LOCUS       NM_021407               1048 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus triggering receptor expressed on myeloid cells 3
            (Trem3), mRNA.
ACCESSION   NM_021407 XM_001003040
VERSION     NM_021407.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1048)
  AUTHORS   McQueen,B.E., Kollipara,A., Gyorke,C.E., Andrews,C.W. Jr.,
            Ezzell,A., Darville,T. and Nagarajan,U.M.
  TITLE     Reduced Uterine Tissue Damage during Chlamydia muridarum Infection
            in TREM-1,3-Deficient Mice
  JOURNAL   Infect Immun 89 (10), e0007221 (2021)
   PUBMED   34125599
  REMARK    GeneRIF: Reduced Uterine Tissue Damage during Chlamydia muridarum
            Infection in TREM-1,3-Deficient Mice.
REFERENCE   2  (bases 1 to 1048)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1048)
  AUTHORS   Hommes,T.J., Dessing,M.C., Veer,Cv., Florquin,S., Colonna,M., de
            Vos,A.F. and van der Poll,T.
  TITLE     Role of triggering receptor expressed on myeloid cells-1/3 in
            Klebsiella-derived pneumosepsis
  JOURNAL   Am J Respir Cell Mol Biol 53 (5), 647-655 (2015)
   PUBMED   25860078
  REMARK    GeneRIF: TREM-1/TREM-3 macrophage expression improved host defense
            against Klebsiella-derived pneumosepsis, whereas TREM-2 did not
            have a role.
REFERENCE   4  (bases 1 to 1048)
  AUTHORS   Tammaro,A., Stroo,I., Rampanelli,E., Blank,F., Butter,L.M.,
            Claessen,N., Takai,T., Colonna,M., Leemans,J.C., Florquin,S. and
            Dessing,M.C.
  TITLE     Role of TREM1-DAP12 in renal inflammation during obstructive
            nephropathy
  JOURNAL   PLoS One 8 (12), e82498 (2013)
   PUBMED   24358193
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1048)
  AUTHORS   Klesney-Tait,J., Keck,K., Li,X., Gilfillan,S., Otero,K., Baruah,S.,
            Meyerholz,D.K., Varga,S.M., Knudson,C.J., Moninger,T.O.,
            Moreland,J., Zabner,J. and Colonna,M.
  TITLE     Transepithelial migration of neutrophils into the lung requires
            TREM-1
  JOURNAL   J Clin Invest 123 (1), 138-149 (2013)
   PUBMED   23241959
REFERENCE   6  (bases 1 to 1048)
  AUTHORS   Chen,L.C., Laskin,J.D., Gordon,M.K. and Laskin,D.L.
  TITLE     Regulation of TREM expression in hepatic macrophages and
            endothelial cells during acute endotoxemia
  JOURNAL   Exp Mol Pathol 84 (2), 145-155 (2008)
   PUBMED   18222421
REFERENCE   7  (bases 1 to 1048)
  AUTHORS   Humphrey,M.B., Ogasawara,K., Yao,W., Spusta,S.C., Daws,M.R.,
            Lane,N.E., Lanier,L.L. and Nakamura,M.C.
  TITLE     The signaling adapter protein DAP12 regulates multinucleation
            during osteoclast development
  JOURNAL   J Bone Miner Res 19 (2), 224-234 (2004)
   PUBMED   14969392
REFERENCE   8  (bases 1 to 1048)
  AUTHORS   Daws,M.R., Sullam,P.M., Niemi,E.C., Chen,T.T., Tchao,N.K. and
            Seaman,W.E.
  TITLE     Pattern recognition by TREM-2: binding of anionic ligands
  JOURNAL   J Immunol 171 (2), 594-599 (2003)
   PUBMED   12847223
REFERENCE   9  (bases 1 to 1048)
  AUTHORS   Chung,D.H., Seaman,W.E. and Daws,M.R.
  TITLE     Characterization of TREM-3, an activating receptor on mouse
            macrophages: definition of a family of single Ig domain receptors
            on mouse chromosome 17
  JOURNAL   Eur J Immunol 32 (1), 59-66 (2002)
   PUBMED   11754004
  REMARK    GeneRIF: Like TREM-1 and TREM-2, TREM-3 signals through DAP12.
REFERENCE   10 (bases 1 to 1048)
  AUTHORS   Bouchon,A., Dietrich,J. and Colonna,M.
  TITLE     Cutting edge: inflammatory responses can be triggered by TREM-1, a
            novel receptor expressed on neutrophils and monocytes
  JOURNAL   J Immunol 164 (10), 4991-4995 (2000)
   PUBMED   10799849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC241601.3, AK079407.1 and
            BY594056.1.
            
            On Jan 10, 2013 this sequence version replaced NM_021407.2.
            
            Summary: The protein encoded by this gene is part of the
            immunoglobulin and lectin-like superfamily and is thought to
            function as part of the innate immune system. This gene forms part
            of a cluster of genes on mouse chromosome 17 thought to be involved
            in innate immunity. This protein has been reported to associate
            with the adaptor protein Dap-12 to form a receptor signaling
            complex that activates myeloid cells. [provided by RefSeq, Jan
            2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079407.1, AF241220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC241601.3         61190-61265         c
            77-823              AK079407.1         2-748
            824-1046            BY594056.1         254-476
            1047-1048           AK079407.1         972-973
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..1048
                     /gene="Trem3"
                     /gene_synonym="TREM-3"
                     /note="triggering receptor expressed on myeloid cells 3"
                     /db_xref="GeneID:58218"
                     /db_xref="MGI:MGI:1930003"
     exon            1..166
                     /gene="Trem3"
                     /gene_synonym="TREM-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..672
                     /gene="Trem3"
                     /gene_synonym="TREM-3"
                     /note="triggering receptor expressed on monocytes 3"
                     /codon_start=1
                     /product="triggering receptor expressed on myeloid cells 3
                     precursor"
                     /protein_id="NP_067382.1"
                     /db_xref="CCDS:CCDS28861.1"
                     /db_xref="GeneID:58218"
                     /db_xref="MGI:MGI:1930003"
                     /translation="MSPLLLWLGLMLCVSGLQAGDEEEHKCFLEGENLTLTCPYNIML
                     YSLSLKAWQRVRSHGSPETLVLTNTRKADFNVARAGKYLLEDYPTESVVKVTVTGLQR
                     QDVGLYQCVVYLSPDNVIILRQRIRLAWCQGKPVMVIVLTCGFILNKGLVFSVLFVFL
                     CKAGPKVLQPSKTSKVQGVSEKQ"
     exon            167..517
                     /gene="Trem3"
                     /gene_synonym="TREM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..618
                     /gene="Trem3"
                     /gene_synonym="TREM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            619..1048
                     /gene="Trem3"
                     /gene_synonym="TREM-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttctatg tggggaagca tgctccagca actgtaagtg atttggccac ttgccttggg
       61 gccattggca gttagcacac caggaaggag cttcatacag aggaggcagg gacctggggg
      121 atgtcaccgc tgctgctatg gctggggctg atgctctgtg tctcgggact ccaagctgga
      181 gatgaggaag aacacaagtg ttttctggag ggcgagaacc tgaccctgac ttgtccttac
      241 aacatcatgc tatactcact gagcctgaag gcctggcagc gggtcagaag ccacggttct
      301 ccagagactc tggtgctcac aaacaccaga aaggcagact tcaacgtggc cagggctggg
      361 aagtacttgc tggaggatta tcccaccgaa tctgtcgtca aggtcacggt gactgggctg
      421 cagaggcaag atgtggggct gtaccagtgt gtggtctacc tctctcctga caatgttatc
      481 attctgcgtc aacggatacg gctggcatgg tgtcaaggga agccagtgat ggtgatcgtt
      541 ctgacgtgtg gcttcatact aaacaagggc ctggtcttct cagtcctgtt tgtctttctc
      601 tgcaaagctg ggcctaaggt gttacagcct tccaagacat ccaaagtaca gggagtctct
      661 gagaaacagt agccttcctg ctacaagctg tgagcacacc ttcccttatc tattaacaac
      721 ataccagatg ttctgtattg gggacaatct gggccttcct acattctcct tgtgaactct
      781 agttagcaca tgatactccc agaggacagc tctgaggaga gctgtgtaga aggaggctca
      841 tgagacatca gtgaagaata taaaattgag agagatttgg acctttggtg gagcagttaa
      901 gcaggaccca cagagaattc acctcaaaat cttatcacca tttctctcct gctaaccagg
      961 tctgccatgc tgtggactgg taaaacctat atgatgtaac ctatctctct tctgataata
     1021 ataaaaaaaa ttgtattttt tttcacgc
//
