS   Gattis,J.L., Washington,A.V., Chisholm,M.M., Quigley,L., Szyk,A.,
            McVicar,D.W. and Lubkowski,J.
  TITLE     The structure of the extracellular domain of triggering receptor
            expressed on myeloid cells like transcript-1 and evidence for a
            naturally occurring soluble fragment
  JOURNAL   J Biol Chem 281 (19), 13396-13403 (2006)
   PUBMED   16505478
  REMARK    GeneRIF: A soluble fragment of the TLT-1 extracellular domain is
            found in serum of humans and mice and that an isoform of similar
            mass is released from platelets following activation with thrombin.
REFERENCE   9  (bases 1 to 1241)
  AUTHORS   Washington,A.V., Schubert,R.L., Quigley,L., Disipio,T., Feltz,R.,
            Cho,E.H. and McVicar,D.W.
  TITLE     A TREM family member, TLT-1, is found exclusively in the
            alpha-granules of megakaryocytes and platelets
  JOURNAL   Blood 104 (4), 1042-1047 (2004)
   PUBMED   15100151
  REMARK    GeneRIF: expressed exclusively in platelets and megakaryocytes;
            expression is up-regulated upon platelet activation; is prepackaged
            into both MK and platelet alpha-granules; may regulate granule
            construction or dispersal
REFERENCE   10 (bases 1 to 1241)
  AUTHORS   Washington,A.V., Quigley,L. and McVicar,D.W.
  TITLE     Initial characterization of TREM-like transcript (TLT)-1: a
            putative inhibitory receptor within the TREM cluster
  JOURNAL   Blood 100 (10), 3822-3824 (2002)
   PUBMED   12393607
  REMARK    GeneRIF: initial characterization of TREM-like transcript (TLT)-1;
            results indicate it is likely that TLT-1 regulates the signaling of
            the TREM family receptors
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017256.1, AY078502.1 and AI553593.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in an isoform (3) that is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY286071.1, AK017256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-743               AK017256.1         2-744
            744-1205            AY078502.1         759-1220
            1206-1233           AK017256.1         1207-1234
            1234-1241           AI553593.1         1-8                 c
FEATURES             Location/Qualifiers
     source          1..1241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..1241
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /note="triggering receptor expressed on myeloid cells-like
                     1"
                     /db_xref="GeneID:71326"
                     /db_xref="MGI:MGI:1918576"
     exon            1..67
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..975
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; trem-like transcript 1 protein; triggering
                     receptor expressed on myeloid cells-like 1d; triggering
                     receptor expressed on myeloid cells-like 1e; triggering
                     receptor expressed on myeloid cells-like 1c; triggering
                     receptor expressed on myeloid cells-like protein 1"
                     /codon_start=1
                     /product="trem-like transcript 1 protein isoform 3
                     precursor"
                     /protein_id="NP_001276386.1"
                     /db_xref="CCDS:CCDS89114.1"
                     /db_xref="GeneID:71326"
                     /db_xref="MGI:MGI:1918576"
                     /translation="MDCYLLLLLLLLGLAGQGSADSHPEVLQAPVGSSILVQCHYRLQ
                     DVRALKVWCQFLQEGCHPLVTSAVDRRAPGNGRIFLTDLGGGLLQVEMVTLQEEDTGE
                     YGCVVEGAAGPQTLHRVSLLVLPPVPGPREGEEAEDEKETYRIGTGSLLEDPSLDPSA
                     SAGPHEFRRRENSIPLIWGAVLLLALVVVAVVIFAVMARKKGNRLVVCGPSQSTGVPG
                     MDPPSAAHRSSDSGLPSDIPHVRLDSPPSFDSIYTGSSLDPPSSEPPAPPSQPPLPPK
                     VLMSSKSVTYATVVFPGGDKGKIASCEPVQDPPNSQTPPSK"
     exon            68..400
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..539
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..625
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..678
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1235
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /note="hexamer: AATAAA"
     polyA_site      1235
                     /gene="Treml1"
                     /gene_synonym="5430401J17Rik; TLT-1"
                     /note="major polyA site"
ORIGIN      
        1 agaacctact actgcccagc catggactgc tacctgctgc tgctgctgct gctcctggga
       61 ctagcaggcc aaggctcagc tgacagtcat cccgaggtgc tacaggcacc ggtggggtca
      121 tccattctag tgcagtgcca ctaccggctc caggatgtga gggctctcaa ggtgtggtgc
      181 cagttcttgc aggaaggctg ccacccacta gtgacctcag cggtggaccg aagagctccg
      241 ggaaacgggc gcatattcct cactgacctg ggtggggggc tcctgcaggt ggaaatggtg
      301 accctgcagg aggaggacac aggggagtat ggttgtgtgg tggagggagc ggcaggaccc
      361 cagaccctgc atagggtctc cctgttggtt cttccaccag tccctggccc aagagagggg
      421 gaggaagcag aggacgagaa agaaacctat agaatcggaa ccggaagtct gctcgaggac
      481 ccctccttgg acccttccgc gagtgctggt cctcacgagt tcagacggcg tgagaacagt
      541 atccccctga tctggggtgc tgtgctcctg ttggccctgg tggtggtggc tgtggtgata
      601 tttgctgtga tggccagaaa gaaagggaac aggcttgttg tctgtggccc gtcccagagc
      661 actggagttc caggaatgga ccctccctca gcagcccacc gtagcagtga ctcgggacta
      721 ccctcggaca ttccacatgt gaggctcgac tcaccgcctt cctttgactc tatctacaca
      781 ggctcctctc ttgatccacc atcaagcgaa cccccagctc caccctcaca gccccctctg
      841 cctcctaagg tcctgatgtc ctccaagtct gtgacatatg ccacagttgt cttcccagga
      901 ggggacaaag gtaaaatagc ctcctgtgag ccagttcagg acccaccaaa cagtcaaact
      961 ccacccagta aataagagta cactttaatt tattactctt gggatcaccc ctggggaatt
     1021 ctctgcagcc cggccaacta gctctgcctt ttatgcccag agtatgtcag cgcctggtga
     1081 ctcagggctc caatctggta tcttggtttg gtgcagtcag ggagtggtgc tccgatatga
     1141 ttggggtgtt tggggaaaga attcttttct gctgcttccc ggtgctgggt ctaccgtcat
     1201 tacatattgg ctaaataaac ctagaggata tataaaaaaa a
//
