LOCUS       NM_026508               2297 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus TNF receptor-associated protein 1 (Trap1), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026508
VERSION     NM_026508.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Kim,S.Y., Yoon,N.G., Im,J.Y., Lee,J.H., Kim,J., Jeon,Y., Choi,Y.J.,
            Lee,J.H., Uemura,A., Park,D.H. and Kang,B.H.
  TITLE     Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular
            Pathologies in Ischemic Retinopathy
  JOURNAL   Adv Sci (Weinh) 11 (2), e2302776 (2024)
   PUBMED   37983591
  REMARK    GeneRIF: Targeting the Mitochondrial Chaperone TRAP1 Alleviates
            Vascular Pathologies in Ischemic Retinopathy.
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Chen,J.F., Wu,Q.S., Xie,Y.X., Si,B.L., Yang,P.P., Wang,W.Y., Hua,Q.
            and He,Q.
  TITLE     TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with
            unilateral ureteral obstruction by protecting renal tubular
            epithelial cell mitochondria
  JOURNAL   FASEB J 31 (10), 4503-4514 (2017)
   PUBMED   28710113
  REMARK    GeneRIF: show that TRAP1 could protect the mitochondrial structure
            in renal tubular epithelial cells; maintain the levels of
            mitochondrial membrane potential, ATP, and mitochondrial DNA copy
            number
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Vartholomaiou,E., Madon-Simon,M., Hagmann,S., Muhlebach,G.,
            Wurst,W., Floss,T. and Picard,D.
  TITLE     Cytosolic Hsp90alpha and its mitochondrial isoform Trap1 are
            differentially required in a breast cancer model
  JOURNAL   Oncotarget 8 (11), 17428-17442 (2017)
   PUBMED   28407697
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Chiellini,C., Costa,M., Novelli,S.E., Amri,E.Z., Benzi,L.,
            Bertacca,A., Cohen,P., Del Prato,S., Friedman,J.M. and Maffei,M.
  TITLE     Identification of cathepsin K as a novel marker of adiposity in
            white adipose tissue
  JOURNAL   J Cell Physiol 195 (2), 309-321 (2003)
   PUBMED   12652657
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132380.6 and AC087900.19.
            
            On Nov 17, 2006 this sequence version replaced NM_026508.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010341.1, BC022912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC132380.6         135840-135957
            119-283             AC132380.6         144629-144793
            284-366             AC132380.6         145312-145394
            367-507             AC132380.6         148277-148417
            508-579             AC132380.6         151249-151320
            580-740             AC132380.6         152733-152893
            741-850             AC132380.6         157211-157320
            851-924             AC132380.6         157780-157853
            925-1080            AC132380.6         158741-158896
            1081-1201           AC132380.6         160049-160169
            1202-1271           AC132380.6         160716-160785
            1272-1419           AC087900.19        177-324
            1420-1605           AC087900.19        3610-3795
            1606-1744           AC087900.19        4094-4232
            1745-1830           AC087900.19        4977-5062
            1831-1976           AC087900.19        5577-5722
            1977-2049           AC087900.19        9244-9316
            2050-2297           AC087900.19        9451-9698
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.38 cM"
     gene            1..2297
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /note="TNF receptor-associated protein 1"
                     /db_xref="GeneID:68015"
                     /db_xref="MGI:MGI:1915265"
     exon            1..118
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2151
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /note="heat shock protein 75 kDa, mitochondrial; HSP 75;
                     TRAP-1; TNFR-associated protein 1; tumor necrosis factor
                     type 1 receptor-associated protein"
                     /codon_start=1
                     /product="heat shock protein 75 kDa, mitochondrial
                     precursor"
                     /protein_id="NP_080784.1"
                     /db_xref="CCDS:CCDS27914.1"
                     /db_xref="GeneID:68015"
                     /db_xref="MGI:MGI:1915265"
                     /translation="MACELRAVLLWGRGLQTVLRAPALAGVRRGKPVLHLQKTTVQFR
                     GPTQSLASGISAGQLYSTQAAEDKEEESLHSIISNTEAVRGSVSKHEFQAETKKLLDI
                     VARSLYSEKEVFIRELISNASDALEKLRHKLVCEGQVLPEMEIHLQTDAKKGTITIQD
                     TGIGMTQEELVSNLGTIARSGSKAFLEALQNQAETSSKIIGQFGVGFYSAFMVADKVE
                     VYSRSAAPESPGYQWLSDGSGVFEIAEASGVRPGTKIIIHLKSDCKDFASESRVQDVV
                     TKYSNFVSFPLYLNGKRINTLQAIWMMDPKDISEFQHEEFYRYIAQAYDKPRFTLHYK
                     TDAPLNIRSIFYVPEMKPSMFDVSRELGSSVALYSRKVLIQTKAADILPKWLRFIRGV
                     VDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFM
                     REGIVTTAEQDIKEDIAKLLRYESSALPAGQLTSLPDYASRMQAGTRNIYYLCAPNRH
                     LAEHSPYYEAMKQKHTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKF
                     EDTSPADERLSEKETEDLMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFL
                     RMQQLAKTQEERAQLLQPTLEINPRHTLIKKLCQLRESEPELAQLLVDQIYENAMIAA
                     GLVDDPRAMVGRLNDLLVKVLEKH"
     exon            119..283
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            284..366
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            367..507
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            508..579
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            580..740
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            741..850
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            851..924
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1080
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1201
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1271
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1419
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1605
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1744
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1830
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1976
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2049
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2297
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /note="hexamer: AATACA"
     polyA_site      2248
                     /gene="Trap1"
                     /gene_synonym="2410002K23Rik; HSP75"
                     /note="major polyA site"
ORIGIN      
        1 aggctgttag ccacacttgg gaaaggaagc atggcgtgcg agctgcgagc tgtgttgctg
       61 tggggccgcg ggctgcagac tgtactgcgg gcccccgcgc tggctggagt tcggcgagga
      121 aagccagttc tgcaccttca gaagactaca gtccagttta ggggccccac acaaagtctg
      181 gcttcaggga tctctgcagg acagttatac agcacacagg cagccgagga caaggaggag
      241 gagagcctgc actccatcat cagcaacact gaggcagtgc ggggttctgt ctccaaacat
      301 gagttccagg cagagacaaa gaaacttttg gacatcgtag cccgttctct gtactcagaa
      361 aaagaggtgt tcatacgaga gctcatctcc aatgccagtg atgccttgga gaaactgcgg
      421 cacaagctgg tgtgtgaagg ccaggtgctg ccagaaatgg agattcacct tcagacggat
      481 gccaagaagg gcactattac cattcaggac actggcattg ggatgacaca ggaggagctg
      541 gtgtccaacc ttggcacaat tgccagatcg gggtcaaagg ccttcctgga agcactgcag
      601 aaccaggcag agaccagcag caagatcatt ggtcagtttg gagtgggttt ctattcagcc
      661 ttcatggtag ctgacaaggt tgaagtctat tctcgatcag cagctccaga gagcccaggt
      721 taccagtggc tttcagatgg ttctggagtg tttgaaattg ccgaagcttc aggagttaga
      781 cctgggacca aaataatcat ccacctcaag tcagactgta aagattttgc cagcgagtcc
      841 cgggtacaag atgtggtaac aaagtacagt aactttgtca gcttcccctt gtaccttaat
      901 ggaaagcgga ttaacacttt gcaggccatc tggatgatgg acccaaagga catcagtgaa
      961 tttcagcatg aggaattcta ccgttatatt gctcaggctt atgataagcc ccgcttcact
     1021 ttgcactaca agacggacgc accactcaac atccgcagca tcttctatgt gccagagatg
     1081 aaaccatcca tgtttgatgt gagcagggag ctgggctcca gcgtggcact gtatagccgc
     1141 aaggtcctca tccagaccaa ggctgcagac atcctgccca agtggctgcg cttcattcga
     1201 ggtgtggtgg atagtgagga cattcccctg aacctcagca gagagctcct gcaggagagt
     1261 gcgctcatcc ggaaactccg ggatgttcta caacagagat tgatcaagtt cttcattgac
     1321 cagagtaaaa aagatgctga aaaatacgca aagttttttg aagattatgg cttgttcatg
     1381 agggagggca ttgtgaccac tgcagagcaa gacatcaagg aggatattgc aaaactgcta
     1441 cggtatgagt cctcagccct gcctgctggg cagctgacca gcttaccaga ctatgccagc
     1501 cgaatgcagg ctggcacccg caacatctat tacctgtgtg cccctaaccg tcacctggct
     1561 gaacattcac cctattacga agccatgaag cagaaacata ctgaggtgct cttctgctat
     1621 gagcagttcg atgagcttac tctgctgcac ctgagggagt ttgacaagaa gaagctcatc
     1681 tctgtggaaa cagacatcgt cgttgatcac tacaaggagg aaaagtttga ggacacatct
     1741 ccagctgatg agcgcctctc ggagaaggaa acagaagatc taatggcgtg gatgagaaat
     1801 gcactagggt cccgtgtcac caatgtgaag gtgactttcc gcctagacac ccaccctgcc
     1861 atggtgaccg tgctggagat gggggctgct cggcatttct tgcgtatgca gcagctggcc
     1921 aagacccagg aggaacgtgc ccaactgcta cagcccacac tggagatcaa ccccaggcac
     1981 acactgataa agaagctctg ccagctgagg gagagcgagc cggagctggc ccagctgctc
     2041 gtggatcaga tctatgagaa tgccatgata gcagcaggac tcgttgatga cccccgggcc
     2101 atggtcggcc gcctgaacga ccttttggtc aaggtcctgg agaaacactg acagccaaga
     2161 cactggattt agtgtcaacc caggtcttct cgggtgataa tggacctgcc tggggaggca
     2221 ggacttaata cacaaacagt gccaccaact gcttgagctc agctttattt acttcaatta
     2281 aacagtattt cttagtc
//
