LOCUS       NM_001415151            2641 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus TNF receptor-associated factor 7 (Traf7), transcript
            variant 3, mRNA.
ACCESSION   NM_001415151
VERSION     NM_001415151.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2641)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Paterno,R.,
            Sherry,D.M., Johnson,A.C. and Dunn,I.F.
  TITLE     Spontaneous mutation in 2310061I04Rik results in reduced expression
            of mitochondrial genes and impaired brain myelination
  JOURNAL   PLoS One 19 (12), e0290487 (2024)
   PUBMED   39631040
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2641)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2641)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Kinter,M.,
            Selland,L., Garman,L., Griffin,C. and Dunn,I.F.
  TITLE     TRAF7 is an essential regulator of blood vessel integrity during
            mouse embryonic and neonatal development
  JOURNAL   iScience 26 (8), 107474 (2023)
   PUBMED   37583551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2641)
  AUTHORS   Zotti,T., Vito,P. and Stilo,R.
  TITLE     The seventh ring: exploring TRAF7 functions
  JOURNAL   J Cell Physiol 227 (3), 1280-1284 (2012)
   PUBMED   22105767
  REMARK    GeneRIF: TRAF7 is involved in signal transduction pathways that
            lead either to activation or repression of NF-kappaB transcription
            factor.
            Review article
REFERENCE   5  (bases 1 to 2641)
  AUTHORS   Tsikitis,M., Acosta-Alvear,D., Blais,A., Campos,E.I., Lane,W.S.,
            Sanchez,I. and Dynlacht,B.D.
  TITLE     Traf7, a MyoD1 transcriptional target, regulates nuclear
            factor-kappaB activity during myogenesis
  JOURNAL   EMBO Rep 11 (12), 969-976 (2010)
   PUBMED   20948544
  REMARK    GeneRIF: These results suggest a new mechanism by which MyoD1
            function is coupled to NF-kappaB activity through Traf7, regulating
            the balance between cell cycle progression and differentiation
            during myogenesis.
REFERENCE   6  (bases 1 to 2641)
  AUTHORS   Morita,Y., Kanei-Ishii,C., Nomura,T. and Ishii,S.
  TITLE     TRAF7 sequesters c-Myb to the cytoplasm by stimulating its
            sumoylation
  JOURNAL   Mol Biol Cell 16 (11), 5433-5444 (2005)
   PUBMED   16162816
  REMARK    GeneRIF: TRAF7 negatively regulates c-Myb activity by sequestering
            c-Myb to the cytosol via sumoylation.
REFERENCE   7  (bases 1 to 2641)
  AUTHORS   Xu,L.G., Li,L.Y. and Shu,H.B.
  TITLE     TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
            apoptosis
  JOURNAL   J Biol Chem 279 (17), 17278-17282 (2004)
   PUBMED   15001576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132367.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.208117.1,
                                           SRR7345562.3117923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC132367.3         116624-116719
            97-212              AC132367.3         125239-125354
            213-270             AC132367.3         125686-125743
            271-365             AC132367.3         127886-127980
            366-482             AC132367.3         129656-129772
            483-575             AC132367.3         130268-130360
            576-609             AC132367.3         130553-130586
            610-793             AC132367.3         131109-131292
            794-928             AC132367.3         131401-131535
            929-1146            AC132367.3         132099-132316
            1147-1220           AC132367.3         132399-132472
            1221-1269           AC132367.3         132661-132709
            1270-1397           AC132367.3         132786-132913
            1398-1480           AC132367.3         133088-133170
            1481-1520           AC132367.3         133787-133826
            1521-1637           AC132367.3         133913-134029
            1638-1760           AC132367.3         134114-134236
            1761-1880           AC132367.3         134410-134529
            1881-2012           AC132367.3         134618-134749
            2013-2132           AC132367.3         134834-134953
            2133-2641           AC132367.3         135127-135635
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.4 cM"
     gene            1..2641
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /note="TNF receptor-associated factor 7"
                     /db_xref="GeneID:224619"
                     /db_xref="MGI:MGI:3042141"
     exon            1..96
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..212
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2147
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3; ring
                     finger and WD repeat domain 1; E3 ubiquitin-protein ligase
                     TRAF7; RING-type E3 ubiquitin transferase TRAF7"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRAF7 isoform 3"
                     /protein_id="NP_001402080.1"
                     /db_xref="GeneID:224619"
                     /db_xref="MGI:MGI:3042141"
                     /translation="MSSAKSARYDRFSGGPANLPSSDSSGTRMETTFGPTFSTVTTIT
                     KAADGTGTYKQHRRTPSSSSTLAYSPRDEEDGMPPINTPRRSDSAISVRSLHSESSMS
                     LRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEK
                     CPVDNAKLTVVVNNIAVAEQIGELFIHCRHGCHAAGTGKPGVFEVDPRGCPFTIKLSA
                     RKDHESSCDYRPVRCPNNPSCPPLLKMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYE
                     THLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLE
                     LKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTF
                     VGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGC
                     KLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGT
                     ELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIA
                     VTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRS
                     LRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC"
     exon            213..270
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..365
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..482
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..575
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..609
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..793
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..928
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1146
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1220
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1269
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1397
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1480
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1520
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1637
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1760
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1880
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2012
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2132
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2641
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /note="hexamer: AATAAA"
     polyA_site      2641
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /note="major polyA site"
ORIGIN      
        1 cggctcctgt atcctgaaac ctttcccggc cgcgggccga gaggggcaag atgatgccgg
       61 tgggtgaagt cgctgctcct aggcagccgc gggcggggga cactgcccaa ggaacctgga
      121 ttcctctcta gagcatgagc tcagccaaga gtgcccgcta cgaccgcttc tccgggggac
      181 ctgccaacct cccctcctca gacagcagtg ggaccaggat ggaaacaacc tttgggccta
      241 ccttttcgac cgtcactacc atcaccaaag cagctgatgg gactggcaca tacaaacagc
      301 atcgcaggac accttcctcc tctagcaccc ttgcctattc gccacgggat gaggaggacg
      361 gcatgccccc catcaacact cctcgccgct ctgactcagc catctctgtc cgttccctac
      421 actccgagtc cagcatgtcc ctgcgctcca cgttctcgct gcctgaggag gaggaggagc
      481 cggagccgtt ggtatttgcc gagcagccct cggtaaagct gtgttgccag ctgtgctgca
      541 gtgtgttcaa ggaccctgtg atcactacat gtgggcacac cttctgcaga cgatgcgcct
      601 tgaagtcaga gaagtgtcct gtggacaatg ccaagctgac agtagtggtg aacaacattg
      661 cagtcgctga gcagattgga gagctcttca tacattgtcg gcatggctgc cacgcagcgg
      721 gcactggaaa gcctggggtc tttgaggtag acccgagggg ctgccccttc accatcaagc
      781 ttagtgcccg gaaggaccac gagagtagtt gtgactacag gcctgtgcgc tgccccaaca
      841 accccagctg cccacccctt ctcaagatga atctcgaggc ccacctgaaa gaatgcgagc
      901 acatcaagtg tccccactct aagtacgggt gcacatttat tgggaatcag gacacctatg
      961 agacacactt agaaacatgc cgcttcgagg gcctgaagga gttcctgcag cagaccgatg
     1021 accgcttcca cgagatgcat gtggcactgg cccaaaagga ccaggagatt gccttcctgc
     1081 gttccatgct gggcaaactc tcagagaaga ttgaccagct agagaagagc cttgagctta
     1141 agtttgacgt actggatgag aaccagagca agctcagcga ggacctcatg gagttccgga
     1201 gggacgcgtc catgctgaat gatgagctgt ctcacatcaa tgcacggctg aacatgggta
     1261 tccttggatc ctatgaccct cagcagatct tcaagtgcaa agggaccttt gtgggacacc
     1321 agggccctgt ctggtgtctc tgtgtctatt ccatgggtga cctgctcttc agtggctctt
     1381 ctgacaagac aatcaaggta tgggacactt gtaccactta caagtgccaa aagacactgg
     1441 aaggtcatga tggtattgtg ctggcgctct gtatccaggg gtgcaaactg tacagtgggt
     1501 ctgcagactg caccatcatt gtgtgggaca tccagaacct acagaaggtg aatactatcc
     1561 gggcccacga caaccctgta tgcacactgg tgtcttccca caacatgctc ttcagtggct
     1621 ccctgaaagc catcaaggtt tgggacatcg tgggcactga gctaaagttg aagaaagaac
     1681 tcacaggcct caaccactgg gtgcgggccc tggtggcagc acagagctat ctgtacagtg
     1741 gctcttacca gacaatcaag atctgggaca ttcggaccct tgactgcatc catgtcctgc
     1801 agacatctgg tggcagtgtg tattccattg ctgtgacgaa tcaccacatt gtctgtggca
     1861 cctatgagaa cctcattcat gtgtgggaca ttgaatccaa agagcaggtt cggaccctca
     1921 caggtcacgt gggcacagtg tatgccctgg cagtcatttc aacaccagac cagaccaaag
     1981 tcttcagtgc atcctatgac cggtccctca gggtctggag tatggacaac atgatctgca
     2041 cacagactct gctgcgccat cagggcagtg taactgcact ggctgtttcc cggggccggc
     2101 tcttctcagg ggctgtggat agcaccgtga aggtctggac atgctaacag aatccaggcc
     2161 aggcttggct ccctctgggt ctgtaagtca ggctggacct ccattggaat gtctgcctgt
     2221 ctgtggagac aggtagacag gctcagctag gcagtgtcct ctctgcctat acttggcgag
     2281 ggatctttcc aaaggccccg ctgttacttg taccagagaa acacccaggc cctcctctgg
     2341 gcaccaggtc tgatgcttgc ccagccccac cgttcatatc actccataga ctcttgttct
     2401 gagacagggt ctcactatgt agctctggct ggcctggaac tcgctatgtc aaccaggctg
     2461 acctccaact cacagatctg cctgcctcca cctcccaagt gctgggagta aaggcccgca
     2521 ccgccgctcc tggcaggacc cagatgaccc aggggtcctt tttactcacc ttttctactg
     2581 gttttagact gtatatagat tttattactt tcctgttgaa ataaaagctg cacagactgt
     2641 g
//
