LOCUS       NM_011635               1178 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus tumor rejection antigen P1A (Trap1a), mRNA.
ACCESSION   NM_011635 XM_977473
VERSION     NM_011635.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Li,C.S., Tang,F., Zhang,P., Jiang,T., Saunders,T.L., Zheng,P. and
            Liu,Y.
  TITLE     Trap1a is an X-linked and cell-intrinsic regulator of thymocyte
            development
  JOURNAL   Cell Mol Immunol 14 (8), 685-692 (2017)
   PUBMED   27063468
  REMARK    GeneRIF: these data reveal that Trap1a is an X-linked regulator
            that affects the differentiation potential of progenitor cells into
            T cells through a Notch-independent mechanism and identify an
            important function for the Trap1a gene
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Huijbers,I.J., Soudja,S.M., Uyttenhove,C., Buferne,M.,
            Inderberg-Suso,E.M., Colau,D., Pilotte,L., Powis de
            Tenbossche,C.G., Chomez,P., Brasseur,F., Schmitt-Verhulst,A.M. and
            Van den Eynde,B.J.
  TITLE     Minimal tolerance to a tumor antigen encoded by a cancer-germline
            gene
  JOURNAL   J Immunol 188 (1), 111-121 (2012)
   PUBMED   22140254
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Hou,J., Charters,A.M., Lee,S.C., Zhao,Y., Wu,M.K., Jones,S.J.,
            Marra,M.A. and Hoodless,P.A.
  TITLE     A systematic screen for genes expressed in definitive endoderm by
            Serial Analysis of Gene Expression (SAGE)
  JOURNAL   BMC Dev Biol 7, 92 (2007)
   PUBMED   17683524
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Bai,X.F., Liu,J.Q., Joshi,P.S., Wang,L., Yin,L., Labanowska,J.,
            Heerema,N., Zheng,P. and Liu,Y.
  TITLE     Different lineages of P1A-expressing cancer cells use divergent
            modes of immune evasion for T-cell adoptive therapy
  JOURNAL   Cancer Res 66 (16), 8241-8249 (2006)
   PUBMED   16912204
  REMARK    GeneRIF: Since multiple lineages of tumor cells share the tumor
            antigen P1A, we adoptively transferred transgenic T cells specific
            for P1A into mice with established P1A-expressing tumors.
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Brandle,D., Bilsborough,J., Rulicke,T., Uyttenhove,C., Boon,T. and
            Van den Eynde,B.J.
  TITLE     The shared tumor-specific antigen encoded by mouse gene P1A is a
            target not only for cytolytic T lymphocytes but also for tumor
            rejection
  JOURNAL   Eur J Immunol 28 (12), 4010-4019 (1998)
   PUBMED   9862337
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Mishra,L., Tully,R.E., Monga,S.P., Yu,P., Cai,T., Makalowski,W.,
            Mezey,E., Pavan,W.J. and Mishra,B.
  TITLE     Praja1, a novel gene encoding a RING-H2 motif in mouse development
  JOURNAL   Oncogene 15 (19), 2361-2368 (1997)
   PUBMED   9393880
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Uyttenhove,C., Godfraind,C., Lethe,B., Amar-Costesec,A.,
            Renauld,J.C., Gajewski,T.F., Duffour,M.T., Warnier,G., Boon,T. and
            Van den Eynde,B.J.
  TITLE     The expression of mouse gene P1A in testis does not prevent safe
            induction of cytolytic T cells against a P1A-encoded tumor antigen
  JOURNAL   Int J Cancer 70 (3), 349-356 (1997)
   PUBMED   9033639
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Van den Eynde,B., Lethe,B., Van Pel,A., De Plaen,E. and Boon,T.
  TITLE     The gene coding for a major tumor rejection antigen of tumor P815
            is identical to the normal gene of syngeneic DBA/2 mice
  JOURNAL   J Exp Med 173 (6), 1373-1384 (1991)
   PUBMED   1903428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL714027.8 and AK146737.1.
            
            On Nov 25, 2015 this sequence version replaced NM_011635.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M36387.1, BC051644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AL714027.8         96358-96543
            187-1174            AK146737.1         2-989
            1175-1178           AL714027.8         100841-100844
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.35 cM"
     gene            1..1178
                     /gene="Trap1a"
                     /gene_synonym="Tra-P1A"
                     /note="tumor rejection antigen P1A"
                     /db_xref="GeneID:22037"
                     /db_xref="MGI:MGI:98818"
     exon            1..725
                     /gene="Trap1a"
                     /gene_synonym="Tra-P1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..946
                     /gene="Trap1a"
                     /gene_synonym="Tra-P1A"
                     /codon_start=1
                     /product="tumor rejection antigen P815A"
                     /protein_id="NP_035765.1"
                     /db_xref="CCDS:CCDS30433.1"
                     /db_xref="GeneID:22037"
                     /db_xref="MGI:MGI:98818"
                     /translation="MSDNKKPDKAHSGSGGDGDGNRCNLLHRYSLEEILPYLGWLVFA
                     VVTTSFLALQMFIDALYEEQYERDVAWIARQSKRMSSVDEDEDDEDDEDDYYDDEDDD
                     DDAFYDDEDDEEEELENLMDDESEDEAEEEMSVEMGAGAEEMGAGANCACVPGHHLRK
                     NEVKCRMIYFFHDPNFLVSIPVNPKEQMECRCENADEEVAMEEEEEEEEEEEEEEMGN
                     PDGFSP"
     exon            726..954
                     /gene="Trap1a"
                     /gene_synonym="Tra-P1A"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1178
                     /gene="Trap1a"
                     /gene_synonym="Tra-P1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1153..1158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trap1a"
                     /gene_synonym="Tra-P1A"
                     /note="hexamer: AATAAA"
     polyA_site      1178
                     /gene="Trap1a"
                     /gene_synonym="Tra-P1A"
                     /note="major polyA site"
ORIGIN      
        1 gtaccctttc acgtaaaaaa gtagtccaga gtttactaca ccctccctcc cccctcccac
       61 ctcgtgctgt gctgagttta gaagtcttcc ttatagaagt cttccgtata gaactcttcc
      121 ggaggaagga gggaggaccc cccccctttg ctctcccagc atgcattgtg tcaacgccat
      181 tgcactgagc tggtcgaaga agtaagccgc tagcttgcga ctctactctt atcttaactt
      241 agctcggctt cctgctggta ccctttgtgc catgtctgat aacaagaagc cagacaaagc
      301 ccacagtggc tcaggtggtg acggtgatgg gaataggtgc aatttattgc accggtactc
      361 cctggaagaa attctgcctt atctagggtg gctggtcttc gctgttgtca caacaagttt
      421 tctggcgctc cagatgttca tagacgccct ttatgaggag cagtatgaaa gggatgtggc
      481 ctggatagcc aggcaaagca agcgcatgtc ctctgtcgat gaggatgaag acgatgagga
      541 tgatgaggat gactactacg acgacgagga cgacgacgac gatgccttct atgatgatga
      601 ggatgatgag gaagaagaat tggagaacct gatggatgat gaatcagaag atgaggccga
      661 agaagagatg agcgtggaaa tgggtgccgg agctgaggaa atgggtgctg gcgctaactg
      721 tgcctgtgtt cctggccatc atttaaggaa gaatgaagtg aagtgtagga tgatttattt
      781 cttccacgac cctaatttcc tggtgtctat accagtgaac cctaaggaac aaatggagtg
      841 taggtgtgaa aatgctgatg aagaggttgc aatggaagag gaagaagaag aagaggagga
      901 ggaggaggaa gaggaaatgg gaaacccgga tggcttctca ccttaggcat gcagttgcaa
      961 agcccagaag aaagaaatgg acagcggaag aagtggttgt ttttttttcc ccttcattaa
     1021 ttttctagtt tttagtaatc cagaaaattt gattttgttc taaagttcat tatgcaaaga
     1081 tgtcaccaac agacttctga ctgcatggtg aactttcata tgatacatag gattacactt
     1141 gtacctgtta aaaataaaag tttgacttgc atacacta
//
