LOCUS       NM_001081055            6354 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus trafficking protein particle complex 10 (Trappc10),
            mRNA.
ACCESSION   NM_001081055 XM_125775
VERSION     NM_001081055.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6354)
  AUTHORS   Hu,M., Bodnar,B., Zhang,Y., Xie,F., Li,F., Li,S., Zhao,J., Zhao,R.,
            Gedupoori,N., Mo,Y., Lin,L., Li,X., Meng,W., Yang,X., Wang,H.,
            Barbe,M.F., Srinivasan,S., Bethea,J.R., Mo,X., Xu,H. and Hu,W.
  TITLE     Defective neurite elongation and branching in Nibp/Trappc9
            deficient zebrafish and mice
  JOURNAL   Int J Biol Sci 19 (10), 3226-3248 (2023)
   PUBMED   37416774
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6354)
  AUTHORS   Rawlins,L.E., Almousa,H., Khan,S., Collins,S.C., Milev,M.P.,
            Leslie,J., Saint-Dic,D., Khan,V., Hincapie,A.M., Day,J.O.,
            McGavin,L., Rowley,C., Harlalka,G.V., Vancollie,V.E., Ahmad,W.,
            Lelliott,C.J., Gul,A., Yalcin,B., Crosby,A.H., Sacher,M. and
            Baple,E.L.
  TITLE     Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy
            disorder in humans and mice
  JOURNAL   PLoS Genet 18 (3), e1010114 (2022)
   PUBMED   35298461
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6354)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6354)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6354)
  AUTHORS   Kim,J.J., Lipatova,Z. and Segev,N.
  TITLE     TRAPP Complexes in Secretion and Autophagy
  JOURNAL   Front Cell Dev Biol 4, 20 (2016)
   PUBMED   27066478
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6354)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   8  (bases 1 to 6354)
  AUTHORS   Cole,S.E., Wiltshire,T., Rue,E.E., Morrow,D., Hieter,P., Brahe,C.,
            Fisher,E.M., Katsanis,N. and Reeves,R.H.
  TITLE     High-resolution comparative physical mapping of mouse chromosome 10
            in the region of homology with human chromosome 21
  JOURNAL   Mamm Genome 10 (3), 229-234 (1999)
   PUBMED   10051316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164573.5.
            
            On Jun 29, 2018 this sequence version replaced NM_001081055.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154290.1, SRR7974084.26527.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC164573.5         161098-161307       c
            211-292             AC164573.5         148116-148197       c
            293-428             AC164573.5         145441-145576       c
            429-625             AC164573.5         139326-139522       c
            626-821             AC164573.5         136851-137046       c
            822-933             AC164573.5         133812-133923       c
            934-1181            AC164573.5         131230-131477       c
            1182-1328           AC164573.5         128138-128284       c
            1329-1443           AC164573.5         127426-127540       c
            1444-1520           AC164573.5         127040-127116       c
            1521-1612           AC164573.5         126046-126137       c
            1613-1753           AC164573.5         124554-124694       c
            1754-1866           AC164573.5         124096-124208       c
            1867-2378           AC164573.5         120543-121054       c
            2379-2520           AC164573.5         119542-119683       c
            2521-2679           AC164573.5         118094-118252       c
            2680-2909           AC164573.5         117280-117509       c
            2910-3010           AC164573.5         115706-115806       c
            3011-3137           AC164573.5         114400-114526       c
            3138-3308           AC164573.5         112950-113120       c
            3309-3486           AC164573.5         110021-110198       c
            3487-3681           AC164573.5         105418-105612       c
            3682-6354           AC164573.5         102084-104756       c
FEATURES             Location/Qualifiers
     source          1..6354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..6354
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /note="trafficking protein particle complex 10"
                     /db_xref="GeneID:216131"
                     /db_xref="MGI:MGI:1336209"
     exon            1..210
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3920
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /note="transmembrane protein 1; TRAPP subunit TMEM1;
                     trafficking protein particle complex subunit TMEM1"
                     /codon_start=1
                     /product="trafficking protein particle complex subunit 10"
                     /protein_id="NP_001074524.1"
                     /db_xref="CCDS:CCDS35959.1"
                     /db_xref="GeneID:216131"
                     /db_xref="MGI:MGI:1336209"
                     /translation="MDAPEEPQPPVVYTMENKPIVTCAGDQNLFTSIYPTLSQQLPRE
                     PMEWRRSYGRAPKMIHLESNFVQFKEELLPKEGNKALLTFPFLHIYWTECCDTEVYKA
                     TVKDDLTKWQNVLKAHSSVDWLIVVVENDAKKKNKTNILPRTSIVDKIRNDFCNKQSD
                     RCVVLSDPLKDSSRTQESWNAFLTKLRTLLLMSFTKNLGKFEDDMRTLREKRTEPGWS
                     FCEYFMVQEELAFVFEMLQQFEDALVQYDELDALFSQYVVNFGAGDGANWLTFFCQPV
                     KSWNGLVLRKPIDMEKRELIQKQEATLLDLRSYLFSRQCTLLLFLQRPWEVAQRALEL
                     LHSCVQELKLLEVSVPPGALDCWVFLSCLEVLQRIEGCCDRAQIDSNIAHMVGLWSYA
                     MEKLKSLGYLCGLVSEKGPNSEDLNRTVDLLAGLGAERPETANTAQSPYKKLQEALSS
                     VEAFEKHYLDLSHATIEMYTSIGRIRSAKLVGKDLAEFYMRKRSPQKAEMYLQGALKN
                     YLAEGWALPVTHTRKQLAECQKHLGQMENYLQTSSLLASDHHLTEEERKYFCQEILSF
                     ASQQEDNPGHKVVLPMQFARLKDLHFDPPNAVVHAGGVLTVEITVCSQMPIPVHVDQI
                     AVNVHFSIEKNNYRKTAEWLTKHKTSNGIITFPAEASLFPASQNSLPALELSEMLERS
                     PSDNSLNTTGIICRNVHMLLRRQESGSSLEPPSGLALEDGAHVLRCSSVTLQPGANKI
                     AFKTQAKEPGTYTLRQLRASVGPVWFVLAHIHPIVQYDVYSQEPQLHVEPLADSLLAG
                     IPQKVKFTVTTGHYTVKNGDSLQLSNVEAMLILCQAENRAVVYSNSREECSTALLRIQ
                     SSDKVTSIGLPTAPAYHVIEFELEVLSLPSAPASGGDTSVPGTPELHRKQKDSQRAGH
                     CMVTTDHKVSIDCPWSIYSTVIALTFSVPFRTEHSLLSAGTRKYVQVCVQNLSELDFE
                     LSDSNLEDKGHATDLRLAPLNTQSQQLIHSKQSVFFVWELTWTQEPPPPLHCQFSVGF
                     SPASEEQLTVSLKPYTYEFQVENFFTLYSVRAEILPASGAEYCKTGSLCSLEVSITRL
                     ADLLDVDKDEALVESEDYFSTKLMYEVVDNSSNWAVCGKSCGVIAMPLAAQATHRVHM
                     EVMPLFAGYLPLPDVRLFKYLPHHSAHASQLDADSWIENDSLSVDKHLDDQLDCSSLR
                     SRGSTHSTSSSEHKGLPMPRLQALPAGQVFNSSTGMQVLVIPSQDDHVLEVSVT"
     exon            211..292
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..428
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..625
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..821
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..933
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1181
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1328
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1443
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1520
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1612
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1753
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1866
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2378
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2520
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2679
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2909
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3010
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3137
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3308
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3486
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3681
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..6354
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5028..5033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /note="hexamer: ATTAAA"
     polyA_site      5051
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /note="major polyA site"
     regulatory      6106..6111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /note="hexamer: AACAAA"
     polyA_site      6125
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
     regulatory      6334..6339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
                     /note="hexamer: AATACA"
     polyA_site      6354
                     /gene="Trappc10"
                     /gene_synonym="B230307C21Rik; b2b2416Clo; b2b2613Clo;
                     Gm870; Tmem1"
ORIGIN      
        1 ggaagtggac gcggccggcg gcggcgggcg gccggctagg agctgccggg ggccggcggc
       61 gaggaggcgc gggctcagcg ggccccgcgc tgcctcgggt gcccatggcg ggcggggggc
      121 cgggccggtg acgccggacg cccatggacg cccctgagga gccacagcca ccggtggtct
      181 acaccatgga gaacaagccc atcgtcacct gtgctggaga tcagaattta tttacctcca
      241 tttatccgac actttcccag cagcttccaa gagaaccaat ggaatggaga aggtcttatg
      301 gccgagctcc aaaaatgatt cacctggaat ccaactttgt tcagttcaag gaggagctgc
      361 tgcccaaaga agggaacaaa gccctgctca ccttcccctt cctccacatc tactggacag
      421 agtgctgcga tactgaagtg tacaaagcta cggtaaaaga cgacctcacc aagtggcaga
      481 atgttctgaa agctcatagc tctgtggact ggctaatagt ggtagttgaa aatgatgcca
      541 agaaaaaaaa caaaaccaac atccttcccc gaacttctat tgtggacaaa ataagaaatg
      601 acttttgtaa taaacagagt gacaggtgtg ttgtgctctc tgaccctttg aaggactctt
      661 ctcgaactca ggaatcctgg aatgccttcc tgaccaaact caggactctg ctgctcatgt
      721 ctttcaccaa aaacctcggc aagtttgagg atgacatgcg gactttgagg gaaaagagga
      781 cagagccagg ctggagcttc tgcgaatact tcatggttca ggaggagctt gcgtttgtct
      841 ttgagatgct gcagcagttt gaggacgccc tggtacagta cgacgagctg gatgccctct
      901 tctcacagta cgtggtcaac ttcggagctg gggatggtgc caactggctg acttttttct
      961 gccagccggt gaagagctgg aacggactgg tgctccgcaa gcctatagac atggagaagc
     1021 gtgagctgat acagaagcaa gaagctactc tgctggacct gcgaagctac ttgttctccc
     1081 gccagtgcac cttgctcctc ttcctacagc ggccctggga ggtggctcag cgcgccctgg
     1141 agctgctgca tagctgtgtg caggagctga agctcttaga agtctctgtc cctcccggtg
     1201 ctctggattg ctgggtcttt ctgagctgtc tagaggtgct gcagaggata gaaggttgct
     1261 gtgaccgggc ccagatagac tccaacattg cccacatggt ggggctgtgg agctatgcaa
     1321 tggaaaagct aaagtcctta gggtacctat gtggacttgt atcagaaaaa gggcccaact
     1381 cagaagatct caacagaaca gttgatcttt tggcaggact aggagccgag agacctgaaa
     1441 cagccaacac agctcagagt ccttataaga agctccagga agcactgtcc tcagtagagg
     1501 cctttgaaaa gcactacctg gacttgtccc atgccaccat tgagatgtat acaagtatcg
     1561 ggcggattcg atctgccaag cttgttggaa aagatctggc agaattttac atgaggaaaa
     1621 ggtcgccaca gaaggcagaa atgtatcttc agggagcttt gaaaaattac ctggctgagg
     1681 gctgggccct gcctgtcaca cacacaagga agcagctagc agagtgccaa aaacaccttg
     1741 ggcaaatgga aaactacttg cagaccagca gtcttctggc cagtgatcat cacctgacag
     1801 aggaggagcg gaaatacttc tgccaggaga tccttagctt tgccagccag caagaggaca
     1861 acccaggtca caaggtggta ctgcccatgc agtttgcaag gctgaaggat ctccattttg
     1921 accctcccaa tgctgtggtc catgcgggtg gtgtcctgac tgtggagata acggtatgca
     1981 gccagatgcc catccctgtc cacgtggacc agattgctgt caatgtccac ttcagcatcg
     2041 aaaaaaacaa ctaccggaag acagccgagt ggctgaccaa gcacaagact tccaatggaa
     2101 tcatcacctt cccagctgag gcctcactgt tccctgcatc tcagaacagc ctgcccgctc
     2161 tggagttgtc ggagatgttg gagagaagcc cctctgataa ctcattgaac accacaggca
     2221 ttatctgtag gaatgtccac atgcttttaa ggaggcagga gagtggctct tctctagagc
     2281 cgccctcagg gttggccctg gaggatgggg cccacgtgct gaggtgcagc agtgtgaccc
     2341 tgcagccagg cgccaacaag atagccttca agacccaggc caaagaacct ggaacataca
     2401 cgctgcggca gcttcgggcc tcagtgggcc ctgtgtggtt tgtcctggca cacatccacc
     2461 ccattgtaca gtatgacgtg tactctcagg agcctcagct gcacgtggaa ccgctggctg
     2521 atagcctttt ggctggcatc cctcagaaag tcaagtttac tgtcactact ggccattaca
     2581 cagtaaaaaa tggagacagc ctccagctca gcaacgtgga agcaatgctc atcttgtgtc
     2641 aggcagagaa cagagccgtg gtctactcca actcaagaga agagtgctcc actgccctgc
     2701 tccggatcca gtcctctgac aaggtcacaa gcatcggtct tcccactgca cctgcgtacc
     2761 acgtgatcga gtttgagctg gaggttctgt ctttaccttc agctccagca tctggcgggg
     2821 acaccagtgt tccggggaca ccagagctcc acaggaagca gaaggattct cagagagctg
     2881 gccattgcat ggtcaccaca gatcacaagg tgtccattga ttgcccgtgg tctatctact
     2941 ccactgtcat tgcactgaca ttcagtgtgc ccttcaggac cgagcactct ctgctgtctg
     3001 ctggaacccg aaaatatgtg caagtctgtg tccagaacct gtcagaactg gactttgagc
     3061 tgtcagacag taatctggaa gacaagggtc atgctactga cctgaggctg gcacctctga
     3121 acacacagtc ccagcagctt atccacagca agcagtccgt gttctttgtc tgggagctga
     3181 cgtggacaca ggagccaccc cctcctctgc actgccagtt ctctgtgggg ttctccccag
     3241 cttctgaaga gcagctgacc gtttccttga agccctacac ttacgagttc caagtggaga
     3301 acttttttac actgtacagt gtgagagctg agatccttcc tgcttcagga gctgagtact
     3361 gtaagacagg ctcgctctgc tccttggagg tgtctatcac gcggctcgcc gacctcctgg
     3421 atgtggacaa ggatgaagca ctcgtggaat ctgaggacta tttttccaca aaacttatgt
     3481 atgaagttgt ggacaacagc agcaattggg ctgtgtgtgg gaagagctgt ggtgtcatcg
     3541 ccatgccttt ggctgcccag gccactcaca gagtccacat ggaagtgatg cctctgtttg
     3601 ctggttacct ccccttgcct gatgtacgac tgttcaagta cctcccccac cactctgctc
     3661 atgcctctca actggatgct gacagctgga tagaaaatga cagcctgtca gtggacaagc
     3721 acctagatga ccagctggac tgcagcagct tgcggagtag aggcagcaca cactccactt
     3781 ccagcagcga gcacaaaggc ttgcccatgc cccggctcca agcactgccc gctggccagg
     3841 tcttcaactc cagcactggc atgcaggtcc tggtcattcc cagtcaagac gaccacgtcc
     3901 tggaagtcag tgttacctga ctgtgccatg gtccagtgaa gccacagatt gggtgtgagt
     3961 gcgcattagg gactgtggct ggattgtggt ctgtggtaac acactagctc taaccagact
     4021 ttggcagtcc tgcctagcta cagacacagc agagaacagt gtccttcagc tgcgcagtgg
     4081 agtagagcgt cacctcatgt tgtctatgac acaggatttg ttttcatttt ttttatccct
     4141 ggccctgtgc cccgtgctgg tatccccaac tcctcagacc ctcccaagag ggtctggtct
     4201 cttctcacag ccctctccta gtggctttcc atacaccgcc atggtttctt taaggtggat
     4261 cttcagcaga ctgcagtcct cttatggcac tgtgtgccct tctcacaaag cccagtccct
     4321 gggcaactgt gggcctcctg ggataaaaca ctgtcctaca cgccagagcc cctggttatg
     4381 gttttatagt aacagctttg gggccgtggg gtggggtggg agggaacata accccttctg
     4441 tgccttggga tgcccagcag atcacaagat ccatctgtag aagccacgtg aaaggtactg
     4501 cagagaagac cagagaggag ggaagtgtgg tgtggagatg gcttaggcta aaagttctgg
     4561 atccccgact cccctaatgt tgattgaata acatatgcac ttggaattaa atctatattt
     4621 attataattg ttggatgtgg gggtaaaatg ttttctctca ctttaaagtc tgctcatgta
     4681 ttgtagctgt ataatcgaca tcttttgcac cttaagtctt ggaactgaag atgctccatc
     4741 tggagtgaag atgagagggg cctctcttgt gctctgatca gtcgtaaagg actcagggcc
     4801 tggaggacct cagctgggcc actgggttgc agtcataccg caccaacggg ttcatttact
     4861 tttggttgta aatttgattg tacatattgt tgatttatta tttttaagag tacagactaa
     4921 ctgatgtaat gtttgtgtat aagttgcacc aaaaatcaag gacaaaataa atgtgtgttt
     4981 gtttttactg gtgtggaagt catagattgt aaatagatgc tgtatgtatt aaacgttctc
     5041 agtcctccaa agtgatgtat ttttgtatat aggagataga gtgctctggg cttattggcg
     5101 tggtgtctgt gagtgggacc tgaggtagaa agctgggaga ggagggagcc ctcttcagga
     5161 gtcgctgccc cctggggacc atgtttgggc ccagagtcag gggcacagag agaaccagga
     5221 gaaccaagcc aacactttca gtattcagtg tatttgcttt tttttttttt taagatttgt
     5281 ttatttatta tatgtaagta cactgtcgct gtcttcagac actccagaag agggcatcag
     5341 atcccattac ggatggttgt gagccaccat gtggttgctg ggatttgaac tcaggacctt
     5401 cagaagagta ctcagtgctc ttaactgcta agccatctct ccagccccag ggtatttgct
     5461 tttaactcag ccagtaaata aaggatagta cgacgcccac aacacaccac caccaagtgg
     5521 ttttcatttg caggaattgg aggaatgctt aaagaaaata aacactgggg ctggagagat
     5581 ggctcagtgg ttaagagcat tggctgctct accagaggtc ctgagttcaa atcccagcaa
     5641 ccacatggtg gctcataacc atatgtaatg ggatctgatg ccctcttcta gtgtgtctga
     5701 agacagtggc agtgtactca cataaacctt aaaaaaaaaa aaaacaaaaa aaaaacaaac
     5761 atttatttaa aaccctctga aaacctattt tatgtgcagt ttaaaactaa taaacttggg
     5821 gagctgggta tgcaaattag aacttggtac ttactgaatg tctacagccc tctgaactct
     5881 gttttcggta aacctttgac agttggcctg cagatgtcaa gtccatgtgt ggggaggtct
     5941 ttgagacttg atcctggcag aaaagcttcc acccggcact gctagcctcc cgcatccgtg
     6001 tgtagtcctt tagagtggag tctggctctt gagttcaccg cccaccccct gagtttcata
     6061 tttctgagtt ctctacggtt ttctaattat atatattaag aataaaacaa aggggagatc
     6121 taaaatgttg gtagttctgt tatttctcat gaagacacct ttctctgtaa gagagttggc
     6181 agctcttgtt ctctgggatg gggtctagga aaggtgacgg ccgcaccttg acactgcagg
     6241 cgttggttcc attttcacag tgttctgtaa cataatgtca gagtaaggcc gctgtactaa
     6301 gatcgtttaa agtgtaagca ttaaaattct aaaaatacac gttttaagaa gaaa
//
