LOCUS       NM_177409               1390 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus translocating chain-associating membrane protein 2
            (Tram2), mRNA.
ACCESSION   NM_177409 NM_133252
VERSION     NM_177409.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Pregizer,S., Barski,A., Gersbach,C.A., Garcia,A.J. and Frenkel,B.
  TITLE     Identification of novel Runx2 targets in osteoblasts: cell
            type-specific BMP-dependent regulation of Tram2
  JOURNAL   J Cell Biochem 102 (6), 1458-1471 (2007)
   PUBMED   17486635
  REMARK    GeneRIF: Identification of novel Runx2 targets in osteoblasts: cell
            type-specific BMP-dependent regulation of Tram2.
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Stefanovic,B., Stefanovic,L., Schnabl,B., Bataller,R. and
            Brenner,D.A.
  TITLE     TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump
            Serca2b and is necessary for collagen type I synthesis
  JOURNAL   Mol Cell Biol 24 (4), 1758-1768 (2004)
   PUBMED   14749390
  REMARK    GeneRIF: TRAM2, as a part of the translocon, is required for the
            biosynthesis of type I collagen by coupling the activity of SERCA2b
            with the activity of the translocon
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Fujimoto,K., Shibasaki,T., Yokoi,N., Kashima,Y., Matsumoto,M.,
            Sasaki,T., Tajima,N., Iwanaga,T. and Seino,S.
  TITLE     Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of
            cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis
  JOURNAL   J Biol Chem 277 (52), 50497-50502 (2002)
   PUBMED   12401793
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK082751.1.
            
            On or before Jun 15, 2012 this sequence version replaced
            NM_133252.2, NM_177409.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082751.1, BC018212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1390              AK082751.1         2-1391
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.5 cM"
     gene            1..1390
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /note="translocating chain-associating membrane protein 2"
                     /db_xref="GeneID:170829"
                     /db_xref="MGI:MGI:1924817"
     exon            1..232
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1225
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /codon_start=1
                     /product="translocating chain-associated membrane protein
                     2"
                     /protein_id="NP_803128.1"
                     /db_xref="CCDS:CCDS14846.1"
                     /db_xref="GeneID:170829"
                     /db_xref="MGI:MGI:1924817"
                     /translation="MAFRRRTKSYPLFSQEFIIHNHADIGFCLVLCVLIGLMFEVTAK
                     TAFLFILPQYNISVPTADSETVHYHYGPKDLVTILFYVVITIIFHAVVQEYILDKISK
                     RLHLSKVKHSKFNESGQLLVFHLSAVAWCFYVIVTEGYLTNPRSLWEDYPHVYLSFQV
                     KFFYLGQLAYWLHSLPELYFQKVRKEEVPRQLQYICLYLLHITGAYLLNLSRLGLILL
                     LLQYSTEALFHMARLFHFADENNERLFNAWAAVFGVTRLFILTLAVLTIGFGLARVEN
                     QVFDPEKGNFNTLPCRLGMLLLVCVAQAWLMWRFIHSQLRHWREYWKEQSAKRRVSAV
                     PRPPAKLLKREPGYHENGVVKAENGTSSRTKKLKSP"
     exon            233..296
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            297..406
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            407..523
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            524..582
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            583..667
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..738
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            739..843
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            844..987
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1151
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1390
                     /gene="Tram2"
                     /gene_synonym="C330003D03Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccgcgct gggctgcggg gctggcgtgc ggaccgggcc gggccggaga agttttcgct
       61 ggggctgctg agcgagggtg cgggcccccg caggcggtga acgcccgctg ccatggcttt
      121 ccgtaggagg acgaaaagtt acccgctctt cagccaggag ttcatcatcc acaaccatgc
      181 agacatcggt ttctgcttgg tgctctgcgt cctcatcggg cttatgttcg aggtcacagc
      241 caagactgcc ttcctattta ttttacctca gtataacatt agtgtgccta cagcagacag
      301 tgagacagtg cactaccact atggcccaaa ggacctggtc accatcttgt tctacgtcgt
      361 catcaccatc atcttccatg ctgtggtcca ggagtacatc ttagacaaaa tcagcaaacg
      421 ccttcatctc tccaaggtca aacacagcaa gttcaatgaa tctggacagc tgcttgtctt
      481 tcatctcagc gcggtggcgt ggtgcttcta tgtgatcgta acagaaggat atttaacaaa
      541 cccaagaagc ctctgggaag attacccgca tgtgtacctc tccttccagg tgaagttttt
      601 ctacttggga cagctggcat actggttgca ctcactacct gaactctact tccagaaggt
      661 gcggaaggaa gaagtcccac gccagctgca atacatttgt ctgtaccttc ttcacatcac
      721 tggggcatac ctcttaaacc tgagccgcct ggggctgatc ttgctactac tgcagtactc
      781 caccgaggcc ctctttcaca tggctcggct cttccacttt gcagacgaga ataacgagag
      841 gctgtttaac gcctgggctg ctgtgtttgg ggtcacgcgt ctcttcatcc tcaccctcgc
      901 tgtgctgacc attggctttg gattggctcg ggtggaaaac caagtgtttg accccgagaa
      961 agggaacttt aacaccttgc cttgtaggct tggcatgctg ctgctggtgt gtgtcgccca
     1021 ggcctggctc atgtggcgct tcatccactc ccagttgcgg cactggcggg agtattggaa
     1081 ggagcagagt gccaagcgta gagtctctgc tgtccccagg cccccagcca agctcctcaa
     1141 gagagaacct ggttaccatg aaaacggagt ggtgaaggca gagaacggga cctcctcacg
     1201 gactaagaaa ctcaagtctc cctagcgcca ctgtgctgag aacagggatc ctctggatga
     1261 ggaagccctg gccccagctc agtctctcca ccctcctgcc catgctcgtc tccaccagca
     1321 gaagccttgg catcaaaggg ggagttcctc tctaccttct agtctttctc ttctttcata
     1381 aaccattctc
//
