LOCUS       NM_011634               2703 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus TRAF-interacting protein (Traip), transcript variant
            1, mRNA.
ACCESSION   NM_011634 XM_976945
VERSION     NM_011634.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2703)
  AUTHORS   Gu,Y. and Liang,C.
  TITLE     TRAIP suppressed apoptosis and cell cycle to promote prostate
            cancer proliferation via TRAF2-PI3K-AKT pathway activation
  JOURNAL   Int Urol Nephrol 56 (5), 1639-1648 (2024)
   PUBMED   38100027
  REMARK    GeneRIF: TRAIP suppressed apoptosis and cell cycle to promote
            prostate cancer proliferation via TRAF2-PI3K-AKT pathway
            activation.
REFERENCE   2  (bases 1 to 2703)
  AUTHORS   Yuan,Y.F., Ren,Y.X., Yuan,P., Yan,L.Y. and Qiao,J.
  TITLE     TRAIP is involved in chromosome alignment and SAC regulation in
            mouse oocyte meiosis
  JOURNAL   Sci Rep 6, 29735 (2016)
   PUBMED   27405720
  REMARK    GeneRIF: Taken together, these data indicate that TRAIP plays
            important roles in oocyte meiosis regulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2703)
  AUTHORS   Zhang,M., Wang,L., Zhao,X., Zhao,K., Meng,H., Zhao,W. and Gao,C.
  TITLE     TRAF-interacting protein (TRIP) negatively regulates IFN-beta
            production and antiviral response by promoting proteasomal
            degradation of TANK-binding kinase 1
  JOURNAL   J Exp Med 209 (10), 1703-1711 (2012)
   PUBMED   22945920
  REMARK    GeneRIF: TRIP as a negative regulator in TLR3/4- and
            RIG-I-triggered antiviral responses and suggested TRIP as a
            potential target for the intervention of diseases with uncontrolled
            IFN-beta production.
REFERENCE   4  (bases 1 to 2703)
  AUTHORS   Park,E.S., Choi,S., Kim,J.M., Jeong,Y., Choe,J., Park,C.S., Choi,Y.
            and Rho,J.
  TITLE     Early embryonic lethality caused by targeted disruption of the
            TRAF-interacting protein (TRIP) gene
  JOURNAL   Biochem Biophys Res Commun 363 (4), 971-977 (2007)
   PUBMED   17927961
  REMARK    GeneRIF: TRIP is an essential factor during early mouse embryonic
            development in vivo
REFERENCE   5  (bases 1 to 2703)
  AUTHORS   Besse,A., Campos,A.D., Webster,W.K. and Darnay,B.G.
  TITLE     TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin
            ligase
  JOURNAL   Biochem Biophys Res Commun 359 (3), 660-664 (2007)
   PUBMED   17544371
REFERENCE   6  (bases 1 to 2703)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2703)
  AUTHORS   Persons,D.A., Paulson,R.F., Loyd,M.R., Herley,M.T., Bodner,S.M.,
            Bernstein,A., Correll,P.H. and Ney,P.A.
  TITLE     Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
  JOURNAL   Nat Genet 23 (2), 159-165 (1999)
   PUBMED   10508511
REFERENCE   8  (bases 1 to 2703)
  AUTHORS   Lee,S.Y., Lee,S.Y. and Choi,Y.
  TITLE     TRAF-interacting protein (TRIP): a novel component of the tumor
            necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes
            that inhibits TRAF2-mediated NF-kappaB activation
  JOURNAL   J Exp Med 185 (7), 1275-1285 (1997)
   PUBMED   9104814
REFERENCE   9  (bases 1 to 2703)
  AUTHORS   Logue,S.F., Paylor,R. and Wehner,J.M.
  TITLE     Hippocampal lesions cause learning deficits in inbred mice in the
            Morris water maze and conditioned-fear task
  JOURNAL   Behav Neurosci 111 (1), 104-113 (1997)
   PUBMED   9109628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731808.26.
            
            On Aug 8, 2022 this sequence version replaced NM_011634.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012948.1, AK012786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL731808.26        54516-54729
            215-272             AL731808.26        59422-59479
            273-356             AL731808.26        59903-59986
            357-396             AL731808.26        62373-62412
            397-524             AL731808.26        62996-63123
            525-619             AL731808.26        64535-64629
            620-733             AL731808.26        65099-65212
            734-821             AL731808.26        65811-65898
            822-911             AL731808.26        66388-66477
            912-1000            AL731808.26        66886-66974
            1001-1156           AL731808.26        72151-72306
            1157-1205           AL731808.26        73561-73609
            1206-1355           AL731808.26        74026-74175
            1356-1406           AL731808.26        74265-74315
            1407-2703           AL731808.26        74531-75827
FEATURES             Location/Qualifiers
     source          1..2703
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..2703
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /note="TRAF-interacting protein"
                     /db_xref="GeneID:22036"
                     /db_xref="MGI:MGI:1096377"
     exon            1..214
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1529
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase TRAIP; RING-type E3 ubiquitin
                     transferase TRAIP"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRAIP isoform 1"
                     /protein_id="NP_035764.2"
                     /db_xref="CCDS:CCDS23511.1"
                     /db_xref="GeneID:22036"
                     /db_xref="MGI:MGI:1096377"
                     /translation="MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSR
                     TCPQCRIQVGKKTIINKLFFDLAQEEENVLDAEFLKNELDSVKAQLSQKDREKRDSQA
                     IIDTLRDTLEERNATVESLQNALNKAEMLCSTLKKQMKFLEQRQDETKQAREEAHRLK
                     CKMKTMEQIELLLQSQRSEVEEMIRDMGVGQSAVEQLAVYCVSLKKEYENLKEARKAT
                     GELADRLKKDLVSSRSKLKTLNTELDQAKLELRSAQKDLQSADQEITSLRKKLMILQG
                     TLSLPPATNETVSRLVFESPAPVEMMNPRLHQPPFGDEIDLNTTFDVNTPPTQTSGSQ
                     HCLPKKLCLERARSPMQNVLKKVHKVSKPESQLSLGGQRCVGELDEELAGAFPLFIRN
                     AVLGQKQPNRTTAESRCSTDVVRIGFDGLGGRTKFIQPRDTTIIRPVPVKSKAKSKQK
                     VRIKTVSSASQPKLDTFLCQ"
     exon            215..272
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            273..356
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            357..396
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            397..524
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            525..619
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            620..733
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            734..821
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            822..911
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1000
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1156
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1205
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1355
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1406
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..2703
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /note="hexamer: AATAAA"
     polyA_site      1963
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /note="major polyA site"
     regulatory      2683..2688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traip"
                     /gene_synonym="Trip"
                     /note="hexamer: AATAAA"
     polyA_site      2703
                     /gene="Traip"
                     /gene_synonym="Trip"
ORIGIN      
        1 accggaagtc gtgcggtgga gcgaaatttg aaggaaccgg agcggtggcc ggttcggcca
       61 ccaaactgtg tctgtcgctg gcagctggtt ccctgggctg cttgagtcga gccatcatgc
      121 ctatccgcgc tctgtgcact atctgctccg acttcttcga tcactcccgt gacgtggctg
      181 ccatccactg tggccacact tttcatctgc aatgcctaat ccagtggttt gagacagcac
      241 caagtcggac ctgcccacag tgtagaatcc aggttggcaa aaagactatt ataaacaaac
      301 ttttctttga cctcgcccag gaagaggaga atgtcttgga tgcagaattc ttaaagaatg
      361 aactggacag cgtcaaagct cagctttccc agaaagacag ggagaaacgg gacagccagg
      421 ccattatcga cactctacgg gacaccctgg aagaacgcaa tgctaccgtg gagtccctac
      481 agaacgcctt aaacaaggca gagatgctgt gttccaccct gaaaaaacag atgaagttcc
      541 tggagcagcg gcaggatgag accaaacaag ctcgggagga ggcccaccga ctcaagtgca
      601 agatgaaaac catggagcaa attgagctcc tactccagag ccagcggtct gaggtggagg
      661 agatgattcg agacatgggt gtgggacagt cagcggtgga gcagctggct gtgtactgcg
      721 tgtccctcaa gaaagagtat gagaatctga aggaagctcg gaaggccaca ggggaactgg
      781 ctgacaggtt gaagaaggat ttggtgtcct ctaggagcaa gttgaagact ctcaacactg
      841 agctggatca ggccaagtta gaactgaggt cagcccagaa ggacttacaa agtgctgacc
      901 aggagatcac gagcctaaga aagaagctga tgatcctcca gggaaccttg agcctgcctc
      961 cggcgaccaa tgagacggtc agccgcctgg tttttgagag cccagcccct gtggagatga
     1021 tgaacccgag gcttcaccag ccacccttcg gtgatgagat tgatctcaat accacctttg
     1081 atgtaaatac ccctccaacc cagacctctg gctcccagca ttgcctcccc aagaagctgt
     1141 gcctggagag ggcacgctct cccatgcaga atgtcctcaa gaaggtgcac aaagtctcca
     1201 agccggagtc ccagctctca ctgggtggcc agcgatgtgt aggagagcta gatgaggaac
     1261 tggctggtgc cttccctctc ttcatccgga atgctgtcct gggtcagaaa cagcccaaca
     1321 ggaccacagc agaatcccgt tgcagcacag atgtggtaag aataggcttt gatgggcttg
     1381 gaggacgaac aaaattcatc cagcctaggg acacaaccat tatccgacca gtgcctgtta
     1441 agtccaaggc caagagtaaa cagaaagtga gaataaagac tgtgagttct gcctcccagc
     1501 ccaagctgga taccttctta tgtcagtgaa cggtgaccag agtcatgttt gcaattagtg
     1561 ggccaagacc tggctaaccg gaagtgtttt tggaagatgg ctcctcttgg accagtccaa
     1621 gagagatgcc cagaaaacac acttcctgtg ttcactgcgc cctgcaccac actgggaagc
     1681 cacatgacca gtttactgtt ccgatcagca gggcctactt ccagttgcag ggttttgctt
     1741 atagctacaa ccaggtgtgg ctggactcct tttgttttta tagaacaggg tcacattgac
     1801 tctaagtgga tgggagtgct ggaggatcct atgcaggctg gaggaccctg cgcttgaact
     1861 cctgcctgcc tccagcttat tgcttgaaat tatggggtga ggtggtgata gggaaaggtt
     1921 ggggaagttt tctgtgtaaa ataaaaaggc atcttttctt ctaggctctg gctgtataaa
     1981 tttgtaccaa aaccttagaa aatttctagg cttagaccta gtattttaag tctaggcatg
     2041 gcattggctc tctcccaggg cacaggaaga ctagcaagaa tggcagccct gcagtccaaa
     2101 ctgtaaacaa agcaggtggg tgagcccagt gagttccagc aagcacaaca gataactact
     2161 gaccaactgt tagcctctag ggcttgggtt caggactttc accaagagaa tttccctatt
     2221 ggccacttgc ctgagtcaga tggcctaagc cactcctgtt attgaacagg agctcactgg
     2281 cttccctctc acaccgcgtg cctcgtgctg aagacaatcc aaccacttgc caggaaatgg
     2341 gaggagcctg aggctgtctg gatggagatg atagccttct ttaagtgatg cttagctttg
     2401 attggcaact cagcatgatc tagagtcacg tggaaagggc ctctccttga gatctagatt
     2461 agcttggcct gtgggcatgt ctgtggaggg ttatcttgat tgtgcctact ataagttggc
     2521 accattcctc ccctaggcgg aggatcctgg gctgtttaaa gagcaaacaa agagctgagc
     2581 acaagaacac atgcactatg tctgctcctg agcgctactc actgctccac cctctgccta
     2641 gacttccctg caatgaacct gtaacctgaa tcttgaagct aaaataaaaa ctttctcccc
     2701 taa
//
