LOCUS       NP_084002                693 aa            linear   ROD 27-APR-2025
DEFINITION  triadin isoform 1 [Mus musculus].
ACCESSION   NP_084002 XP_483890 XP_911751
VERSION     NP_084002.2
DBSOURCE    REFSEQ: accession NM_029726.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 693)
  AUTHORS   Zhao,Y., Riching,A.S., Knight,W.E., Chi,C., Broadwell,L.J., Du,Y.,
            Abdel-Hafiz,M., Ambardekar,A.V., Irwin,D.C., Proenza,C., Xu,H.,
            Leinwand,L.A., Walker,L.A., Woulfe,K.C., Bristow,M.R.,
            Buttrick,P.M. and Song,K.
  TITLE     Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative
            Splicing of the Triadin Gene in the Heart
  JOURNAL   Circulation 146 (9), 699-714 (2022)
   PUBMED   35862102
  REMARK    GeneRIF: Cardiomyocyte-Specific Long Noncoding RNA Regulates
            Alternative Splicing of the Triadin Gene in the Heart.
REFERENCE   2  (residues 1 to 693)
  AUTHORS   Manno,C., Tammineni,E., Figueroa,L., Marty,I. and Rios,E.
  TITLE     Quantification of the calcium signaling deficit in muscles devoid
            of triadin
  JOURNAL   PLoS One 17 (2), e0264146 (2022)
   PUBMED   35213584
  REMARK    GeneRIF: Quantification of the calcium signaling deficit in muscles
            devoid of triadin.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 693)
  AUTHORS   Seo,M.H., Lim,S. and Yeo,S.
  TITLE     Association of decreased triadin expression level with apoptosis of
            dopaminergic cells in Parkinson's disease mouse model
  JOURNAL   BMC Neurosci 22 (1), 65 (2021)
   PUBMED   34736417
  REMARK    GeneRIF: Association of decreased triadin expression level with
            apoptosis of dopaminergic cells in Parkinson's disease mouse model.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 693)
  AUTHORS   Sebastien,M., Aubin,P., Brocard,J., Brocard,J., Marty,I. and
            Faure,J.
  TITLE     Dynamics of triadin, a muscle-specific triad protein, within
            sarcoplasmic reticulum subdomains
  JOURNAL   Mol Biol Cell 31 (4), 261-272 (2020)
   PUBMED   31877066
  REMARK    GeneRIF: Dynamics of triadin, a muscle-specific triad protein,
            within sarcoplasmic reticulum subdomains.
REFERENCE   5  (residues 1 to 693)
  AUTHORS   Zhang,L., Salgado-Somoza,A., Vausort,M., Leszek,P. and Devaux,Y.
  CONSRTM   Cardiolinctrade mark network. Electronic address:
            https://www.cardiolinc.org
  TITLE     A heart-enriched antisense long non-coding RNA regulates the
            balance between cardiac and skeletal muscle triadin
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (2), 247-258 (2018)
   PUBMED   29126880
  REMARK    GeneRIF: The lncRNA TRDN-AS regulates the balance between cardiac
            and skeletal isoforms of triadin.
REFERENCE   6  (residues 1 to 693)
  AUTHORS   Arvanitis,D.A., Vafiadaki,E., Fan,G.C., Mitton,B.A., Gregory,K.N.,
            Del Monte,F., Kontrogianni-Konstantopoulos,A., Sanoudou,D. and
            Kranias,E.G.
  TITLE     Histidine-rich Ca-binding protein interacts with sarcoplasmic
            reticulum Ca-ATPase
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (3), H1581-H1589 (2007)
   PUBMED   17526652
  REMARK    GeneRIF: Histidine-rich Ca-binding protein may play a key role in
            the regulation of SR Ca cycling through its direct interactions
            with SERCA2 and triadin, mediating a fine cross talk between SR Ca
            uptake and release in the heart.
REFERENCE   7  (residues 1 to 693)
  AUTHORS   Kirchhof,P., Klimas,J., Fabritz,L., Zwiener,M., Jones,L.R.,
            Schafers,M., Hermann,S., Boknik,P., Schmitz,W., Breithardt,G.,
            Kirchhefer,U. and Neumann,J.
  TITLE     Stress and high heart rate provoke ventricular tachycardia in mice
            expressing triadin
  JOURNAL   J Mol Cell Cardiol 42 (5), 962-971 (2007)
   PUBMED   17408688
  REMARK    GeneRIF: Triadin(TRD)xjunctin(JCN) mice were studied to compensate
            the down-regulation of junctin expression in triadin-expressing
            mice; exercise or stress provoked repetitive ventricular
            tachycardia in freely roaming TRDxJCN mice.
REFERENCE   8  (residues 1 to 693)
  AUTHORS   Hong,S., Kim,T.W., Choi,I., Woo,J.M., Oh,J., Park,W.J., Kim,D.H.
            and Cho,C.
  TITLE     Complementary DNA cloning, genomic characterization and expression
            analysis of a mammalian gene encoding histidine-rich calcium
            binding protein
  JOURNAL   Biochim Biophys Acta 1727 (3), 188-196 (2005)
   PUBMED   15777620
REFERENCE   9  (residues 1 to 693)
  AUTHORS   Kirchhefer,U., Baba,H.A., Kobayashi,Y.M., Jones,L.R., Schmitz,W.
            and Neumann,J.
  TITLE     Altered function in atrium of transgenic mice overexpressing
            triadin 1
  JOURNAL   Am J Physiol Heart Circ Physiol 283 (4), H1334-H1343 (2002)
   PUBMED   12234783
  REMARK    GeneRIF: triadin 1 overexpression triggered time-dependent
            alterations in SR protein expression, Ca(2+) homeostasis, and
            contractility, indicating for the first time an inhibitory function
            of triadin 1 on SR-Ca(2+) release in vivo.
REFERENCE   10 (residues 1 to 693)
  AUTHORS   Hong,C.S., Ji,J.H., Kim,J.P., Jung,D.H. and Kim,D.H.
  TITLE     Molecular cloning and characterization of mouse cardiac triadin
            isoforms
  JOURNAL   Gene 278 (1-2), 193-199 (2001)
   PUBMED   11707337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB658668.1, AK009816.1, AC157017.3, AI642378.1, AC153966.4,
            AC109214.6 and AK036470.1.
            
            On or before Apr 9, 2009 this sequence version replaced
            XP_911751.3, XP_483890.5, NP_084002.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN01164133, SAMN01766820
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.37 cM"
     Protein         1..693
                     /product="triadin isoform 1"
                     /note="cardiac triadin"
                     /calculated_mol_wt=77713
     Region          45..>74
                     /region_name="Asp-B-Hydro_N"
                     /note="Aspartyl beta-hydroxylase N-terminal region;
                     pfam05279"
                     /db_xref="CDD:428406"
     Site            48..68
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q9K5.1)"
     Region          117..260
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q9K5.1)"
     Region          278..649
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q9K5.1)"
     Site            301
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QX75; propagated from
                     UniProtKB/Swiss-Prot (E9Q9K5.1)"
     Region          <383..>646
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Site            515
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q9K5.1)"
     Site            584
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (E9Q9K5.1)"
     Region          666..693
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q9K5.1)"
     CDS             1..693
                     /gene="Trdn"
                     /gene_synonym="2310045H21Rik; EG432451; TDN"
                     /coded_by="NM_029726.2:242..2323"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48532.1"
                     /db_xref="GeneID:76757"
                     /db_xref="MGI:MGI:1924007"
ORIGIN      
        1 mteitaegna sttttvidnk ngcipkspgk vlkrsvtedi vttfsspaaw llvialiitw
       61 savaivmfdl vdyknfsass iakigsdplk lvndaveett dwiygffsll sdiissegde
      121 ddedadedid kgeieepplk rkeihqekae keekpekkiq tkashrerek gkeklkgekp
      181 ektathkekl ekkerpetkm makedkkikt kekteekakk emkvgkqekv kptaakaket
      241 pktppkarkk ddkempavhe qkdqyafcry midmfvhgdl kpgqspvmpp psltpskpal
      301 sttaleekek eekkkmekkd tsdtkkkeke vkkkseetti dgkgkepgkp petkqmtakl
      361 ttqaaarkde kkeeskkmrk pteeqpkgkk qekkekhiep aktpkkehpg pseklkkaka
      421 eqakeeiaaa stkkalhgkk eekaktveqe vkkeksgkss sdlkdkevkk eksgksssdl
      481 kdkepqlkne ekskpqvkke aklassdkgq trkqnitrpe qviphvkpek aehqekghps
      541 ikkdkpkpss kgapevpdsg kkkiekseke skvptreenl qvynvtkaek pgkipkdske
      601 apaskkdked skeaptskkd kedskdvphs kkdkevtddv sspkkqtrpi sffqcvylng
      661 yngygfqfpv tpvqqpgenp gktnspgqkq qeq
//
