LOCUS       NP_112544                227 aa            linear   ROD 03-JUN-2025
DEFINITION  triggering receptor expressed on myeloid cells 2 isoform 1
            precursor [Mus musculus].
ACCESSION   NP_112544 NP_067385 NP_112543
VERSION     NP_112544.1
DBSOURCE    REFSEQ: accession NM_031254.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 227)
  AUTHORS   Messenger,E.J., Baar,S.A., Bedford,L.M., Tsai,A.P., Lin,P.B.,
            Ferguson,C.A., Xu,G., Wallace,A., Landreth,G.E., Lamb,B.T. and
            Bissel,S.J.
  TITLE     PLCG2 modulates TREM2 expression and signaling in response to
            Alzheimer's disease pathology
  JOURNAL   Alzheimers Dement 21 (5), e70231 (2025)
   PUBMED   40346446
REFERENCE   2  (residues 1 to 227)
  AUTHORS   Pierro,E.W., Cottam,M.A., An,H., Lehmann,B.D., Pietenpol,J.A.,
            Wellen,K.E., Makowski,L., Rathmell,J.C., Fingleton,B. and
            Hasty,A.H.
  TITLE     Comparison of Lean, Obese, and Weight-Loss Models Reveals TREM2
            Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice
            and Alters Clonal T-cell Populations
  JOURNAL   Cancer Res 85 (7), 1219-1235 (2025)
   PUBMED   39841585
REFERENCE   3  (residues 1 to 227)
  AUTHORS   Zhou,L., Lu,Y., Qiu,X., Chen,Z., Tang,Y., Meng,Z., Yan,C., Du,H.,
            Li,S. and Lin,J.D.
  TITLE     Lipid droplet efferocytosis attenuates proinflammatory signaling in
            macrophages via TREM2- and MS4A7-dependent mechanisms
  JOURNAL   Cell Rep 44 (2), 115310 (2025)
   PUBMED   39954254
REFERENCE   4  (residues 1 to 227)
  AUTHORS   De Ponti,F.F., Bujko,A., Liu,Z., Collins,P.J., Schuermans,S.,
            Maueroder,C., Amstelveen,S., Thone,T., Martens,L., McKendrick,J.G.,
            Louwe,P.A., Sanchez Cruz,A., Saelens,W., Matchett,K.P.,
            Waller,K.J., Zwicker,C., Buglar-Lamb,A., Vanneste,B.,
            Parmentier,F., Binte Abdul Latib,M., Remmerie,A., Kertesz,L.,
            Kremer,A., Verbeke,J., Ipsen,D.H., Pfister,D.R., Liu,Z.,
            Guilliams,M., Henderson,N.C., Ravichandran,K., Marques,P.E. and
            Scott,C.L.
  TITLE     Spatially restricted and ontogenically distinct hepatic macrophages
            are required for tissue repair
  JOURNAL   Immunity 58 (2), 362-380 (2025)
   PUBMED   39862865
REFERENCE   5  (residues 1 to 227)
  AUTHORS   Correale,C., Genua,M., Vetrano,S., Mazzini,E., Martinoli,C.,
            Spinelli,A., Arena,V., Peyrin-Biroulet,L., Caprioli,F., Passini,N.,
            Panina-Bordignon,P., Repici,A., Malesci,A., Rutella,S., Rescigno,M.
            and Danese,S.
  TITLE     Bacterial sensor triggering receptor expressed on myeloid cells-2
            regulates the mucosal inflammatory response
  JOURNAL   Gastroenterology 144 (2), 346-356 (2013)
   PUBMED   23108068
REFERENCE   6  (residues 1 to 227)
  AUTHORS   Daws,M.R., Sullam,P.M., Niemi,E.C., Chen,T.T., Tchao,N.K. and
            Seaman,W.E.
  TITLE     Pattern recognition by TREM-2: binding of anionic ligands
  JOURNAL   J Immunol 171 (2), 594-599 (2003)
   PUBMED   12847223
  REMARK    GeneRIF: TREM-2a and TREM-2b binding to both Gram-positive and
            Gram-negative bacteria is disrupted by anionic bacterial products
            or other anionic carbohydrates and suggests that TREM-2 recognizes
            pathogens via charged carbohydrates expressed on pathogen surface.
REFERENCE   7  (residues 1 to 227)
  AUTHORS   Schmid,C.D., Sautkulis,L.N., Danielson,P.E., Cooper,J., Hasel,K.W.,
            Hilbush,B.S., Sutcliffe,J.G. and Carson,M.J.
  TITLE     Heterogeneous expression of the triggering receptor expressed on
            myeloid cells-2 on adult murine microglia
  JOURNAL   J Neurochem 83 (6), 1309-1320 (2002)
   PUBMED   12472885
REFERENCE   8  (residues 1 to 227)
  AUTHORS   Chung,D.H., Seaman,W.E. and Daws,M.R.
  TITLE     Characterization of TREM-3, an activating receptor on mouse
            macrophages: definition of a family of single Ig domain receptors
            on mouse chromosome 17
  JOURNAL   Eur J Immunol 32 (1), 59-66 (2002)
   PUBMED   11754004
REFERENCE   9  (residues 1 to 227)
  AUTHORS   Daws,M.R., Lanier,L.L., Seaman,W.E. and Ryan,J.C.
  TITLE     Cloning and characterization of a novel mouse myeloid
            DAP12-associated receptor family
  JOURNAL   Eur J Immunol 31 (3), 783-791 (2001)
   PUBMED   11241283
REFERENCE   10 (residues 1 to 227)
  AUTHORS   Bouchon,A., Dietrich,J. and Colonna,M.
  TITLE     Cutting edge: inflammatory responses can be triggered by TREM-1, a
            novel receptor expressed on neutrophils and monocytes
  JOURNAL   J Immunol 164 (10), 4991-4995 (2000)
   PUBMED   10799849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166164.2.
            
            On or before Jun 13, 2003 this sequence version replaced
            NP_067385.1, NP_112543.1.
            
            Summary: The protein encoded by this gene is part of the
            immunoglobulin and lectin-like superfamily and functions as part of
            the innate immune system. This gene forms part of a cluster of
            genes on mouse chromosome 17 thought to be involved in innate
            immunity. This protein associates with the adaptor protein Dap-12
            and recruits several factors, such as kinases and phospholipase
            C-gamma, to form a receptor signaling complex that activates
            myeloid cells, including dendritic cells and microglia. In humans
            homozygous loss-of-function mutations in this gene cause
            Nasu-Hakola disease and mutations in this gene may be risk factors
            to the development of Alzheimer's disease. In mouse mutations of
            this gene serve as a pathophysiological model for polycystic
            lipomembranous osteodysplasia with sclerosing leukoencephalopathy
            (Nasu-Hakola disease) and for inflammatory bowel disease.
            Alternative splicing results in multiple transcript variants that
            encode different protein isoforms. [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052784.1, AY024348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..227
                     /product="triggering receptor expressed on myeloid cells 2
                     isoform 1 precursor"
                     /note="triggering receptor expressed on myeloid cells 2b;
                     triggering receptor expressed on myeloid cells 2c;
                     triggering receptor expressed on myeloid cells 2a;
                     triggering receptor expressed on monocytes 2"
                     /calculated_mol_wt=22579
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1966
     mat_peptide     19..227
                     /product="Triggering receptor expressed on myeloid cells
                     2. /id=PRO_0000014988"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99NH8.1)"
                     /calculated_mol_wt=22579
     Site            20
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99NH8.1)"
     Region          21..128
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          32..36
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          47..51
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            79
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q9NZC2; propagated from
                     UniProtKB/Swiss-Prot (Q99NH8.1)"
     Region          93..97
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          107..112
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          123..126
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            157..158
                     /site_type="cleavage"
                     /note="Cleavage of ectodomain.
                     /evidence=ECO:0000269|PubMed:28855301; propagated from
                     UniProtKB/Swiss-Prot (Q99NH8.1)"
     Site            172..192
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99NH8.1)"
     CDS             1..227
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /coded_by="NM_031254.4:82..765"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS28865.1"
                     /db_xref="GeneID:83433"
                     /db_xref="MGI:MGI:1913150"
ORIGIN      
        1 mgplhqflll litalsqaln ttvlqgmagq slrvsctyda lkhwgrrkaw crqlgeegpc
       61 qrvvsthgvw llaflkkrng stviaddtla gtvtitlknl qagdaglyqc qslrgreaev
      121 lqkvlvevle dplddqdagd lwvpeesssf egaqvehsts rnqetsfppt sillllacvl
      181 lskflaasil wavargrqkp gtpvvrgldc gqdaghqlqi ltgpggt
//
