LOCUS       NM_021481               2053 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus trehalase (brush-border membrane glycoprotein) (Treh),
            transcript variant 1, mRNA.
ACCESSION   NM_021481
VERSION     NM_021481.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Bara,A.M., Chen,L., Ma,C., Underwood,J., Moreci,R.S., Sumigray,K.,
            Sun,T., Diao,Y., Verzi,M. and Lechler,T.
  TITLE     Maf family transcription factors are required for nutrient uptake
            in the mouse neonatal gut
  JOURNAL   Development 149 (23) (2022)
   PUBMED   36504079
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Arai,C., Suyama,A., Arai,S., Arai,N., Yoshizane,C., Koya-Miyata,S.,
            Mizote,A., Endo,S., Ariyasu,T., Mitsuzumi,H. and Ushio,S.
  TITLE     Trehalose itself plays a critical role on lipid metabolism:
            Trehalose increases jejunum cytoplasmic lipid droplets which
            negatively correlated with mesenteric adipocyte size in both
            HFD-fed trehalase KO and WT mice
  JOURNAL   Nutr Metab (Lond) 17, 22 (2020)
   PUBMED   32206077
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Srivillibhuthur,M., Warder,B.N., Toke,N.H., Shah,P.P., Feng,Q.,
            Gao,N., Bonder,E.M. and Verzi,M.P.
  TITLE     TFAM is required for maturation of the fetal and adult intestinal
            epithelium
  JOURNAL   Dev Biol 439 (2), 92-101 (2018)
   PUBMED   29684311
REFERENCE   5  (bases 1 to 2053)
  AUTHORS   Redmann,M., Wani,W.Y., Volpicelli-Daley,L., Darley-Usmar,V. and
            Zhang,J.
  TITLE     Trehalose does not improve neuronal survival on exposure to
            alpha-synuclein pre-formed fibrils
  JOURNAL   Redox Biol 11, 429-437 (2017)
   PUBMED   28068606
  REMARK    GeneRIF: Trehalose was also able to restore cell viability to
            control levels, but pre-formed fibrils (PFFs)still exhibited toxic
            effects on the cells. These data provide essential information
            regarding effects of trehalose on alphaSyn accumulation and
            neuronal survival on exposure to PFF
REFERENCE   6  (bases 1 to 2053)
  AUTHORS   Muncan,V., Heijmans,J., Krasinski,S.D., Buller,N.V.,
            Wildenberg,M.E., Meisner,S., Radonjic,M., Stapleton,K.A.,
            Lamers,W.H., Biemond,I., van den Bergh Weerman,M.A., O'Carroll,D.,
            Hardwick,J.C., Hommes,D.W. and van den Brink,G.R.
  TITLE     Blimp1 regulates the transition of neonatal to adult intestinal
            epithelium
  JOURNAL   Nat Commun 2, 452 (2011)
   PUBMED   21878906
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2053)
  AUTHORS   Harper,J., Mould,A., Andrews,R.M., Bikoff,E.K. and Robertson,E.J.
  TITLE     The transcriptional repressor Blimp1/Prdm1 regulates postnatal
            reprogramming of intestinal enterocytes
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10585-10590 (2011)
   PUBMED   21670299
REFERENCE   8  (bases 1 to 2053)
  AUTHORS   Nanthakumar,N.N., Dai,D., Meng,D., Chaudry,N., Newburg,D.S. and
            Walker,W.A.
  TITLE     Regulation of intestinal ontogeny: effect of glucocorticoids and
            luminal microbes on galactosyltransferase and trehalase induction
            in mice
  JOURNAL   Glycobiology 15 (3), 221-232 (2005)
   PUBMED   15483270
  REMARK    GeneRIF: in mature gut of conventional mice, both beta
            1,4-galactosyltransferase and trehalase are elevated and
            insensitive to cartisone acetate
REFERENCE   9  (bases 1 to 2053)
  AUTHORS   Quezada-Calvillo,R., Rodriguez-Zuniga,F. and Underdown,B.J.
  TITLE     Partial characterization of murine intestinal maltase-glucoamylase
  JOURNAL   Biochem Biophys Res Commun 295 (2), 394-400 (2002)
   PUBMED   12150962
REFERENCE   10 (bases 1 to 2053)
  AUTHORS   Oesterreicher,T.J., Markesich,D.C. and Henning,S.J.
  TITLE     Cloning, characterization and mapping of the mouse trehalase (Treh)
            gene
  JOURNAL   Gene 270 (1-2), 211-220 (2001)
   PUBMED   11404018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151971.3, AK008912.1 and
            BX630594.1.
            
            On Apr 24, 2013 this sequence version replaced NM_021481.2.
            
            Summary: This gene belongs to the alpha-glucosidase family, whose
            members encode enzymes that carry out hydrolysis of alpha-glucoside
            bonds of a variety of carbohydrates. The enzyme encoded by this
            gene uses the disaccharide trehalose as a highly specific substrate
            and converts it into two glucose molecules. Alternative splicing of
            this gene results in multiple transcript variants encoding
            different isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008912.1, AF136944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC151971.3         49528-49543         c
            17-2047             AK008912.1         2-2032
            2048-2053           BX630594.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..2053
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /note="trehalase (brush-border membrane glycoprotein)"
                     /db_xref="GeneID:58866"
                     /db_xref="MGI:MGI:1926230"
     exon            1..108
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1759
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /EC_number="3.2.1.28"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alpha,alpha-trehalase; alpha,alpha-trehalose
                     glucohydrolase"
                     /codon_start=1
                     /product="trehalase isoform 1 precursor"
                     /protein_id="NP_067456.1"
                     /db_xref="CCDS:CCDS23117.1"
                     /db_xref="GeneID:58866"
                     /db_xref="MGI:MGI:1926230"
                     /translation="MTWELHLLLLLGLGLRSQEALPPPCESQIYCHGELLHQVQMAQL
                     YQDDKQFVDMSLATSPDEVLQKFSELATVHNHSIPKEQLQEFVQSHFQPVGQELQSWT
                     PEDWKDSPQFLQKISDANLRVWAEELHKIWKKLGKKMKAEVLSYPERSSLIYSKHPFI
                     VPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRIYYLQR
                     SQPPLLTLMMDRYVAHTKDVAFLQENIGTLASELDFWTVNRTVSVVSGGQSYVLNRYY
                     VPYGGPRPESYRKDAELANSVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLS
                     SIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEATKYRNLRAQRLAAMEAVLWDEQ
                     KGAWFDYDLEKGKKNLEFYPSNLSPLWAGCFSDPSVADKALKYLEDSKILTYQYGIPT
                     SLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNWIKTNFKVYSQKSA
                     MFEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLV
                     AALLLSLLLQ"
     exon            109..209
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            210..354
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            355..442
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..543
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..636
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            637..753
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            754..876
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..926
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1121
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1339
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1451
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1564
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1618
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..2048
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2024..2029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /note="hexamer: AATATA"
     polyA_site      2048
                     /gene="Treh"
                     /gene_synonym="2210412M19Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcattccgtt ctaggcaccg tgcccaggat gacctgggag ctgcacctgc tgcttctgct
       61 ggggctggga cttaggtccc aggaggccct gccaccaccc tgtgagagcc agatctactg
      121 ccatggagag ctcctgcacc aagttcagat ggcccagctc taccaagatg acaagcagtt
      181 tgtggatatg tcactggcca catctccaga tgaagtcctg cagaagttca gtgagctggc
      241 cacagtccac aaccacagca tccccaagga acagcttcag gaatttgtcc agagtcactt
      301 ccagcccgtg gggcaggagc tgcagtcctg gacccctgag gactggaagg acagccctca
      361 gttcctgcag aagatctcgg atgctaatct gcgtgtctgg gcggaggagc tacacaagat
      421 ctggaaaaag ctgggaaaga agatgaaagc agaagtcctc agctaccccg agaggtcctc
      481 cctaatctac tcaaagcacc ccttcattgt gcccgggggg cgctttgttg aattctacta
      541 ctgggactcg tactgggtga tggaaggcct gcttctttct gagatggcct caacagtgaa
      601 gggtatgctg caaaactttc tggatctggt gaagacctac ggacatatcc ccaacggtgg
      661 acgcatatat tacctgcaac ggagccagcc cccactcctg actctcatga tggatcgata
      721 tgtagctcat accaaggatg tcgccttcct tcaggagaat attgggactc tagcctctga
      781 actggacttc tggactgtga acaggactgt ctctgtagtc tcaggaggac aaagctatgt
      841 cttaaatcgc tactatgtcc cttatggggg acccaggcca gagtcctaca ggaaagacgc
      901 agaattggca aactctgtgc cagaagggga ccgagagact ctgtgggctg agctcaaggc
      961 tggggctgag tctggctggg acttctcttc acgctggctt gttggaggcc cagaccctga
     1021 tttgctcagc agcatccgaa ccagcaaaat ggtacccgct gatctgaacg cgttcctgtg
     1081 ccaagcagag gaactgatga gtaacttcta ctccagacta gggaacgaca cagaggccac
     1141 aaagtacagg aacctgcggg cccagcgctt ggccgccatg gaagctgtcc tgtgggacga
     1201 gcagaagggt gcctggtttg actatgactt ggaaaagggg aagaagaacc tggagtttta
     1261 tccctccaac ctctccccac tttgggctgg ctgcttctca gaccctagtg ttgctgacaa
     1321 ggctctgaag tacttggagg acagcaagat cttgacctac caatatggaa tcccaacctc
     1381 tcttcgtaac acaggccagc agtgggactt ccccaatgcc tgggccccac tgcaggacct
     1441 ggtcattaga ggtttggcca agtcagcttc cccccggact caggaggtgg ctttccagct
     1501 ggcccagaat tggatcaaaa ccaacttcaa agtctactcc caaaagtcag cgatgtttga
     1561 gaagtatgac atcagcaacg gtggacatcc aggtggagga ggggagtatg aagttcagga
     1621 aggatttggc tggacaaacg gattggccct gatgcttctg gatcgctatg gtgaccagtt
     1681 gacttcaggg acccagttag cttccctggg accccactgc ctagtggctg cccttcttct
     1741 cagtcttctg ctacagtgac aagaacaaga atggactcac tgcctgcgct ttctcccctg
     1801 gccccagctc atggttcatt aaacccttgc tctacctccc ttctagcccc acccccaccc
     1861 cgccccttcc tgctcatagt gtcctgagcc aagaagtgac caagaggtca agactgtaat
     1921 tttcacagtg ttctgagcca agaagtgacc aagaggtcaa ggttgtaatt ttcacgaggg
     1981 cggaaactga atcctgatac ctaaagtatc ctatcgggta ccaaatatag ctcagacttc
     2041 cacactcaaa aaa
//
