LOCUS       NM_021406               3025 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus triggering receptor expressed on myeloid cells 1
            (Trem1), transcript variant 1, mRNA.
ACCESSION   NM_021406 XM_001004014 XM_001004019
VERSION     NM_021406.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Ramatchandirin,B., Balamurugan,M.A., Desiraju,S., Chung,Y.,
            Wojczyk,B.S. and MohanKumar,K.
  TITLE     Stored RBC transfusions leads to the systemic inflammatory response
            syndrome in anemic murine neonates
  JOURNAL   Inflamm Res 73 (11), 1859-1873 (2024)
   PUBMED   39235608
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Quan,M., Zhang,H., Han,X., Ba,Y., Cui,X., Bi,Y., Yi,L. and Li,B.
  TITLE     Single-Cell RNA Sequencing Reveals Transcriptional Landscape of
            Neutrophils and Highlights the Role of TREM-1 in EAE
  JOURNAL   Neurol Neuroimmunol Neuroinflamm 11 (5), e200278 (2024)
   PUBMED   38954781
  REMARK    GeneRIF: Single-Cell RNA Sequencing Reveals Transcriptional
            Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE.
REFERENCE   3  (bases 1 to 3025)
  AUTHORS   Zhou,M., Aziz,M., Li,J., Jha,A., Ma,G., Murao,A. and Wang,P.
  TITLE     BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance
  JOURNAL   Front Immunol 15, 1426682 (2024)
   PUBMED   38938563
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3025)
  AUTHORS   Wilson,E.N., Wang,C., Swarovski,M.S., Zera,K.A., Ennerfelt,H.E.,
            Wang,Q., Chaney,A., Gauba,E., Ramos Benitez,J.A., Le Guen,Y.,
            Minhas,P.S., Panchal,M., Tan,Y.J., Blacher,E., A Iweka,C.,
            Cropper,H., Jain,P., Liu,Q., Mehta,S.S., Zuckerman,A.J., Xin,M.,
            Umans,J., Huang,J., Durairaj,A.S., Serrano,G.E., Beach,T.G.,
            Greicius,M.D., James,M.L., Buckwalter,M.S., McReynolds,M.R.,
            Rabinowitz,J.D. and Andreasson,K.I.
  TITLE     TREM1 disrupts myeloid bioenergetics and cognitive function in
            aging and Alzheimer disease mouse models
  JOURNAL   Nat Neurosci 27 (5), 873-885 (2024)
   PUBMED   38539014
  REMARK    GeneRIF: TREM1 disrupts myeloid bioenergetics and cognitive
            function in aging and Alzheimer disease mouse models.
REFERENCE   5  (bases 1 to 3025)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3025)
  AUTHORS   Murakami,Y., Kohsaka,H., Kitasato,H. and Akahoshi,T.
  TITLE     Lipopolysaccharide-induced up-regulation of triggering receptor
            expressed on myeloid cells-1 expression on macrophages is regulated
            by endogenous prostaglandin E2
  JOURNAL   J Immunol 178 (2), 1144-1150 (2007)
   PUBMED   17202378
  REMARK    GeneRIF: Regulation of TREM-1 and the soluble form of TREM-1
            expression by prostaglandin E2 may modulate the inflammatory
            response to microbial pathogens
REFERENCE   7  (bases 1 to 3025)
  AUTHORS   Kelker,M.S., Debler,E.W. and Wilson,I.A.
  TITLE     Crystal structure of mouse triggering receptor expressed on myeloid
            cells 1 (TREM-1) at 1.76 A
  JOURNAL   J Mol Biol 344 (5), 1175-1181 (2004)
   PUBMED   15561137
  REMARK    GeneRIF: crystal structure of the mouse TREM-1 extracellular domain
            at 1.76A resolution
REFERENCE   8  (bases 1 to 3025)
  AUTHORS   Gibot,S., Kolopp-Sarda,M.N., Bene,M.C., Bollaert,P.E.,
            Lozniewski,A., Mory,F., Levy,B. and Faure,G.C.
  TITLE     A soluble form of the triggering receptor expressed on myeloid
            cells-1 modulates the inflammatory response in murine sepsis
  JOURNAL   J Exp Med 200 (11), 1419-1426 (2004)
   PUBMED   15557347
REFERENCE   9  (bases 1 to 3025)
  AUTHORS   Chung,D.H., Seaman,W.E. and Daws,M.R.
  TITLE     Characterization of TREM-3, an activating receptor on mouse
            macrophages: definition of a family of single Ig domain receptors
            on mouse chromosome 17
  JOURNAL   Eur J Immunol 32 (1), 59-66 (2002)
   PUBMED   11754004
REFERENCE   10 (bases 1 to 3025)
  AUTHORS   Bouchon,A., Dietrich,J. and Colonna,M.
  TITLE     Cutting edge: inflammatory responses can be triggered by TREM-1, a
            novel receptor expressed on neutrophils and monocytes
  JOURNAL   J Immunol 164 (10), 4991-4995 (2000)
   PUBMED   10799849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC241601.3 and AK089439.1.
            
            On Mar 23, 2012 this sequence version replaced NM_021406.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089439.1, AK171753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC241601.3         76223-76255         c
            34-1618             AK089439.1         3-1587
            1619-1770           AC241601.3         63325-63476         c
            1771-3025           AK089439.1         1737-2991
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..3025
                     /gene="Trem1"
                     /note="triggering receptor expressed on myeloid cells 1"
                     /db_xref="GeneID:58217"
                     /db_xref="MGI:MGI:1930005"
     exon            1..105
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..749
                     /gene="Trem1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; triggering receptor expressed in monocytes 1"
                     /codon_start=1
                     /product="triggering receptor expressed on myeloid cells 1
                     isoform 1 precursor"
                     /protein_id="NP_067381.1"
                     /db_xref="CCDS:CCDS28860.1"
                     /db_xref="GeneID:58217"
                     /db_xref="MGI:MGI:1930005"
                     /translation="MRKAGLWGLLCVFFVSEVKAAIVLEEERYDLVEGQTLTVKCPFN
                     IMKYANSQKAWQRLPDGKEPLTLVVTQRPFTRPSEVHMGKFTLKHDPSEAMLQVQMTD
                     LQVTDSGLYRCVIYHPPNDPVVLFHPVRLVVTKGSSDVFTPVIIPITRLTERPILITT
                     KYSPSDTTTTRSLPKPTAVVSSPGLGVTIINGTDADSVSTSSVTISVICGLLSKSLVF
                     IILFIVTKRTFG"
     exon            106..462
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..646
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..3025
                     /gene="Trem1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1013..1018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trem1"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="Trem1"
                     /note="major polyA site"
     regulatory      3004..3009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trem1"
                     /note="hexamer: AATAAA"
     polyA_site      3023
                     /gene="Trem1"
                     /note="major polyA site"
ORIGIN      
        1 gtcttctagc tgtcccagca gcccacagag gcagtcgttg gagctgagct tgaaggatga
       61 ggaaggctgg gctctgggga ctgctgtgcg tgttctttgt ctcagaagtc aaagctgcca
      121 ttgttctaga ggaagaaagg tatgacctag tggagggcca gactttgaca gtgaagtgtc
      181 ccttcaacat catgaagtat gccaacagcc agaaggcttg gcagagacta ccagacggga
      241 aggaaccctt gaccctggtg gtcacacaga ggccctttac aagacccagt gaagtccaca
      301 tggggaagtt caccctgaaa catgacccta gtgaggccat gctacaagtt caaatgactg
      361 accttcaagt gacagactct ggattgtatc gttgtgtgat ttaccatcct ccgaatgacc
      421 ctgttgtgct cttccatcct gtccgcctgg tggtgaccaa gggttcttca gatgtgttca
      481 ctcctgtcat cattcctatt acaaggctga cagagcgtcc catccttatt accacaaaat
      541 actcacccag tgacacaact acaacccgat ccctacccaa gcccactgcg gttgtttcct
      601 ctcctggtct tggagtcact atcataaatg ggacagatgc tgacagtgtc tccacatcca
      661 gtgttactat ttcagtcatc tgtggacttc tcagcaagag cctggttttc atcatcttat
      721 tcattgtcac aaagaggaca tttggatgac agaacttgaa gctatacaat agtgaccttc
      781 agcggtgtct atttcacagg aggagctgag gtggtggggc tgaggaggag ctatgacatg
      841 aattgaacct gtaatcaccg gtgacgtcta aggctcagga tatcctcagc tgaccctgtc
      901 cactctcctc attttatcca tcatcttggg gatgtgctct gcacccttag aaaaggggaa
      961 accattccca gaacactctg gccattcccc ctaaatagtt gggttggcct gaaataaaga
     1021 gaaactccag agcttccccc tgtctcttgt tgtgggagtc aagaagatta catggtcacc
     1081 actgatatcc ccacctcttg tccttctcct ggatggtaca attctagtca ttttagcagg
     1141 gcccttgctc atgaagcagc ctgtcctcct acctctgggc cttcctttct gggagtcaga
     1201 cactcagatt tctgtcttca tctgtagtcc tctgaacact cccaaccatg gaccaagaag
     1261 acatgatcct accttgacaa taatgcaact gggagagaga aatcaagtta agctggatgc
     1321 tgttgcctgg gaaacacctg gaagagatag tatccgtagc attgaatcag tacatggatg
     1381 gcatcaacat gctgtgtgca ttttattatt gacttctcag tgcatgaggg ttaaagtgta
     1441 tgtgatcaga gtaaggccac aggggtagca ggccatcacc tcctggcagg aatgaaatct
     1501 agagagttcc cttactcaag agctccagag gcagggagat ggggagccag actctgctgc
     1561 tagctgaatg cctttttgcc tggactgaga cagggtctag catggcgggg gggggggggg
     1621 caggatccta tctcagactg ccccctgtgt gagtctacct cccactcacc ttccttcacc
     1681 tctcagtctc agcctgggta ccctgtggct cctgtgcttt ctctaggaca cactggcatt
     1741 tgcttgtttc cacctctttg ggtgggaaaa ggatggtaga tccattcctt ctacttcagc
     1801 agtggctgga atcaacttca tcgaaaggtt cccaagatca aaccgcatca ccacaaagca
     1861 tccagctcac ttgatcgcac ccagaaggcc gaggagtggc tgaaccacgt atcttatatc
     1921 aggaaagcac tttcctgtca gggagacttt cccttccacc tcctgtgaag atcccaggtc
     1981 ttaaggtgtg cttctgtcac ataaggacgg ttcactgtga acgtggctct ctgtgtaact
     2041 ccaccctggg gtggcatcgc tgagcacagg gtattcacag ctgcataatc tccagtctgc
     2101 tgggagaggc cgcagtggaa tccactttgg gttggtgctc tgggacacgt ctttggaggg
     2161 ctggtgcaga tgctgttcat ctcagtaggt ttgtttcctg actgaagaat caagcagggg
     2221 tttatagtca ggggctaaaa tgcttcccaa gaaagcctgg ggaccagagt tcaagccatt
     2281 agagcaaaat gtaaaaaagc tgcttagggc gggccatacc tataatctcg gcactgggaa
     2341 agccaagaca gccagttctc tggggcttag tgactagtta gagaccctct tgtggtcagt
     2401 gagagacctt gtttcagata caacaacaac aacaaaaaaa caataacaac acacacacac
     2461 acgttgtatg ataactgtca tatttcttag gttattcaat ttgcagtagt ccagaaacca
     2521 ccctggagga gagcctcagt tgatgaattg tcccctgcag gcatgcctgt gctgtattgc
     2581 cttcgctgtt aattgaggtg ggagtatcca ccctgtatat ggctggtgcc acttcataca
     2641 ctgggtccca actgtgtata aaaataagga agcctagttg atcagaagca ggcagacccc
     2701 aagggtccag tttatcctct gctcttgact atggatatga tgtgactagt gcttaagttc
     2761 ctgcctcgac ttctccacaa taagggactg tgacctgtgt tgttgttgtt gttgttgttg
     2821 ttgttgttgt tgttgtattt ggggggtggg gtcagggtgc cttcccaggg catcagagta
     2881 aaactggaac aatgacacat gtctgtgatc ccagcacttg ggggactaag gcaaggggcc
     2941 tgaggattca aggacagttt ggactttgtt gtgaaatccc atcccaaact gaaaaataaa
     3001 taaaataaaa gcagttgaga ttctg
//
