LOCUS       NM_025432               1448 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus trafficking protein particle complex 2 (Trappc2),
            transcript variant 1, mRNA.
ACCESSION   NM_025432
VERSION     NM_025432.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Kim,J.J., Lipatova,Z. and Segev,N.
  TITLE     TRAPP Complexes in Secretion and Autophagy
  JOURNAL   Front Cell Dev Biol 4, 20 (2016)
   PUBMED   27066478
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Duarte,D.T., Hul,S. and Sacher,M.
  TITLE     A yeast two hybrid screen identifies SPATA4 as a TRAPP interactor
  JOURNAL   FEBS Lett 585 (17), 2676-2681 (2011)
   PUBMED   21827752
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Zong,M., Wu,X.G., Chan,C.W., Choi,M.Y., Chan,H.C., Tanner,J.A. and
            Yu,S.
  TITLE     The adaptor function of TRAPPC2 in mammalian TRAPPs explains
            TRAPPC2-associated SEDT and TRAPPC9-associated congenital
            intellectual disability
  JOURNAL   PLoS One 6 (8), e23350 (2011)
   PUBMED   21858081
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Choi,M.Y., Chan,C.C., Chan,D., Luk,K.D., Cheah,K.S. and Tanner,J.A.
  TITLE     Biochemical consequences of sedlin mutations that cause
            spondyloepiphyseal dysplasia tarda
  JOURNAL   Biochem J 423 (2), 233-242 (2009)
   PUBMED   19650763
  REMARK    GeneRIF: The sedlin mutations S73L, F83S and V130D cause SEDT by
            sedlin misfolding, whereas the D47Y mutation may influence normal
            TRAPP (transport protein particle) dynamics.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Menon,S., Cai,H., Lu,H., Dong,G., Cai,Y., Reinisch,K. and
            Ferro-Novick,S.
  TITLE     mBET3 is required for the organization of the TRAPP complexes
  JOURNAL   Biochem Biophys Res Commun 350 (3), 669-677 (2006)
   PUBMED   17027922
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Jang,S.B., Kim,Y.G., Cho,Y.S., Suh,P.G., Kim,K.H. and Oh,B.H.
  TITLE     Crystal structure of SEDL and its implications for a genetic
            disease spondyloepiphyseal dysplasia tarda
  JOURNAL   J Biol Chem 277 (51), 49863-49869 (2002)
   PUBMED   12361953
  REMARK    GeneRIF: x-ray crystallography analysis of mouse SEDL
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002658.1 and BC099551.1.
            
            On Aug 27, 2015 this sequence version replaced NM_025432.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061087.1, AK004389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK002658.1         2-29
            29-1448             BC099551.1         1-1420
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 77.43 cM"
     gene            1..1448
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /note="trafficking protein particle complex 2"
                     /db_xref="GeneID:66226"
                     /db_xref="MGI:MGI:1913476"
     exon            1..85
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /inference="alignment:Splign:2.1.0"
     exon            86..197
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..527
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spondyloepiphyseal dysplasia, late; trafficking protein
                     particle complex subunit 2; spondyloepiphyseal dysplasia
                     tarda protein; sedlin"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 2
                     isoform 1"
                     /protein_id="NP_079708.2"
                     /db_xref="CCDS:CCDS41208.1"
                     /db_xref="GeneID:66226"
                     /db_xref="MGI:MGI:1913476"
                     /translation="MSGSFYFVIVGHHDNPVFEMEFLPPGKAESKDDHRHLNQFIAHA
                     ALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDV
                     YDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS"
     exon            198..342
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /inference="alignment:Splign:2.1.0"
     exon            343..428
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /inference="alignment:Splign:2.1.0"
     exon            429..1432
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1414..1419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /note="hexamer: AATAAA"
     polyA_site      1432
                     /gene="Trappc2"
                     /gene_synonym="1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl;
                     TRS20"
                     /note="major polyA site"
ORIGIN      
        1 gagagtgatt ttgggactcc caggctgagg ctcccgagcg cagattaaag aggcggccgg
       61 ttctcatctc ggctcctccc tacaggagct gtgtattgaa gacaatgtct gggagcttct
      121 acttcgtaat tgttggccac catgataatc cagtttttga aatggaattt ttgccacctg
      181 ggaaagcaga atccaaagat gatcaccgtc atctgaacca gtttatagct catgctgctc
      241 ttgaccttgt ggacgaaaat atgtggcttt cgaacaacat gtacttaaaa acggtggaca
      301 aatttaatga gtggtttgta tcagcctttg tcactgcagg gcatatgaga tttattatgc
      361 ttcatgatgt gaggcaagaa gatgggataa agaacttctt tactgatgtc tatgatctgt
      421 atataaagtt tgcaatgaat ccattttatg aacccaattc tcccattcga tcgagtgcat
      481 tcgacaggaa agtccagttt cttgggaaga aacacctttt aagctaaatg agaacaactc
      541 ggaaatcagc tgtctcatcg tgggtatcag gaaggtgtgc tctgtaaatc attcgaaatt
      601 gcctggaaaa catcccctta aaattgtact ttgttttcat gttgactatc agcattaata
      661 ttggcttgtg aactgtgata tgtataaaca actctttacc agtagttctg aacagtttta
      721 tttaaaaact tgagaaaact tttcttgccg aagataatat gatcttaatt tattaattca
      781 aaagcatatg tcatagttaa tatttgttag attgattaaa gactgaaaag ttctggagac
      841 atgactgaaa tgagttattt atacatttag agatgtcctt ttaaaatgca taatacactg
      901 cagtaccaag aagctgaagc agaaagccca tgccaagtgt tccatgcttg cctacctctg
      961 ccagaggctg agaataaccg tcctgctgta actctagacc ccctagatct atgtatgctg
     1021 caccagttac aggccttggc aaaatgtggt gcctctgtca ccttacattc tagtgtttcc
     1081 tttctcttag taaactagag gtttatttga atttattagt atctgtactt ggaaaatgtt
     1141 ataatatgga tttagtatta ctaataaaag cctgggttac actgacattt gcactttacc
     1201 tttatgctat atacagggtg ggaggtggca gatgtggcct cttgtattag aaatgttggt
     1261 ttgattttac agtagtacat atgtatggaa aagcaaacca gattttcatg tacacactgg
     1321 aaaatttctc tccattctaa cttttgagta agtacttcta aactttcttg tattctttgg
     1381 tgaagttatc atcactcttt tttttatttc ttaaataaat atttatatcc aaaaaaaaaa
     1441 aaaaaaaa
//
