LOCUS       NM_175114               4809 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus trafficking protein, kinesin binding 1 (Trak1),
            transcript variant 1, mRNA.
ACCESSION   NM_175114 XM_001001035
VERSION     NM_175114.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4809)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4809)
  AUTHORS   van Spronsen,M., Mikhaylova,M., Lipka,J., Schlager,M.A., van den
            Heuvel,D.J., Kuijpers,M., Wulf,P.S., Keijzer,N., Demmers,J.,
            Kapitein,L.C., Jaarsma,D., Gerritsen,H.C., Akhmanova,A. and
            Hoogenraad,C.C.
  TITLE     TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking
            to axons and dendrites
  JOURNAL   Neuron 77 (3), 485-502 (2013)
   PUBMED   23395375
REFERENCE   3  (bases 1 to 4809)
  AUTHORS   Webber,E., Li,L. and Chin,L.S.
  TITLE     Hypertonia-associated protein Trak1 is a novel regulator of
            endosome-to-lysosome trafficking
  JOURNAL   J Mol Biol 382 (3), 638-651 (2008)
   PUBMED   18675823
REFERENCE   4  (bases 1 to 4809)
  AUTHORS   Gilbert,S.L., Zhang,L., Forster,M.L., Anderson,J.R., Iwase,T.,
            Soliven,B., Donahue,L.R., Sweet,H.O., Bronson,R.T., Davisson,M.T.,
            Wollmann,R.L. and Lahn,B.T.
  TITLE     Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic
            mice
  JOURNAL   Nat Genet 38 (2), 245-250 (2006)
   PUBMED   16380713
  REMARK    GeneRIF: Our data implicate Trak1 as a crucial regulator of GABA(A)
            receptor homeostasis and underscore the importance of hyrt mice as
            a model for studying the molecular etiology of hypertonia
            associated with human neurological diseases.
            Erratum:[Nat Genet. 2006 Mar;38(3):389. Anderson, Jeffrey R
            [added]]
REFERENCE   5  (bases 1 to 4809)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 4809)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 4809)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4809)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115863.17 and AC131660.4.
            
            On Nov 9, 2022 this sequence version replaced NM_175114.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058971.1, SRR9219383.17827.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC115863.17        86377-86533         c
            158-352             AC115863.17        61517-61711         c
            353-429             AC115863.17        22013-22089         c
            430-546             AC115863.17        12782-12898         c
            547-647             AC115863.17        10776-10876         c
            648-756             AC115863.17        9834-9942           c
            757-835             AC115863.17        7675-7753           c
            836-966             AC115863.17        6748-6878           c
            967-1041            AC115863.17        5386-5460           c
            1042-1173           AC115863.17        4615-4746           c
            1174-1250           AC115863.17        1841-1917           c
            1251-1487           AC115863.17        124-360             c
            1488-1804           AC131660.4         142852-143168       c
            1805-2023           AC131660.4         136870-137088       c
            2024-2126           AC131660.4         128360-128462       c
            2127-4809           AC131660.4         122528-125210       c
FEATURES             Location/Qualifiers
     source          1..4809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.41 cM"
     gene            1..4809
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="trafficking protein, kinesin binding 1"
                     /db_xref="GeneID:67095"
                     /db_xref="MGI:MGI:1914345"
     exon            1..157
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2889
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="isoform 1 is encoded by transcript variant 1;
                     trafficking kinesin-binding protein 1; protein Milton"
                     /codon_start=1
                     /product="trafficking kinesin-binding protein 1 isoform 1"
                     /protein_id="NP_780323.2"
                     /db_xref="CCDS:CCDS40810.1"
                     /db_xref="GeneID:67095"
                     /db_xref="MGI:MGI:1914345"
                     /translation="MALAIQLRQPSRAQPLPGLSHTLAGTDSCDVCNSTNLPEVEIIS
                     LLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVG
                     QMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEV
                     SQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKD
                     LEEENVVLRSEACQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDA
                     ARQQEEITHLLSQIVDLQKKAKSCAVENEELVQHLGAAKDAQRQLTAELRELEDKYAE
                     CMEMLHEAQEELKNLRNKTMPTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEELESPD
                     ITHQKRVFETVRNVNQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSD
                     VSNVVLDNKTNSILLETEAADLGNEDHNKKPGTPGTPGSHDLETALRRLSLRRENYLS
                     ERRFFEEEQERKLRELAEKGELHSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSY
                     LPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLND
                     FEEDDTGDHISLAGLATSTPIQHPETSAHHPGKCMSQTNSTFTFTTCRILHPSDELTR
                     VTPSLNSAPAPACSSTSHLKSTPVATPCTPRRLSLAESFTNVRESTTTMSTSLGLVWL
                     LKERGISAAVYDPQSWDRAGRGSLLHSYTPRMAVIPSTPPNSPMQTPSASPPSFEFKC
                     TSPPYNNFLASKPASSILREVREKRPVRSSESQTDVSVSNLNLVDKVRRFGVARVVNS
                     GRARIPTLTEEQGPLLCGPTGPAQALVPGGLVPEGLPLGCPSGIRRNRSFPTMVGSSV
                     QMRAPVILTSGILMGAKLPKQTSLR"
     exon            158..352
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            353..429
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            430..546
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            547..647
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            648..756
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            757..835
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            836..966
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1041
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1173
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1250
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1487
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1804
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2023
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2126
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..4809
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4785..4790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="hexamer: AATAAA"
     regulatory      4790..4795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="hexamer: AACAAG"
     polyA_site      4805
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
     polyA_site      4809
                     /gene="Trak1"
                     /gene_synonym="2310001H13Rik; hyrt; mKIAA1042"
                     /note="major polyA site"
ORIGIN      
        1 agagctgtgg ccaagcttgc atggaggacc gctctctctc caagtcctct ttggagtttg
       61 tgtctgccca tggcattggc aattcagctc aggcagccct ccagggccca acctctgcca
      121 ggactcagcc acacactggc tgggacagac tcatgtgacg tgtgcaacag caccaacctt
      181 ccagaagttg agatcattag cctgctggag gaacagctgc cccattacaa gctaagagcg
      241 gacaccatct atggttacga ccacgatgac tggctgcata cgcccctcat ctccccagat
      301 gccaacatcg acctcacaac tgagcagatc gaagagacgc tgaaatactt ccttctatgt
      361 gccgaaagag ttggccagat gactaagaca tacaatgaca ttgatgctgt cacgaggctt
      421 cttgaggaga aagagcggga tttggagctg gctgcgagga tcggtcagtc attgttgaag
      481 aagaacaaga ccctaactga gaggaatgaa ctgctggaag agcaggtgga gcacatccgg
      541 gaggaggtgt ctcagctccg acatgagctg tccatgaaag acgagctgct tcaattctac
      601 accagtgccg ctgaggagag cgagcctgag tccgtctgct caaccccgct gaagaggaac
      661 gagtcctcct cctccgtcca gaattacttc cacctggact ctcttcagaa gaagctcaag
      721 gacctcgaag aggagaacgt tgtacttcga tccgaggcct gtcagctgaa gacagagacc
      781 atcacctatg aggagaagga gcagcagctg gtgaacgact gcgtgaagga gctgagggat
      841 gccaacgtcc agattgcgag catctctgag gagctggcta agaagacgga agatgccgcc
      901 cgccagcagg aggagatcac ccacctgctg tcgcaaatcg tggacttaca gaagaaggca
      961 aaatcttgcg cggtggaaaa tgaagagctt gtccagcacc tgggcgctgc caaggacgcc
     1021 cagcgtcaac tcacagccga gctccgagag ctggaggata agtacgcgga gtgcatggag
     1081 atgcttcatg aggctcagga ggagttgaag aacctgcgga acaagacgat gcccacgtcc
     1141 cggcgctacc actctctggg cctgttcccc atggactcgt tggctgcaga aatcgaggga
     1201 actatgcgca aggagctgca gctggaagag ctggagtctc cagacatcac ccaccagaag
     1261 cgtgtcttcg agacggtgag gaacgtcaat caagtggtca agcagagatc actaacccct
     1321 tctcccatga acatcccggg ctccaaccag tcctcagcca tgaactccct cctgtccagc
     1381 tgcgtcagca cccctcgctc cagcttctac ggcagcgacg tcagcaacgt ggtcctcgat
     1441 aacaaaacca acagcatcct cctggagacc gaggcagccg acctggggaa cgaggaccac
     1501 aataagaagc cgggcactcc aggcacgcca ggctcccatg acctggagac ggcacttagg
     1561 cggctatccc tacgccggga gaactacctg tctgagcgga ggttcttcga ggaggagcag
     1621 gagaggaagc tgcgagagct ggctgagaag ggggagctgc acagtggctc gctcacgccc
     1681 accgagagca tcatgtccct gggaacacac tcacgcttct ccgagttcac gggcttctct
     1741 ggcatgtcct tcagcagccg ctcctacctg cccgagaagc tgcagatcgt gaagccactc
     1801 gaaggttcag ccacgcttca ccactggcag caattggccc agcctcatct tgggggcatc
     1861 ctggaccccc gtcctggtgt ggtcaccaag ggcttccgga ctttggatgt tgacctggat
     1921 gaagtgtact gccttaacga ctttgaggaa gatgacacag gtgaccacat ttctctggcg
     1981 ggcctagcta cctccacgcc aattcagcac ccggagacct cagcgcacca ccctgggaag
     2041 tgcatgtcac agaccaactc aactttcacc tttaccactt gccgcatcct gcacccttca
     2101 gacgagctca ctcgggtcac gccaagcctt aactctgccc cagctccggc ttgtagcagt
     2161 accagccact tgaaatccac accagtggcc acgccatgca ccccccggag actgagcctg
     2221 gctgagtctt tcacaaatgt ccgtgagtcc acgacaacca tgagcacgtc cctggggctg
     2281 gtatggttgc tgaaggagcg aggcatctcg gcggccgtgt acgaccccca gagttgggac
     2341 agagccggca ggggctccct cctccactcc tacaccccta ggatggctgt gatcccgtcc
     2401 accccaccaa actcccctat gcagacacct tcggcctccc cgccctcctt cgagttcaag
     2461 tgcacgagcc ctccctacaa caacttcctg gcttccaagc cggccagctc tatcctgagg
     2521 gaggtgaggg aaaagaggcc cgtgcggagc agcgagagcc aaacagatgt gtctgtctcc
     2581 aacctcaacc ttgtggacaa agtcaggagg tttggggtgg ccagagtggt gaactcagga
     2641 cgtgcccgta tccccacctt gactgaggaa cagggacctc tcctctgtgg acccacaggg
     2701 ccagcacagg ctcttgtccc tgggggcctg gtccccgagg gcctgcctct ggggtgcccc
     2761 agtggcatcc gacggaatcg cagcttcccc actatggtcg ggtccagcgt gcagatgaga
     2821 gcccccgtga tcctcacctc gggcatcttg atgggtgcta agctccccaa acagactagc
     2881 ttgcggtgag gctggggatt gctgtcctgt ctgcttcctg cctcctgtcc ccgacagagc
     2941 actcacaccc ctgtctcctc tgaggtccac tccttctgag ttagagagat caattgtgtg
     3001 cctcttgggg ggagagtgga actccatatg gtgtgtatac aggacttggg gaccttgcat
     3061 ctgctctctc atccaatcca caggaagtaa taaccctaca aggtcacaat ctcgtgagga
     3121 tgtcacctga gctcatttgg gggaaggtgg cgtcctttct tccttacttt aaagaagcac
     3181 tgaaattccc aaggctgttc ttatcccatg gataggaatc tggtgaattc tgcataagac
     3241 tgtcagggtg cacacagagc cgccgtgtgg cacaggtctc ctcgctcacc tatgacagcc
     3301 gacacacagg gctgctcgcc atcggagagc tgtcctttca gttgtaggtg acccagcttc
     3361 atcaaggtct gcactatcct gccccaatgg actgtctgtt ctccagactt cttttcacgt
     3421 ctctgacttg aagttacctt gcattttgtc acaagctgtc agggttagag cctgacgcga
     3481 aaagaatgta tttacactct gatgcgcaat caggcggccc ctccgtgttc tgagtgattg
     3541 attttttctt tttttccttc ccatttctaa aatttttatt tgcagggaag tctcagtact
     3601 ggcagtttct cttggttctg acaccaaagt gcagacggca cacacgctaa ctctctaatg
     3661 acagagctta tttctgggac ccaatgtcac agccagggtg atgtatgacc agttctcact
     3721 gtaacaatag gatcatgggg aaggggacag gactgttaaa cctatacacg gtggagggga
     3781 agggccgaag tcacagcaca cctcagggca tcctgagcca aggtgtgtca agcgtgatgg
     3841 ctgctggccc cttttcactc tgaagggagc tcaggccaca tcgtagagct ctgtggtcct
     3901 cagtggctgc agtttttagt cccctcattt caaaactaga attaaatttc ctcctcatcc
     3961 cccaagtcca ttgtcccctc atcccatttc tgcccatagg aaaagatcag aggtgcttat
     4021 gagtggaaga agtgtgagca agtgagcgtg gcctgggcct gctgctgtca cctgtgcagt
     4081 tatgaatttt tatttattat ccatgtgtgc tgtattttaa tcagatgccg tctccgcttc
     4141 cagctcaagc ctctgtgtgt gtgtgtgtgt gtgtgtgaga gagagagaga gagagagaga
     4201 gaatccagcc caggtatatt atttatttac ttttgtctga ggatggctgt atgtctgtgt
     4261 gtcacatggt cacctgcccc agacatcggt ggaaggatag catcctgtgt acaagaaatt
     4321 gtcacatgaa caactccccc accctcagca aaagatgtgt ccttgaatgg aggcgggtca
     4381 ccttatgccc accaaggatg ctttgagaag gtccccaagc agccagcgtc agtcccacga
     4441 tttcaaacta tttattctcc aaacagagtg ctggttcatc acgttctctg ctctcctggc
     4501 tgctgcaaat acgtgcagtc acttacactt tatttgaatg tattttaaag cggtaggtag
     4561 aagaggaaag gagggtgaca actttggctt ggatggacca cgtcacgtgt tcagaggggc
     4621 ctccctcccg tccacactgg aagcgccagt gttaagaacc ggcactttag aggtggtgat
     4681 aggattgtta gcaaaccggt gatcaacatt aagcaacact accaaaaaaa tcgtgttgtg
     4741 atgcgtcagg atcagccaca agatttcatt cactaacgaa tatcaataaa acaagctcaa
     4801 agatggaaa
//
