LOCUS       NM_031254               1091 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus triggering receptor expressed on myeloid cells 2
            (Trem2), transcript variant 1, mRNA.
ACCESSION   NM_031254 NM_021410 NM_031253
VERSION     NM_031254.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1091)
  AUTHORS   Shan,S., Chao,S., Liu,Z., Wang,S., Liu,Z., Zhang,C., Cheng,D.,
            Su,Z. and Song,F.
  TITLE     TREM2 protects against inflammation by regulating the release of
            mito-DAMPs from hepatocytes during liver fibrosis
  JOURNAL   Free Radic Biol Med 220, 154-165 (2024)
   PUBMED   38710340
  REMARK    GeneRIF: TREM2 protects against inflammation by regulating the
            release of mito-DAMPs from hepatocytes during liver fibrosis.
REFERENCE   2  (bases 1 to 1091)
  AUTHORS   Cui,Y., Chen,C., Tang,Z., Yuan,W., Yue,K., Cui,P., Qiu,X.,
            Zhang,H., Li,T., Zhu,X., Luo,J., Sun,S., Li,Y., Feng,C., Peng,L.,
            Xie,X., Guo,Y., Xie,Y., Jiang,X., Qi,Z., Thomson,A.W. and Dai,H.
  TITLE     TREM2 deficiency aggravates renal injury by promoting macrophage
            apoptosis and polarization via the JAK-STAT pathway in mice
  JOURNAL   Cell Death Dis 15 (6), 401 (2024)
   PUBMED   38849370
  REMARK    GeneRIF: TREM2 deficiency aggravates renal injury by promoting
            macrophage apoptosis and polarization via the JAK-STAT pathway in
            mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1091)
  AUTHORS   Yan,Y., Bai,S., Han,H., Dai,J., Niu,L., Wang,H., Dong,Q., Yin,H.,
            Yuan,G. and Pan,Y.
  TITLE     Knockdown of trem2 promotes proinflammatory microglia and inhibits
            glioma progression via the JAK2/STAT3 and NF-kappaB pathways
  JOURNAL   Cell Commun Signal 22 (1), 272 (2024)
   PUBMED   38750472
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1091)
  AUTHORS   Yang,F., Chen,M., Liu,Y., Hu,Y., Chen,Y., Yu,Y. and Deng,L.
  TITLE     ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage
            pyroptosis by reducing LILRB2-mediated inhibition of TREM2
  JOURNAL   J Cell Mol Med 28 (10), e18280 (2024)
   PUBMED   38758159
  REMARK    GeneRIF: ANGPTL2 knockdown induces autophagy to relieve alveolar
            macrophage pyroptosis by reducing LILRB2-mediated inhibition of
            TREM2.
REFERENCE   5  (bases 1 to 1091)
  AUTHORS   Correale,C., Genua,M., Vetrano,S., Mazzini,E., Martinoli,C.,
            Spinelli,A., Arena,V., Peyrin-Biroulet,L., Caprioli,F., Passini,N.,
            Panina-Bordignon,P., Repici,A., Malesci,A., Rutella,S., Rescigno,M.
            and Danese,S.
  TITLE     Bacterial sensor triggering receptor expressed on myeloid cells-2
            regulates the mucosal inflammatory response
  JOURNAL   Gastroenterology 144 (2), 346-356 (2013)
   PUBMED   23108068
REFERENCE   6  (bases 1 to 1091)
  AUTHORS   Daws,M.R., Sullam,P.M., Niemi,E.C., Chen,T.T., Tchao,N.K. and
            Seaman,W.E.
  TITLE     Pattern recognition by TREM-2: binding of anionic ligands
  JOURNAL   J Immunol 171 (2), 594-599 (2003)
   PUBMED   12847223
  REMARK    GeneRIF: TREM-2a and TREM-2b binding to both Gram-positive and
            Gram-negative bacteria is disrupted by anionic bacterial products
            or other anionic carbohydrates and suggests that TREM-2 recognizes
            pathogens via charged carbohydrates expressed on pathogen surface.
REFERENCE   7  (bases 1 to 1091)
  AUTHORS   Schmid,C.D., Sautkulis,L.N., Danielson,P.E., Cooper,J., Hasel,K.W.,
            Hilbush,B.S., Sutcliffe,J.G. and Carson,M.J.
  TITLE     Heterogeneous expression of the triggering receptor expressed on
            myeloid cells-2 on adult murine microglia
  JOURNAL   J Neurochem 83 (6), 1309-1320 (2002)
   PUBMED   12472885
REFERENCE   8  (bases 1 to 1091)
  AUTHORS   Chung,D.H., Seaman,W.E. and Daws,M.R.
  TITLE     Characterization of TREM-3, an activating receptor on mouse
            macrophages: definition of a family of single Ig domain receptors
            on mouse chromosome 17
  JOURNAL   Eur J Immunol 32 (1), 59-66 (2002)
   PUBMED   11754004
REFERENCE   9  (bases 1 to 1091)
  AUTHORS   Daws,M.R., Lanier,L.L., Seaman,W.E. and Ryan,J.C.
  TITLE     Cloning and characterization of a novel mouse myeloid
            DAP12-associated receptor family
  JOURNAL   Eur J Immunol 31 (3), 783-791 (2001)
   PUBMED   11241283
REFERENCE   10 (bases 1 to 1091)
  AUTHORS   Bouchon,A., Dietrich,J. and Colonna,M.
  TITLE     Cutting edge: inflammatory responses can be triggered by TREM-1, a
            novel receptor expressed on neutrophils and monocytes
  JOURNAL   J Immunol 164 (10), 4991-4995 (2000)
   PUBMED   10799849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC166164.2, AK039477.1 and
            BY541740.1.
            
            [WARNING] On Jul 24, 2024 this sequence was replaced by
            NM_031254.4.
            
            On Jan 10, 2013 this sequence version replaced NM_031254.2.
            
            Summary: The protein encoded by this gene is part of the
            immunoglobulin and lectin-like superfamily and functions as part of
            the innate immune system. This gene forms part of a cluster of
            genes on mouse chromosome 17 thought to be involved in innate
            immunity. This protein associates with the adaptor protein Dap-12
            and recruits several factors, such as kinases and phospholipase
            C-gamma, to form a receptor signaling complex that activates
            myeloid cells, including dendritic cells and microglia. In humans
            homozygous loss-of-function mutations in this gene cause
            Nasu-Hakola disease and mutations in this gene may be risk factors
            to the development of Alzheimer's disease. In mouse mutations of
            this gene serve as a pathophysiological model for polycystic
            lipomembranous osteodysplasia with sclerosing leukoencephalopathy
            (Nasu-Hakola disease) and for inflammatory bowel disease.
            Alternative splicing results in multiple transcript variants that
            encode different protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052784.1, AK039477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC166164.2         81418-81512         c
            96-1086             AK039477.1         1-991
            1087-1091           BY541740.1         373-377
FEATURES             Location/Qualifiers
     source          1..1091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..1091
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /note="triggering receptor expressed on myeloid cells 2"
                     /db_xref="GeneID:83433"
                     /db_xref="MGI:MGI:1913150"
     exon            1..195
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..839
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; triggering receptor expressed on myeloid cells
                     2b; triggering receptor expressed on myeloid cells 2c;
                     triggering receptor expressed on myeloid cells 2a;
                     triggering receptor expressed on monocytes 2"
                     /codon_start=1
                     /product="triggering receptor expressed on myeloid cells 2
                     isoform 1 precursor"
                     /protein_id="NP_112544.1"
                     /db_xref="CCDS:CCDS28865.1"
                     /db_xref="GeneID:83433"
                     /db_xref="MGI:MGI:1913150"
                     /translation="MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHW
                     GRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQA
                     GDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTS
                     RNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQL
                     QILTGPGGT"
     exon            196..546
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /inference="alignment:Splign:2.1.0"
     exon            547..637
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /inference="alignment:Splign:2.1.0"
     exon            638..822
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1091
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1066..1071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /note="hexamer: ATTAAA"
     polyA_site      1088
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctaccc tagtcctgac tgttgctcaa tccaggagca cagttcctgt gggctgagcc
       61 tgactggctt ggtcatctct tttctgcact tcaagggaaa agcaagatct tgcacaaggt
      121 cccctccggc tggctgctgg caaaggaaag gtgccatggg acctctccac cagtttctcc
      181 tgctgctgat cacagccctg tcccaagccc tcaacaccac ggtgctgcag ggcatggccg
      241 gccagtcctt gagggtgtca tgtacttatg acgccttgaa gcactggggg agacgcaagg
      301 cctggtgtcg gcagctgggt gaggagggcc catgccagcg tgtggtgagc acacacggtg
      361 tgtggctgct ggccttcctg aagaagcgga atgggagcac agtcatcgca gatgacaccc
      421 ttgctggaac cgtcaccatc actctgaaga acctccaagc cggtgacgcg ggcctctacc
      481 agtgtcagag tctccgaggc cgagaggctg aggtcctgca gaaagtactg gtggaggtgc
      541 tggaggaccc tctagatgac caagatgctg gagatctctg ggtccccgag gagtcatcga
      601 gtttcgaggg tgcccaagtg gaacacagca cctccaggaa tcaagagacc tccttcccac
      661 ccacctccat tcttctcctc ctggcctgcg ttctcctgag caagtttctt gcagccagca
      721 tcctctgggc tgtggccagg ggcaggcaga agccgggaac acctgtggtc agagggctgg
      781 actgtggcca agatgctggg caccaacttc agatcctcac tggacccgga ggtacgtgag
      841 agaattctga gtgggaggag aactacagct taagtccagc caggagtcaa tccagcctgc
      901 atgctctccc ctcctccacc aagacttctg tttctgctac ttttgcttca gaggccgcct
      961 ctgcctcaag cccacctatc ctgggagcag gaatactggt gtgtacatct gtgttgagtg
     1021 gggaagacag ctggatggtt gtctgtcaac ttctgcactt tggacattaa acattctcca
     1081 cacaccaacc c
//
